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Molecular mechanisms and treatment options for muscle wasting eiseases

Rüegg, Markus A. and Glass, David J.. (2010) Molecular mechanisms and treatment options for muscle wasting eiseases. Annual Review of Pharmacology and Toxicology, 51. pp. 373-395.

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Abstract

Loss of muscle mass can be the consequence of pathological changes, as observed in muscular dystrophies; or it can be secondary to cachexia-inducing diseases that cause muscle atrophy, such as cancer, heart disease, or chronic obstructive pulmonary disease; or it can be a consequence of aging or simple disuse. Although muscular dystrophies are rare, muscle loss affects millions of people worldwide.Wediscuss the molecular mechanisms involved in muscular dystrophy and in muscle atrophy and present current strategies aimed at ameliorating these diseases. Finally, we discuss whether lessons learned from studying muscular dystrophies will also be helpful for halting muscle loss secondary to nondystrophic diseases and whether strategies to halt muscle atrophy have potential for the treatment of muscular dystrophies.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)
UniBasel Contributors:Rüegg, Markus A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Annual Review
ISSN:0362-1642
e-ISSN:1545-4304
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:12 Apr 2019 15:21
Deposited On:14 Sep 2012 06:37

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