Items where Division is "05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)"

2024

Louche, Chris. Investigation and targeting of early degenerative response in retinal cells in Ischemia-Reperfusion glaucoma mouse model: paving the way for therapeutic neuroprotection strategy. 2024, Doctoral Thesis, University of Basel, Faculty of Science.

20 February 2023

Thürkauf, Marco and Lin, Shuo and Oliveri, Filippo and Grimm, Dirk and Platt, Randall J. and Rüegg, Markus A.. (2023) Fast, multiplexable and highly efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9.

2023

Ham, Alexander. Studying the healthy, denervated and aged neuromuscular system using single nuclei RNA-seq. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

Reinhard, Judith R. and Porrello, Emanuela and Lin, Shuo and Pelczar, Pawel and Previtali, Stefano C. and Rüegg, Markus A.. (2023) Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy. PNAS Nexus, 2 (4). pgad083.

Thürkauf, Marco. Deciphering the function of candidate genes in skeletal muscle aging using AAV-CRISPR/Cas9. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

Thürkauf, Marco and Lin, Shuo and Oliveri, Filippo and Grimm, Dirk and Platt, Randall J. and Rüegg, Markus A.. (2023) Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Nature communications, 14 (1). p. 6116.

19 May 2022

Reinhard, Judith R. and Porrello, Emanuela and Lin, Shuo and Pelczar, Pawel and Previtali, Stefano C. and Rüegg, Markus A.. (2022) Nerve pathology is prevented by linker proteins in mouse models for LAMA2- related muscular dystrophy.

2022

Blandino-Rosano, Manuel and Scheys, Joshua O. and Werneck-de-Castro, Joao Pedro and Louzada, Ruy A. and Almaça, Joana and Leibowitz, Gil and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2022) Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American Journal of Physiology, Endocrinology and Metabolism, 323 (2). E133-E144.

Ham, Daniel J. and Börsch, Anastasiya and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2022) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13. p. 2025.

Kaiser, Marco S. and Milan, Giulia and Ham, Daniel J. and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Rüegg, Markus A.. (2022) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. Communications biology, 5 (1). p. 1141.

Leuchtmann, Aurel B.. Molecular transducers of exercise training adaptations in young and aged skeletal muscle. 2022, Doctoral Thesis, University of Basel, Faculty of Science.

30 May 2021

Ham, Daniel J. and Börsch, Anastasyia and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2021) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.

2021

Börsch, Anastasiya and Ham, Daniel J. and Mittal, Nitish and Tintignac, Lionel A. and Migliavacca, Eugenia and Feige, Jérôme N. and Rüegg, Markus A. and Zavolan, Mihaela. (2021) Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia. Communications Biology, 4 (1). p. 194.

Kaiser, Marco S. and Milan, Giulia and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Ham, Daniel J. and Rüegg, Markus A.. (2021) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. bioRxiv. pp. 1-39.

Previtali, Stefano C. and Cohn, Ronald D. and Ruegg, Markus A.. (2021) Editorial: Current Insights Into LAMA2 Disease. Frontiers in molecular neuroscience, 14. p. 780635.

Winkler, Sabine Celine/SCW. PKCγ-mediated phosphorylation of CRMP2 regulates dendritic outgrowth in cerebellar Purkinje cells. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

2020

Castets, Perrine and Ham, Daniel J. and Rüegg, Markus A.. (2020) The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? Frontiers in molecular neuroscience, 13. p. 162.

Ding, Xiaolei and Willenborg, Sebastian and Bloch, Wilhelm and Wickström, Sara A. and Wagle, Prerana and Brodesser, Susanne and Roers, Axel and Jais, Alexander and Brüning, Jens C. and Hall, Michael N. and Rüegg, Markus A. and Eming, Sabine A.. (2020) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology, 145 (1). pp. 283-300.E8.

Falcetta, Denis. Understanding the pathomechanisms leading to muscle alterations in Myotonic Dystrophy type 1: Consequences of CaMKII deregulation on the maintenance of neuromuscular junctions. 2020, Doctoral Thesis, University of Basel, Faculty of Science.

Federer-Gsponer, Joël. DNA content based flow sorting combined with genomic high-resolution profiling in the context of the development of castration resistance in prostate cancer. 2020, Doctoral Thesis, University of Basel, Cross-disciplinary Subjects.

Ham, Alexander S. and Chojnowska, Kathrin and Tintignac, Lionel A. and Lin, Shuo and Schmidt, Alexander and Ham, Daniel J. and Sinnreich, Michael and Rüegg, Markus A.. (2020) mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice. Journal of Cachexia, Sarcopenia and Muscle, 11 (1). pp. 259-273.

Ham, Daniel J. and Börsch, Anastasiya and Lin, Shuo and Thürkauf, Marco and Weihrauch, Martin and Reinhard, Judith R. and Delezie, Julien and Battilana, Fabienne and Wang, Xueyong and Kaiser, Marco S. and Guridi, Maitea and Sinnreich, Michael and Rich, Mark M. and Mittal, Nitish and Tintignac, Lionel A. and Handschin, Christoph and Zavolan, Mihaela and Rüegg, Markus A.. (2020) The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11 (1). p. 4510.

Pereira, Jorge A. and Gerber, Joanne and Ghidinelli, Monica and Gerber, Daniel and Tortola, Luigi and Ommer, Andrea and Bachofner, Sven and Santarella, Francesco and Tinelli, Elisa and Lin, Shuo and Rüegg, Markus A. and Kopf, Manfred and Toyka, Klaus V. and Suter, Ueli. (2020) Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy. Human Molecular Genetics, 29 (8). pp. 1253-1273.

2019

Castets, Perrine and Rion, Nathalie and Théodore, Marine and Falcetta, Denis and Lin, Shuo and Reischl, Markus and Wild, Franziska and Guérard, Laurent and Eickhorst, Christopher and Brockhoff, Marielle and Guridi, Maitea and Ibebunjo, Chikwendu and Cruz, Joseph and Sinnreich, Michael and Rudolf, Rüdiger and Glass, David J. and Rüegg, Markus A.. (2019) mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nature communications, 10 (1). p. 3187.

Chojnowska, Kathrin. Deciphering additional mechanisms of mTORC1 signaling in skeletal muscle. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

Delezie, Julien and Weihrauch, Martin and Maier, Geraldine and Tejero, Rocío and Ham, Daniel J. and Gill, Jonathan F. and Karrer-Cardel, Bettina and Rüegg, Markus A. and Tabares, Lucía and Handschin, Christoph. (2019) BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116 (32). pp. 16111-16120.

Donadon, Irving and Bussani, Erica and Riccardi, Federico and Licastro, Danilo and Romano, Giulia and Pianigiani, Giulia and Pinotti, Mirko and Kostantinova, Pavlina and Evers, Melvin and Lin, Shuo and Rüegg, Markus A. and Pagani, Franco. (2019) Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic acids research, 47 (14). pp. 7618-7632.

Flores-Dominguez, Diana. The role of the Calcium-binding of Copine-6 in synapse function and plasticity. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

Kaiser, Marco. The role of mTORC1 in muscle proteostasis. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Eickhorst, Christopher and Rüegg, Markus A.. (2019) mTOR controls embryonic and adult myogenesis via mTORC1. Development, 146 (7). pp. 1-15.

Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Rüegg, Markus A.. (2019) mTORC2 affects the maintenance of the muscle stem cell pool. Skeletal Muscle, 9 (1). p. 30.

2018

Boido, Marina and De Amicis, Elena and Valsecchi, Valeria and Trevisan, Marco and Ala, Ugo and Ruegg, Markus A. and Hettwer, Stefan and Vercelli, Alessandro. (2018) Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Frontiers in cellular neuroscience, 12. p. 17.

Heim, Philippe. Regulation of glucose uptake in neonatal rat cardiomyocytes by Neuregulin1β. 2018, Doctoral Thesis, University of Basel, Faculty of Science.

Martin, Sally K. and Fitter, Stephen and El Khawanky, Nadia and Grose, Randall H. and Walkley, Carl R. and Purton, Louise E. and Ruegg, Markus A. and Hall, Michael N. and Gronthos, Stan and Zannettino, Andrew C. W.. (2018) mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8 (1). p. 14501.

Yurchenco, Peter D. and McKee, Karen K. and Reinhard, Judith R. and Rüegg, Markus A.. (2018) Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix biology : journal of the International Society for Matrix Biology, 71-72. pp. 174-187.

Zainul, Zarin and Heikkinen, Anne and Koivisto, Hennariikka and Rautalahti, Iina and Kallio, Mika and Lin, Shuo and Härönen, Heli and Norman, Oula and Rüegg, Markus A. and Tanila, Heikki and Pihlajaniemi, Taina. (2018) Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury. The Journal of neuroscience, 38 (17). pp. 4243-4258.

van Putten, Maaike and Aartsma-Rus, Annemieke and Grounds, Miranda D. and Kornegay, Joe N. and Mayhew, Anna and Gillingwater, Thomas H. and Takeda, Shin'ichi and Rüegg, Markus A. and De Luca, Annamaria and Nagaraju, Kanneboyina and Willmann, Raffaella. (2018) Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. Journal of Neuromuscular Diseases, 5 (1). pp. 29-34.

2017

Bozadjieva, Nadejda and Blandino-Rosano, Manuel and Chase, Jennifer and Dai, Xiao-Qing and Cummings, Kelsey and Gimeno, Jennifer and Dean, Danielle and Powers, Alvin C. and Gittes, George K. and Rüegg, Markus A. and Hall, Michael N. and MacDonald, Patrick E. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127 (12). pp. 4379-4393.

Brockhoff, Marielle and Rion, Nathalie and Chojnowska, Kathrin and Wiktorowicz, Tatiana and Eickhorst, Christopher and Erne, Beat and Frank, Stephan and Angelini, Corrado and Furling, Denis and Rüegg, Markus A. and Sinnreich, Michael and Castets, Perrine. (2017) Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127 (2). pp. 549-563.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Hodson, Nathan and McGlory, Chris and Oikawa, Sara Y. and Jeromson, Stewart and Song, Zhe and Ruegg, Markus A. and Hamilton, D. Lee and Phillips, Stuart M. and Philp, Andrew. (2017) Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. American Journal of Physiology - Cell Physiology, 313 (6). C604-C611.

Hoffman, E. P.. (2017) Facilitating orphan drug development: Proceedings of the TREAT-NMD International Conference, December 2015, Washington, DC, USA. Neuromuscular Disorders, 27 (7). pp. 693-701.

Karakatsani, Andromachi and Marichal, Nicolás and Urban, Severino and Kalamakis, Georgios and Ghanem, Alexander and Schick, Anna and Zhang, Yina and Conzelmann, Karl-Klaus and Rüegg, Markus A. and Berninger, Benedikt and Ruiz de Almodovar, Carmen and Gascón, Sergio and Kröger, Stephan. (2017) Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144 (24). pp. 4604-4615.

Kleinert, Maximilian and Parker, Benjamin L. and Fritzen, Andreas M. and Knudsen, Jonas R. and Jensen, Thomas E. and Kjøbsted, Rasmus and Sylow, Lykke and Ruegg, Markus and James, David E. and Richter, Erik A.. (2017) Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595 (14). pp. 4845-4855.

Lebboukh, Sonia. Cardiac effects of ovarian hormones and gender in a mouse model of obesity. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

McKee, Karen K. and Crosson, Stephanie C. and Meinen, Sarina and Reinhard, Judith R. and Rüegg, Markus A. and Yurchenco, Peter D.. (2017) Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127 (3). pp. 1075-1089.

Reinhard, Judith R. and Lin, Shuo and McKee, Karen K. and Meinen, Sarina and Crosson, Stephanie C. and Sury, Maurizio and Hobbs, Samantha and Maier, Geraldine and Yurchenco, Peter D. and Rüegg, Markus A.. (2017) Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9 (396). eaal4649.

Rion, Nathalie. Understanding the role of mTORC1 and mTORC2 in embryonic and adult myogenesis. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Rion, Nathalie and Rüegg, Markus A.. (2017) LncRNA-encoded peptides: More than translational noise? Cell Research, 27 (5). pp. 604-605.

Willmann, Raffaella and Gordish-Dressman, Heather and Meinen, Sarina and Rüegg, Markus A. and Yu, Qing and Nagaraju, Kanneboyina and Kumar, Ayar and Girgenrath, Mahasweta and Coffey, Caroline B. M. and Cruz, Vivian and Van Ry, Pam M. and Bogdanik, Laurent and Lutz, Cathleen and Rutkowski, Anne and Burkin, Dean J.. (2017) Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4 (2). pp. 115-126.

May 2016

Grahammer, Florian and Nesterov, Viatcheslav and Ahmed, Azaz and Steinhardt, Frederic and Sandner, Lukas and Arnold, Frederic and Cordts, Tomke and Negrea, Silvio and Bertog, Marko and Ruegg, Marcus A. and Hall, Michael N. and Walz, Gerd and Korbmacher, Christoph and Artunc, Ferruh and Huber, Tobias B.. (2016) mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, 126 (5). pp. 1773-1782.

Reinhard, Judith R. and Kriz, Alexander and Galic, Milos and Angliker, Nico and Rajalu, Mathieu and Vogt, Kaspar E. and Rüegg, Markus A.. (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7. p. 11613.

21 March 2016

Guridi, Maitea and Kupr, Barbara and Romanino, Klaas and Lin, Shuo and Falcetta, Denis and Tintignac, Lionel and Rüegg, Markus A.. (2016) Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6 (13). pp. 1-14.

9 February 2016

Zhang, Lianjun and Tschumi, Benjamin O. and Lopez-Mejia, Isabel C. and Oberle, Susanne G. and Meyer, Marten and Samson, Guerric and Rüegg, Markus A. and Hall, Michael N. and Fajas, Lluis and Zehn, Dietmar and Mach, Jean-Pierre and Donda, Alena and Romero, Pedro. (2016) Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports , 14 (5). pp. 1206-1217.

February 2016

Schell, Christoph and Kretz, Oliver and Liang, Wei and Kiefer, Betina and Schneider, Simon and Sellung, Dominik and Bork, Tillmann and Leiber, Christian and Rüegg, Markus A. and Mallidis, Con and Schlatt, Stefan and Mayerhofer, Artur and Huber, Tobias B. and Grahammer, Florian. (2016) The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186 (2). pp. 324-336.

6 January 2016

Ruegsegger, Céline and Stucki, David M. and Steiner, Silvio and Angliker, Nico and Radecke, Julika and Keller, Eva and Zuber, Benoît and Rüegg, Markus A. and Saxena, Smita. (2016) Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1). pp. 129-146.

2016

Brockhoff, Marielle. Identification of deregulated AMPK and mTORC1 signalling in myotonic dystrophy type I and their potential as therapeutic targets. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

Castets, Perrine and Frank, Stephan and Sinnreich, Michael and Rüegg, Markus A.. (2016) "Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3 (2). pp. 127-155.

Kleinert, Maximilian and Parker, Benjamin L. and Chaudhuri, Rima and Fazakerley, Daniel J. and Serup, Annette and Thomas, Kristen C. and Krycer, James R. and Sylow, Lykke and Fritzen, Andreas M. and Hoffman, Nolan J. and Jeppesen, Jacob and Schjerling, Peter and Rüegg, Markus A. and Kiens, Bente and James, David E. and Richter, Erik A.. (2016) mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5 (8). pp. 646-655.

Klionsky, Daniel J. and Abdelmohsen, Kotb and Abe, Akihisa and Abedin, Md Joynal and Abeliovich, Hagai and Acevedo Arozena, Abraham and Adachi, Hiroaki and Adams, Christopher M. and Adams, Peter D. and Adeli, Khosrow and Adhihetty, Peter J. and Adler, Sharon G. and Agam, Galila and Agarwal, Rajesh and Aghi, Manish K. and Agnello, Maria and Agostinis, Patrizia and Aguilar, Patricia V. and Aguirre-Ghiso, Julio and Airoldi, Edoardo M. and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akporiaye, Emmanuel T. and Al-Rubeai, Mohamed and Albaiceta, Guillermo M. and Albanese, Chris and Albani, Diego and Albert, Matthew L. and Aldudo, Jesus and Algül, Hana and Alirezaei, Mehrdad and Alloza, Iraide and Almasan, Alexandru and Almonte-Beceril, Maylin and Alnemri, Emad S. and Alonso, Covadonga and Altan-Bonnet, Nihal and Altieri, Dario C. and Alvarez, Silvia and Alvarez-Erviti, Lydia and Alves, Sandro and Amadoro, Giuseppina and Amano, Atsuo and Amantini, Consuelo and Ambrosio, Santiago and Amelio, Ivano and Amer, Amal O. and Amessou, Mohamed and Amon, Angelika and An, Zhenyi and Anania, Frank A. and Andersen, Stig U. and Andley, Usha P. and Andreadi, Catherine K. and Andrieu-Abadie, Nathalie and Anel, Alberto and Ann, David K. and Anoopkumar-Dukie, Shailendra and Antonioli, Manuela and Aoki, Hiroshi and Apostolova, Nadezda and Aquila, Saveria and Aquilano, Katia and Araki, Koichi and Arama, Eli and Aranda, Agustin and Araya, Jun and Arcaro, Alexandre and Arias, Esperanza and Arimoto, Hirokazu and Ariosa, Aileen R. and Armstrong, Jane L. and Arnould, Thierry and Arsov, Ivica and Asanuma, Katsuhiko and Askanas, Valerie and Asselin, Eric and Atarashi, Ryuichiro and Atherton, Sally S. and Atkin, Julie D. and Attardi, Laura D. and Auberger, Patrick and Auburger, Georg and Aurelian, Laure and Autelli, Riccardo and Avagliano, Laura and Avantaggiati, Maria Laura and Avrahami, Limor and Awale, Suresh and Azad, Neelam and Bachetti, Tiziana and Backer, Jonathan M. and Bae, Dong-Hun and Bae, Jae-Sung and Bae, Ok-Nam and Bae, Soo Han and Baehrecke, Eric H. and Baek, Seung-Hoon and Baghdiguian, Stephen and Bagniewska-Zadworna, Agnieszka and Bai, Hua and Bai, Jie and Bai, Xue-Yuan and Bailly, Yannick and Balaji, Kithiganahalli Narayanaswamy and Balduini, Walter and Ballabio, Andrea and Balzan, Rena and Banerjee, Rajkumar and Bánhegyi, Gábor and Bao, Haijun and Barbeau, Benoit and Barrachina, Maria D. and Barreiro, Esther and Bartel, Bonnie and Bartolomé, Alberto and Bassham, Diane C. and Bassi, Maria Teresa and Bast, Robert C. and Basu, Alakananda and Batista, Maria Teresa and Batoko, Henri and Battino, Maurizio and Bauckman, Kyle and Baumgarner, Bradley L. and Bayer, K. Ulrich and Beale, Rupert and Beaulieu, Jean-François and Beck, George R. and Becker, Christoph and Beckham, J. David and Bédard, Pierre-André and Bednarski, Patrick J. and Begley, Thomas J. and Behl, Christian and Behrends, Christian and Behrens, Georg Mn and Behrns, Kevin E. and Bejarano, Eloy and Belaid, Amine and Belleudi, Francesca and Bénard, Giovanni and Berchem, Guy and Bergamaschi, Daniele and Bergami, Matteo and Berkhout, Ben and Berliocchi, Laura and Bernard, Amélie and Bernard, Monique and Bernassola, Francesca and Bertolotti, Anne and Bess, Amanda S. and Besteiro, Sébastien and Bettuzzi, Saverio and Bhalla, Savita and Bhattacharyya, Shalmoli and Bhutia, Sujit K. and Biagosch, Caroline and Bianchi, Michele Wolfe and Biard-Piechaczyk, Martine and Billes, Viktor and Bincoletto, Claudia and Bingol, Baris and Bird, Sara W. and Bitoun, Marc and Bjedov, Ivana and Blackstone, Craig and Blanc, Lionel and Blanco, Guillermo A. and Blomhoff, Heidi Kiil and Boada-Romero, Emilio and Böckler, Stefan and Boes, Marianne and Boesze-Battaglia, Kathleen and Boise, Lawrence H. and Bolino, Alessandra and Boman, Andrea and Bonaldo, Paolo and Bordi, Matteo and Bosch, Jürgen and Botana, Luis M. and Botti, Joelle and Bou, German and Bouché, Marina and Bouchecareilh, Marion and Boucher, Marie-Josée and Boulton, Michael E. and Bouret, Sebastien G. and Boya, Patricia and Boyer-Guittaut, Michaël and Bozhkov, Peter V. and Brady, Nathan and Braga, Vania Mm and Brancolini, Claudio and Braus, Gerhard H. and Bravo-San Pedro, José M. and Brennan, Lisa A. and Bresnick, Emery H. and Brest, Patrick and Bridges, Dave and Bringer, Marie-Agnès and Brini, Marisa and Brito, Glauber C. and Brodin, Bertha and Brookes, Paul S. and Brown, Eric J. and Brown, Karen and Broxmeyer, Hal E. and Bruhat, Alain and Brum, Patricia Chakur and Brumell, John H. and Brunetti-Pierri, Nicola and Bryson-Richardson, Robert J. and Buch, Shilpa and Buchan, Alastair M. and Budak, Hikmet and Bulavin, Dmitry V. and Bultman, Scott J. and Bultynck, Geert and Bumbasirevic, Vladimir and Burelle, Yan and Burke, Robert E. and Burmeister, Margit and Bütikofer, Peter and Caberlotto, Laura and Cadwell, Ken and Cahova, Monika and Cai, Dongsheng and Cai, Jingjing and Cai, Qian and Calatayud, Sara and Camougrand, Nadine and Campanella, Michelangelo and Campbell, Grant R. and Campbell, Matthew and Campello, Silvia and Candau, Robin and Caniggia, Isabella and Cantoni, Lavinia and Cao, Lizhi and Caplan, Allan B. and Caraglia, Michele and Cardinali, Claudio and Cardoso, Sandra Morais and Carew, Jennifer S. and Carleton, Laura A. and Carlin, Cathleen R. and Carloni, Silvia and Carlsson, Sven R. and Carmona-Gutierrez, Didac and Carneiro, Leticia Am and Carnevali, Oliana and Carra, Serena and Carrier, Alice and Carroll, Bernadette and Casas, Caty and Casas, Josefina and Cassinelli, Giuliana and Castets, Perrine and Castro-Obregon, Susana and Cavallini, Gabriella and Ceccherini, Isabella and Cecconi, Francesco and Cederbaum, Arthur I. and Ceña, Valentín and Cenci, Simone and Cerella, Claudia and Cervia, Davide and Cetrullo, Silvia and Chaachouay, Hassan and Chae, Han-Jung and Chagin, Andrei S. and Chai, Chee-Yin and Chakrabarti, Gopal and Chamilos, Georgios and Chan, Edmond Yw and Chan, Matthew Tv and Chandra, Dhyan and Chandra, Pallavi and Chang, Chih-Peng and Chang, Raymond Chuen-Chung and Chang, Ta Yuan and Chatham, John C. and Chatterjee, Saurabh and Chauhan, Santosh and Che, Yongsheng and Cheetham, Michael E. and Cheluvappa, Rajkumar and Chen, Chun-Jung and Chen, Gang and Chen, Guang-Chao and Chen, Guoqiang and Chen, Hongzhuan and Chen, Jeff W. and Chen, Jian-Kang and Chen, Min and Chen, Mingzhou and Chen, Peiwen and Chen, Qi and Chen, Quan and Chen, Shang-Der and Chen, Si and Chen, Steve S.-L. and Chen, Wei and Chen, Wei-Jung and Chen, Wen Qiang and Chen, Wenli and Chen, Xiangmei and Chen, Yau-Hung and Chen, Ye-Guang and Chen, Yin and Chen, Yingyu and Chen, Yongshun and Chen, Yu-Jen and Chen, Yue-Qin and Chen, Yujie and Chen, Zhen and Chen, Zhong and Cheng, Alan and Cheng, Christopher Hk and Cheng, Hua and Cheong, Heesun and Cherry, Sara and Chesney, Jason and Cheung, Chun Hei Antonio and Chevet, Eric and Chi, Hsiang Cheng and Chi, Sung-Gil and Chiacchiera, Fulvio and Chiang, Hui-Ling and Chiarelli, Roberto and Chiariello, Mario and Chieppa, Marcello and Chin, Lih-Shen and Chiong, Mario and Chiu, Gigi Nc and Cho, Dong-Hyung and Cho, Ssang-Goo and Cho, William C. and Cho, Yong-Yeon and Cho, Young-Seok and Choi, Augustine Mk and Choi, Eui-Ju and Choi, Eun-Kyoung and Choi, Jayoung and Choi, Mary E. and Choi, Seung-Il and Chou, Tsui-Fen and Chouaib, Salem and Choubey, Divaker and Choubey, Vinay and Chow, Kuan-Chih and Chowdhury, Kamal and Chu, Charleen T. and Chuang, Tsung-Hsien and Chun, Taehoon and Chung, Hyewon and Chung, Taijoon and Chung, Yuen-Li and Chwae, Yong-Joon and Cianfanelli, Valentina and Ciarcia, Roberto and Ciechomska, Iwona A. and Ciriolo, Maria Rosa and Cirone, Mara and Claerhout, Sofie and Clague, Michael J. and Clària, Joan and Clarke, Peter Gh and Clarke, Robert and 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Ashley and Cox, Jeffery S. and Coxon, Fraser P. and Coyne, Carolyn B. and Cragg, Mark S. and Craven, Rolf J. and Crepaldi, Tiziana and Crespo, Jose L. and Criollo, Alfredo and Crippa, Valeria and Cruz, Maria Teresa and Cuervo, Ana Maria and Cuezva, Jose M. and Cui, Taixing and Cutillas, Pedro R. and Czaja, Mark J. and Czyzyk-Krzeska, Maria F. and Dagda, Ruben K. and Dahmen, Uta and Dai, Chunsun and Dai, Wenjie and Dai, Yun and Dalby, Kevin N. and Dalla Valle, Luisa and Dalmasso, Guillaume and D'Amelio, Marcello and Damme, Markus and Darfeuille-Michaud, Arlette and Dargemont, Catherine and Darley-Usmar, Victor M. and Dasarathy, Srinivasan and Dasgupta, Biplab and Dash, Srikanta and Dass, Crispin R. and Davey, Hazel Marie and Davids, Lester M. and Dávila, David and Davis, Roger J. and Dawson, Ted M. and Dawson, Valina L. and Daza, Paula and de Belleroche, Jackie and de Figueiredo, Paul and de Figueiredo, Regina Celia Bressan Queiroz and de la Fuente, José and De Martino, Luisa and De Matteis, Antonella and De Meyer, Guido Ry and De Milito, Angelo and De Santi, Mauro and de Souza, Wanderley and De Tata, Vincenzo and De Zio, Daniela and Debnath, Jayanta and Dechant, Reinhard and Decuypere, Jean-Paul and Deegan, Shane and Dehay, Benjamin and Del Bello, Barbara and Del Re, Dominic P. and Delage-Mourroux, Régis and Delbridge, Lea Md and Deldicque, Louise and Delorme-Axford, Elizabeth and Deng, Yizhen and Dengjel, Joern and Denizot, Melanie and Dent, Paul and Der, Channing J. and Deretic, Vojo and Derrien, Benoît and Deutsch, Eric and Devarenne, Timothy P. and Devenish, Rodney J. and Di Bartolomeo, Sabrina and Di Daniele, Nicola and Di Domenico, Fabio and Di Nardo, Alessia and Di Paola, Simone and Di Pietro, Antonio and Di Renzo, Livia and DiAntonio, Aaron and Díaz-Araya, Guillermo and Díaz-Laviada, Ines and Diaz-Meco, Maria T. and Diaz-Nido, Javier and Dickey, Chad A. and Dickson, Robert C. and Diederich, Marc and Digard, Paul and Dikic, Ivan and Dinesh-Kumar, Savithrama P. and Ding, Chan and Ding, Wen-Xing and Ding, Zufeng and Dini, Luciana and Distler, Jörg Hw and Diwan, Abhinav and Djavaheri-Mergny, Mojgan and Dmytruk, Kostyantyn and Dobson, Renwick Cj and Doetsch, Volker and Dokladny, Karol and Dokudovskaya, Svetlana and Donadelli, Massimo and Dong, X. Charlie and Dong, Xiaonan and Dong, Zheng and Donohue, Terrence M. and Doran, Kelly S. and D'Orazi, Gabriella and Dorn, Gerald W. and Dosenko, Victor and Dridi, Sami and Drucker, Liat and Du, Jie and Du, Li-Lin and Du, Lihuan and du Toit, André and Dua, Priyamvada and Duan, Lei and Duann, Pu and Dubey, Vikash Kumar and Duchen, Michael R. and Duchosal, Michel A. and Duez, Helene and Dugail, Isabelle and Dumit, Verónica I. and Duncan, Mara C. and Dunlop, Elaine A. and Dunn, William A. and Dupont, Nicolas and Dupuis, Luc and Durán, Raúl V. and Durcan, Thomas M. and Duvezin-Caubet, Stéphane and Duvvuri, Umamaheswar and Eapen, Vinay and Ebrahimi-Fakhari, Darius and Echard, Arnaud and Eckhart, Leopold and Edelstein, Charles L. and Edinger, Aimee L. and Eichinger, Ludwig and Eisenberg, Tobias and Eisenberg-Lerner, Avital and Eissa, N. Tony and El-Deiry, Wafik S. and El-Khoury, Victoria and Elazar, Zvulun and Eldar-Finkelman, Hagit and Elliott, Chris Jh and Emanuele, Enzo and Emmenegger, Urban and Engedal, Nikolai and Engelbrecht, Anna-Mart and Engelender, Simone and Enserink, Jorrit M. and Erdmann, Ralf and Erenpreisa, Jekaterina and Eri, Rajaraman and Eriksen, Jason L. and Erman, Andreja and Escalante, Ricardo and Eskelinen, Eeva-Liisa and Espert, Lucile and Esteban-Martínez, Lorena and Evans, Thomas J. and Fabri, Mario and Fabrias, Gemma and Fabrizi, Cinzia and Facchiano, Antonio and Færgeman, Nils J. and Faggioni, Alberto and Fairlie, W. 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Murat and Ke, Po-Yuan and Ke, Zun-Ji and Kehrl, John H. and Keller, Kate E. and Kemper, Jongsook Kim and Kenworthy, Anne K. and Kepp, Oliver and Kern, Andreas and Kesari, Santosh and Kessel, David and Ketteler, Robin and Kettelhut, Isis do Carmo and Khambu, Bilon and Khan, Muzamil Majid and Khandelwal, Vinoth Km and Khare, Sangeeta and Kiang, Juliann G. and Kiger, Amy A. and Kihara, Akio and Kim, Arianna L. and Kim, Cheol Hyeon and Kim, Deok Ryong and Kim, Do-Hyung and Kim, Eung Kweon and Kim, Hye Young and Kim, Hyung-Ryong and Kim, Jae-Sung and Kim, Jeong Hun and Kim, Jin Cheon and Kim, Jin Hyoung and Kim, Kwang Woon and Kim, Michael D. and Kim, Moon-Moo and Kim, Peter K. and Kim, Seong Who and Kim, Soo-Youl and Kim, Yong-Sun and Kim, Yonghyun and Kimchi, Adi and Kimmelman, Alec C. and Kimura, Tomonori and King, Jason S. and Kirkegaard, Karla and Kirkin, Vladimir and Kirshenbaum, Lorrie A. and Kishi, Shuji and Kitajima, Yasuo and Kitamoto, Katsuhiko and Kitaoka, Yasushi and Kitazato, Kaio and Kley, Rudolf A. and Klimecki, Walter T. and Klinkenberg, Michael and Klucken, Jochen and Knævelsrud, Helene and Knecht, Erwin and Knuppertz, Laura and Ko, Jiunn-Liang and Kobayashi, Satoru and Koch, Jan C. and Koechlin-Ramonatxo, Christelle and Koenig, Ulrich and Koh, Young Ho and Köhler, Katja and Kohlwein, Sepp D. and Koike, Masato and Komatsu, Masaaki and Kominami, Eiki and Kong, Dexin and Kong, Hee Jeong and Konstantakou, Eumorphia G. and Kopp, Benjamin T. and Korcsmaros, Tamas and Korhonen, Laura and Korolchuk, Viktor I. and Koshkina, Nadya V. and Kou, Yanjun and Koukourakis, Michael I. and Koumenis, Constantinos and Kovács, Attila L. and Kovács, Tibor and Kovacs, Werner J. and Koya, Daisuke and Kraft, Claudine and Krainc, Dimitri and Kramer, Helmut and Kravic-Stevovic, Tamara and Krek, Wilhelm and Kretz-Remy, Carole and Krick, Roswitha and Krishnamurthy, Malathi and Kriston-Vizi, Janos and Kroemer, Guido and Kruer, Michael C. and Kruger, Rejko and Ktistakis, Nicholas T. and Kuchitsu, Kazuyuki and Kuhn, Christian and Kumar, Addanki Pratap and Kumar, Anuj and Kumar, Ashok and Kumar, Deepak and Kumar, Dhiraj and Kumar, Rakesh and Kumar, Sharad and Kundu, Mondira and Kung, Hsing-Jien and Kuno, Atsushi and Kuo, Sheng-Han and Kuret, Jeff and Kurz, Tino and Kwok, Terry and Kwon, Taeg Kyu and Kwon, Yong Tae and Kyrmizi, Irene and La Spada, Albert R. and Lafont, Frank and Lahm, Tim and Lakkaraju, Aparna and Lam, Truong and Lamark, Trond and Lancel, Steve and Landowski, Terry H. and Lane, Darius J. 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and Lekli, Istvan and Lemaire, Stéphane D. and Lemasters, John J. and Lemberg, Marius K. and Lemoine, Antoinette and Leng, Shuilong and Lenz, Guido and Lenzi, Paola and Lerman, Lilach O. and Lettieri Barbato, Daniele and Leu, Julia I-Ju and Leung, Hing Y. and Levine, Beth and Lewis, Patrick A. and Lezoualc'h, Frank and Li, Chi and Li, Faqiang and Li, Feng-Jun and Li, Jun and Li, Ke and Li, Lian and Li, Min and Li, Min and Li, Qiang and Li, Rui and Li, Sheng and Li, Wei and Li, Wei and Li, Xiaotao and Li, Yumin and Lian, Jiqin and Liang, Chengyu and Liang, Qiangrong and Liao, Yulin and Liberal, Joana and Liberski, Pawel P. and Lie, Pearl and Lieberman, Andrew P. and Lim, Hyunjung Jade and Lim, Kah-Leong and Lim, Kyu and Lima, Raquel T. and Lin, Chang-Shen and Lin, Chiou-Feng and Lin, Fang and Lin, Fangming and Lin, Fu-Cheng and Lin, Kui and Lin, Kwang-Huei and Lin, Pei-Hui and Lin, Tianwei and Lin, Wan-Wan and Lin, Yee-Shin and Lin, Yong and Linden, Rafael and Lindholm, Dan and Lindqvist, Lisa M. and Lingor, Paul and Linkermann, Andreas and Liotta, Lance A. and Lipinski, Marta M. and Lira, Vitor A. and Lisanti, Michael P. and Liton, Paloma B. and Liu, Bo and Liu, Chong and Liu, Chun-Feng and Liu, Fei and Liu, Hung-Jen and Liu, Jianxun and Liu, Jing-Jing and Liu, Jing-Lan and Liu, Ke and Liu, Leyuan and Liu, Liang and Liu, Quentin and Liu, Rong-Yu and Liu, Shiming and Liu, Shuwen and Liu, Wei and Liu, Xian-De and Liu, Xiangguo and Liu, Xiao-Hong and Liu, Xinfeng and Liu, Xu and Liu, Xueqin and Liu, Yang and Liu, Yule and Liu, Zexian and Liu, Zhe and Liuzzi, Juan P. and Lizard, Gérard and Ljujic, Mila and Lodhi, Irfan J. and Logue, Susan E. and Lokeshwar, Bal L. and Long, Yun Chau and Lonial, Sagar and Loos, Benjamin and López-Otín, Carlos and López-Vicario, Cristina and Lorente, Mar and Lorenzi, Philip L. and Lõrincz, Péter and Los, Marek and Lotze, Michael T. and Lovat, Penny E. and Lu, Binfeng and Lu, Bo and Lu, Jiahong and Lu, Qing and Lu, She-Min and Lu, Shuyan and Lu, Yingying and Luciano, Frédéric and Luckhart, Shirley and Lucocq, John Milton and Ludovico, Paula and Lugea, Aurelia and Lukacs, Nicholas W. and Lum, Julian J. and Lund, Anders H. and Luo, Honglin and Luo, Jia and Luo, Shouqing and Luparello, Claudio and Lyons, Timothy and Ma, Jianjie and Ma, Yi and Ma, Yong and Ma, Zhenyi and Machado, Juliano and Machado-Santelli, Glaucia M. and Macian, Fernando and MacIntosh, Gustavo C. and MacKeigan, Jeffrey P. and Macleod, Kay F. and MacMicking, John D. and MacMillan-Crow, Lee Ann and Madeo, Frank and Madesh, Muniswamy and Madrigal-Matute, Julio and Maeda, Akiko and Maeda, Tatsuya and Maegawa, Gustavo and Maellaro, Emilia and Maes, Hannelore and Magariños, Marta and Maiese, Kenneth and Maiti, Tapas K. and Maiuri, Luigi and Maiuri, Maria Chiara and Maki, Carl G. and Malli, Roland and Malorni, Walter and Maloyan, Alina and Mami-Chouaib, Fathia and Man, Na and Mancias, Joseph D. and Mandelkow, Eva-Maria and Mandell, Michael A. and 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and Matus, Soledad and Maugeri, Norma and Mauvezin, Caroline and Mayer, Andreas and Maysinger, Dusica and Mazzolini, Guillermo D. and McBrayer, Mary Kate and McCall, Kimberly and McCormick, Craig and McInerney, Gerald M. and McIver, Skye C. and McKenna, Sharon and McMahon, John J. and McNeish, Iain A. and Mechta-Grigoriou, Fatima and Medema, Jan Paul and Medina, Diego L. and Megyeri, Klara and Mehrpour, Maryam and Mehta, Jawahar L. and Mei, Yide and Meier, Ute-Christiane and Meijer, Alfred J. and Meléndez, Alicia and Melino, Gerry and Melino, Sonia and de Melo, Edesio Jose Tenorio and Mena, Maria A. and Meneghini, Marc D. and Menendez, Javier A. and Menezes, Regina and Meng, Liesu and Meng, Ling-Hua and Meng, Songshu and Menghini, Rossella and Menko, A. Sue and Menna-Barreto, Rubem Fs and Menon, Manoj B. and Meraz-Ríos, Marco A. and Merla, Giuseppe and Merlini, Luciano and Merlot, Angelica M. and Meryk, Andreas and Meschini, Stefania and Meyer, Joel N. and Mi, Man-Tian and Miao, Chao-Yu and Micale, Lucia and Michaeli, Simon and Michiels, Carine and Migliaccio, Anna Rita and Mihailidou, Anastasia Susie and Mijaljica, Dalibor and Mikoshiba, Katsuhiko and Milan, Enrico and Miller-Fleming, Leonor and Mills, Gordon B. and Mills, Ian G. and Minakaki, Georgia and Minassian, Berge A. and Ming, Xiu-Fen and Minibayeva, Farida and Minina, Elena A. and Mintern, Justine D. and Minucci, Saverio and Miranda-Vizuete, Antonio and Mitchell, Claire H. and Miyamoto, Shigeki and Miyazawa, Keisuke and Mizushima, Noboru and Mnich, Katarzyna and Mograbi, Baharia and Mohseni, Simin and Moita, Luis Ferreira and Molinari, Marco and Molinari, Maurizio and Møller, Andreas Buch and Mollereau, Bertrand and Mollinedo, Faustino and Mongillo, Marco and Monick, Martha M. and Montagnaro, Serena and Montell, Craig and Moore, Darren J. and Moore, Michael N. and Mora-Rodriguez, Rodrigo and Moreira, Paula I. and Morel, Etienne and Morelli, Maria Beatrice and Moreno, Sandra and Morgan, Michael J. and Moris, Arnaud and Moriyasu, Yuji and Morrison, Janna L. and Morrison, Lynda A. and Morselli, Eugenia and Moscat, Jorge and Moseley, Pope L. and Mostowy, Serge and Motori, Elisa and Mottet, Denis and Mottram, Jeremy C. and Moussa, Charbel E.-H. and Mpakou, Vassiliki E. and Mukhtar, Hasan and Mulcahy Levy, Jean M. and Muller, Sylviane and Muñoz-Moreno, Raquel and Muñoz-Pinedo, Cristina and Münz, Christian and Murphy, Maureen E. and Murray, James T. and Murthy, Aditya and Mysorekar, Indira U. and Nabi, Ivan R. and Nabissi, Massimo and Nader, Gustavo A. and Nagahara, Yukitoshi and Nagai, Yoshitaka and Nagata, Kazuhiro and Nagelkerke, Anika and Nagy, Péter and Naidu, Samisubbu R. and Nair, Sreejayan and Nakano, Hiroyasu and Nakatogawa, Hitoshi and Nanjundan, Meera and Napolitano, Gennaro and Naqvi, Naweed I. and Nardacci, Roberta and Narendra, Derek P. and Narita, Masashi and Nascimbeni, Anna Chiara and Natarajan, Ramesh and Navegantes, Luiz C. and Nawrocki, Steffan T. and Nazarko, Taras Y. and Nazarko, Volodymyr Y. and Neill, Thomas and Neri, Luca M. and Netea, Mihai G. and Netea-Maier, Romana T. and Neves, Bruno M. and Ney, Paul A. and Nezis, Ioannis P. and Nguyen, Hang Tt and Nguyen, Huu Phuc and Nicot, Anne-Sophie and Nilsen, Hilde and Nilsson, Per and Nishimura, Mikio and Nishino, Ichizo and Niso-Santano, Mireia and Niu, Hua and Nixon, Ralph A. and Njar, Vincent Co and Noda, Takeshi and Noegel, Angelika A. and Nolte, Elsie Magdalena and Norberg, Erik and Norga, Koenraad K. and Noureini, Sakineh Kazemi and Notomi, Shoji and Notterpek, Lucia and Nowikovsky, Karin and Nukina, Nobuyuki and Nürnberger, Thorsten and O'Donnell, Valerie B. and O'Donovan, Tracey and O'Dwyer, Peter J. and Oehme, Ina and Oeste, Clara L. and Ogawa, Michinaga and Ogretmen, Besim and Ogura, Yuji and Oh, Young J. and Ohmuraya, Masaki and Ohshima, Takayuki and Ojha, Rani and Okamoto, Koji and Okazaki, Toshiro and Oliver, F. 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Ashutosh and Rasmussen, Blake B. and Rasse, Tobias M. and Ratovitski, Edward A. and Rautou, Pierre-Emmanuel and Ray, Swapan K. and Razani, Babak and Reed, Bruce H. and Reggiori, Fulvio and Rehm, Markus and Reichert, Andreas S. and Rein, Theo and Reiner, David J. and Reits, Eric and Ren, Jun and Ren, Xingcong and Renna, Maurizio and Reusch, Jane Eb and Revuelta, Jose L. and Reyes, Leticia and Rezaie, Alireza R. and Richards, Robert I. and Richardson, Des R. and Richetta, Clémence and Riehle, Michael A. and Rihn, Bertrand H. and Rikihisa, Yasuko and Riley, Brigit E. and Rimbach, Gerald and Rippo, Maria Rita and Ritis, Konstantinos and Rizzi, Federica and Rizzo, Elizete and Roach, Peter J. and Robbins, Jeffrey and Roberge, Michel and Roca, Gabriela and Roccheri, Maria Carmela and Rocha, Sonia and Rodrigues, Cecilia Mp and Rodríguez, Clara I. and de Cordoba, Santiago Rodriguez and Rodriguez-Muela, Natalia and Roelofs, Jeroen and Rogov, Vladimir V. and Rohn, Troy T. and Rohrer, Bärbel and Romanelli, Davide and Romani, Luigina and Romano, Patricia Silvia and Roncero, M. 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A. and Vierstra, Richard D. and Vigneswaran, Nadarajah and Vij, Neeraj and Vila, Miquel and Villar, Margarita and Villar, Victor H. and Villarroya, Joan and Vindis, Cécile and Viola, Giampietro and Viscomi, Maria Teresa and Vitale, Giovanni and Vogl, Dan T. and Voitsekhovskaja, Olga V. and von Haefen, Clarissa and von Schwarzenberg, Karin and Voth, Daniel E. and Vouret-Craviari, Valérie and Vuori, Kristina and Vyas, Jatin M. and Waeber, Christian and Walker, Cheryl Lyn and Walker, Mark J. and Walter, Jochen and Wan, Lei and Wan, Xiangbo and Wang, Bo and Wang, Caihong and Wang, Chao-Yung and Wang, Chengshu and Wang, Chenran and Wang, Chuangui and Wang, Dong and Wang, Fen and Wang, Fuxin and Wang, Guanghui and Wang, Hai-Jie and Wang, Haichao and Wang, Hong-Gang and Wang, Hongmin and Wang, Horng-Dar and Wang, Jing and Wang, Junjun and Wang, Mei and Wang, Mei-Qing and Wang, Pei-Yu and Wang, Peng and Wang, Richard C. and Wang, Shuo and Wang, Ting-Fang and Wang, Xian and Wang, Xiao-Jia and Wang, Xiao-Wei and Wang, Xin and Wang, Xuejun and Wang, Yan and Wang, Yanming and Wang, Ying and Wang, Ying-Jan and Wang, Yipeng and Wang, Yu and Wang, Yu Tian and Wang, Yuqing and Wang, Zhi-Nong and Wappner, Pablo and Ward, Carl and Ward, Diane McVey and Warnes, Gary and Watada, Hirotaka and Watanabe, Yoshihisa and Watase, Kei and Weaver, Timothy E. and Weekes, Colin D. and Wei, Jiwu and Weide, Thomas and Weihl, Conrad C. and Weindl, Günther and Weis, Simone Nardin and Wen, Longping and Wen, Xin and Wen, Yunfei and Westermann, Benedikt and Weyand, Cornelia M. and White, Anthony R. and White, Eileen and Whitton, J. Lindsay and Whitworth, Alexander J. and Wiels, Joëlle and Wild, Franziska and Wildenberg, Manon E. and Wileman, Tom and Wilkinson, Deepti Srinivas and Wilkinson, Simon and Willbold, Dieter and Williams, Chris and Williams, Katherine and Williamson, Peter R. and Winklhofer, Konstanze F. and Witkin, Steven S. and Wohlgemuth, Stephanie E. and Wollert, Thomas and Wolvetang, Ernst J. and Wong, Esther and Wong, G. William and Wong, Richard W. and Wong, Vincent Kam Wai and Woodcock, Elizabeth A. and Wright, Karen L. and Wu, Chunlai and Wu, Defeng and Wu, Gen Sheng and Wu, Jian and Wu, Junfang and Wu, Mian and Wu, Min and Wu, Shengzhou and Wu, William Kk and Wu, Yaohua and Wu, Zhenlong and Xavier, Cristina Pr and Xavier, Ramnik J. and Xia, Gui-Xian and Xia, Tian and Xia, Weiliang and Xia, Yong and Xiao, Hengyi and Xiao, Jian and Xiao, Shi and Xiao, Wuhan and Xie, Chuan-Ming and Xie, Zhiping and Xie, Zhonglin and Xilouri, Maria and Xiong, Yuyan and Xu, Chuanshan and Xu, Congfeng and Xu, Feng and Xu, Haoxing and Xu, Hongwei and Xu, Jian and Xu, Jianzhen and Xu, Jinxian and Xu, Liang and Xu, Xiaolei and Xu, Yangqing and Xu, Ye and Xu, Zhi-Xiang and Xu, Ziheng and Xue, Yu and Yamada, Takahiro and Yamamoto, Ai and Yamanaka, Koji and Yamashina, Shunhei and Yamashiro, Shigeko and Yan, Bing and Yan, Bo and Yan, Xianghua and Yan, Zhen and Yanagi, Yasuo and Yang, Dun-Sheng and Yang, Jin-Ming and Yang, Liu and Yang, Minghua and Yang, Pei-Ming and Yang, Peixin and Yang, Qian and Yang, Wannian and Yang, Wei Yuan and Yang, Xuesong and Yang, Yi and Yang, Ying and Yang, Zhifen and Yang, Zhihong and Yao, Meng-Chao and Yao, Pamela J. and Yao, Xiaofeng and Yao, Zhenyu and Yao, Zhiyuan and Yasui, Linda S. and Ye, Mingxiang and Yedvobnick, Barry and Yeganeh, Behzad and Yeh, Elizabeth S. and Yeyati, Patricia L. and Yi, Fan and Yi, Long and Yin, Xiao-Ming and Yip, Calvin K. and Yoo, Yeong-Min and Yoo, Young Hyun and Yoon, Seung-Yong and Yoshida, Ken-Ichi and Yoshimori, Tamotsu and Young, Ken H. and Yu, Huixin and Yu, Jane J. and Yu, Jin-Tai and Yu, Jun and Yu, Li and Yu, W. Haung and Yu, Xiao-Fang and Yu, Zhengping and Yuan, Junying and Yuan, Zhi-Min and Yue, Beatrice Yjt and Yue, Jianbo and Yue, Zhenyu and Zacks, David N. and Zacksenhaus, Eldad and Zaffaroni, Nadia and Zaglia, Tania and Zakeri, Zahra and Zecchini, Vincent and Zeng, Jinsheng and Zeng, Min and Zeng, Qi and Zervos, Antonis S. and Zhang, Donna D. and Zhang, Fan and Zhang, Guo and Zhang, Guo-Chang and Zhang, Hao and Zhang, Hong and Zhang, Hong and Zhang, Hongbing and Zhang, Jian and Zhang, Jian and Zhang, Jiangwei and Zhang, Jianhua and Zhang, Jing-Pu and Zhang, Li and Zhang, Lin and Zhang, Lin and Zhang, Long and Zhang, Ming-Yong and Zhang, Xiangnan and Zhang, Xu Dong and Zhang, Yan and Zhang, Yang and Zhang, Yanjin and Zhang, Yingmei and Zhang, Yunjiao and Zhao, Mei and Zhao, Wei-Li and Zhao, Xiaonan and Zhao, Yan G. and Zhao, Ying and Zhao, Yongchao and Zhao, Yu-Xia and Zhao, Zhendong and Zhao, Zhizhuang J. and Zheng, Dexian and Zheng, Xi-Long and Zheng, Xiaoxiang and Zhivotovsky, Boris and Zhong, Qing and Zhou, Guang-Zhou and Zhou, Guofei and Zhou, Huiping and Zhou, Shu-Feng and Zhou, Xu-Jie and Zhu, Hongxin and Zhu, Hua and Zhu, Wei-Guo and Zhu, Wenhua and Zhu, Xiao-Feng and Zhu, Yuhua and Zhuang, Shi-Mei and Zhuang, Xiaohong and Ziparo, Elio and Zois, Christos E. and Zoladek, Teresa and Zong, Wei-Xing and Zorzano, Antonio and Zughaier, Susu M.. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1). pp. 1-222.

Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114.

Skachokova, Zhiva Kalinova. Seeding properties of amyloid-beta and tau in the cerebrospinal fluid. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

4 December 2015

Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705.

10 November 2015

Guridi, Maitea and Tintignac, Lionel A. and Lin, Shuo and Kupr, Barbara and Castets, Perrine and Rüegg, Markus A.. (2015) Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8 (402). ra113.

October 2015

Angliker, Nico and Burri, Michael and Zaichuk, Mariana and Fritschy, Jean-Marc and Rüegg, Markus A.. (2015) mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42 (8). pp. 2595-2612.

2015

Angliker, Nico. Distinct and common functions of mTORC1 and mTORC2 in Purkinje cells. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Carr, T. D. and Feehan, R. P. and Hall, M. N. and Rüegg, M. A. and Shantz, L. M.. (2015) Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36 (4). pp. 487-497.

Domi, Teuta and Porrello, Emanuela and Velardo, Daniele and Capotondo, Alessia and Biffi, Alessandra and Tonlorenzi, Rossana and Amadio, Stefano and Ambrosi, Alessandro and Miyagoe-Suzuki, Yuko and Takeda, Shin'ichi and Ruegg, Markus A. and Previtali, Stefano Carlo. (2015) Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5 (30). pp. 1-17.

Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135.

Ma, S. and Venkatesh, A. and Langellotto, F. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135. pp. 1-13.

Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem Cells, 33 (4). pp. 1359-1365.

Ormazabal, Maitea Guridi. Skeletal muscle mTORC1 regulates whole-body metabolism. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Tintignac, Lionel A. and Brenner, Hans-Rudolf and Rüegg, Markus A.. (2015) Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95 (3). pp. 809-852.

Venkatesh, A. and Ma, S. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125 (4). pp. 1446-1458.

Willmann, Raffaella and De Luca, Annamaria and Nagaraju, Kanneboyina and Rüegg, Markus A.. (2015) Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of Neuromuscular Diseases, 2 (2). pp. 113-117.

Zhang, Yina and Lin, Shuo and Karakatsani, Andromachi and Rüegg, Markus A. and Kröger, Stephan. (2015) Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41 (1). pp. 69-78.

2014

Chen, J. and Tu, X. and Esen, E. and Joeng, K. S. and Lin, C. and Arbeit, J. M. and Rüegg, M. A. and Hall, M. N. and Ma, L. and Long, F.. (2014) WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10 (1). e1004145.

Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170.

Grahammer, F. and Haenisch, N. and Steinhardt, F. and Sander, L. and Roerden, M. and Arnold, F. and Cordts, T. and Wanner, N. and Reichardt, W. and Kerjaschki, D. and Ruegg, M. A. and Hall, M. N. and Moulin, P. and Busch, H. and Boerries, M. and Walz, G. and Artunc, F. and Huber, T. B.. (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111 (27). E2817-E2826.

Hettwer, Stefan and Lin, Shuo and Kucsera, Stefan and Haubitz, Monika and Oliveri, Filippo and Fariello, Ruggero G. and Ruegg, Markus A. and Vrijbloed, Jan W.. (2014) Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9 (2). e88739.

Kleinert, Maximilian and Sylow, Lykke and Fazakerley, Daniel J. and Krycer, James R. and Thomas, Kristen C. and Oxbøll, Anne-Julie and Jordy, Andreas B. and Jensen, Thomas E. and Yang, Guang and Schjerling, Peter and Kiens, Bente and James, David E. and Ruegg, Markus A. and Richter, Erik A.. (2014) Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3 (6). pp. 630-641.

Lebrun-Julien, F. and Bachmann, L. and Norrmén, C. and Trötzmüller, M. and Köfeler, H. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34 (25). pp. 8432-8448.

Miloslavski, Rachel and Cohen, Elad and Avraham, Adam and Iluz, Yifat and Hayouka, Zvi and Kasir, Judith and Mudhasani, Rajini and Jones, Stephen N. and Cybulski, Nadine and Rüegg, Markus A. and Larsson, Ola and Gandin, Valentina and Rajakumar, Arjuna and Topisirovic, Ivan and Meyuhas, Oded. (2014) Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6 (3). pp. 255-266.

Norrmén, C. and Figlia, G. and Lebrun-Julien, F. and Pereira, J. A. and Trötzmüller, M. and Köfeler, H. C. and Rantanen, V. and Wessig, C. and van Deijk, A. F. and Smit, A. B. and Verheijen, M. G. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports , 9 (2). pp. 646-660.

Olivieri, Stefano. Biosynthesis and release of brain-derived neurotrophic factor : a study using neurons derived from embryonic stem cells. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Steiner, Esther and Enzmann, Gaby U. and Lyck, Ruth and Lin, Shuo and Rüegg, Markus A. and Kröger, Stephan and Engelhardt, Britta. (2014) The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358 (2). pp. 465-479.

Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765.

2013

Angliker, Nico and Rüegg, Markus A.. (2013) In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3 (4). pp. 113-118.

Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1). p. 6.

Castets, Perrine and Lin, Shuo and Rion, Nathalie and Di Fulvio, Sabrina and Romanino, Klaas and Guridi, Maitea and Frank, Stephan and Tintignac, Lionel A. and Sinnreich, Michael and Ruegg, Markus A.. (2013) Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, 17 (5). pp. 731-744.

Castets, Perrine and Rüegg, Markus A.. (2013) MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9 (9). pp. 1435-1437.

Cloëtta, Dimitri and Thomanetz, Venus and Baranek, Constanze and Lustenberger, Regula M. and Lin, Shuo and Oliveri, Filippo and Atanasoski, Suzana and Rüegg, Markus A.. (2013) Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, Vol. 33, H. 18. pp. 7799-7810.

Song, Jian and Lokmic, Zerina and Lämmermann, Tim and Rolf, Julia and Wu, Chuan and Zhang, Xueli and Hallmann, Rupert and Hannocks, Melanie-Jane and Horn, Nathalie and Ruegg, Markus A. and Sonnenberg, Arnoud and Georges-Labouesse, Elisabeth and Winkler, Thomas H. and Kearney, John F. and Cardell, Susanna and Sorokin, Lydia. (2013) Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31). pp. 2915-E2924.

Thomanetz, Venus and Angliker, Nico and Cloëtta, Dimitri and Lustenberger, Regula M. and Schweighauser, Manuel and Oliveri, Filippo and Suzuki, Noboru and Rüegg, Markus A.. (2013) Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, Vol. 201, H. 2. pp. 293-308.

2012

Blättler, Sharon M. and Cunningham, John T. and Verdeguer, Francisco and Chim, Helen and Haas, Wilhelm and Liu, Huifei and Romanino, Klaas and Rüegg, Markus A. and Gygi, Steven P. and Shi, Yang and Puigserver, Pere. (2012) Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15 (4). pp. 505-517.

Blättler, Sharon M. and Verdeguer, Francisco and Liesa, Marc and Cunningham, John T. and Vogel, Rutger O. and Chim, Helen and Liu, Huifei and Romanino, Klaas and Shirihai, Orian S. and Vazquez, Francisca and Rüegg, Markus A. and Shi, Yang and Puigserver, Pere. (2012) Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32 (16). pp. 3333-3346.

Haefeli, Roman Hans. Molecular effects of Idebenone. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738.

Lustenberger, Regula Maria. The role of raptor during brain development and in adult forebrain neurons. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Meinen, Sarina and Lin, Shuo and Ruegg, Markus A.. (2012) Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal muscle, Vol. 2, H. 1. p. 18.

Meinen, Sarina and Lin, Shuo and Rüegg, Markus A. and Punga, Anna Rostedt. (2012) Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS ONE, Vol. 7, H. 8 , e44148.

Punga, Anna Rostedt and Ruegg, Markus A.. (2012) Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3). pp. 340-346.

Reinhard, Judith. The function of Copine 6 in the brain. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Romanino, Klaas Emilio Antonius Anna. The role of mTOR complex 1 in skeletal muscle. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Steiner, Esther and Enzmann, Gaby U. and Lin, Shuo and Ghavampour, Sharang and Hannocks, Melanie-Jane and Zuber, Benoît and Rüegg, Markus A. and Sorokin, Lydia and Engelhardt, Britta. (2012) Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia, 60 (11). pp. 1646-1659.

Thomanetz, Venus. mTORC2 controls neuron size and Purkinje cell morphology independent of mTORC1. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Willmann, R. and De Luca, A. and Benatar, M. and Grounds, M. and Dubach, J. and Raymackers, J. M. and Nagaraju, K.. (2012) Enhancing translation: Guidelines for standard pre-clinical experiments in mdx mice. Neuromuscular Disorders, 22 (1). pp. 43-49.

2011

Baldo, Barbara. Innovative approaches to monitor mutant huntingtin and to facilitate its degradation in Huntington's disease models. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Escher, Claudia Andrea. Proteomic profiling of Duchenne muscular dystrophy : protein patterns and candidate markers of disease. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Godel, M. and Hartleben, B. and Herbach, N. and Liu, S. and Zschiedrich, S. and Lu, S. and Debreczeni-Mor, A. and Lindenmeyer, M. T. and Rastaldi, M. -P. and Hartleben, G. and Wiech, T. and Fornoni, A. and Nelson, R. G. and Kretzler, M. and Wanke, R. and Pavenstadt, H. and Kerjaschki, D. and Cohen, C. D. and Hall, M. N. and Ruegg, M. A. and Inoki, K. and Walz, G. and Huber, T. B.. (2011) Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. Journal of Clinical Investigation, 121 (6). pp. 2197-2209.

Inoki, K. and Mori, H. and Wang, J. and Suzuki, T. and Hong, S. and Yoshida, S. and Blattner, S. M. and Ikenoue, T. and Ruegg, M. A. and Hall, M. N. and Kwiatkowski, D. J. and Rastaldi, M. P. and Huber, T. B. and Kretzler, M. and Holzman, L. B. and Wiggins, R. C. and Guan, K. -L.. (2011) mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. Journal of Clinical Investigation, 121 (6). pp. 2181-2196.

Laxhmi Chellappa, Sarah. Circadian and ultradian NREM-REM sleep modulation of dream recall : effects of age and spectral activity. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Meinen, Sarina and Lin, Shuo and Thurnherr, Raphael and Erb, Michael and Meier, Thomas and Rüegg, Markus A.. (2011) Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Molecular Medicine, 3 (8). pp. 465-479.

Punga, A. R. and Lin, S. and Oliveri, F. and Meinen, S. and Ruegg, M. A.. (2011) Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Experimental Neurology, 230 (2). pp. 207-217.

Punga, A. R. and Maj, M. and Lin, S. and Meinen, S. and Ruegg, M. A.. (2011) MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity. The European journal of neuroscience, Vol. 33, H. 5. pp. 890-898.

Rieker, Claus and Dev, Kumlesh K. and Lehnhoff, Katja and Barbieri, Samuel and Ksiazek, Iwona and Kauffmann, Sabine and Danner, Simone and Schell, Heinrich and Boden, Cindy and Ruegg, Markus A. and Kahle, Philipp J. and van der Putten, Herman and Shimshek, Derya R.. (2011) Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE, Vol. 6, H. 9 , e24834.

Romanino, Klaas and Mazelin, Laetitia and Albert, Verena and Conjard-Duplany, Agnès and Lin, Shuo and Bentzinger, C. Florian and Handschin, Christoph and Puigserver, Pere and Zorzato, Francesco and Schaeffer, Laurent and Gangloff, Yann-Gaël and Rüegg, Markus A.. (2011) Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 51. pp. 20808-20813.

Shende, P. and Plaisance, I. and Morandi, C. and Pellieux, C. and Berthonneche, C. and Zorzato, F. and Krishnan, J. and Lerch, R. and Hall, M. N. and Ruegg, M. A. and Pedrazzini, T. and Brink, M.. (2011) Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation, 123 (10). pp. 1073-1082.

Sutter, Raoul and Tschudin-Sutter, Sarah and Grize, Leticia and Widmer, Andreas F. and Marsch, Stephan and Rüegg, Stephan. (2011) Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus. Critical care, 15 (6). R274.

Yazdani Shektaei, Morteza. Disease modelling of a human neurodevelopmental disorder using mouse embryonic stem cells. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

2010

Cloëtta, Dimitri Yves Reto. A conditional mouse model for the characterization of mTORC1 function in muscle and brain. 2010, Doctoral Thesis, University of Basel, Faculty of Science.

Escher, Claudia and Lochmüller, Hanns and Fischer, Dirk and Frank, Stephan and Reimann, Jens and Walter, Maggie C. and Ehrat, Markus and Ruegg, Markus A. and Gygax, Daniel. (2010) Reverse protein arrays as novel approach for protein quantification in muscular dystrophies. Neuromuscular disorders, 20. pp. 302-309.

Kriz, Alexander. Copine 6, a novel calcium sensor translating synaptic activity into spine plasticity : or, "Copine 6 a brainsporter in action". 2010, Doctoral Thesis, University of Basel, Faculty of Science.

Miglino, Nicola Romolo. Novel molecular pathologies in asthma and COPD. 2010, Doctoral Thesis, University of Basel, Faculty of Science.

Rüegg, Markus A. and Glass, David J.. (2010) Molecular mechanisms and treatment options for muscle wasting eiseases. Annual Review of Pharmacology and Toxicology, 51. pp. 373-395.

Willmann, R. and Dubach, J. and Chen, K.. (2010) Developing standard procedures for pre-clinical efficacy studies in mouse models of spinal muscular atrophy: report of the expert workshop "Pre-clinical testing for SMA", Zurich, March 29-30th 2010. Neuromuscular disorders, 21 (1). pp. 74-77.

2009

Bentzinger, Conrad Florian. Function of mTOR complex 1 and 2 in skeletal muscle. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Clavaguera, Florence. Initiation and spreading of Tau pathology. is β-Amyloid the only key? 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Cybulski, N. and Polak, P. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2009) mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proceedings of the National Academy of Sciences of the United States of America, 106 (24). pp. 9902-9907.

Egler, Viviane. A combinatorial preclinical in vitro strategy against human glioblastoma cells. specific targeting of protein kinases, histone deacetylases and glycolysis. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Erb, M. and Meinen, S. and Barzaghi, P. and Sumanovski, L. T. and Courdier-Fruh, I. and Ruegg, M. A. and Meier, T.. (2009) Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-α2 deficiency. Journal of pharmacology and experimental therapeutics, 331 (3). pp. 787-795.

Huze, C. and Bauche, S. and Richard, P. and Chevessier, F. and Goillot, E. and Gaudon, K. and Ben Ammar, A. and Chaboud, A. and Grosjean, I. and Lecuyer, H. -A. and Bernard, V. and Rouche, A. and Alexandri, N. and Kuntzer, T. and Fardeau, M. and Fournier, E. and Brancaccio, A. and Ruegg, M. A. and Koenig, J. and Eymard, B. and Schaeffer, L. and Hantai, D.. (2009) Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. American Journal of Human Genetics, 85 (2). pp. 155-167.

Nagaraju, K. and Willmann, R.. (2009) Developing standard procedures for murine and canine efficacy studies of DMD therapeutics: report of two expert workshops on "Pre-clinical testing for Duchenne dystrophy": Washington DC, October 27th-28th 2007 and Zurich, June 30th-July 1st 2008. Neuromuscular Disorders, 19 (7). pp. 502-506.

Patursky-Polischuk, I. and Stolovich-Rain, M. and Hausner-Hanochi, M. and Kasir, J. and Cybulski, N. and Avruch, J. and Ruegg, M. A. and Hall, M. N. and Meyuhas, O.. (2009) The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Molecular and cellular biology, Vol. 29, H. 3. pp. 640-649.

Risson, Valérie and Mazelin, Laetitia and Roceri, Mila and Sanchez, Hervé and Moncollin, Vincent and Corneloup, Claudine and Richard-Bulteau, Hélène and Vignaud, Alban and Baas, Dominique and Defour, Aurélia and Freyssenet, Damien and Tanti, Jean-François and Le-Marchand-Brustel, Yannick and Ferrier, Bernard and Conjard-Duplany, Agnès and Romanino, Klaas and Bauché, Stéphanie and Hantaï, Daniel and Mueller, Matthias and Kozma, Sara C. and Thomas, George and Rüegg, Markus A. and Ferry, Arnaud and Pende, Mario and Bigard, Xavier and Koulmann, Nathalie and Schaeffer, Laurent and Gangloff, Yann-Gaël. (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. The Journal of cell biology, Vol. 187, H. 6. pp. 859-874.

Willmann, Raffaella and Possekel, Stefanie and Dubach-Powell, Judith and Meier, Thomas and Rüegg, Markus A.. (2009) Mammalian animal models for Duchenne muscular dystrophy. Neuromuscular Disorders, 19 (4). pp. 241-249.

2008

Annaheim, Christine. Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75 basierend auf embryonalen Stammzellen der Maus. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Bentzinger, C. F. and Romanino, K. and Cloetta, D. and Lin, S. and Mascarenhas, J. B. and Oliveri, F. and Xia, J. and Casanova, E. and Costa, C. F. and Brink, M. and Zorzato, F. and Hall, M. N. and Ruegg, M. A.. (2008) Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism, 8 (5). pp. 411-424.

Giacometti, Emanuela. Epigenetic and central nervous system function : insights from the study of the rett syndrome mouse model. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Heitz, Stéphane. Neuronal death mechanisms in cerebellar Purkinje cells. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Lin, S. and Landmann, L. and Ruegg, M. A. and Brenner, H. R.. (2008) The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. Journal of neuroscience, Vol. 28, H. 13. pp. 3333-3340.

Lin, S. and Maj, M. and Bezakova, G. and Magyar, J. P. and Brenner, H. R. and Ruegg, M. A.. (2008) Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11406-11411.

Maj, Marcin. Functional characterization of MuSK, receptor tyrosine kinase required for the formation and the maintenance of nerve-muscle synapses : "in vivo" and "in vitro" approaches. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Polak, P. and Cybulski, N. and Feige, J. N. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2008) Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration. Cell Metabolism, Vol. 8, H. 5. pp. 399-410.

Reiterer, V. and Maier, S. and Sitte, H. H. and Kriz, A. and Ruegg, M. A. and Hauri, H. P. and Freissmuth, M. and Farhan, H.. (2008) Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. Journal of Neuroscience, 28 (47). pp. 12453-12464.

Sivasankaran, Balasubramanian. The role of NOTCH2 gene in human malignant glial brain tumours. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Zhang, Yan-Ping. Optical analysis of synaptic plasticity in rat hippocampus. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

2007

Camilleri, A. A. and Willmann, R. and Sadasivam, G. and Lin, S. and Ruegg, M. A. and Gesemann, M. and Fuhrer, C.. (2007) Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors. BMC Neuroscience, 8 (46). pp. 1-16.

Cueni, Lucius D.. Low-voltage-activated Ca²+ channels. from burst generators to Ca²+ sources in thalamic oscillatory activity. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Failly, Mike. Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies". 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Hausser, Heinz-Juergen and Ruegg, Markus A. and Brenner, Rolf E. and Ksiazek, Iwona. (2007) Agrin is highly expressed by chondrocytes and is required for normal growth. Histochemistry and Cell Biology, 127 (4). pp. 363-374.

Ksiazek, Iwona and Burkhardt, Constanze and Lin, Shuo and Seddik, Riad and Maj, Marcin and Bezakova, Gabriela and Jucker, Mathias and Arber, Silvia and Caroni, Pico and Sanes, Joshua R. and Bettler, Bernhard and Ruegg, Markus A.. (2007) Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. Journal of Neuroscience, 27 (27). pp. 7183-7195.

Meinen, S. and Barzaghi, P. and Lin, S. and Lochmuller, H. and Ruegg, M. A.. (2007) Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages. The Journal of cell biology, Vol. 176, H. 7. pp. 979-993.

Plachta, N. and Annaheim, C. and Bissiere, S. and Lin, S. and Ruegg, M. and Hoving, S. and Muller, D. and Poirier, F. and Bibel, M. and Barde, Y. -A.. (2007) Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nature neuroscience, Vol. 10, H. 6. pp. 712-719.

Ruiz, Christian. Identification and validation of novel amplification target genes in human breast cancer. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

2006

Annies, M. and Bittcher, G. and Ramseger, R. and Loschinger, J. and Woll, S. and Porten, E. and Abraham, C. and Ruegg, M. A. and Kroger, S.. (2006) Clustering transmembrane-agrin induces filopodia-like processes on axons and dendrites. Molecular and cellular neuroscience, Vol. 31, H. 3. pp. 515-524.

Bittcher, Godela. The role of transmembrane agrin in reorganizing the cytoskeleton in neurons and non-neuronal cells. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Bolmont, Tristan. Mechanisms underlying the initiation of cerebral betaamyloidosis and neurofibrillary tau pathology : new insights form transgenic mice. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Ermini, Florian V.. Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Galic, Milos. Regulation of dendritic spine morphogenesis and synapse formation by copines. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Güntert, Andreas. Characterization of amyloid-ß and other proteins related to Alzheimer's disease, their role in neurodegeneration and biomarker discovery. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Jokic, N. and Gonzalez de Aguilar, J. -L. and Dimou, L. and Lin, S. and Fergani, A. and Ruegg, M. A. and Schwab, M. E. and Dupuis, L. and Loeffler, J. -P.. (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO reports, Vol. 7, H. 11. pp. 1162-1167.

Meinen, S. and Ruegg, M. A.. (2006) Congenital muscular dystrophy: mini-agrin delivers in mice. Gene Therapy, Vol. 13, H. 11. pp. 869-870.

Possekel, S. and Meier, T. and Ruegg, M. A.. (2006) Peripheral signaling pathways involved in muscle loss. In: Pharmacotherapy of Cachexia. Boca Raton, FL, USA, pp. 543-564.

Ruegg, M. A.. (2006) Commonalities and differences in muscular dystrophies : mechanisms and molecules involved in merosin-deficient congenital muscular dystrophy. In: Molecular mechanisms of muscular dystrophies. Georgetown, Tex., pp. 74-81.

Scotton, P. and Bleckmann, D. and Stebler, M. and Sciandra, F. and Brancaccio, A. and Meier, T. and Stetefeld, J. and Ruegg, M. A.. (2006) Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin. Journal of Biological Chemistry, 281 (48). pp. 36835-36845.

Scotton, Patrick. New approaches to identify interactors of MuSK, a receptor tyrosine kinase required for the formation of the nerve-muscle synapse. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

2005

Bentzinger, C. F. and Barzaghi, P. and Lin, S. and Ruegg, M. A.. (2005) Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice. FASEB Journal, 19 (8). pp. 934-942.

Madhavan, R. and Zhao, X. T. and Ruegg, M. A. and Peng, H. B.. (2005) Tyrosine phosphatase regulation of MuSK-dependent acetylcholine receptor clustering. Molecular and cellular neuroscience, Vol. 28, H. 3. pp. 403-416.

Mascarenhas, J. B. and Ruegg, M. A. and Sasaki, T. and Eble, J. A. and Engel, J. and Stetefeld, J.. (2005) Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells. Matrix Biology, Vol. 23, H. 8. pp. 507-513.

Meinen, Sarina. Artificial restoration of the linkage between laminin and dystroglycan ameliorates the disease progression of MDC1A muscular dystrophy at all stages. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Ruegg, M. A.. (2005) Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse. Proceedings of the National Academy of Sciences of the United States of America, 102 (16). pp. 5643-5644.

Sadasivam, G. and Willmann, R. and Lin, S. and Erb-Vogtli, S. and Kong, X. C. and Ruegg, M. A. and Fuhrer, C.. (2005) Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors. Journal of Neuroscience, 25 (45). pp. 10479-10493.

Smirnov, S. P. and Barzaghi, P. and McKee, K. K. and Ruegg, M. A. and Yurchenco, P. D.. (2005) Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering. Journal of Biological Chemistry, 280 (50). pp. 41449-41457.

Stetefeld, J. and Ruegg, M. A.. (2005) Structural and functional diversity generated by alternative mRNA splicing. Trends in biochemical sciences, Vol. 30, H. 9. pp. 515-521.

2004

Jacinto, E. and Loewith, R. and Schmidt, A. and Lin, S. and Ruegg, M. A. and Hall, A. and Hall, M. N.. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology, Vol. 6, H. 11. pp. 1122-1128.

Kong, X. C. and Barzaghi, P. and Ruegg, M. A.. (2004) Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO reports, Vol. 5, H. 2. pp. 183-188.

Ruegg, M. A. and McMahan, U. J.. (2004) Agrin. In: Encyclopedia of Neuroscience. Amsterdam.

Stetefeld, J. and Alexandrescu, A. T. and Maciejewski, M. W. and Jenny, M. and Rathgeb-Szabo, K. and Schulthess, T. and Landwehr, R. and Frank, S. and Ruegg, M. A. and Kammerer, R. A.. (2004) Modulation of agrin function by alternative splicing and Ca2+ binding. Structure: with folding and design, Vol. 12, H. 3. pp. 503-515.

2003

Bartoccioni, E. and Marino, M. and Evoli, A. and Ruegg, M. A. and Scuderi, F. and Provenzano, C.. (2003) Identification of disease-specific autoantibodies in seronegative myasthenia gravis. Annals of the New York Academy of Sciences, 998. pp. 356-358.

Bezakova, G. and Ruegg, M. A.. (2003) New insights into the roles of agrin. Nature reviews. Molecular cell biology, Vol. 4, H. 4. pp. 295-308.

De Paola, Vincenzo. Pre-synaptic terminal dynamics in the hippocampus. 2003, Doctoral Thesis, University of Basel, Faculty of Science.

Eusebio, A. and Oliveri, F. and Barzaghi, P. and Ruegg, M. A.. (2003) Expression of mouse agrin in normal, denervated and dystrophic muscle. Neuromuscular Disorders, Vol. 13, H. 5. pp. 408-415.

Guo, L. T. and Zhang, X. U. and Kuang, W. and Xu, H. and Liu, L. A. and Vilquin, J. -T. and Miyagoe-Suzuki, Y. and Takeda, S. and Ruegg, M. A. and Wewer, U. M. and Engvall, E.. (2003) Laminin alpha2 deficiency and muscular dystrophy : genotype-phenotype correlation in mutant mice. Neuromuscular Disorders, Vol. 13, H. 3. pp. 207-215.

Kong, Xian Chu. RNA interference: a new tool to study gene functions in adult mammalian muscle "in vivo". 2003, Doctoral Thesis, University of Basel, Faculty of Science.

Mascarenhas, J. B. and Ruegg, M. A. and Winzen, U. and Halfter, W. and Engel, J. and Stetefeld, J.. (2003) Mapping of the laminin-binding site of the N-terminal agrin domain (NtA). The EMBO Journal, 22 (3). pp. 529-536.

2002

Abicht, A. and Stucka, R. and Schmidt, C. and Briguet, A. and Hopfner, S. and Song, I. -H. and Pongratz, D. and Muller-Felber, W. and Ruegg, M. A. and Lochmuller, H.. (2002) A newly identified chromosomal microdeletion and an N-box mutation of the AChR epsilon gene cause a congenital myasthenic syndrome. Brain, 125 (5). pp. 1005-1013.

Bixby, J. L. and Baerwald-De la Torre, K. and Wang, C. and Rathjen, F. G. and Ruegg, M. A.. (2002) A neuronal inhibitory domain in the N-terminal half of agrin. Journal of Neurobiology, 50 (2). pp. 164-179.

Pun, S. and Sigrist, M. and Santos, A. F. and Ruegg, M. A. and Sanes, J. R. and Jessell, T. M. and Arber, S. and Caroni, P.. (2002) An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. Neuron, Vol. 34, H. 3. pp. 357-370.

2001

Alexandrescu, A. T. and Maciejewski, M. W. and Ruegg, M. A. and Engel, J. and Kammerer, R. A.. (2001) 1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin. Journal of Biomolecular NMR, 20 (3). pp. 295-296.

Moll, J. and Barzaghi, P. and Lin, S. and Bezakova, G. and Lochmuller, H. and Engvall, E. and Muller, U. and Ruegg, M. A.. (2001) An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature, 413 (6853). pp. 302-307.

Neumann, Frank R. and Bittcher, Godela and Annies, Maik and Schumacher, Beat and Kroger, Stephan and Ruegg, Markus A.. (2001) An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein. Molecular and cellular neuroscience, 17 (1). pp. 208-225.

Ruegg, M. A.. (2001) Molecules involved in the formation of synaptic connections in muscle and brain. Matrix Biology, Vol. 20, H. 1. pp. 3-12.

Stetefeld, J. and Jenny, M. and Schulthess, T. and Landwehr, R. and Schumacher, B. and Frank, S. and Ruegg, M. A. and Engel, J. and Kammerer, R. A.. (2001) The laminin-binding domain of agrin is structurally related to N-TIMP-1. Nature Structural biology, Vol. 8, H. 8. pp. 705-709.

2000

Briguet, A. and Ruegg, M. A.. (2000) The Ets transcription factor GABP is required for postsynaptic differentiation in vivo. Journal of neuroscience, Vol. 20, H. 16. pp. 5989-5996.

Halfter, W. and Dong, S. and Schurer, B. and Osanger, A. and Schneider, W. and Ruegg, M. and Cole, G. J.. (2000) Composition, synthesis, and assembly of the embryonic chick retinal basal lamina. Developmental biology, Vol. 220, H. 2. pp. 111-128.

Meier, T. and Ruegg, M. A.. (2000) The Role of Dystroglycan and Its Ligands in Physiology and Disease. News in physiological sciences, Vol. 15. pp. 255-259.

Sommer, B. and Barbieri, S. and Hofele, K. and Wiederhold, K. and Probst, A. and Mistl, C. and Danner, S. and Kauffmann, S. and Spooren, W. and Tolnay, M. and Bilbe, G. and Kafmann, S. and Caromi, P. and Ruegg, M. A.. (2000) Mouse models of alpha-synucleinopathy and Lewy pathology. Experimental gerontology, Vol. 35, no. 9-10. pp. 1389-1403.

van der Putten, H. and Wiederhold, K. H. and Probst, A. and Barbieri, S. and Mistl, C. and Danner, S. and Kauffmann, S. and Hofele, K. and Spooren, W. P. and Ruegg, M. A. and Lin, S. and Caroni, P. and Sommer, B. and Tolnay, M. and Bilbe, G.. (2000) Neuropathology in mice expressing human alpha-synuclein. Journal of Neuroscience, 20 (16). pp. 6021-6029.

1999

Kammerer, R. A. and Schulthess, T. and Landwehr, R. and Schumacher, B. and Lustig, A. and Yurchenco, P. D. and Ruegg, M. A. and Engel, J. and Denzer, A. J.. (1999) Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain. The EMBO Journal, 18 (23). pp. 6762-6770.

1998

Denzer, A. J. and Schulthess, T. and Fauser, C. and Schumacher, B. and Kammerer, R. A. and Engel, J. and Ruegg, M. A.. (1998) Electron microscopic structure of agrin and mapping of its binding site in laminin-1. The EMBO Journal, 17 (2). pp. 335-343.

Gesemann, M. and Brancaccio, A. and Schumacher, B. and Ruegg, M. A.. (1998) Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue. Journal of Biological Chemistry, 273 (1). pp. 600-605.

Groffen, A. J. and Ruegg, M. A. and Dijkman, H. and van de Velden, T. J. and Buskens, C. A. and van den Born, J. and Assmann, K. J. and Monnens, L. A. and Veerkamp, J. H. and van den Heuvel, L. P.. (1998) Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. Journal of Histochemistry and Cytochemistry, 46 (1). pp. 19-27.

Meier, T. and Marangi, P. A. and Moll, J. and Hauser, D. M. and Brenner, H. R. and Ruegg, M. A.. (1998) A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres. The European journal of neuroscience, Vol. 10, H. 10. pp. 3141-3152.

Meier, T. and Ruegg, M. A. and Wallace, B. G.. (1998) Muscle-specific agrin isoforms reduce phosphorylation of AChR gamma and delta subunits in cultured muscle cells. Molecular and cellular neuroscience, Vol. 11, H. 4. pp. 206-216.

Nawrotzki, R. and Loh, N. Y. and Ruegg, M. A. and Davies, K. E. and Blake, D. J.. (1998) Characterisation of alpha-dystrobrevin in muscle. Journal of Cell Science, 111 (17). pp. 2595-2605.

Ruegg, M. A. and Bixby, J. L.. (1998) Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction. Trends in Neurosciences, 21 (1). pp. 22-27.

Sieb, J. P. and Dorfler, P. and Tzartos, S. and Wewer, U. M. and Ruegg, M. A. and Meyer, D. and Baumann, I. and Lindemuth, R. and Jakschik, J. and Ries, F.. (1998) Congenital myasthenic syndromes in two kinships with end-plate acetylcholine receptor and utrophin deficiency. Neurology, 50 (1). pp. 54-61.

1997

Campagna, J. A. and Ruegg, M. A. and Bixby, J. L.. (1997) Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro. The European journal of neuroscience, Vol. 9, H. 11. pp. 2269-2283.

Denzer, A. J. and Brandenberger, R. and Gesemann, M. and Chiquet, M. and Ruegg, M. A.. (1997) Agrin binds to the nerve-muscle basal lamina via laminin. The Journal of cell biology, Vol. 137, H. 3. pp. 671-683.

Denzer, A. J. and Hauser, D. M. and Gesemann, M. and Ruegg, M. A.. (1997) Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction. Cell and Tissue Research, 290 (2). pp. 357-365.

Meier, T. and Hauser, D. M. and Chiquet, M. and Landmann, L. and Ruegg, M. A. and Brenner, H. R.. (1997) Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers. Journal of neuroscience, 17 (17). pp. 6534-6544.

1996

Gesemann, M. and Cavalli, V. and Denzer, A. J. and Brancaccio, A. and Schumacher, B. and Ruegg, M. A.. (1996) Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor. Neuron, Vol. 16, H. 4. pp. 755-767.

Jones, G. and Herczeg, A. and Ruegg, M. A. and Lichtsteiner, M. and Kroger, S. and Brenner, H. R.. (1996) Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 93 (12). pp. 5985-5990.

Meier, T. and Gesemann, M. and Cavalli, V. and Ruegg, M. A. and Wallace, B. G.. (1996) AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan. The EMBO Journal, 15 (11). pp. 2625-2631.

Ruegg, M. A.. (1996) Agrin, laminin beta 2 (s-laminin) and ARIA : their role in neuromuscular development. Current Opinion in Neurobiology, Vol. 6, H. 1. pp. 97-103.

Yamada, H. and Denzer, A. J. and Hori, H. and Tanaka, T. and Anderson, L. V. and Fujita, S. and Fukuta-Ohi, H. and Shimizu, T. and Ruegg, M. A. and Matsumura, K.. (1996) Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. Journal of Biological Chemistry, 271 (38). pp. 23418-23423.

1995

Brancaccio, A. and Ruegg, M. A. and Engel, J.. (1995) Cloning and sequencing of mouse skeletal muscle alpha-dystroglycan. Matrix biology, Vol. 14, H. 8. pp. 681-685.

Campagna, J. A. and Ruegg, M. A. and Bixby, J. L.. (1995) Agrin is a differentiation-inducing "stop signal" for motoneurons in vitro. Neuron, Vol. 15, H. 6. pp. 1365-1374.

Denzer, A. J. and Gesemann, M. and Schumacher, B. and Ruegg, M. A.. (1995) An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. The Journal of cell biology, Vol. 131, H. 6. pp. 1547-1560.

Gesemann, M. and Denzer, A. J. and Ruegg, M. A.. (1995) Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. The Journal of cell biology, Vol. 128, H. 4. pp. 625-636.

1992

McMahan, U. J. and Horton, S. E. and Werle, M. J. and Honig, L. S. and Kroger, S. and Ruegg, M. A. and Escher, G.. (1992) Agrin isoforms and their role in synaptogenesis. Current opinion in cell biology, Vol. 4, H. 5. pp. 869-874.

Ruegg, M. A. and Tsim, K. W. and Horton, S. E. and Kroger, S. and Escher, G. and Gensch, E. M. and McMahan, U. J.. (1992) The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron, Vol. 8, H. 4. pp. 691-699.

Tsim, K. W. and Ruegg, M. A. and Escher, G. and Kroger, S. and McMahan, U. J.. (1992) cDNA that encodes active agrin. Neuron, Vol. 8, H. 4. pp. 677-689.

1991

Stoeckli, E. T. and Kuhn, T. B. and Duc, C. O. and Ruegg, M. A. and Sonderegger, P.. (1991) The axonally secreted protein axonin-1 is a potent substratum for neurite growth. Journal of Cell Biology, 112 (3). pp. 449-455.

1989

Ruegg, M. A. and Stoeckli, E. T. and Kuhn, T. B. and Heller, M. and Zuellig, R. and Sonderegger, P.. (1989) Purification of axonin-1, a protein that is secreted from axons during neurogenesis. The EMBO Journal, 8 (1). pp. 55-63.

Ruegg, M. A. and Stoeckli, E. T. and Lanz, R. B. and Streit, P. and Sonderegger, P.. (1989) A homologue of the axonally secreted protein axonin-1 is an integral membrane protein of nerve fiber tracts involved in neurite fasciculation. Journal of cell biology, 109, H. 5 (5). pp. 2363-2378.

Stoeckli, E. T. and Lemkin, P. F. and Kuhn, T. B. and Ruegg, M. A. and Heller, M. and Sonderegger, P.. (1989) Identification of proteins secreted from axons of embryonic dorsal-root-ganglia neurons. European Journal of Biochemistry, 180 (2). pp. 249-258.