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The extended clearance model and its use for the interpretation of hepatobiliary elimination data

Camenisch, Gian and Riede, Julia and Kunze, Annett and Huwyler, Jörg and Poller, Birk and Umehara, Kanichi. (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET & DMPK, 3 (1). pp. 1-14.

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Official URL: http://edoc.unibas.ch/40825/

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Abstract

Hepatic elimination is a function of the interplay between different processes such as sinusoidal uptake,intracellular metabolism, canalicular (biliary) secretion, and sinusoidal efflux. In this review, we outlinehow drugs can be classified according to their in vitro determined clearance mechanisms using theextended clearance model as a reference. The approach enables the determination of the ratedetermininghepatic clearance step. Some successful applications will be highlighted, together with adiscussion on the major consequences for the pharmacokinetics and the drug-drug interaction potential ofdrugs. Special emphasize is put on the role of passive permeability and active transport processes inhepatic elimination.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Huwyler, Jörg
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:International Association of Physical Chemists
e-ISSN:1848-7718
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:11 Aug 2016 06:01
Deposited On:11 Aug 2016 06:01

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