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A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters

Schittny, A. and Ogawa, H. and Huwyler, J. and Puchkov, M.. (2018) A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters. European Journal of Pharmaceutics and Biopharmaceutics, 132. pp. 127-145.

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Official URL: https://edoc.unibas.ch/65616/

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Abstract

Hot-melt extrusion allows for the continuous production of amorphous solid dispersions, which are used to enhance bioavailability of poorly soluble drugs in pharmaceutical drug delivery. To facilitate formulation and extrusion process development, we propose a mathematical model describing the formation of amorphous solid dispersions in the context of this process. The model is based on the calculation of two key process values: 1) time to dissolution of solid drug particles in molten polymer during extrusion and 2) mean residence of material in the extruder. We suggest that their linking allows for rational process design. Experimental data support the validity of our model for both key process values as well as the overall process. This modeling approach allows for fast and cost-effective formulation and extrusion process development as well as feasibility estimations in early stages of drug development.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Technologie (Huwyler)
UniBasel Contributors:Huwyler, Jörg and Schittny, Andreas and Puchkov, Maxim
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0939-6411
e-ISSN:1873-3441
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Oct 2018 09:48
Deposited On:31 Oct 2018 09:48

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