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Items where Author is "Huwyler, Jörg "

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Number of items: 116.

2020

Einfalt, Tomaz and Garni, Martina and Witzigmann, Dominik and Sieber, Sandro and Baltisberger, Niklaus and Huwyler, Jörg and Meier, Wolfgang and Palivan, Cornelia. (2020) Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics. Advanced Science, 7 (4). p. 1901923.

Liu, Juan and Craciun, Ioana and Belluati, Andrea and Wu, Dalin and Sieber, Sandro and Einfalt, Tomaz and Witzigmann, Dominik and Chami, Mohamed and Huwyler, Jörg and Palivan, Cornelia G.. (2020) DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo. Nanoscale, 12 (17). pp. 9786-9799.

Ehrsam, Daniel and Sieber, Sandro and Oufir, Mouhssin and Porta, Fabiola and Hamburger, Matthias and Huwyler, Jörg and Meyer zu Schwabedissen, Henriette E.. (2020) Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9. Bioconjugate Chemistry, 31 (3). pp. 781-793.

Keller, Ladina and Palmeirim, Marta S. and Ame, Shaali M. and Ali, Said M. and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2020) Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clinical Infectious Diseases, 70 (6). pp. 1193-1201.

2019

Häuser, Christina and Goldbach, Pierre and Huwyler, Jörg and Fiess, Wolfgang and Allmendinger, Andrea. (2019) Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations. Pharmaceutics, 11 (11). p. 616.

Häuser, Christina and Goldbach, Pierre and Huwyler, Jörg and Friess, Wolfgang and Allmendinger, Andrea. (2019) Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations. European Journal of Pharmaceutics and Biopharmaceutics, 147. pp. 45-56.

Neodo, Anna and Schulz, Jessica D. and Huwyler, Jörg and Keiser, Jennifer. (2019) In vitro and In vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine. Antimicrobial agents and chemotherapy, 63 (1). e00762-18.

Buck, Jonas and Grossen, Philip and Cullis, Pieter R. and Huwyler, Jörg and Witzigmann, Dominik. (2019) Lipid-Based DNA Therapeutics - Hallmarks of Non-Viral Gene Delivery. ACS Nano, 13 (4). pp. 3754-3782.

Farzan, Maryam and Roth, Roger and Québatte, Gabriela and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2019) Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry. Pharmaceutics, 11 (1). pp. 32- .

Kiene, Klara and Hayasi, Noriyuki and Burhenne, Jürgen and Uchitomi, Ryo and Sünderhauf, Claudia and Schmid, Yasmin and Haschke, Manuel and Haefeli, Walter Emil and Krähenbühl, Stephan and Mikus, Gerd and Inada, Hirohiko and Huwyler, Jörg. (2019) Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film. European Journal of Pharmaceutical Sciences, 135. pp. 77-82.

Witzigmann, Dominik and Uhl, Philipp and Sieber, Sandro and Kaufman, Christina and Einfalt, Tomaz and Schöneweis, Katrin and Grossen, Philip and Buck, Jonas and Ni, Yi and Schenk, Susanne H. and Hussner, Janine and Meyer Zu Schwabedissen, Henriette E. and Québatte, Gabriela and Mier, Walter and Urban, Stephan and Huwyler, Jörg. (2019) Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide. eLife, 8. e42276.

Bleher, Stefan and Buck, Jonas and Muhl, Christian and Sieber, Sandro and Barnert, Sabine and Witzigmann, Dominik and Huwyler, Jörg and Braz, Matthias and Süss, Regine. (2019) Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes. Small, 15 (50). p. 1904716.

Meister, Isabel and Assawasuwannakit, Piyanan and Vanobberghen, Fiona and Penny, Melissa A. and Odermatt, Peter and Sayasone, Somphou and Huwyler, Jörg and Tarning, Joel and Keiser, Jennifer. (2019) Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrobial Agents and Chemotherapy, 63 (4). e01391-18.

Sedighi, Mahsa and Sieber, Sandro and Rahimi, Fereshteh and Shahbazi, Mohammad-Ali and Rezayan, Ali Hossein and Huwyler, Jörg and Witzigmann, Dominik. (2019) Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach. Drug delivery and translational research, 9 (1). pp. 404-413.

Sieber, Sandro and Grossen, Philip and Bussmann, Jeroen and Campbell, Frederick and Kros, Alexander and Witzigmann, Dominik and Huwyler, Jörg. (2019) Zebrafish as a preclinical in vivo screening model for nanomedicines. Advanced drug delivery reviews (151-152). pp. 152-168.

Sieber, Sandro and Grossen, Philip and Uhl, Philipp and Detampel, Pascal and Mier, Walter and Witzigmann, Dominik and Huwyler, Jörg. (2019) Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo. Nanomedicine: nanotechnology, biology and medicine, 17. pp. 82-93.

February 2018

Ditter, Dominique and Nieto, Alejandra and Mahler, Hanns-Christian and Roehl, Holger and Wahl, Michael and Huwyler, Jörg and Allmendinger, Andrea. (2018) Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials. Journal of Pharmaceutical Sciences, 107 (2). pp. 624-637.

2018

Einfalt, Tomaz and Witzigmann, Dominik and Edlinger, Christoph and Sieber, Sandro and Goers, Roland and Najer, Adrian and Spulber, Mariana and Onaca-Fischer, Ozana and Huwyler, Jörg and Palivan, Cornelia G.. (2018) Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment. Nature Communications, 9. p. 1127.

Ditter, Dominique and Mahler, Hanns-Christian and Roehl, Holger and Wahl, Michael and Huwyler, Jörg and Nieto, Alejandra and Allmendinger, Andrea. (2018) Characterization of surface properties of glass vials used as primary packaging material for parenterals. European Journal of Pharmaceutics and Biopharmaceutics, 125. pp. 58-67.

Sedighi, Mahsa and Rahimi, Fereshteh and Rezayan, Ali Hossein and Shahbazi, Mohammad-Ali and Witzigmann, Dominik and Huwyler, Jörg. (2018) Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release. Journal of Materials Science, 53. pp. 14975-14988.

Campbell, Frederick and Bos, Frank L. and Sieber, Sandro and Arias-Alpizar, Gabriela and Koch, Björn E. and Huwyler, Jörg and Kros, Alexander and Bussmann, Jeroen. (2018) Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. ACS Nano, 12 (3). pp. 2138-2150.

Wimmersberger, David and Coulibaly, Jean T. and Schulz, Jessica D. and Puchkov, Maxim and Huwyler, Jörg and N'Gbesso, Yves and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67 (8). pp. 1247-1255.

Wimmersberger, David and Coulibaly, Jean T. and Schulz, Jessica D. and Puchkow, Maxim and Huwyler, Jörg and N'Gbesso, Yves and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and safety of ivermectin against Trichuris trichiura in preschool- and school-aged children : a randomized controlled dose-finding trial. Clinical Infectious Diseases, 67 (8). pp. 1247-1255.

Barda, Beatrice and Ame, Shaali M. and Ali, Said M. and Albonico, Marco and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections : a randomised, non-inferiority, single-blind trial. The Lancet infectious diseases, 18 (8). pp. 864-873.

Moser, Wendelin and Sayasone, Somphou and Xayavong, Syda and Bounheuang, Bangon and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2018) Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos : a randomised, single-blind trial. The Lancet infectious diseases, 18 (7). pp. 729-737.

Roth, Roger and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2018) Functionalized calcium carbonate microparticles for the delivery of proteins. European Journal of Pharmaceutics and Biopharmaceutics, 122. pp. 96-103.

Boll, Björn and Josse, Lena and Heubach, Anja and Hochenauer, Sophie and Finkler, Christof and Huwyler, Jörg and Koulov, Atanas V.. (2018) Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation. Journal of Separation Science, 2018; 41. pp. 2854-2864.

Yokoyama, Reiji and Kimura, Go and Schlepütz, Christian M. and Huwyler, Jörg and Puchkov, Maxim. (2018) Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics, 10 (4). p. 259.

Hiroshige, Noemi and Coulibaly, Jean and Huwyler, Jörg and Bonate, Peter L. and Keiser, Jennifer. (2018) Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children. Antimicrobial agents and chemotherapy, 62 (9). e00959.

Siegrist, Stefan and Cörek, Emre and Detampel, Pascal and Sandström, Jenny and Wick, Peter and Huwyler, Jörg. (2018) Preclinical hazard evaluation strategy for nanomedicines. Nanotoxicology. pp. 1-27.

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2018) Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs. Drug development and industrial pharmacy. pp. 1-9.

2017

Riede, Julia and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2017) Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations. Drug Metabolism and Disposition, 45 (5). pp. 523-532.

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development. Drug Development and Industrial Pharmacy, 43 (10). pp. 1669-1676.

Thalmann, Peter and Bikis, Christos and Schulz, Georg and Paleo, Pierre and Mirone, Alessandro and Rack, Alexander and Siegrist, Stefan and Cörek, Emre and Huwyler, Jörg and Müller, Bert. (2017) Conference Proceedings: Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data. Proceedings of SPIE, 10391. pp. 1039114-1039111.

Riede, Julia and Camenisch, Gian and Huwyler, Jörg and Poller, Birk. (2017) Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations. Journal of Pharmaceutical Sciences, 106 (9). pp. 2805-2814.

Moser, Wendelin and Coulibaly, Jean and Ali, Said M. and Ame, Shaali M. and Amour, Amour K. and Yapi, Richard B. and Albonico, Marco and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial. Lancet Infectious Diseases, 17 (11). pp. 1162-1171.

Barda, Beatrice and Sayasone, Somphou and Phongluxa, Khampheng and Xayavong, Syda and Keoduangsy, Khonsavanh and Odermatt, Peter and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial. Clinical Infectious Diseases, 65 (2). pp. 276-281.

Barda, Beatrice and Sayasone, Somphou and Phongluxa, Khampheng and Xayavong, Syda and Keoduangsy, Khonsavanh and Odermatt, Peter and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial. Clinical Infectious Diseases, 65 (2). pp. 276-281.

Boll, Björn and Bessa, Juliana and Folzer, Emilien and RÍos Quiroz, Anacelia and Schmidt, Roland and Bulau, Patrick and Finkler, Christof and Mahler, Hanns-Christian and Huwyler, Jörg and Iglesias, Antonio and Koulov, Atanas V.. (2017) Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance. Molecular Pharmaceutics, 14 (4). pp. 1292-1299.

Sieber, Sandro and Siegrist, Stefan and Schwarz, Stéphanie and Porta, Fabiola and Schenk, Susanne H. and Huwyler, Jörg. (2017) Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition. Macromolecular Bioscience, 17 (8). p. 1700015.

Wagner-Hattler, Leonie and Wyss, Katharina and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets. International Journal of Pharmaceutics, 534. pp. 50-59.

Uhl, Philipp and Pantze, Silvia and Storck, Philip and Parmentier, Johannes and Witzigmann, Dominik and Hofhaus, Götz and Huwyler, Jörg and Mier, Walter and Fricker, Gert. (2017) Oral delivery of vancomycin by tetraether lipid liposomes. European Journal of Pharmaceutical Sciences, 108. pp. 111-118.

Kiene, Klara and Schenk, Susanne H. and Porta, Fabiola and Ernst, Alexandra and Witzigmann, Dominik and Grossen, Philip and Huwyler, Jörg. (2017) PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity. European Journal of Pharmaceutics and Biopharmaceutics, 119. pp. 322-332.

Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro and Huwyler, Jörg. (2017) PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application. Journal of Controlled Release, 260. pp. 46-60.

Siegrist, Stefan and Kettiger, Helene and Fasler-Kan, E. and Huwyler, Jörg. (2017) Selective stimulation of the JAK/ ST AT signaling pathway by silica nanoparticles in human endothelial cells. Toxicology in Vitro, 42. pp. 308-318.

Kiene, Klara and Porta, Fabiola and Topacogullari, Buket and Detampel, Pascal and Huwyler, Jörg. (2017) Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins. Journal of Applied Polymer Science, 135 (1). p. 45638.

Sieber, Sandro and Grossen, Philip and Detampel, Pascal and Siegfried, Salome and Witzigmann, Dominik and Huwyler, Jörg. (2017) Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo. Journal of Controlled Release, 264. pp. 180-191.

September 2016

Kettiger, Helene and Québatte, Gabriela and Perrone, Barbara and Huwyler, Jörg. (2016) Interactions between silica nanoparticles and phospholipid membranes. Biochimica et biophysica acta, 1858 (9). pp. 2163-2170.

August 2016

Preisig, Daniel and Roth, Roger and Tognola, Sandy and Varum, Felipe J. O. and Bravo, Roberto and Cetinkaya, Yalcin and Huwyler, Jörg and Puchkov, Maxim. (2016) Mucoadhesive microparticles for local treatment of gastrointestinal diseases. European journal of pharmaceutics and biopharmaceutics, 105. pp. 156-165.

Buck, Jonas and Huwyler, Jörg and Kühl, Peter and Dischinger, Angela. (2016) Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping. Pharmaceutical research, 33 (8). pp. 2043-2055.

July 2016

Gliesche, Daniel G. and Hussner, Janine and Witzigmann, Dominik and Porta, Fabiola and Glatter, Timo and Schmidt, Alexander and Huwyler, Jörg and Meyer Zu Schwabedissen, Henriette E.. (2016) Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries. Molecular Pharmaceutics, 13 (7). pp. 2290-2300.

June 2016

Witzigmann, Dominik and Quagliata, Luca and Schenk, Susanne H. and Quintavalle, Cristina and Terracciano, Luigi M. and Huwyler, Jörg. (2016) Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention. Hepatology research , 46 (7). pp. 686-696.

3 May 2016

Eberle, Veronika A. and Häring, Armella and Schoelkopf, Joachim and Gane, Patric A. C. and Huwyler, Jörg and Puchkov, Maxim. (2016) In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets. Drug development and industrial pharmacy, 42 (5). pp. 808-817.

30 April 2016

Riede, Julia and Poller, Birk and Umehara, Ken-ichi and Huwyler, Jörg and Camenisch, Gian. (2016) New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data. European journal of pharmaceutical sciences, 86. pp. 96-102.

February 2016

Ríos Quiroz, Anacelia and Lamerz, Jens and De Cunha, Thierry and Boillon, Adeline and Adler, Michael and Finkler, Christof and Huwyler, Jörg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V.. (2016) Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe. Pharmaceutical research, 33 (2). pp. 450-461.

Mathaes, Roman and Mahler, Hanns-Christian and Buettiker, Jean-Pierre and Roehl, Holger and Lam, Philippe and Brown, Helen and Luemkemann, Joerg and Adler, Michael and Huwyler, Jörg and Streubel, Alexander and Mohl, Silke. (2016) The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests. European journal of pharmaceutics and biopharmaceutics, 99. pp. 54-64.

2016

Camblin, Marine and Berger, Benjamin and Haschke, Manuel and Krähenbühl, Stephan and Huwyler, Jörg and Puchkov, Maxim. (2016) CombiCap: A novel drug formulation for the basel phenotyping cocktail. International Journal of Pharmaceutics, 512 (1). pp. 253-261.

Meister, Isabel and Leonidova, Anna and Kovač, Jana and Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2016) Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots. Journal of pharmaceutical and biomedical analysis, 118. pp. 81-88.

Barda, Beatrice and Coulibaly, Jean T. and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2016) Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial. PLoS Neglected Tropical Diseases, 10 (9). e0005008.

Grossen, Philip and Québatte, Gabriela and Witzigmann, Dominik and Prescianotto-Baschong, Cristina and Dieu, Le-Ha and Huwyler, Jörg. (2016) Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro. Journal of Nanomaterials, 2016. p. 7818501.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Huwyler, Jörg and Eder, Jürgen and Fritsch, Kamil and Posset, Tobias and Mohl, Silke and Streubel, Alexander. (2016) Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing. PDA Journal of Pharmaceutical Science and Technology, 70 (2). pp. 109-119.

Witzigmann, Dominik and Detampel, Pascal and Porta, Fabiola and Huwyler, Jörg. (2016) Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor. RSC Advances, 6. pp. 97636-97640.

Meister, Isabel and Kovac, Jana and Duthaler, Urs and Odermatt, Peter and Huwyler, Jörg and Vanobberghen, Fiona and Sayasone, Somphou and Keiser, Jennifer. (2016) Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients. PLoS Neglected Tropical Diseases, 10 (5). e0004700.

Leonidova, Anna and Vargas, Mireille and Huwyler, Jörg and Keiser, Jennifer. (2016) Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry. Antimicrobial Agents and Chemotherapy, 60 (12). pp. 7364-7371.

Leonidova, Anna and Vargas, Mireille and Huwyler, Jörg and Keiser, Jennifer. (2016) Pharmacokinetics of the antischistosomal lead OZ418 in uninfected mice determined by LC-MS/MS. Antimicrobial agents and chemotherapy, 60 (12). pp. 7364-7371.

Duthaler, Urs and Sayasone, Somphou and Vanobbergen, Fiona and Penny, Melissa A. and Odermatt, Peter and Huwyler, Jörg and Keiser, Jennifer. (2016) Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients. Antimicrobial agents and chemotherapy, 60 (10). pp. 5705-5715.

Duthaler, Urs and Sayasone, Somphou and Vanobbergen, Fiona and Penny, Melissa A. and Odermatt, Peter and Huwyler, Jörg and Keiser, Jennifer. (2016) Single-ascending-Ddse pharmacokinetic study of tribendimidine in opisthorchis viverrini-infected patients. Antimicrobial Agents and Chemotherapy, 60 (10). pp. 5705-5715.

Mathaes, Roman and Mahler, Hanns-Christian and Vorgrimler, Lothar and Steinberg, Henrik and Dreher, Sascha and Roggo, Yves and Nieto, Alejandra and Brwon, Helen and Roehl, Holger and Adler, Michael and Luemkemann, Joerg and Huwyler, Jörg and Lam, Philippe and Stauch, Oliver and Mohl, Silke and Streubel, Alexander. (2016) The Pharmaceutical Capping Process - Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force. PDA Journal of Pharmaceutical Science and Technology, 70 (3). pp. 218-229.

25 December 2015

Kettiger, Helene and Karaman, Didem Sen and Schiesser, Laura and Rosenholm, Jessica M. and Huwyler, Jörg. (2015) Comparative safety evaluation of silica-based particles. Toxicology in vitro, 30 (1). pp. 355-363.

December 2015

Boll, Björn and Folzer, Emilien and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Schmidt, Roland and Koulov, Atanas V.. (2015) Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS. Pharmaceutical research, 32 (12). pp. 3952-3964.

Folzer, Emilien and Khan, Tarik and Schmidt, Roland and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator. Journal of pharmaceutical sciences, 104 (12). pp. 4034-4040.

October 2015

Allmendinger, Andrea and Mueller, Robert and Huwyler, Jörg and Mahler, Hans-Christian and Fischer, Stefan. (2015) Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material. Journal of pharmaceutical sciences, 104 (10). pp. 3319-3329.

September 2015

Werk, Tobias and Huwyler, Jörg and Hafner, Mathias and Luemkemann, Jörg and Mahler, Hanns-Christian. (2015) An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals. Journal of pharmaceutical sciences, 104 (9). pp. 2948-2955.

Kunze, Annett and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-188.

Folzer, Emilien and Diepold, Katharina and Bomans, Katrin and Finkler, Christof and Schmidt, Roland and Bulau, Patrick and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule. Journal of pharmaceutical sciences, 104 (9). pp. 2824-2831.

July 2015

Allmendinger, Andrea and Mueller, Robert and Schwarb, Edward and Chipperfield, Mark and Huwyler, Jörg and Mahler, Hanns-Christian and Fischer, Stefan. (2015) Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection. Pharmaceutical research, 32 (7). pp. 2229-2240.

20 June 2015

Preisig, Daniel and Weingartner, Michael and Varum, Felipe J. O. and Bravo, Roberto and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2015) Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays. International journal of pharmaceutics, 487 (1-2). pp. 157-166.

March 2015

Seeland, Swen and Kettiger, Helene and Murphy, Mark and Treiber, Alexander and Giller, Jasmin and Kiss, Andrea and Sube, Romain and Krähenbühl, Stephan and Hafner, Mathias and Huwyler, Jörg. (2015) ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacology Research & Perspecitves, 3 (2). e00123.

Camenisch, Gian and Riede, Julia and Kunze, Annett and Huwyler, Jörg and Poller, Birk and Umehara, Kanichi. (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET & DMPK, 3 (1). pp. 1-14.

28 February 2015

Wicki, Andreas and Witzigmann, Dominik and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2015) Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications. Journal of controlled release, 200. pp. 138-157.

12 February 2015

Jaeschke, Georg and Kolczewski, Sabine and Spooren, Will and Vieira, Eric and Bitter-Stoll, Nadia and Boissin, Patrick and Borroni, Edilio and Büttelmann, Bernd and Ceccarelli, Simona and Clemann, Nicole and David, Beatrice and Funk, Christoph and Guba, Wolfgang and Harrison, Anthony and Hartung, Thomas and Honer, Michael and Huwyler, Jörg and Kuratli, Martin and Niederhauser, Urs and Pähler, Axel and Peters, Jens-Uwe and Petersen, Ann and Prinssen, Eric and Ricci, Antonio and Rueher, Daniel and Rueher, Marianne and Schneider, Manfred and Spurr, Paul and Stoll, Theodor and Tännler, Daniel and Wichmann, Jürgen and Porter, Richard H. and Wettstein, Joseph G. and Lindemann, Lothar. (2015) Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of medicinal chemistry, 58 (3). pp. 1358-1371.

2015

Witzigmann, Dominik and Wu, Dalin and Schenk, Susanne H. and Balasubramanian, Vimalkumar and Meier, Wolfgang and Huwyler, Jörg. (2015) Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery. ACS applied materials & interfaces, 7 (19). pp. 10446-10456.

Witzigmann, Dominik and Wu, Dalin and Schenk, Susanne H. and Balasubramanian, Vimalkumar and Meier, Wolfgang P. and Huwyler, Jörg . (2015) Biocompatible Polymer–Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery. ACS Applied Materials and Interfaces, 7 (19). pp. 10446-10456.

Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Speich, Benjamin and Puchkov, Maxim and Huwyler, Jörg and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2015) Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. The Lancet infectious diseases, 16 (1). pp. 53-60.

Witzigmann, Dominik and Sieber, Sandro and Porta, Fabiola and Grossen, Philip and Bieri, Andrej and Strelnikova, Natalja and Pfohl, Thomas and Prescianotto-Baschong, Cristina and Huwyler, Jörg. (2015) Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach. RSC Advances, 5 (91). pp. 74320-74328.

Eberle, Veronika A. and Donzelli, Massimiliano and Alles, Rainer and Puchkov, Maxim and Huwyler, Jörg. (2015) In Vivo Evaluation of a Gastroretentive Drug Delivery System Based on Enteric-Coated Floating Tablets. Clinical Research: Open Access, 1.2.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2015) LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. Journal of pharmaceutical and biomedical analysis, 105. pp. 163-173.

Studer, Christoph and Aicher, Lothar and Gasic, Bojan and von Goetz, Natalie and Hoet, Peter and Huwyler, Jörg and Kägi, Ralf and Kase, Robert and Kobe, Andrej and Nowack, Bernd and Rothen-Rutishauser, Barbara and Schirmer, Kristin and Schneider, Gregor and Vermeissen, Etienne and Wick, Peter and Walser, Tobias. (2015) Scientific Basis for Regulatory Decision-Making of Nanomaterials; Report on the Workshop, 20-21 January 2014; Center of Applied Ecotoxicology, Dübendorf. In: Scientific Basis for Regulatory Decision-Making of Nanomaterials. Switzerland, pp. 52-56.

2014

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. pp. 232-241.

Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Alles, Rainer and Huwyler, Jörg and Hattendorf, Jan and Utzinger, Jürg and Albonico, Marco and Keiser, Jennifer. (2014) Oxantel pamoate-albendazole for Trichuris trichiura infection. The New England journal of medicine, Vol. 370, H. 7. pp. 610-620.

Dieu, Le-Ha and Wu, Dalin and Palivan, Cornelia G. and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2014) Polymersomes conjugated to 83-14 monoclonal antibodies : in vitro targeting of brain capillary endothelial cells. European journal of pharmaceutics and biopharmaceutics, 88 (2). pp. 316-324.

2013

Meister, Isabel and Duthaler, Urs and Huwyler, Jörg and Rinaldi, Laura and Bosco, Antonio and Cringoli, Giuseppe and Keiser, Jennifer. (2013) Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 198, H. 1-2. pp. 102-110.

Stirnimann, Tanja and Di Maiuta, Nicola and Gerard, Daniel E. and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2013) Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets. Pharmaceutical research, Vol. 30, H. 7. pp. 1915-1925.

2012

Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg. (2012) Drug interaction potential of resveratrol. Drug metabolism reviews, Vol. 44, H. 3. pp. 253-265.

2011

Suenderhauf, Claudia and Hammann, Felix and Maunz, Andreas and Helma, Christoph and Huwyler, Jörg. (2011) Combinatorial QSAR Modeling of human Intestinal Absorption. Molecular pharmaceutics, Vol. 8, H. 1. pp. 213-224.

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2011) Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of Mass Spectrometry, 46 (2). pp. 172-181.

Schmutz, Hans-Rudolf and Detampel, Pascal and Bühler, Theo and Büttler, André and Gygax, Benjamin and Huwyler, Jörg. (2011) In Vitro Assessment of the Formation of Ceftriaxone-Calcium Precipitates in Human Plasma. Journal of pharmaceutical sciences, Vol. 100, H. 6. pp. 2300-2310.

2010

Fasler-Kan, Elizaveta and Suenderhauf, Claudia and Barteneva, Natasha and Poller, Birk and Gygax, Daniel and Huwyler, Jörg. (2010) Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3. Brain research, Vol. 1354. pp. 15-22.

Kirchhofer, Carla and Keiser, Jennifer and Huwyler, Jörg. (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Vol. 878, H. 28. pp. 2770-2774.

Keiser, Jennifer and Kirchhofer, Carla and Haschke, Manuel and Huwyler, Jörg and Dong, Yuxiang and Vennerstrom, Jonathan L. and Vanhoff, Kathleen and Kaminsky, Ronald and Malikides, Nick. (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 173, H. 3-4. pp. 228-235.

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. pp. 63-70.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Gatti, Silvia. (2010) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives : Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic & medicinal chemistry letters, Vol. 20, H. 23. pp. 6969-6974.

2009

Pierson, Pascale David and Fettes, Alec and Freichel, Christian and Gatti-McArthur, Silvia and Hertel, Cornelia and Huwyler, Jörg and Mohr, Peter and Nakagawa, Toshito and Nettekoven, Matthias and Plancher, Jean-Marc and Raab, Susanne and Richter, Hans and Roche, Olivier and Rodríguez Sarmiento, Rosa María and Schmitt, Monique and Schuler, Franz and Takahashi, Tadakatsu and Taylor, Sven and Ullmer, Christoph and Wiegand, Ruby. (2009) 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. Journal of Medicinal Chemistry, 52 (13). pp. 3855-3868.

Vieira, Eric and Huwyler, Jörg and Jolidon, Synèse and Knoflach, Frédéric and Mutel, Vincent and Wichmann, Jürgen. (2009) Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorganic and Medicinal Chemistry Letters, 19 (6). pp. 1666-1669.

Pierson, Pascale David and Freichel, Christian and Gatti-Mac Arthur, Silvia and Hertel, Cornelia and Huwyler, Jörg and Mohr, Peter and Nakagawa, Toshito and Nettekoven, Matthias and Plancher, Jean-Marc and Raab, Susanne and Richter, Hans and Roche, Olivier and Rodríguez Sarmiento, Rosa María and Schmitt, Monique and Schuler, Franz and Takahashi, Tadakatsu and Taylor, Sven and Ullmer, Christoph and Wiegand, Ruby. (2009) Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series. Chimia, 63 (5). pp. 275-278(4).

2008

Du-Cuny, Lei and Huwyler, Jörg and Wiese, Michael and Kansy, Manfred. (2008) Computational aqueous solubility prediction for drug-like compounds in congeneric series. European Journal of Medicinal Chemistry, 43 (3). pp. 501-512.

Tuffin, Gérald and Huwyler, Jörg and Waelti, Ernst and Hammer, Caroline and Marti, Hans-Peter. (2008) Drug targeting using OX7-immunoliposomes: Correlation between Thy1.1 antigen expression and tissue distribution in the rat. Journal of Drug Targeting, 16 (2). pp. 156-166.

Bendels, Stefanie and Kansy, Manfred and Wagner, Björn and Huwyler, Jörg. (2008) In silico prediction of brain and CSF permeation of small molecules using PLS regression models. European Journal of Medicinal Chemistry, 43 (8). pp. 1581-1592.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Adam, Geo and Kew, James N. C. and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Mutel, Vincent and Gatti, Silvia. (2008) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic and Medicinal Chemistry Letters, 18 (8). pp. 2725-2729.

2007

Du-Cuny, Lei and Huwyler, Jörg and Fischer, Holger and Kansy, Manfred. (2007) A potentiometric titration method for the crystallization of drug-like organic molecules. International Journal of Pharmaceutics, 342 (1-2). pp. 161-167.

Ceccarelli, Simona M. and Jaeschke, Georg and Buettelmann, Bernd and Huwyler, Jörg and Kolczewski, Sabine and Peters, Jens-Uwe and Prinssen, Eric and Porter, Richard and Spooren, Will and Vieira, Eric. (2007) Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1302-1306.

Jaeschke, Georg and Porter, Richard and Büttelmann, Bernd and Ceccarelli, Simona M. and Guba, Wolfgang and Kuhn, Bernd and Kolczewski, Sabine and Huwyler, Jörg and Mutel, Vincent and Peters, Jens-Uwe and Ballard, Theresa and Prinssen, Eric and Vieira, Eric and Wichmann, Jürgen and Spooren, Will. (2007) Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1307-1311.

2006

Büttelmann, Bernd and Peters, Jens-Uwe and Ceccarelli, Simona and Kolczewski, Sabine and Vieira, Eric and Prinssen, Eric P. and Spooren, Will and Schuler, Franz and Huwyler, Jörg and Porter, Richard H. P. and Jaeschke, Georg. (2006) Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 16 (7). pp. 1892-1897.

Huwyler, Jörg and Wright, Matthew B. and Gutmann, Heike and Drewe, Juergen. (2006) Induction of Cytochrome P450 3A4 and P-Glycoprotein by the Isoxazolyl-Penicillin Antibiotic Flucloxacillin. Current Drug Metabolism, 7 (2). pp. 119-126.

2005

Tuffin, Gérald and Waelti, Ernst and Huwyler, Jörg and Hammer, Caroline and Marti, Hans-Peter. (2005) Immunoliposome Targeting to Mesangial Cells: A Promising Strategy for Specific Drug Delivery to the Kidney. Journal of the American Society of Nephrology, 16 (11). pp. 3295-3305.

Schnyder, Anita and Krähenbühl, Stephan and Drewe, Jürgen and Huwyler, Jörg. (2005) Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects. Journal of Drug Targeting, 13 (5). pp. 325-335.

This list was generated on Thu Dec 3 15:04:32 2020 CET.