Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

Wagner-Hattler , Leonie and Québatte, Gabriela and Keiser, Jennifer and Schoelkopf, Joachim and Schleputz, Christian M. and Huwyler, Jörg and Puchkov, Maxim. (2020) Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. International Journal of Pharmaceutics, 573. p. 118827.

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Official URL: https://edoc.unibas.ch/74051/

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Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients. In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast X-ray microtomography. Mini-tablets had a weight of 9.5 mg and a drug load from 2.5% to 20%. Moxidectin, a drug used for treatment of parasitic infections, was used as a model compound. Drug content covered a range from 91% to 121% of the target dose. A linear iterative clustering (SLIC) superpixel method was used for segmentation, analysis, and visualization of the spatial distribution of individual tablet components (i.e., pores, excipients, and drug). Results show that the drug was not uniformly distributed within the tablet, revealing an increasing drug load towards the tablets' outer boundaries and thus indicative of a radial displacement of drug particles during compaction. The presented method can be used for the quantitative analysis of drug content and drug distribution within pharmaceutical tablets, allowing for the optimization of fast disintegrating formulations. The results also affirm that that drug loads up to 20% will not lead to segregation for moxidectin.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Keiser, Jennifer and Huwyler, Jörg and Wagner-Hattler, Leonie and Québatte, Gabriela and Puchkov, Maxim
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Jul 2023 13:33
Deposited On:05 Mar 2020 07:39

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