Structural basis of the allosteric behaviour of phosphofructokinase

Schirmer, T. and Evans, P. R.. (1990) Structural basis of the allosteric behaviour of phosphofructokinase. Nature, Vol. 343. pp. 140-145.

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Official URL: http://edoc.unibas.ch/dok/A5258293

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Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schirmer)
UniBasel Contributors:Schirmer, Tilman
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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