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Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases

Punga, Anna Rostedt and Ruegg, Markus A.. (2012) Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3). pp. 340-346.

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Abstract

The neuromuscular junction (NMJ) is a specialized synapse between motor neurons and skeletal muscle with a complex signaling network that assures highly reliable neuromuscular transmission. Diseases of the NMJ cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Moreover, fragmentation of the NMJ contributes to sarcopenia, the loss of muscle mass during aging. Studies from recent years indicate that the formation and stabilization of NMJs differs between various muscles and that this difference affects their response under pathological conditions. This review summarizes the most important mechanisms involved in the development, maintenance and dysfunction of the NMJ and it discusses their significance in myasthenic disorders and aging and as targets for possible future treatment of NMJ dysfunction.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)
UniBasel Contributors:Rüegg, Markus A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4892
e-ISSN:1471-4973
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:12 Apr 2019 14:54
Deposited On:11 Oct 2012 15:20

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