Köhler, Valentin and Mao, Jincheng and Heinisch, Tillmann and Pordea, Anca and Sardo, Alessia and Wilson, Yvonne and Knörr, Livia and Creus, Marc and Prost, Jean-Christophe and Schirmer, Tilman and Ward, Thomas R.. (2011) OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins. Angewandte Chemie International Edition, 50 (46). pp. 10863-10866.
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Official URL: http://edoc.unibas.ch/dok/A6002020
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Abstract
Taking control: Selective catalysts for olefin dihydroxylation have been generated by the combination of apo-streptavidin and OsO4. Site-directed mutagenesis allows improvement of enantioselectivity and even inversion of enantiopreference in certain cases. Notably allyl phenyl sulfide and cis-β-methylstyrene were converted with unprecedented enantiomeric excess.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schirmer) |
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| UniBasel Contributors: | Ward, Thomas R. R. and Köhler, Valentin and Heinisch, Tillmann and Sardo, Alessia and Wilson, Yvonne Martha and Knörr, Livia and Schirmer, Tilman and Creus, Marc |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 05 Sep 2023 13:06 |
| Deposited On: | 08 Nov 2012 16:10 |
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