Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Song, Jian and Lokmic, Zerina and Lämmermann, Tim and Rolf, Julia and Wu, Chuan and Zhang, Xueli and Hallmann, Rupert and Hannocks, Melanie-Jane and Horn, Nathalie and Ruegg, Markus A. and Sonnenberg, Arnoud and Georges-Labouesse, Elisabeth and Winkler, Thomas H. and Kearney, John F. and Cardell, Susanna and Sorokin, Lydia. (2013) Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31). pp. 2915-E2924.

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We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)
UniBasel Contributors:Rüegg, Markus A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2019 14:44
Deposited On:13 Sep 2013 07:52

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