The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

Ruegg, M. A. and Tsim, K. W. and Horton, S. E. and Kroger, S. and Escher, G. and Gensch, E. M. and McMahan, U. J.. (1992) The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron, Vol. 8, H. 4. pp. 691-699.

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We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction. Both proteins are the result of alternative splicing of the product of the agrin gene, but unlike agrin, they are inactive in standard acetylcholine receptor aggregation assays. They lack one (agrin-related protein 1) or two (agrin-related protein 2) regions in agrin that are required for its activity. Expression studies provide evidence that both proteins are present in the nervous system and muscle and that, in muscle, myofibers and Schwann cells synthesize the agrin-related proteins while the axon terminals of motor neurons are the sole source of agrin.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)
UniBasel Contributors:Rüegg, Markus A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 Apr 2019 12:25
Deposited On:22 Mar 2012 13:20

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