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Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

Monnard, Fabien W. and Heinisch, Tillmann and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2011) Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chemical Communications, 47 (29). pp. 8238-8240.

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Official URL: http://edoc.unibas.ch/dok/A6001511

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Abstract

d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η(6)-C(6)Me(6))Ru(bispy 3)Cl](+)⊂ hCA II highlights the nature of the host-guest interactions.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Schirmer)
UniBasel Contributors:Ward, Thomas R. R. and Monnard, Fabien and Nogueira, Elisa S. and Schirmer, Tilman and Heinisch, Tillmann
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:0022-4936
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Dec 2016 07:44
Deposited On:11 Oct 2012 15:18

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