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Tumor targeting using liposomal antineoplastic drugs

Huwyler, J. and Drewe, J. and Krähenbuhl, S.. (2008) Tumor targeting using liposomal antineoplastic drugs. International Journal of Nanomedicine, 3 (1). pp. 21-29.

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Official URL: http://edoc.unibas.ch/dok/A6007515

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Abstract

During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
UniBasel Contributors:Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Dove Medical Press
ISSN:1176-9114
e-ISSN:1178-2013
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:28 Nov 2017 10:20
Deposited On:23 May 2014 08:34

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