Mechanisms of increased bioavailability through amorphous solid dispersions: a review

Schittny, Andreas and Huwyler, Jörg and Puchkov, Maxim. (2020) Mechanisms of increased bioavailability through amorphous solid dispersions: a review. Drug delivery, 27 (1). pp. 110-127.

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Official URL: https://edoc.unibas.ch/74159/

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Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understanding of mechanisms governing drug liberation and absorption; in vivo; . Furthermore, the lack of a unified nomenclature hampers the interpretation and classification of research data. In this review, we therefore summarize and conceptualize mechanisms covering the dissolution of ASDs, formation of supersaturated ASD solutions, factors responsible for solution stabilization, drug uptake from ASD solutions, and drug distribution within these complex systems as well as effects of excipients. Furthermore, we discuss the importance of these findings on the development of ASDs. This improved overall understanding of these mechanisms will facilitate a rational ASD formulation development and will serve as a basis for further mechanistic research on drug delivery by ASDs.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Huwyler, Jörg and Schittny, Andreas and Puchkov, Maxim
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor and Francis
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 Dec 2020 11:26
Deposited On:22 Dec 2020 11:26

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