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2023

Alter, Claudio L. and Detampel, Pascal and Schefer, Roman B. and Lotter, Claudia and Hauswirth, Patrick and Puligilla, Ramya D. and Weibel, Vera J. and Schenk, Susanne H. and Heusermann, Wolf and Schürz, Melanie and Meisner-Kober, Nicole and Palivan, Cornelia and Einfalt, Tomaž and Huwyler, Jörg. (2023) High efficiency preparation of monodisperse plasma membrane derived extracellular vesicles for therapeutic applications. Communications biology, 6 (1). p. 478.

2022

Lotter, Claudia and Alter, Claudio Luca and Bolten, Jan Stephan and Detampel, Pascal and Palivan, Cornelia G. and Einfalt, Tomaž and Huwyler, Jörg. (2022) Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 172. pp. 134-143.

Lötscher, Jonas and Marti Lindez, Adria-Arnau and Kirchhammer, Nicole and Cribioli, Elisabetta and Giordano, Greta and Trefny, Marcel P. and Lenz, Markus and Rothschild, Sacha I. and Strati, Paolo and Künzli, Marco and Lotter, Claudia and Schenk, Susanne H. and Dehio, Philippe and Löliger, Jordan and Litzler, Ludivine and Schreiner, David and Koch, Victoria and Page, Nicolas and Lee, Dahye and Grählert, Jasmin and Kuzmin, Dmitry and Burgener, Anne-Valérie and Merkler, Doron and Pless, Miklos and Balmer, Maria L. and Reith, Walter and Huwyler, Jörg and Irving, Melita and King, Carolyn G. and Zippelius, Alfred and Hess, Christoph. (2022) Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell, 185. pp. 1-18.

Migga, Alexandra and Schulz, Georg and Rodgers, Griffin and Osterwalder, Melissa and Tanner, Christine and Blank, Holger and Jerjen, Iwan and Salmon, Phil and Twengström, William and Scheel, Mario and Weitkamp, Timm and Schlepütz, Christian M. and Bolten, Jan S. and Huwyler, Jörg and Hotz, Gerhard and Madduri, Srinivas and Müller, Bert. (2022) Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve. Journal of medical imaging, 9 (3). 031507-031501.

Batista, João V. C. and Uecker, Annekathrin and Holandino, Carla and Boylan, Fabio and Maier, Jakob and Huwyler, Jörg and Baumgartner, Stephan. (2022) A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds. Frontiers in Pharmacology, 13. p. 895838.

2021

Sanad, Mahmoud Tarek and Alter, Claudio and Detampel, Pascal and Einfalt, Tomaz and Huwyler, Jörg. (2021) Manufacturing of Liposomes: A Direct Comparison of Extrusion and Microfluidics Protocols. Washington.

Wagner-Hattler, Leonie and Kiene, Klara and Bielicki, Julia and Pfister, Marc and Puchkov, Maxim and Huwyler, Jörg. (2021) High Acceptability of an Orally Dispersible Tablet Formulation by Children. Children, 8 (3). p. 194.

Einfalt, Tomaz and Detampel, Pascal and Häussinger, Daniel and Casper, Jens and Meier, Christoph and Puchkov, Maxim and Huwyler, Jörg. (2021) Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form. ChemRxiv Preprint.

Jere, Dhananjay and Sediq, Ahmad S. and Huwyler, Jörg and Vollrath, Ilona and Kardorff, Markus and Mahler, Hanns-Christian. (2021) Challenges for cell-based medicinal products from a pharmaceutical product perspective. Journal of Pharmaceutical Sciences, 110 (5). pp. 1900-1908.

Osterwalder, Melissa and Bolten, Jan Stephan and Rodgers, Griffin and Schulz, Georg and Tanner, Christine and Cörek, Emre and Huwyler, Jörg and Müller, Bert. (2021) Three-dimensional X-ray microscopy of zebra sh larvae. Bioinspiration, Biomimetics, and Bioreplication XI, 11586. 115860J.

Witzigmann, Dominik and Grossen, Philip and Quintavalle, Cristina and Lanzafame, Manuela and Schenk, Susanne H. and Tran, Xue-Ting and Englinger, Bernhard and Hauswirth, Patrick and Grünig, David and van Schoonhoven, Sushilla and Krähenbühl, Stephan and Terracciano, Luigi M. and Berger, Walter and Piscuoglio, Salvatore and Quagliata, Luca and Rommelaere, Jean and Nüesch, Jürg P. F. and Huwyler, Jörg. (2021) Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma. Journal of Controlled Release, 334. pp. 138-152.

Schuster, Joachim and Mahler, Hanns-Christian and Joerg, Susanne and Kamuju, Vinay and Huwyler, Joerg and Mathaes, Roman. (2021) Stability of Monoclonal Antibodies after Simulated Subcutaneous Administration. Journal of Pharmaceutical Sciences, 110 (6). pp. 2386-2394.

Schreiner, Viktoria and Detampel, Pascal and Jirkof, Paulin and Puchkov, Maxim and Huwyler, Jörg. (2021) Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation. Journal of Drug Delivery Science and Technology, 63. p. 102558.

Preisig, Daniel and Varum, Felipe and Bravo, Roberto and Hartig, Claudia and Spleiss, Johannes and Abbes, Sonia and Caobelli, Federico and Wild, Damian and Puchkov, Maxim and Huwyler, Jörg and Haschke, Manuel. (2021) Colonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: a clinical pharmacoscintigraphy study. European Journal of Pharmaceutics and Biopharmaceutics, 165. pp. 22-30.

Bachmann, Fabio and Duthaler, Urs and Meyer Zu Schwabedissen, Henriette E. and Puchkov, Maxim and Huwyler, Jörg and Haschke, Manuel and Krähenbühl, Stephan. (2021) Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clinical Pharmacology and Therapeutics, 109 (6). pp. 1505-1516.

2020

Schuster, Joachim and Mahler, Hanns-Christian and Koulov, Atanas and Joerg, Susanne and Racher, Andy and Huwyler, Joerg and Detampel, Pascal and Mathaes, Roman. (2020) Tracking the physical stability of fluorescent-labeled mAbs under physiologic invitro conditions in human serum and PBS. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 152. pp. 193-201.

Schmidt, Ariane and Koulov, Atanas and Huwyler, Joerg and Mahler, Hanns-Christian and Jahn, Michael. (2020) Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation. Journal of Pharmaceutical Sciences, 109 (6). pp. 1924-1932.

Schuster, Joachim and Koulov, Atanas and Mahler, Hanns-Christian and Joerg, Susanne and Huwyler, Joerg and Schleicher, Kai and Detampel, Pascal and Mathaes, Roman. (2020) Particle Analysis of Biotherapeutics in Human Serum Using Machine Learning. Journal of Pharmaceutical Sciences, 109 (5). pp. 1827-1832.

Dreckmann, Tim and Ludwig, Imke-Sonja and Boeuf, Julien and Lümkemann, Jörg and Huwyler, Jörg. (2020) Low Volume Aseptic Filling: Impact of Pump Systems on Shear Stress. European Journal of Pharmaceutics and Biopharmaceutics, 147. pp. 10-18.

Wagner-Hattler , Leonie and Québatte, Gabriela and Keiser, Jennifer and Schoelkopf, Joachim and Schleputz, Christian M. and Huwyler, Jörg and Puchkov, Maxim. (2020) Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. International Journal of Pharmaceutics, 573. p. 118827.

Häuser, Christina and Goldbach, Pierre and Huwyler, Jörg and Friess, Wolfgang and Allmendinger, Andrea. (2020) Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations. Journal of Pharmaceutical Sciences, 109 (1). pp. 807-817.

Suenderhauf, Claudia and Berger, Benjamin and Puchkov, Maxim and Schmid, Yasmin and Müller, Sabine and Huwyler, Jörg and Haschke, Manuel and Krähenbühl, Stephan and Duthaler, Urs. (2020) Pharmacokinetics and phenotyping properties of the "Basel" phenotyping cocktail combination capsule in healthy male adults. British journal of clinical pharmacology, 86 (2). pp. 352-361.

Schittny, Andreas and Huwyler, Jörg and Puchkov, Maxim. (2020) Mechanisms of increased bioavailability through amorphous solid dispersions: a review. Drug delivery, 27 (1). pp. 110-127.

Vollrath, Ilona and Mathaes, Roman and Sediq, Ahmad S. and Jere, Dhananjay and Jörg, Susanne and Huwyler, Jörg and Mahler, Hanns-Christian. (2020) Subvisible Particulate Contamination in Cell Therapy Products-Can We Distinguish? Journal of pharmaceutical sciences, 109 (1). pp. 216-219.

Schuster, Joachim and Koulov, Atanas and Mahler, Hanns-Christian and Detampel, Pascal and Huwyler, Joerg and Singh, Satish and Mathaes, Roman. (2020) In Vivo Stability of Therapeutic Proteins. Pharmaceutical research, 37 (2). p. 23.

Einfalt, Tomaz and Garni, Martina and Witzigmann, Dominik and Sieber, Sandro and Baltisberger, Niklaus and Huwyler, Jörg and Meier, Wolfgang and Palivan, Cornelia. (2020) Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics. Advanced Science, 7 (4). p. 1901923.

Schittny, Andreas and Philipp-Bauer, Selina and Detampel, Pascal and Huwyler, Jörg and Puchkov, Maxim. (2020) Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions. Journal of Controlled Release, 320. pp. 214-225.

Sedighi, Mahsa and Rahimi, Fereshteh and Shahbazi, Mohammad-Ali and Rezayan, Ali Hossein and Kettiger, Helene and Einfalt, Tomaz and Huwyler, Jörg and Witzigmann, Dominik. (2020) Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles. ACS Applied Bio Materials, 3 (1). pp. 239-251.

Liu, Juan and Craciun, Ioana and Belluati, Andrea and Wu, Dalin and Sieber, Sandro and Einfalt, Tomaz and Witzigmann, Dominik and Chami, Mohamed and Huwyler, Jörg and Palivan, Cornelia G.. (2020) DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo. Nanoscale, 12 (17). pp. 9786-9799.

Cörek, Emre and Rodgers, Griffin and Siegrist, Stefan and Einfalt, Tomaz and Detampel, Pascal and Schlepütz, Christian M. and Sieber, Sandro and Fluder, Pascal and Schulz, Georg and Unterweger, Harald and Alexiou, Christoph and Müller, Bert and Puchkov, Maxim and Huwyler, Jörg. (2020) Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution. Small , 16 (31). p. 2000746.

Yokoyama, Reiji and Kimura, Go and Huwyler, Jörg and Hosoya, Ken-ichi and Puchkov, Maxim. (2020) Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets. Pharmaceutics, 12 (6). p. 495.

Farzan, Maryam and Québatte, Gabriela and Strittmatter, Katrin and Hilty, Florentine Marianne and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2020) Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery. Pharmaceutics, 12 (8). p. 777.

Buck, Jonas and Mueller, Dennis and Mettal, Ute and Ackermann, Miriam and Grisch-Chan, Hiu Man and Thöny, Beat and Zumbuehl, Andreas and Huwyler, Jörg and Witzigmann, Dominik. (2020) Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids. ACS Omega, 5 (38). pp. 24724-24732.

Schreiner, Viktoria and Durst, Mattea and Arras, Margarete and Detampel, Pascal and Jirkof, Paulin and Huwyler, Jörg. (2020) Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use. Scientific Reports, 10. p. 17295.

Ehrsam, Daniel and Sieber, Sandro and Oufir, Mouhssin and Porta, Fabiola and Hamburger, Matthias and Huwyler, Jörg and Meyer zu Schwabedissen, Henriette E.. (2020) Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9. Bioconjugate Chemistry, 31 (3). pp. 781-793.

Dreckmann, Tim and Aipperspach, Wolfgang and Pfleghar, Kevin and Tröndle, Julien and Ernst, Andreas and Huwyler, Joerg and Ludwig, Imke-Sonja and Luemkemann, Joerg. (2020) Assessment of Sensor Concepts for 100% In-Process Control of Low-Volume Aseptic Fill-Finish Processes. PDA Journal of Pharmaceutical Science and Technology, 74 (6). pp. 660-673.

Osterwalder, Melissa and Bolten, Jan Stephan and Rodgers, Griffin and Humbel, Mattia and Schulz, Georg and Tanner, Christine and Huwyler, Jörg and Müller, Bert. (2020) Hard X-ray microtomography of Zebrafish larvae. Spiedigitallibrary, Conference Proceedings of SPIE, 11886. p. 118864.

Matter, Madlaina and Mühlebach, Stefan and Puchkov, Maxim and Huwyler, Jörg. (2020) Missbrauch von Opioiden und mögliche Auswege aus der Opioid-Krise. Therapeutische Umschau, 77 (1). pp. 24-28.

2019

Sedighi, Mahsa and Sieber, Sandro and Rahimi, Fereshteh and Shahbazi, Mohammad-Ali and Rezayan, Ali Hossein and Huwyler, Jörg and Witzigmann, Dominik. (2019) Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach. Drug delivery and translational research, 9 (1). pp. 404-413.

Neodo, Anna and Schulz, Jessica D. and Huwyler, Jörg and Keiser, Jennifer. (2019) In vitro and In vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine. Antimicrobial agents and chemotherapy, 63 (1). e00762-18.

Farzan, Maryam and Roth, Roger and Québatte, Gabriela and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2019) Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry. Pharmaceutics, 11 (1). pp. 32- .

Sieber, Sandro and Grossen, Philip and Uhl, Philipp and Detampel, Pascal and Mier, Walter and Witzigmann, Dominik and Huwyler, Jörg. (2019) Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo. Nanomedicine: nanotechnology, biology and medicine, 17. pp. 82-93.

Sieber, Sandro and Grossen, Philip and Bussmann, Jeroen and Campbell, Frederick and Kros, Alexander and Witzigmann, Dominik and Huwyler, Jörg. (2019) Zebrafish as a preclinical in vivo screening model for nanomedicines. Advanced drug delivery reviews (151-152). pp. 152-168.

Buck, Jonas and Grossen, Philip and Cullis, Pieter R. and Huwyler, Jörg and Witzigmann, Dominik. (2019) Lipid-Based DNA Therapeutics - Hallmarks of Non-Viral Gene Delivery. ACS Nano, 13 (4). pp. 3754-3782.

Meister, Isabel and Assawasuwannakit, Piyanan and Vanobberghen, Fiona and Penny, Melissa A. and Odermatt, Peter and Sayasone, Somphou and Huwyler, Jörg and Tarning, Joel and Keiser, Jennifer. (2019) Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrobial Agents and Chemotherapy, 63 (4). e01391-18.

Kiene, Klara and Hayasi, Noriyuki and Burhenne, Jürgen and Uchitomi, Ryo and Sünderhauf, Claudia and Schmid, Yasmin and Haschke, Manuel and Haefeli, Walter Emil and Krähenbühl, Stephan and Mikus, Gerd and Inada, Hirohiko and Huwyler, Jörg. (2019) Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film. European Journal of Pharmaceutical Sciences, 135. pp. 77-82.

Witzigmann, Dominik and Uhl, Philipp and Sieber, Sandro and Kaufman, Christina and Einfalt, Tomaz and Schöneweis, Katrin and Grossen, Philip and Buck, Jonas and Ni, Yi and Schenk, Susanne H. and Hussner, Janine and Meyer Zu Schwabedissen, Henriette E. and Québatte, Gabriela and Mier, Walter and Urban, Stephan and Huwyler, Jörg. (2019) Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide. eLife, 8. e42276.

Bleher, Stefan and Buck, Jonas and Muhl, Christian and Sieber, Sandro and Barnert, Sabine and Witzigmann, Dominik and Huwyler, Jörg and Braz, Matthias and Süss, Regine. (2019) Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes. Small, 15 (50). p. 1904716.

Häuser, Christina and Goldbach, Pierre and Huwyler, Jörg and Fiess, Wolfgang and Allmendinger, Andrea. (2019) Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations. Pharmaceutics, 11 (11). p. 616.

Häuser, Christina and Goldbach, Pierre and Huwyler, Jörg and Friess, Wolfgang and Allmendinger, Andrea. (2019) Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations. European Journal of Pharmaceutics and Biopharmaceutics, 147. pp. 45-56.

2018

Ditter, Dominique and Nieto, Alejandra and Mahler, Hanns-Christian and Roehl, Holger and Wahl, Michael and Huwyler, Jörg and Allmendinger, Andrea. (2018) Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials. Journal of Pharmaceutical Sciences, 107 (2). pp. 624-637.

Ditter, Dominique and Mahler, Hanns-Christian and Roehl, Holger and Wahl, Michael and Huwyler, Jörg and Nieto, Alejandra and Allmendinger, Andrea. (2018) Characterization of surface properties of glass vials used as primary packaging material for parenterals. European Journal of Pharmaceutics and Biopharmaceutics, 125. pp. 58-67.

Roth, Roger and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2018) Functionalized calcium carbonate microparticles for the delivery of proteins. European Journal of Pharmaceutics and Biopharmaceutics, 122. pp. 96-103.

Einfalt, Tomaz and Witzigmann, Dominik and Edlinger, Christoph and Sieber, Sandro and Goers, Roland and Najer, Adrian and Spulber, Mariana and Onaca-Fischer, Ozana and Huwyler, Jörg and Palivan, Cornelia G.. (2018) Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment. Nature Communications, 9. p. 1127.

Campbell, Frederick and Bos, Frank L. and Sieber, Sandro and Arias-Alpizar, Gabriela and Koch, Björn E. and Huwyler, Jörg and Kros, Alexander and Bussmann, Jeroen. (2018) Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. ACS Nano, 12 (3). pp. 2138-2150.

Barda, Beatrice and Ame, Shaali M. and Ali, Said M. and Albonico, Marco and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections : a randomised, non-inferiority, single-blind trial. The Lancet infectious diseases, 18 (8). pp. 864-873.

Ditter, Dominique and Mahler, Hanns-Christian and Gohlke, Linus and Nieto, Alejandra and Roehl, Holger and Huwyler, Joerg and Wahl, Michael and Allmendinger, Andrea. (2018) Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials. Pharmaceutical research, 35 (7). p. 146.

Boll, Björn and Josse, Lena and Heubach, Anja and Hochenauer, Sophie and Finkler, Christof and Huwyler, Jörg and Koulov, Atanas V.. (2018) Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation. Journal of Separation Science, 2018; 41. pp. 2854-2864.

Moser, Wendelin and Sayasone, Somphou and Xayavong, Syda and Bounheuang, Bangon and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos : a randomised, single-blind trial. The Lancet infectious diseases, 18 (7). pp. 729-737.

Sedighi, Mahsa and Rahimi, Fereshteh and Rezayan, Ali Hossein and Shahbazi, Mohammad-Ali and Witzigmann, Dominik and Huwyler, Jörg. (2018) Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release. Journal of Materials Science, 53. pp. 14975-14988.

Siegrist, Stefan and Cörek, Emre and Detampel, Pascal and Sandström, Jenny and Wick, Peter and Huwyler, Jörg. (2018) Preclinical hazard evaluation strategy for nanomedicines. Nanotoxicology. pp. 1-27.

Schittny, A. and Ogawa, H. and Huwyler, J. and Puchkov, M.. (2018) A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters. European Journal of Pharmaceutics and Biopharmaceutics, 132. pp. 127-145.

Mech, A. and Rasmussen, K. and Jantunen, P. and Aicher, L. and Alessandrelli, M. and Bernauer, U. and Bleeker, E. A. J. and Bouillard, J. and Di Prospero Fanghella, P. and Draisci, R. and Dusinska, M. and Encheva, G. and Flament, G. and Haase, A. and Handzhiyski, Y. and Herzberg, F. and Huwyler, J. and Jacobsen, N. R. and Jeliazkov, V. and Jeliazkova, N. and Nymark, P. and Grafström, R. and Oomen, A. G. and Polci, M. L. and Riebeling, C. and Sandström, J. and Shivachev, B. and Stateva, S. and Tanasescu, S. and Tsekovska, R. and Wallin, H. and Wilks, M. F. and Zellmer, S. and Apostolova, M. D.. (2018) Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation. Nanotoxicology. pp. 1-23.

Haeuser, Christina and Goldbach, Pierre and Huwyler, Joerg and Friess, Wolfgang and Allmendinger, Andrea. (2018) Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products. Journal of pharmaceutical sciences, 107 (11). pp. 2810-2822.

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2018) Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs. Drug development and industrial pharmacy. pp. 1-9.

Yokoyama, Reiji and Kimura, Go and Schlepütz, Christian M. and Huwyler, Jörg and Puchkov, Maxim. (2018) Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics, 10 (4). p. 259.

Wimmersberger, David and Coulibaly, Jean T. and Schulz, Jessica D. and Puchkov, Maxim and Huwyler, Jörg and N'Gbesso, Yves and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67 (8). pp. 1247-1255.

2017

Boll, Björn and Bessa, Juliana and Folzer, Emilien and RÍos Quiroz, Anacelia and Schmidt, Roland and Bulau, Patrick and Finkler, Christof and Mahler, Hanns-Christian and Huwyler, Jörg and Iglesias, Antonio and Koulov, Atanas V.. (2017) Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance. Molecular Pharmaceutics, 14 (4). pp. 1292-1299.

Sieber, Sandro and Siegrist, Stefan and Schwarz, Stéphanie and Porta, Fabiola and Schenk, Susanne H. and Huwyler, Jörg. (2017) Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition. Macromolecular Bioscience, 17 (8). p. 1700015.

Riede, Julia and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2017) Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations. Drug Metabolism and Disposition, 45 (5). pp. 523-532.

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development. Drug Development and Industrial Pharmacy, 43 (10). pp. 1669-1676.

Riede, Julia and Camenisch, Gian and Huwyler, Jörg and Poller, Birk. (2017) Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations. Journal of Pharmaceutical Sciences, 106 (9). pp. 2805-2814.

Siegrist, Stefan and Kettiger, Helene and Fasler-Kan, E. and Huwyler, Jörg. (2017) Selective stimulation of the JAK/ ST AT signaling pathway by silica nanoparticles in human endothelial cells. Toxicology in Vitro, 42. pp. 308-318.

Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro and Huwyler, Jörg. (2017) PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application. Journal of Controlled Release, 260. pp. 46-60.

Kiene, Klara and Schenk, Susanne H. and Porta, Fabiola and Ernst, Alexandra and Witzigmann, Dominik and Grossen, Philip and Huwyler, Jörg. (2017) PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity. European Journal of Pharmaceutics and Biopharmaceutics, 119. pp. 322-332.

Kiene, Klara and Porta, Fabiola and Topacogullari, Buket and Detampel, Pascal and Huwyler, Jörg. (2017) Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins. Journal of Applied Polymer Science, 135 (1). p. 45638.

Uhl, Philipp and Pantze, Silvia and Storck, Philip and Parmentier, Johannes and Witzigmann, Dominik and Hofhaus, Götz and Huwyler, Jörg and Mier, Walter and Fricker, Gert. (2017) Oral delivery of vancomycin by tetraether lipid liposomes. European Journal of Pharmaceutical Sciences, 108. pp. 111-118.

Sieber, Sandro and Grossen, Philip and Detampel, Pascal and Siegfried, Salome and Witzigmann, Dominik and Huwyler, Jörg. (2017) Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo. Journal of Controlled Release, 264. pp. 180-191.

Moser, Wendelin and Coulibaly, Jean and Ali, Said M. and Ame, Shaali M. and Amour, Amour K. and Yapi, Richard B. and Albonico, Marco and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial. Lancet Infectious Diseases, 17 (11). pp. 1162-1171.

Wagner-Hattler, Leonie and Wyss, Katharina and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets. International Journal of Pharmaceutics, 534. pp. 50-59.

Thalmann, Peter and Bikis, Christos and Schulz, Georg and Paleo, Pierre and Mirone, Alessandro and Rack, Alexander and Siegrist, Stefan and Cörek, Emre and Huwyler, Jörg and Müller, Bert. (2017) Conference Proceedings: Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data. Proceedings of SPIE, 10391. pp. 1039114-1039111.

Barda, Beatrice and Sayasone, Somphou and Phongluxa, Khampheng and Xayavong, Syda and Keoduangsy, Khonsavanh and Odermatt, Peter and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled noninferiority trial. Clinical Infectious Diseases, 65 (2). pp. 276-281.

2016

Kettiger, Helene and Québatte, Gabriela and Perrone, Barbara and Huwyler, Jörg. (2016) Interactions between silica nanoparticles and phospholipid membranes. Biochimica et biophysica acta, 1858 (9). pp. 2163-2170.

Preisig, Daniel and Roth, Roger and Tognola, Sandy and Varum, Felipe J. O. and Bravo, Roberto and Cetinkaya, Yalcin and Huwyler, Jörg and Puchkov, Maxim. (2016) Mucoadhesive microparticles for local treatment of gastrointestinal diseases. European journal of pharmaceutics and biopharmaceutics, 105. pp. 156-165.

Buck, Jonas and Huwyler, Jörg and Kühl, Peter and Dischinger, Angela. (2016) Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping. Pharmaceutical research, 33 (8). pp. 2043-2055.

Gliesche, Daniel G. and Hussner, Janine and Witzigmann, Dominik and Porta, Fabiola and Glatter, Timo and Schmidt, Alexander and Huwyler, Jörg and Meyer Zu Schwabedissen, Henriette E.. (2016) Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries. Molecular Pharmaceutics, 13 (7). pp. 2290-2300.

Witzigmann, Dominik and Quagliata, Luca and Schenk, Susanne H. and Quintavalle, Cristina and Terracciano, Luigi M. and Huwyler, Jörg. (2016) Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention. Hepatology research , 46 (7). pp. 686-696.

Eberle, Veronika A. and Häring, Armella and Schoelkopf, Joachim and Gane, Patric A. C. and Huwyler, Jörg and Puchkov, Maxim. (2016) In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets. Drug development and industrial pharmacy, 42 (5). pp. 808-817.

Riede, Julia and Poller, Birk and Umehara, Ken-ichi and Huwyler, Jörg and Camenisch, Gian. (2016) New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data. European journal of pharmaceutical sciences, 86. pp. 96-102.

Mathaes, Roman and Mahler, Hanns-Christian and Buettiker, Jean-Pierre and Roehl, Holger and Lam, Philippe and Brown, Helen and Luemkemann, Joerg and Adler, Michael and Huwyler, Jörg and Streubel, Alexander and Mohl, Silke. (2016) The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests. European journal of pharmaceutics and biopharmaceutics, 99. pp. 54-64.

Ríos Quiroz, Anacelia and Lamerz, Jens and De Cunha, Thierry and Boillon, Adeline and Adler, Michael and Finkler, Christof and Huwyler, Jörg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V.. (2016) Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe. Pharmaceutical research, 33 (2). pp. 450-461.

Meister, Isabel and Leonidova, Anna and Kovač, Jana and Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2016) Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots. Journal of pharmaceutical and biomedical analysis, 118. pp. 81-88.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Ovadia, Robert and Lam, Philippe and Stauch, Oliver and Vogt, Martin and Roehl, Holger and Huwyler, Joerg and Mohl, Silke and Streubel, Alexander. (2016) Impact of Vial Capping on Residual Seal Force and Container Closure Integrity. PDA Journal of Pharmaceutical Science and Technology, 70 (1). pp. 12-29.

Grossen, Philip and Québatte, Gabriela and Witzigmann, Dominik and Prescianotto-Baschong, Cristina and Dieu, Le-Ha and Huwyler, Jörg. (2016) Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro. Journal of Nanomaterials, 2016. p. 7818501.

Camblin, Marine and Berger, Benjamin and Haschke, Manuel and Krähenbühl, Stephan and Huwyler, Jörg and Puchkov, Maxim. (2016) CombiCap: A novel drug formulation for the basel phenotyping cocktail. International Journal of Pharmaceutics, 512 (1). pp. 253-261.

Barda, Beatrice and Coulibaly, Jean T. and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2016) Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial. PLoS Neglected Tropical Diseases, 10 (9). e0005008.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Huwyler, Jörg and Eder, Jürgen and Fritsch, Kamil and Posset, Tobias and Mohl, Silke and Streubel, Alexander. (2016) Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing. PDA Journal of Pharmaceutical Science and Technology, 70 (2). pp. 109-119.

Mathaes, Roman and Mahler, Hanns-Christian and Vorgrimler, Lothar and Steinberg, Henrik and Dreher, Sascha and Roggo, Yves and Nieto, Alejandra and Brwon, Helen and Roehl, Holger and Adler, Michael and Luemkemann, Joerg and Huwyler, Jörg and Lam, Philippe and Stauch, Oliver and Mohl, Silke and Streubel, Alexander. (2016) The Pharmaceutical Capping Process - Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force. PDA Journal of Pharmaceutical Science and Technology, 70 (3). pp. 218-229.

Witzigmann, Dominik and Detampel, Pascal and Porta, Fabiola and Huwyler, Jörg. (2016) Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor. RSC Advances, 6. pp. 97636-97640.

Duthaler, Urs and Sayasone, Somphou and Vanobbergen, Fiona and Penny, Melissa A. and Odermatt, Peter and Huwyler, Jörg and Keiser, Jennifer. (2016) Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients. Antimicrobial agents and chemotherapy, 60 (10). pp. 5705-5715.

Leonidova, Anna and Vargas, Mireille and Huwyler, Jörg and Keiser, Jennifer. (2016) Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry. Antimicrobial Agents and Chemotherapy, 60 (12). pp. 7364-7371.

Werk, T. and Ludwig, I. S. and Luemkemann, J. and Huwyler, J. and Mahler, H. -C. and Haeuser, C. R. and Hafner, M.. (2016) New Processes for Freeze-Drying in Dual-Chamber Systems. PDA Journal of Pharmaceutical Science and Technology, 70 (3). pp. 191-207.

Werk, Tobias and Mahler, Hanns-Christian and Ludwig, Imke Sonja and Luemkemann, Joerg and Huwyler, Joerg and Hafner, Mathias. (2016) A Method to Determine the Kinetics of Sulute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes. PDA Journal of Pharmaceutical Science and Technology, 71 (1). pp. 2-10.

Werk, Tobias and Ludwig, Imke S. and Mahler, Hanns-Christian and Luemkemann, Joerg and Huwyler, Joerg and Hafner, Mathias. (2016) The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes. PDA Journal of Pharmaceutical Science and Technology, 70 (6). pp. 508-522.

2015

Kettiger, Helene and Karaman, Didem Sen and Schiesser, Laura and Rosenholm, Jessica M. and Huwyler, Jörg. (2015) Comparative safety evaluation of silica-based particles. Toxicology in vitro, 30 (1). pp. 355-363.

Boll, Björn and Folzer, Emilien and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Schmidt, Roland and Koulov, Atanas V.. (2015) Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS. Pharmaceutical research, 32 (12). pp. 3952-3964.

Folzer, Emilien and Khan, Tarik and Schmidt, Roland and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator. Journal of pharmaceutical sciences, 104 (12). pp. 4034-4040.

Allmendinger, Andrea and Mueller, Robert and Huwyler, Jörg and Mahler, Hans-Christian and Fischer, Stefan. (2015) Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material. Journal of pharmaceutical sciences, 104 (10). pp. 3319-3329.

Kunze, Annett and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-188.

Folzer, Emilien and Diepold, Katharina and Bomans, Katrin and Finkler, Christof and Schmidt, Roland and Bulau, Patrick and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule. Journal of pharmaceutical sciences, 104 (9). pp. 2824-2831.

Werk, Tobias and Huwyler, Jörg and Hafner, Mathias and Luemkemann, Jörg and Mahler, Hanns-Christian. (2015) An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals. Journal of pharmaceutical sciences, 104 (9). pp. 2948-2955.

Allmendinger, Andrea and Mueller, Robert and Schwarb, Edward and Chipperfield, Mark and Huwyler, Jörg and Mahler, Hanns-Christian and Fischer, Stefan. (2015) Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection. Pharmaceutical research, 32 (7). pp. 2229-2240.

Preisig, Daniel and Weingartner, Michael and Varum, Felipe J. O. and Bravo, Roberto and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2015) Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays. International journal of pharmaceutics, 487 (1-2). pp. 157-166.

Camenisch, Gian and Riede, Julia and Kunze, Annett and Huwyler, Jörg and Poller, Birk and Umehara, Kanichi. (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET & DMPK, 3 (1). pp. 1-14.

Seeland, Swen and Kettiger, Helene and Murphy, Mark and Treiber, Alexander and Giller, Jasmin and Kiss, Andrea and Sube, Romain and Krähenbühl, Stephan and Hafner, Mathias and Huwyler, Jörg. (2015) ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacology Research & Perspecitves, 3 (2). e00123.

Wicki, Andreas and Witzigmann, Dominik and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2015) Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications. Journal of controlled release, 200. pp. 138-157.

Jaeschke, Georg and Kolczewski, Sabine and Spooren, Will and Vieira, Eric and Bitter-Stoll, Nadia and Boissin, Patrick and Borroni, Edilio and Büttelmann, Bernd and Ceccarelli, Simona and Clemann, Nicole and David, Beatrice and Funk, Christoph and Guba, Wolfgang and Harrison, Anthony and Hartung, Thomas and Honer, Michael and Huwyler, Jörg and Kuratli, Martin and Niederhauser, Urs and Pähler, Axel and Peters, Jens-Uwe and Petersen, Ann and Prinssen, Eric and Ricci, Antonio and Rueher, Daniel and Rueher, Marianne and Schneider, Manfred and Spurr, Paul and Stoll, Theodor and Tännler, Daniel and Wichmann, Jürgen and Porter, Richard H. and Wettstein, Joseph G. and Lindemann, Lothar. (2015) Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of medicinal chemistry, 58 (3). pp. 1358-1371.

Keiser, Jenifer and [et al.], . (2015) Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial. The Lancet infectious diseases, Vol. 15, H. 3. pp. 277-284.

Mueller, B. and Hieber, S. E. and Zumbuehl, A. and Walter, M. A. and Huwyler, J. and Pfohl, T. and Cattin, Ph. C.. (2015) Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care. In: The Nano-Micro Interface: Bridging the Micro and Nano Worlds. Weinheim, pp. 291-309.

Ríos Quiroz, Anacelia and Québatte, Gabriela and Stump, Fabian and Finkler, Christof and Huwyler, Joerg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V. and Adler, Michael. (2015) Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities. Analytical chemistry, Vol. 87, H. 12. pp. 6119-6124.

Witzigmann, Dominik and Wu, Dalin and Schenk, Susanne H. and Balasubramanian, Vimalkumar and Meier, Wolfgang P. and Huwyler, Jörg . (2015) Biocompatible Polymer–Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery. ACS Applied Materials and Interfaces, 7 (19). pp. 10446-10456.

Witzigmann, Dominik and Sieber, Sandro and Porta, Fabiola and Grossen, Philip and Bieri, Andrej and Strelnikova, Natalja and Pfohl, Thomas and Prescianotto-Baschong, Cristina and Huwyler, Jörg. (2015) Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach. RSC Advances, 5 (91). pp. 74320-74328.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2015) LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. Journal of Pharmaceutical and Biomedical Analysis, 105. pp. 163-173.

Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Speich, Benjamin and Puchkov, Maxim and Huwyler, Jörg and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2015) Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. The Lancet infectious diseases, 16 (1). pp. 53-60.

Eberle, Veronika A. and Donzelli, Massimiliano and Alles, Rainer and Puchkov, Maxim and Huwyler, Jörg. (2015) In Vivo Evaluation of a Gastroretentive Drug Delivery System Based on Enteric-Coated Floating Tablets. Clinical Research: Open Access, 1.2.

Studer, Christoph and Aicher, Lothar and Gasic, Bojan and von Goetz, Natalie and Hoet, Peter and Huwyler, Jörg and Kägi, Ralf and Kase, Robert and Kobe, Andrej and Nowack, Bernd and Rothen-Rutishauser, Barbara and Schirmer, Kristin and Schneider, Gregor and Vermeissen, Etienne and Wick, Peter and Walser, Tobias. (2015) Scientific Basis for Regulatory Decision-Making of Nanomaterials; Report on the Workshop, 20-21 January 2014; Center of Applied Ecotoxicology, Dübendorf. In: Scientific Basis for Regulatory Decision-Making of Nanomaterials. Switzerland, pp. 52-56.

2014

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. pp. 232-241.

Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Alles, Rainer and Huwyler, Jörg and Hattendorf, Jan and Utzinger, Jürg and Albonico, Marco and Keiser, Jennifer. (2014) Oxantel pamoate-albendazole for Trichuris trichiura infection. The New England journal of medicine, Vol. 370, H. 7. pp. 610-620.

Dieu, Le-Ha and Wu, Dalin and Palivan, Cornelia G. and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2014) Polymersomes conjugated to 83-14 monoclonal antibodies : in vitro targeting of brain capillary endothelial cells. European journal of pharmaceutics and biopharmaceutics, 88 (2). pp. 316-324.

Eberle, V. A. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Floating gastroretentive drug delivery systems : comparison of experimental and simulated dissolution profiles and floatation behavior. European journal of pharmaceutical sciences, Vol. 58. pp. 34-43.

Kunze, A. and Huwyler, J. and Camenisch, G. and Poller, B.. (2014) Prediction of OATP1B1 and OATP1B3 Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug metabolism and disposition, Vol. 42, H. 9. pp. 1514-1521.

Kunze, A. and Huwyler, J. and Poller, B. and Gutmann, H. and Camenisch, G.. (2014) In vitro-in vivo extrapolation method to predict human renal clearance of drugs. Journal of pharmaceutical sciences, Vol. 103, H. 3. pp. 994-1001.

Preisig, D. and Haid, D. and Varum, F. J. and Bravo, R. and Huwyler, J. and Puchkov, M.. (2014) Drug loading into porous calcium carbonate microparticles by solvent evaporation. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 3. pp. 548-558.

Camblin, M. and Detampel, P. and Kettiger, H. and Wu, D. and Balasubramanian, V. and Huwyler, J.. (2014) Polymersomes containing quantum dots for cellular imaging. International journal of nanomedicine, Vol. 9. pp. 2287-2298.

Stirnimann, T. and Atria, S. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface. International journal of pharmaceutics, Vol. 466, H. 1-2 , S. 266–275.

Allmendinger, A. and Dieu, L. H. and Fischer, S. and Mueller, R. and Mahler, H. C. and Huwyler, J.. (2014) High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation. Journal of pharmaceutical and biomedical analysis, Vol. 99. pp. 51-58.

Allmendinger, A. and Fischer, S. and Huwyler, J. and Mahler, H. C. and Schwarb, E. and Zarraga, I. E. and Mueller, R.. (2014) Rheological characterization and injection forces of concentrated protein formulations : an alternative predictive model for non-Newtonian solutions. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 2. pp. 318-328.

2013

Stirnimann, Tanja and Di Maiuta, Nicola and Gerard, Daniel E. and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2013) Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets. Pharmaceutical research, Vol. 30, H. 7. pp. 1915-1925.

Fasler-Kan, E. and Barteneva, N. S. and Ketterer, S. and Wunderlich, K. and Reschner, A. and Nurzhanova, A. and Flammer, J. and Huwyler, J. and Meyer, P.. (2013) Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue. Xenotransplantation, Vol. 20, H. 6. pp. 469-480.

Kettiger, H. and Schipanski, A. and Wick, P. and Huwyler, J.. (2013) Engineered nanomaterial uptake and tissue distribution : from cell to organism. International journal of nanomedicine, Vol. 8. pp. 3255-3269.

Seeland, S. and Torok, M. and Kettiger, H. and Treiber, A. and Hafner, M. and Huwyler, J.. (2013) A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells. Toxicology in vitro, Vol. 27, H. 3. pp. 1109-1120.

Schoenbaechler, A. and Olfa, G. and Huwyler, J. and Frenz, M. and Pieles, U.. (2013) Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(; e; -caprolactone) grafted nanocomposites. Journal of photochemistry and photobiology. A, Chemistry, Vol. 261. pp. 12-19.

Meister, Isabel and Duthaler, Urs and Huwyler, Jörg and Rinaldi, Laura and Bosco, Antonio and Cringoli, Giuseppe and Keiser, Jennifer. (2013) Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 198, H. 1-2. pp. 102-110.

Alles, R. and Puchkov, M. and Jablonski, C. and Speich, B. and Keiser, J. and Huwyler, J.. (2013) Development of oxantel tablets for pediatric clinical studies : a technical note. Journal of drug delivery science and technology, Vol. 23, H. 6. pp. 623-625.

2012

Kunze, A. and Huwyler, J. and Camenisch, G. and Gutmann, H.. (2012) Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters. Biochemical pharmacology, Vol. 84, Issue 8. pp. 1096-1102.

Suenderhauf, C. and Hammann, F. and Huwyler, J.. (2012) Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction. Molecules, Vol. 17, H. 9. pp. 10429-10445.

Duthaler, U. and Huwyler, J. and Rinaldi, L. and Cringoli, G. and Keiser, J.. (2012) Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica. Veterinary parasitology, Vol. 186, H. 3-4. pp. 270-280.

Hysek, C. M. and Simmler, L. D. and Nicola, V. G. and Vischer, N. and Donzelli, M. and Krahenbuhl, S. and Grouzmann, E. and Huwyler, J. and Hoener, M. C. and Liechti, M. E.. (2012) Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS ONE, Vol. 7, H. 5 , e36476.

Simmler, L. D. and Buser, T. A. and Donzelli, M. and Schramm, Y. and Dieu, L. H. and Huwyler, J. and Chaboz, S. and Hoener, M. C. and Liechti, M. E.. (2012) Pharmacological characterization of designer cathinones in vitro. British journal of pharmacology, Vol. 168, no. 2. pp. 458-470.

Kirchhofer, C. and Vargas, M. and Huwyler, J. and Keiser, J.. (2012) Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 121-125.

Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg. (2012) Drug interaction potential of resveratrol. Drug metabolism reviews, Vol. 44, H. 3. pp. 253-265.

Sano, Y. and Kashiwamura, Y. and Abe, M. and Dieu, L. H. and Huwyler, J. and Shimizu, F. and Haruki, H. and Maeda, T. and Saito, K. and Tasaki, A. and Kanda, T.. (2012) A stable human brain microvascular endothelial cell line retaining its barrier-specific nature, independent of the passage number. Clinical and experimental neuroimmunology, Vol. 3. pp. 1-12.

2011

Suenderhauf, Claudia and Hammann, Felix and Maunz, Andreas and Helma, Christoph and Huwyler, Jörg. (2011) Combinatorial QSAR Modeling of human Intestinal Absorption. Molecular pharmaceutics, Vol. 8, H. 1. pp. 213-224.

Schroeder, K. and Bremm, K. D. and Alepee, N. and Bessems, J. G. and Blaauboer, B. and Boehn, S. N. and Burek, C. and Coecke, S. and Gombau, L. and Hewitt, N. J. and Heylings, J. and Huwyler, J. and Jaeger, M. and Jagelavicius, M. and Jarrett, N. and Ketelslegers, H. and Kocina, I. and Koester, J. and Kreysa, J. and Note, R. and Poth, A. and Radtke, M. and Rogiers, V. and Scheel, J. and Schulz, T. and Steinkellner, H. and Toeroek, M. and Whelan, M. and Winkler, P. and Diembeck, W.. (2011) Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors. Toxicology in vitro, Vol. 25, H. 3. pp. 589-604.

Hammann, F. and Suenderhauf, C. and Huwyler, J.. (2011) A Binary Ant Colony Optimization Classifier for Molecular Activities. Journal of Chemical Information and Modeling, Vol. 51. pp. 2690-2696.

Seeland, S. and Treiber, A. and Hafner, M. and Huwyler, J.. (2011) On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells. Biochimica et biophysica acta, Vol. 1808, H. 7. pp. 1827-1831.

Schmutz, Hans-Rudolf and Detampel, Pascal and Bühler, Theo and Büttler, André and Gygax, Benjamin and Huwyler, Jörg. (2011) In Vitro Assessment of the Formation of Ceftriaxone-Calcium Precipitates in Human Plasma. Journal of pharmaceutical sciences, Vol. 100, H. 6. pp. 2300-2310.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2011) Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of Mass Spectrometry, 46 (2). pp. 172-181.

Hysek, C. M. and Simmler, L. D. and Ineichen, M. and Grouzmann, E. and Hoener, M. C. and Brenneisen, R. and Huwyler, J. and Liechti, M. E.. (2011) The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA ("Ecstasy") in Humans. Clinical pharmacology and therapeutics, 90 (2). pp. 246-255.

Huwyler, Jörg. (2011) Die neue pharmazeutische Technologie der Universität Basel. Swiss Journal of the pharmaceutical industry, 33. pp. 3-11. Zürich.

2010

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. pp. 63-70.

Keiser, Jennifer and Kirchhofer, Carla and Haschke, Manuel and Huwyler, Jörg and Dong, Yuxiang and Vennerstrom, Jonathan L. and Vanhoff, Kathleen and Kaminsky, Ronald and Malikides, Nick. (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 173, H. 3-4. pp. 228-235.

Mattei, P. and Boehringer, M. and Di Giorgio, P. and Fischer, H. and Hennig, M. and Huwyler, J. and Kocer, B. and Kuhn, B. and Loeffler, B. M. and Macdonald, A. and Narquizian, R. and Rauber, E. and Sebokova, E. and Sprecher, U.. (2010) Discovery of carmegliptin : a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. pp. 1109-1113.

Kirchhofer, C. and Keiser, J. and Huwyler, J.. (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. Journal of chromatography B, 878 (28). pp. 2770-2774.

Fasler-Kan, Elizaveta and Suenderhauf, Claudia and Barteneva, Natasha and Poller, Birk and Gygax, Daniel and Huwyler, Jörg. (2010) Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3. Brain research, Vol. 1354. pp. 15-22.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Gatti, Silvia. (2010) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives : Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic & medicinal chemistry letters, Vol. 20, H. 23. pp. 6969-6974.

Richter, H. G. and Freichel, C. and Huwyler, J. and Nakagawa, T. and Nettekoven, M. and Plancher, J. M. and Raab, S. and Roche, O. and Schuler, F. and Taylor, S. and Ullmer, C. and Wiegand, R.. (2010) Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorganic & medicinal chemistry letters, Vol. 20, H. 19. pp. 5713-5717.

Boehringer, M. and Fischer, H. and Hennig, M. and Hunziker, D. and Huwyler, J. and Kuhn, B. and Loeffler, B. M. and Luebbers, T. and Mattei, P. and Narquizian, R. and Sebokova, E. and Sprecher, U. and Wessel, H. P.. (2010) Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. pp. 1106-1108.

Fasler-Kan, E. and Barteneva, N. and Ketterer, S. and Wunderlich, K. and Huwyler, J. and Gygax, D. and Flammer, J. and Meyer, P.. (2010) Activation of the JAK?STAT intracellular pathway in human retinal pigment epithelialcell line ARPE-19. International Journal of Interferon, Cytokine and Mediator Research, Vol. 2. pp. 127-136.

2009

Pierson, Pascale David and Fettes, Alec and Freichel, Christian and Gatti-McArthur, Silvia and Hertel, Cornelia and Huwyler, Jörg and Mohr, Peter and Nakagawa, Toshito and Nettekoven, Matthias and Plancher, Jean-Marc and Raab, Susanne and Richter, Hans and Roche, Olivier and Rodríguez Sarmiento, Rosa María and Schmitt, Monique and Schuler, Franz and Takahashi, Tadakatsu and Taylor, Sven and Ullmer, Christoph and Wiegand, Ruby. (2009) 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. Journal of Medicinal Chemistry, 52 (13). pp. 3855-3868.

Vieira, Eric and Huwyler, Jörg and Jolidon, Synèse and Knoflach, Frédéric and Mutel, Vincent and Wichmann, Jürgen. (2009) Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorganic and Medicinal Chemistry Letters, 19 (6). pp. 1666-1669.

Pierson, Pascale David and Freichel, Christian and Gatti-Mac Arthur, Silvia and Hertel, Cornelia and Huwyler, Jörg and Mohr, Peter and Nakagawa, Toshito and Nettekoven, Matthias and Plancher, Jean-Marc and Raab, Susanne and Richter, Hans and Roche, Olivier and Rodríguez Sarmiento, Rosa María and Schmitt, Monique and Schuler, Franz and Takahashi, Tadakatsu and Taylor, Sven and Ullmer, Christoph and Wiegand, Ruby. (2009) Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series. Chimia, 63 (5). pp. 275-278(4).

2008

Poller, B. and Gutmann, H. and Krähenbühl, S. and Weksler, B. and Romero, I. and Couraud, P. O. and Tuffin, G. and Drewe, J. and Huwyler, J.. (2008) The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies. Journal of Neurochemistry, Vol. 107, H. 5. pp. 1358-1368.

Huwyler, J. and Drewe, J. and Krähenbuhl, S.. (2008) Tumor targeting using liposomal antineoplastic drugs. International Journal of Nanomedicine, 3 (1). pp. 21-29.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Adam, Geo and Kew, James N. C. and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Mutel, Vincent and Gatti, Silvia. (2008) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic and Medicinal Chemistry Letters, 18 (8). pp. 2725-2729.

Tuffin, Gérald and Huwyler, Jörg and Waelti, Ernst and Hammer, Caroline and Marti, Hans-Peter. (2008) Drug targeting using OX7-immunoliposomes: Correlation between Thy1.1 antigen expression and tissue distribution in the rat. Journal of Drug Targeting, 16 (2). pp. 156-166.

Bendels, Stefanie and Kansy, Manfred and Wagner, Björn and Huwyler, Jörg. (2008) In silico prediction of brain and CSF permeation of small molecules using PLS regression models. European Journal of Medicinal Chemistry, 43 (8). pp. 1581-1592.

Du-Cuny, Lei and Huwyler, Jörg and Wiese, Michael and Kansy, Manfred. (2008) Computational aqueous solubility prediction for drug-like compounds in congeneric series. European Journal of Medicinal Chemistry, 43 (3). pp. 501-512.

2007

Du-Cuny, Lei and Huwyler, Jörg and Fischer, Holger and Kansy, Manfred. (2007) A potentiometric titration method for the crystallization of drug-like organic molecules. International Journal of Pharmaceutics, 342 (1-2). pp. 161-167.

Jaeschke, Georg and Porter, Richard and Büttelmann, Bernd and Ceccarelli, Simona M. and Guba, Wolfgang and Kuhn, Bernd and Kolczewski, Sabine and Huwyler, Jörg and Mutel, Vincent and Peters, Jens-Uwe and Ballard, Theresa and Prinssen, Eric and Vieira, Eric and Wichmann, Jürgen and Spooren, Will. (2007) Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1307-1311.

Ceccarelli, Simona M. and Jaeschke, Georg and Buettelmann, Bernd and Huwyler, Jörg and Kolczewski, Sabine and Peters, Jens-Uwe and Prinssen, Eric and Porter, Richard and Spooren, Will and Vieira, Eric. (2007) Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1302-1306.

2006

Huwyler, Jörg and Wright, Matthew B. and Gutmann, Heike and Drewe, Juergen. (2006) Induction of Cytochrome P450 3A4 and P-Glycoprotein by the Isoxazolyl-Penicillin Antibiotic Flucloxacillin. Current Drug Metabolism, 7 (2). pp. 119-126.

Büttelmann, Bernd and Peters, Jens-Uwe and Ceccarelli, Simona and Kolczewski, Sabine and Vieira, Eric and Prinssen, Eric P. and Spooren, Will and Schuler, Franz and Huwyler, Jörg and Porter, Richard H. P. and Jaeschke, Georg. (2006) Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 16 (7). pp. 1892-1897.

2005

Schnyder, Anita and Krähenbühl, Stephan and Drewe, Jürgen and Huwyler, Jörg. (2005) Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects. Journal of Drug Targeting, 13 (5). pp. 325-335.

Tuffin, Gérald and Waelti, Ernst and Huwyler, Jörg and Hammer, Caroline and Marti, Hans-Peter. (2005) Immunoliposome Targeting to Mesangial Cells: A Promising Strategy for Specific Drug Delivery to the Kidney. Journal of the American Society of Nephrology, 16 (11). pp. 3295-3305.