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Items where Author is "Handschin, Christoph"

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Number of items: 70.

2020

Furrer, Regula and Handschin, Christoph. (2020) Lifestyle vs. pharmacological interventions for healthy aging. Aging, 12 (1). pp. 5-7.

Delezie, Julien and Gill, Jonathan F. and Santos, Gesa and Karrer-Cardel, Bettina and Handschin, Christoph. (2020) PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse. Scientific Reports, 10 (1). p. 16888.

2019

Brinkkoetter, Paul T. and Bork, Tillmann and Salou, Sarah and Liang, Wei and Mizi, Athanasia and Özel, Cem and Koehler, Sybille and Hagmann, H. Henning and Ising, Christina and Kuczkowski, Alexander and Schnyder, Svenia and Abed, Ahmed and Schermer, Bernhard and Benzing, Thomas and Kretz, Oliver and Puelles, Victor G. and Lagies, Simon and Schlimpert, Manuel and Kammerer, Bernd and Handschin, Christoph and Schell, Christoph and Huber, Tobias B.. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Reports, 27 (5). pp. 1551-1566.e5.

Delezie, Julien and Weihrauch, Martin and Maier, Geraldine and Tejero, Rocío and Ham, Daniel J. and Gill, Jonathan F. and Karrer-Cardel, Bettina and Rüegg, Markus A. and Tabares, Lucía and Handschin, Christoph. (2019) BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 116 (32). pp. 16111-16120.

Krämer, Anne I. and Handschin, Christoph. (2019) How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism. International journal of molecular sciences, 20 (21). E5449.

Nageswara Rao, Tata and Hansen, Nils and Hilfiker, Julian and Rai, Shivam and Majewska, Julia-Magdalena and Lekovic, Danijela and Gezer, Deniz and Andina, Nicola and Galli, Serena and Cassel, Teresa and Geier, Florian and Delezie, Julien and Nienhold, Ronny and Hao-Shen, Hui and Beisel, Christian and Di Palma, Serena and Dimeloe, Sarah and Trebicka, Jonel and Wolf, Dominik and Gassmann, Max and Fan, Teresa W.-M. and Lane, Andrew N. and Handschin, Christoph and Dirnhofer, Stefan and Kröger, Nicolaus and Hess, Christoph and Radimerski, Thomas and Koschmieder, Steffen and Cokic, Vladan P. and Skoda, Radek C.. (2019) JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134 (21). pp. 1832-1846.

Furrer, Regula and Handschin, Christoph. (2019) Muscle Wasting Diseases: Novel Targets and Treatments. Annual review of pharmacology and toxicology, 59. pp. 315-339.

Gill, Jonathan F. and Delezie, Julien and Santos, Gesa and McGuirk, Shawn and Schnyder, Svenia and Frank, Stephan and Rausch, Martin and St-Pierre, Julie and Handschin, Christoph. (2019) Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. Aging cell, 18 (5). e12993.

Agudelo, Leandro Z. and Ferreira, Duarte M. S. and Dadvar, Shamim and Cervenka, Igor and Ketscher, Lars and Izadi, Manizheh and Zhengye, Liu and Furrer, Regula and Handschin, Christoph and Venckunas, Tomas and Brazaitis, Marius and Kamandulis, Sigitas and Lanner, Johanna T. and Ruas, Jorge L.. (2019) Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. Nature communications, 10 (1). p. 2767.

2018

Delezie, Julien and Handschin, Christoph. (2018) Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology, 9. p. 698.

Haralampieva, Deana and Salemi, Souzan and Betzel, Thomas and Dinulovic, Ivana and Krämer, Stefanie D. and Schibli, Roger and Sulser, Tullio and Handschin, Christoph and Ametamey, Simon M. and Eberli, Daniel. (2018) Injected Human Muscle Precursor Cells Overexpressing PGC-1α. Enhance Functional Muscle Regeneration after Trauma. Stem cells international, 2018. p. 4658503.

Whitehead, Natasha and Gill, Jonathan F. and Brink, Marijke and Handschin, Christoph. (2018) Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart. Frontiers in Physiology, 9. p. 242.

Ruiz, Alexis and Dror, Erez and Handschin, Christoph and Furrer, Regula and Perez-Schindler, Joaquin and Bachmann, Christoph and Treves, Susan and Zorzato, Francesco. (2018) Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports, 8 (1). p. 636.

Gill, Jonathan F. and Santos, Gesa and Schnyder, Svenia and Handschin, Christoph. (2018) PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice. Aging Cell, 17 (1). e12697.

Weihrauch, Martin and Handschin, Christoph. (2018) Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical pharmacology, 147. pp. 211-220.

Pérez-Schindler, Joaquín and Handschin, Christoph. (2018) Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy. In: Nutrition and Skeletal Muscle. London, pp. 139-150.

Baum, Oliver and Aaldijk, Dea and Engeli, Anna Lena and Spree, Matthias and Summermatter, Serge and Handschin, Christoph and Zakrzewicz, Andreas. (2018) Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice. Nitric Oxide: Biology and Chemistry, 77. pp. 35-43.

2017

Schnyder, Svenia and Kupr, Barbara and Handschin, Christoph. (2017) Coregulator-mediated control of skeletal muscle plasticity - A mini-review. Biochimie, 136. pp. 49-54.

Ross, Jacob Alexander and Pearson, Adam and Levy, Yotam and Cardel, Bettina and Handschin, Christoph and Ochala, Julien. (2017) Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres. Journal of Cellular Physiology, 232 (6). pp. 1270-1274.

Haralampieva, Deana and Salemi, Souzan and Dinulovic, Ivana and Sulser, Tullio and Ametamey, Simon and Handschin, Christoph and Eberli, Daniel. (2017) Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation. Cell Transplantation, 26 (6). pp. 1103-1114.

Schnyder, Svenia and Svensson, Kristoffer and Cardel, Bettina and Handschin, Christoph. (2017) Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. American Journal of Physiology. Endocrinology and Metabolism, 312 (5). E437-E446.

Handschin, Christoph. (2017) Muskeln: mehr als nur "schön anzusehen". In: natura obscura. 200 Naturforschende - 200 Naturphänomene - 200 Jahre Naturforschende Gesellschaft in Basel. Basel, p. 85.

Furrer, Regula and Handschin, Christoph. (2017) Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle. In: Hormones, Metabolism and the Benefits of Exercise. Cham, pp. 57-66.

Furrer, Regula and Eisele, Petra S. and Schmidt, Alexander and Beer, Markus and Handschin, Christoph. (2017) Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7. p. 40789.

Dinulovic, Ivana and Furrer, Regula and Handschin, Christoph. (2017) Plasticity of the Muscle Stem Cell Microenvironment. Advances in experimental medicine and biology, 1041. pp. 141-169.

Kupr, Barbara and Schnyder, Svenia and Handschin, Christoph. (2017) Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harbor perspectives in medicine, 7 (6). a029835.

2016

Svensson, Kristoffer and Schnyder, Svenia and Cardel, Bettina and Handschin, Christoph. (2016) Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE, 11 (7). e0158716.

Stölting, Meline N. L. and Arnold, Anne Sophie and Haralampieva, Deana and Handschin, Christoph and Sulser, Tullio and Eberli, Daniel. (2016) Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle and Nerve, 53 (4). pp. 598-607.

Dinulovic, Ivana and Furrer, Regula and Beer, Markus and Ferry, Arnaud and Cardel, Bettina and Handschin, Christoph. (2016) Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle, 6 (1). p. 39.

Haralampieva, Deana and Betzel, Thomas and Dinulovic, Ivana and Salemi, Souzan and Stoelting, Meline and Krämer, Stefanie D. and Schibli, Roger and Sulser, Tullio and Handschin, Christoph and Eberli, Daniel and Ametamey, Simon M.. (2016) Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering. Journal of Nuclear Medicine, 57 (9). pp. 1467-1473.

Dinulovic, Ivana and Furrer, Regula and Di Fulvio, Sabrina and Ferry, Arnaud and Beer, Markus and Handschin, Christoph. (2016) PGC-1alpha modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal Muscle, 6. p. 38.

Gill, Jonathan F. and Delezie, Julien and Santos, Gesa and Handschin, Christoph. (2016) PGC-1α expression in murine AgRP neurons regulates food intake and energy balance. Molecular metabolism, 5 (7). pp. 580-588.

Dinulovic, Ivana and Furrer, Regula and Di Fulvio, Sabrina and Ferry, Arnaud and Beer, Markus and Handschin, Christoph. (2016) PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal muscle, 6 (38). pp. 1-11.

Svensson, Kristoffer and Albert, Verena and Cardel, Bettina and Salatino, Silvia and Handschin, Christoph. (2016) Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB Journal, 30 (5). pp. 1976-1986.

Salatino, Silvia and Kupr, Barbara and Baresic, Mario and van Nimwegen, Erik and Handschin, Christoph. (2016) The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Molecular Endocrinology, 30 (7). pp. 809-825.

Albert, Verena and Svensson, Kristoffer and Shimobayashi, Mitsugu and Colombi, Marco and Muñoz, Sergio and Jimenez, Veronica and Handschin, Christoph and Bosch, Fatima and Hall, Michael N.. (2016) mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8 (3). pp. 232-246.

2015

Handschin, Christoph. (2015) Caloric restriction and exercise "mimetics'': Ready for prime time? Pharmacological research, 103. pp. 158-166.

Kupr, Barbara and Handschin, Christoph. (2015) Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle. Frontiers in physiology, 6. p. 325.

Furrer, Regula and Handschin, Christoph. (2015) Exercise and PGC-1α in inflammation and chronic disease. Deutsche Zeitschrift für Sportmedizin, 66 (12). pp. 317-320.

Handschin, Christoph and Mortezavi, Ashkan and Plock, Jan and Eberli, Daniel. (2015) External physical and biochemical stimulation to enhance skeletal muscle bioengineering. Advanced drug delivery reviews, Vol. 82-83. pp. 168-175.

Soler, Fernando and Fernández-Belda, Francisco and Pérez-Schindler, Joaquín and Handschin, Christoph and Fuente, Teodomiro and Hernandez-Cascales, Jesús. (2015) PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects. Experimental biology and medicine, Vol. 240, H. 9. pp. 1205-1213.

Svensson, Kristoffer and Schnyder, Svenia and Albert, Verena and Cardel, Bettina and Quagliata, Luca and Terracciano, Luigi M. and Handschin, Christoph. (2015) Resveratrol and SRT1720 elicit differential effects in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). Journal of biological chemistry, 290 (26). pp. 16059-16076.

Schnyder, Svenia and Handschin, Christoph. (2015) Skeletal muscle as an endocrine organ : PGC-1α, myokines and exercise. Bone, Vol. 80, H. 11. pp. 115-125.

Eisele, Petra Sabine and Furrer, Regula and Beer, Markus and Handschin, Christoph. (2015) The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochemical and Biophysical Research Communications, 464 (3). pp. 692-697.

2014

Morand, Réjane and Bouitbir, Jamal and Felser, Andrea and Hench, Jürgen and Handschin, Christoph and Frank, Stephan and Krähenbühl, Stephan. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6). pp. 1313-1325.

Eisele, Petra S. and Handschin, Christoph. (2014) Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Seminars in immunopathology, Vol. 36, no. 1. pp. 27-53.

Svensson, Kristoffer and Handschin, Christoph. (2014) MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle. Diabetes, Vol. 63, H. 5. pp. 1451-1453.

Svensson, Kristoffer and Handschin, Christoph. (2014) Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases. Drug discovery today, Vol. 19, H. 7. pp. 1024-1029.

Arnold, Anne-Sophie and Gill, Jonathan and Christe, Martine and Ruiz, Rocío and McGuirk, Shawn and St-Pierre, Julie and Tabares, Lucía and Handschin, Christoph. (2014) Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α. Nature communications, Vol. 5 , Article Nr. 3569.

Pérez-Schindler, Joaquín and Svensson, Kristoffer and Vargas-Fernández, Elyzabeth and Santos, Gesa and Wahli, Walter and Handschin, Christoph. (2014) The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia, Vol. 57, no. 11. pp. 2405-2412.

Baresic, Mario and Salatino, Silvia and Kupr, Barbara and van Nimwegen, Erik and Handschin, Christoph. (2014) Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program. Molecular and cellular biology, Vol. 34, H. 16. pp. 2996-3012.

2013

Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal muscle, Vol. 3, H. 1 , 6.

Stölting, Meline Nogueira Lucena and Ferrari, Stefano and Handschin, Christoph and Becskei, Attila and Provenzano, Maurizio and Sulser, Tullio and Eberli, Daniel. (2013) Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α. Journal of Urology, 189 (5). pp. 1952-1959.

Pérez-Schindler, Joaquín and Handschin, Christoph. (2013) New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10 (2). e79-e85.

Summermatter, Serge and Shui, Guanghou and Maag, Daniela and Santos, Gesa and Wenk, Markus R. and Handschin, Christoph. (2013) PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes, Vol. 62, H. 1. pp. 85-95.

Summermatter, Serge and Santos, Gesa and Pérez-Schindler, Joaquín and Handschin, Christoph. (2013) Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, H. 21. pp. 8738-8743.

Eisele, Petra S. and Salatino, Silvia and Sobek, Jens and Hottiger, Michael O. and Handschin, Christoph. (2013) The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288 (4). pp. 2246-2260.

Pérez-Schindler, Joaquín and Summermatter, Serge and Santos, Gesa and Zorzato, Francesco and Handschin, Christoph. (2013) The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, H. 50. pp. 20314-20319.

2012

Arnold, Anne-Sophie and Christe, Martine and Handschin, Christoph. (2012) A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells. Journal of visualized experiments, H. 62 , e3616.

Summermatter, Serge and Thurnheer, Raphael and Santos, Gesa and Mosca, Barbara and Baum, Oliver and Treves, Susan and Hoppeler, Hans and Zorzato, Francesco and Handschin, Christoph. (2012) Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. American Journal of Physiology, 302 (1). C88-99.

Pérez-Schindler, Joaquín and Summermatter, Serge and Salatino, Silvia and Zorzato, Francesco and Beer, Markus and Balwierz, Piotr J. and van Nimwegen, Erik and Feige, Jérôme N. and Auwerx, Johan and Handschin, Christoph. (2012) The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, Vol. 32, H. 24. pp. 4913-4924.

Handschin, Christoph and Meyer, Urs A.. (2012) Warum reagiert mein Patient anders auf dieses Medikament? : Pharmakogenomik und personalisierte Medizin in der Praxis. Swiss medical forum = Schweizerisches Medizin-Forum, Vol. 12, H. 22. pp. 425-433.

2011

Romanino, Klaas and Mazelin, Laetitia and Albert, Verena and Conjard-Duplany, Agnès and Lin, Shuo and Bentzinger, C. Florian and Handschin, Christoph and Puigserver, Pere and Zorzato, Francesco and Schaeffer, Laurent and Gangloff, Yann-Gaël and Rüegg, Markus A.. (2011) Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 51. pp. 20808-20813.

Handschin, Christoph and Spiegelman, Bruce M.. (2011) PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell metabolism, Vol. 13, H. 4. p. 351.

2010

Handschin, Christoph and Summermatter, Serge and LeBrasseur, Nathan K. and Lin, Jiandie and Spiegelman, Bruce M.. (2010) For a pragmatic approach to exercise studies. Journal of Applied Physiology, 108 (1). pp. 222-225.

Stein, Sokrates and Schäfer, Nicola and Breitenstein, Alexander and Besler, Christian and Winnik, Stephan and Lohmann, Christine and Heinrich, Kathrin and Brokopp, Chad E. and Handschin, Christoph and Landmesser, Ulf and Tanner, Felix C. and Lüscher, Thomas F. and Matter, Christian M.. (2010) SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, Vol. 2, H. 6. pp. 353-360.

2008

Handschin, Christoph. (2008) Induction of drug metabolism : role for nuclear receptors. In: Nuclear Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry, Vol. 39). Weinheim, pp. 453-468.

Handschin, Christoph and Spiegelman, Bruce M.. (2008) The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, Vol. 454. pp. 463-469.

2004

Mootha, Vamsi K. and Handschin, Christoph and Arlow, Dan and Xie, Xiaohui and St Pierre, Julie and Sihag, Smita and Yang, Wenli and Altshuler, David and Puigserver, Pere and Patterson, Nick and Willy, Patricia J. and Schulman, Ira G. and Heyman, Richard A. and Lander, Eric S. and Spiegelman, Bruce M.. (2004) Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101 (17). pp. 6570-6575.

2003

Handschin, Christoph and Podvinec, Michael and Meyer, Urs A.. (2003) In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives, 16 (7). pp. 423-434.

This list was generated on Tue Dec 1 00:52:02 2020 CET.