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Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction

Denzer, A. J. and Hauser, D. M. and Gesemann, M. and Ruegg, M. A.. (1997) Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction. Cell and Tissue Research, 290 (2). pp. 357-365.

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Official URL: http://edoc.unibas.ch/dok/A5258425

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Abstract

Upon arrival of a motor axon at the muscle fiber, signals released from its growth cone initiate the formation of a synapse. This process consists of two stages: arrest of axon growth at the target area and differentiation of pre- and postsynaptic cells at the site of nerve-muscle contact. Studies of regenerating neuromuscular junctions in vertebrates have revealed that important signals for the formation of this synapse are located in the synaptic basal lamina, and attempts to identify these signals have led to the isolation of agrin and other components. In this review, we discuss the evidence for the involvement of these molecules and their potential functional role in the formation and maintenance of the neuromuscular junction, with emphasis on agrin.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)
UniBasel Contributors:Rüegg, Markus A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0302-766X
e-ISSN:1432-0878
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:15 Nov 2017 14:34
Deposited On:22 Mar 2012 13:20

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