Items where Author is "Schirmer, Tilman"
Number of items: 66. 2023Dubey, Badri Nath and Shyp, Viktoriya and Fucile, Geoffrey and Sondermann, Holger and Jenal, Urs and Schirmer, Tilman. (2023) Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization. Scientific reports, 13 (1). p. 2727. Brüderlin, Mitchell and Böhm, Raphael and Fadel, Firas and Hiller, Sebastian and Schirmer, Tilman and Dubey, Badri N.. (2023) Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs. Nature communications, 14 (1). p. 1002. 2022Agustoni, Elia and Teixeira, Raphael Dias and Huber, Markus and Flister, Susanne and Hiller, Sebastian and Schirmer, Tilman. (2022) Acquisition of enzymatic progress curves in real time by quenching-free ion exchange chromatography. Analytical biochemistry, 639. p. 114523. 2021Perkins, Arden and Tudorica, Dan A. and Teixeira, Raphael D. and Schirmer, Tilman and Zumwalt, Lindsay and Ogba, O. Maduka and Cassidy, C. Keith and Stansfeld, Phillip J. and Guillemin, Karen. (2021) A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation. mBio, 12 (3). e0017321. Teixeira, Raphael D. and Holzschuh, Fabian and Schirmer, Tilman. (2021) Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase. Nature Communications, 12. p. 2162. Reinders, Alberto and Sellner, Benjamin and Fadel, Firas and van Berkum, Margo and Kaczmarczyk, Andreas and Ozaki, Shogo and Rueher, Johanna and Manfredi, Pablo and Sangermani, Matteo and Harms, Alexander and Perez, Camilo and Schirmer, Tilman and Jenal, Urs. (2021) Digital control of c-di-GMP in E. coli balances population-wide developmental transitions and phage sensitivity. Schirmer, Tilman and de Beer, Tjaart A. P. and Tamegger, Stefanie and Harms, Alexander and Dietz, Nikolaus and Dranow, David M. and Edwards, Thomas E. and Myler, Peter J. and Phan, Isabelle and Dehio, Christoph. (2021) Evolutionary Diversification of Host-Targeted; Bartonella; Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module. Microorganisms, 9 (8). p. 23. Shyp, Viktoriya and Dubey, Badri Nath and Böhm, Raphael and Hartl, Johannes and Nesper, Jutta and Vorholt, Julia A. and Hiller, Sebastian and Schirmer, Tilman and Jenal, Urs. (2021) Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus. Nature Microbiology, 6 (1). pp. 59-72. Dietz, Nikolaus and Huber, Markus and Sorg, Isabel and Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2021) Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1). Proceedings of the National Academy of Sciences, 118 (12). e2023245118. 11 October 2020Perkins, Arden and Tudorica, Dan A. and D. Teixeira, Raphael and Schirmer, Tilman and Zumwalt, Lindsay and Ogba, O. Maduka and Cassidy, C. Keith and Stansfeld, Phillip J. and Guillemin, Karen. (2020) A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation. 28 August 2020Teixeira, Raphael D. and Holzschuh, Fabian and Schirmer, Tilman. (2020) Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase. 2 July 2020Dietz, Nikolaus Balthasar and Huber, Markus and Sorg, Isabel and Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2020) Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein. 2020Dubey, Badri N. and Agustoni, Elia and Böhm, Raphael and Kaczmarczyk, Andreas and Mangia, Francesca and von Arx, Christoph and Jenal, Urs and Hiller, Sebastian and Plaza-Menacho, Iván and Schirmer, Tilman. (2020) Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation. Proceedings of the National Academy of Sciences of the United States of America, 117 (2). pp. 1000-1008. Hee, Chee-Seng and Habazettl, Judith and Schmutz, Christoph and Schirmer, Tilman and Jenal, Urs and Grzesiek, Stephan. (2020) Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP. Proceedings of the National Academy of Sciences of the United States of America, 117 (29). pp. 17211-17220. Kaczmarczyk, Andreas and Hempel, Antje M. and von Arx, Christoph and Böhm, Raphael and Dubey, Badri N. and Nesper, Jutta and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2020) Precise Timing of Transcription by c-di-GMP Coordinates Cell Cycle and Morphogenesis in Caulobacter. Nature Communications, 11 (1). p. 816. 2019Stampfli, Anja R. and Goncharenko, Kristina V. and Meury, Marcel and Dubey, Badri N. and Schirmer, Tilman and Seebeck, Florian P.. (2019) An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum. Journal of American Chemical Society, 141 (13). pp. 5275-5285 . 2017Nesper, Jutta and Hug, Isabelle and Kato, Setsu and Hee, Chee-Seng and Habazettl, Judith Maria and Manfredi, Pablo and Grzesiek, Stephan and Schirmer, Tilman and Emonet, Thierry and Jenal, Urs. (2017) Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators. eLife, 6. e28842. Stanger, Frédéric V. and de Beer, Tjaart A. P. and Dranow, David M. and Schirmer, Tilman and Phan, Isabelle and Dehio, Christoph. (2017) The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure , 25 (1). pp. 203-211. 2016Schirmer, Tilman. (2016) C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation. Journal of molecular biology, 428 (19). pp. 3683-3701. Stanger, Frédéric V. and Harms, Alexander and Dehio, Christoph and Schirmer, Tilman. (2016) Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PLoS ONE, 11 (9). e0163654. Dubey, Badri N. and Lori, Christian and Ozaki, Shogo and Fucile, Geoffrey and Plaza-Menacho, Ivan and Jenal, Urs and Schirmer, Tilman. (2016) Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2 (9). e1600823. Reinders, Alberto and Hee, Chee-Seng and Ozaki, Shogo and Mazur, Adam and Boehm, Alex and Schirmer, Tilman and Jenal, Urs. (2016) Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198 (3). pp. 448-462. Stanger, Frédéric V. and Burmann, Björn M. and Harms, Alexander and Aragão, Hugo and Mazur, Adam and Sharpe, Timothy and Dehio, Christoph and Hiller, Sebastian and Schirmer, Tilman. (2016) Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). E529-E537. September 2015Harms, Alexander and Stanger, Frédéric Valentin and Scheu, Patrick Daniel and de Jong, Imke Greet and Goepfert, Arnaud and Glatter, Timo and Gerdes, Kenn and Schirmer, Tilman and Dehio, Christoph. (2015) Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology. Cell Reports, 12 (9). pp. 1497-1507. 2015Lori, Christian and Ozaki, Shogo and Steiner, Samuel and Böhm, Raphael and Abel, Sören and Dubey, Badri N. and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2015) Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, Vol. 523, H. 7559. pp. 236-239. Bosshart, Andreas and Hee, Chee Seng and Bechtold, Matthias and Schirmer, Tilman and Panke, Sven. (2015) Directed Divergent Evolution of a Thermostable D-Tagatose Epimerase towards Improved Activity for Two Hexose Substrates. ChemBioChem, 16 (4). pp. 592-601. 2014Ozaki, Shogo and Schalch-Moser, Annina and Zumthor, Ludwig and Manfredi, Pablo and Ebbensgaard, Anna and Schirmer, Tilman and Jenal, Urs. (2014) Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94 (3). pp. 580-594. Sundriyal, Amit and Massa, Claudia and Samoray, Dietrich and Zehender, Fabian and Sharpe, Timothy and Jenal, Urs and Schirmer, Tilman. (2014) Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10). pp. 6978-6990. Munoz-Robles, Victor and Dürrenberger, Marc and Tillmann, Heinisch and Lledos, Agustí and Schirmer, Tilman and Ward, Thomas R. and Maréchal, Jean-Didier. (2014) Structural, Kinetic, and Docking Studies of Artificial Imine Reductases Based on Biotin–Streptavidin Technology: An Induced Lock-and-Key Hypothesis. Journal of the American Chemical Society, 136 (44). pp. 15676-15683. Stanger, Frédéric V. and Dehio, Christoph and Schirmer, Tilman. (2014) Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis. PLoS ONE, Vol. 9, H. 9 , e107289. 2013Zimbron, Jeremy M. and Heinisch, Tillmann and Schmid, Maurus and Hamels, Didier and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2013) A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society, 135 (14). pp. 5384-5388. Goepfert, Arnaud and Stanger, Frédéric V. and Dehio, Christoph and Schirmer, Tilman. (2013) Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS ONE, Vol. 8, H. 5 , e64901. Monnard, Fabien W. and Nogueira, Elisa S. and Heinisch, Tillmann and Schirmer, Tilman and Ward, Thomas R.. (2013) Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes : the Asymmetric Transfer Hydrogenation of Imines. Chemical Science, 4 (6). p. 3269. Zähringer, Franziska and Lacanna, Egidio and Jenal, Urs and Schirmer, Tilman and Boehm, Alex. (2013) Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure: with folding and design, 21 (7). pp. 1149-1157. Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2013) Type II Toxin-Antitoxin Loci: The fic Family. In: Prokaryotic Toxin-Antitoxins. Heidelberg, pp. 177-187. 2012Engel, Philipp and Goepfert, Arnaud and Stanger, Frédéric V. and Harms, Alexander and Schmidt, Alexander and Schirmer, Tilman and Dehio, Christoph. (2012) Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482 (7383). pp. 107-110. Gentner, Martin and Allan, Martin G. and Zaehringer, Franziska and Schirmer, Tilman and Grzesiek, Stephan. (2012) Oligomer formation of the bacterial second messenger c-di-GMP : reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations. The journal of the American Chemical Society, 134 (2). pp. 1019-1029. 2011Dürrenberger, Marc and Heinisch, Tillmann and Wilson, Yvonne and Rossel, Thibaud and Nogueira, Elisa and Knörr, Livia and Mutschler, Annette and Kersten, Karoline and Zimbron, Mallcom and Pierron, Julien and Schirmer, Tilman and Ward, Thomas R.. (2011) Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines. Angewandte Chemie International Edition, 50 (13). pp. 3026-3029. Borer, Aline S. and Wassmann, Paul and Schmidt, Margit and Hoffman, Donald R. and Zhou, Jing-Jiang and Wright, Christine and Schirmer, Tilman and Marković-Housley, Zora. (2011) Crystal structure of Sol i 2 : a major allergen from fire ant venom. Journal of molecular biology, Vol. 415, H. 4. pp. 635-648. Monnard, Fabien W. and Heinisch, Tillmann and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2011) Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chemical Communications, 47 (29). pp. 8238-8240. Köhler, Valentin and Mao, Jincheng and Heinisch, Tillmann and Pordea, Anca and Sardo, Alessia and Wilson, Yvonne and Knörr, Livia and Creus, Marc and Prost, Jean-Christophe and Schirmer, Tilman and Ward, Thomas R.. (2011) OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins. Angewandte Chemie International Edition, 50 (46). pp. 10863-10866. Abel, Sören and Chien, Peter and Wassmann, Paul and Schirmer, Tilman and Kaever, Volkhard and Laub, Michael T. and Baker, Tania A. and Jenal, Urs. (2011) Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular cell, Vol. 43, H. 4. pp. 550-560. 2010Zimbron, Jeremy M. and Sardo, Alessia and Heinisch, Tillmann and Wohlschlager, Therese and Gradinaru, Julieta and Massa, Claudia and Schirmer, Tilman and Creus, Marc and Ward, Thomas R.. (2010) Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry - A European Journal, 16 (43). pp. 12883-12889. Zähringer, Franziska and Massa, Claudia and Schirmer, Tilman. (2010) Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli. Applied biochemistry and biotechnology, Vol. 163, H. 1. p. 71. 2009Minasov, George and Padavattan, Sivaraman and Shuvalova, Ludmilla and Brunzelle, Joseph S. and Miller, Darcie J. and Baslé, Arnaud and Massa, Claudia and Collart, Frank R. and Schirmer, Tilman and Anderson, Wayne F.. (2009) Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains. Journal of biological chemistry, Vol. 284, H. 19. pp. 13174-13184. Padavattan, Sivaraman and Flicker, Sabine and Schirmer, Tilman and Madritsch, Christoph and Randow, Stefanie and Reese, Gerald and Vieths, Stefan and Lupinek, Christian and Ebner, Christof and Valenta, Rudolf and Markovic-Housley, Zora. (2009) High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. Journal of immunology, Vol. 182, H. 4. pp. 2141-2151. Wirth, Christophe and Condemine, Guy and Boiteux, Céline and Bernèche, Simon and Schirmer, Tilman and Peneff, Caroline M.. (2009) NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. Journal of molecular biology, Vol. 394, H. 4. pp. 718-731. Boehm, Alex and Steiner, Samuel and Zaehringer, Franziska and Casanova, Alain and Hamburger, Fabienne and Ritz, Daniel and Keck, Wolfgang and Ackermann, Martin and Schirmer, Tilman and Jenal, Urs. (2009) Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, Vol. 72, H. 6. pp. 1500-1516. Schirmer, Tilman and Jenal, Urs. (2009) Structural and mechanistic determinants of c-di-GMP signalling. Nature Reviews Microbiology, Vol. 7. pp. 724-735. Markovic-Housley, Zora and Basle, Arnaud and Padavattan, Sivaraman and Maderegger, Bernhard and Schirmer, Tilman and Hoffmann-Sommergruber, Karin. (2009) Structure of the major carrot allergen Dau c 1. Acta crystallographica. Section D, Biological crystallography, Vol. 65, Pt. 11. pp. 1206-1212. 2007Padavattan, Sivaraman and Schirmer, Tilman and Schmidt, Margit and Akdis, Cezmi and Valenta, Rudolf and Mittermann, Irene and Soldatova, Lyudmila and Slater, Jay and Mueller, Ulrich and Markovic-Housley, Zora. (2007) Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. Journal of molecular biology, Vol. 368, H. 3. pp. 742-752. 2006Miedema, Henk and Vrouenraets, Maarten and Wierenga, Jenny and Eisenberg, Bob and Schirmer, Tilman and Baslé, Arnaud and Meijberg, Wim. (2006) Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. European biophysics journal, Vol. 36, H. 1. pp. 13-22. Baslé, Arnaud and Rummel, Gabriele and Storici, Paola and Rosenbusch, Juerg P. and Schirmer, Tilman. (2006) Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Journal of molecular biology, Vol. 362, H. 5. pp. 933-942. 2005Schirmer, Tilman and Hoffimann-Sommergrube, Karin and Susani, Markus and Breiteneder, Heimo and Marković-Housley, Zora. (2005) Crystal structure of the major celery allergen Api g 1 : molecular analysis of cross-reactivity. Journal of molecular biology, Vol. 351, H. 5. pp. 1101-1109. Markova, Michaela and Peneff, Caroline and Hewlins, Michael J. E. and Schirmer, Tilman and John, Robert A.. (2005) Determinants of substrate specificity in omega-aminotransferases. Journal of Biological Chemistry, Vol. 280, H. 43. pp. 36409-36416. Hui, Kwok-Min and Orriss, George L. and Schirmer, Tilman and Magnadóttir, Bergljót and Schifferli, Jürg A. and Inal, Jameel M.. (2005) Expression of functional recombinant von Willebrand factor-A domain from human complement C2 : a potential binding site for C4 and CRIT. The Biochemical Journal, Vol. 389, Pt. 3. pp. 863-868. Philippsen, Ansgar and Schirmer, Tilman and Stein, Martin A. and Giffhorn, Friedrich and Stetefeld, Jörg. (2005) Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Acta Crystallographica. Section D, Biological Crystallography, Vol. 61, Pt. 4. pp. 374-379. 2004Storici, Paola and Qiu, Jian and Schirmer, Tilman and Silverman, Richard B.. (2004) Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry, Vol. 43, H. 44. pp. 14057-14063. Schirmer, Tilman. (2004) Structure-Function Relationships in Sugar-Specific Porins. In: Bacterial and Eukaryotic Porins: Structure, Function, Mechanism. Switzerland, pp. 169-181. Storici, Paola and De Biase, Daniela and Bossa, Francesco and Bruno, Stefano and Mozzarelli, Andrea and Peneff, Caroline and Silverman, Richard B. and Schirmer, Tilman. (2004) Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. Journal of Biological Chemistry, 279 (1). pp. 363-373. 2003Orriss, George L. and Erni, Bernhard and Schirmer, Tilman. (2003) Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution. Journal of molecular biology, Vol. 327, H. 5. pp. 1111-1119. 2002Choi, Sun and Storici, Paola and Schirmer, Tilman and Silverman, Richard B.. (2002) Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. Journal of the American Chemical Society, Vol. 124, H. 8. pp. 1620-1624. Sauer, Oliver and Roth, Michel and Schirmer, Tilman and Rummel, Gabriele and Kratky, Christoph. (2002) Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast. Acta Crystallographica. Section D, Biological Crystallography, Vol. 58, Pt. 1. pp. 60-69. Rodríguez-Marañón, María José and Bush, Robin M. and Peterson, Ellena M. and Schirmer, Tilman and de la Maza, Luis M.. (2002) Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia. Protein Science, Vol. 11, H. 7. pp. 1854-1861. Van Gelder, Patrick and Dumas, Fabrice and Bartoldus, Ingrid and Saint, Nathalie and Prilipov, Alexei and Winterhalter, Mathias and Wang, Yanfei and Philippsen, Ansgar and Rosenbusch, Jürg P. and Schirmer, Tilman. (2002) Sugar transport through maltoporin of Escherichia coli : role of the greasy slide. Journal of Bacteriology, 184 (11). pp. 2994-2999. Dutzler, Raimund and Schirmer, Tilman and Karplus, Martin and Fischer, Stefan. (2002) Translocation mechanism of long sugar chains across the maltoporin membrane channel. Structure: with folding and design, Vol. 10, H. 9. pp. 1273-1284. |
