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ArticleReinhard, Judith R. and Porrello, Emanuela and Lin, Shuo and Pelczar, Pawel and Previtali, Stefano C. and Rüegg, Markus A.. (2023) Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy. PNAS Nexus, 2 (4). pgad083. Thürkauf, Marco and Lin, Shuo and Oliveri, Filippo and Grimm, Dirk and Platt, Randall J. and Rüegg, Markus A.. (2023) Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Nature communications, 14 (1). p. 6116. Ham, Daniel J. and Börsch, Anastasiya and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2022) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13. p. 2025. Blandino-Rosano, Manuel and Scheys, Joshua O. and Werneck-de-Castro, Joao Pedro and Louzada, Ruy A. and Almaça, Joana and Leibowitz, Gil and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2022) Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American Journal of Physiology, Endocrinology and Metabolism, 323 (2). E133-E144. Kaiser, Marco S. and Milan, Giulia and Ham, Daniel J. and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Rüegg, Markus A.. (2022) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. Communications biology, 5 (1). p. 1141. Börsch, Anastasiya and Ham, Daniel J. and Mittal, Nitish and Tintignac, Lionel A. and Migliavacca, Eugenia and Feige, Jérôme N. and Rüegg, Markus A. and Zavolan, Mihaela. (2021) Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia. Communications Biology, 4 (1). p. 194. Previtali, Stefano C. and Cohn, Ronald D. and Ruegg, Markus A.. (2021) Editorial: Current Insights Into LAMA2 Disease. Frontiers in molecular neuroscience, 14. p. 780635. Kaiser, Marco S. and Milan, Giulia and Lin, Shuo and Oliveri, Filippo and Chojnowska, Kathrin and Tintignac, Lionel A. and Mittal, Nitish and Zimmerli, Christian E. and Glass, David J. and Zavolan, Mihaela and Ham, Daniel J. and Rüegg, Markus A.. (2021) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. bioRxiv. pp. 1-39. Ding, Xiaolei and Willenborg, Sebastian and Bloch, Wilhelm and Wickström, Sara A. and Wagle, Prerana and Brodesser, Susanne and Roers, Axel and Jais, Alexander and Brüning, Jens C. and Hall, Michael N. and Rüegg, Markus A. and Eming, Sabine A.. (2020) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology, 145 (1). pp. 283-300.E8. Ham, Alexander S. and Chojnowska, Kathrin and Tintignac, Lionel A. and Lin, Shuo and Schmidt, Alexander and Ham, Daniel J. and Sinnreich, Michael and Rüegg, Markus A.. (2020) mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice. Journal of Cachexia, Sarcopenia and Muscle, 11 (1). pp. 259-273. Pereira, Jorge A. and Gerber, Joanne and Ghidinelli, Monica and Gerber, Daniel and Tortola, Luigi and Ommer, Andrea and Bachofner, Sven and Santarella, Francesco and Tinelli, Elisa and Lin, Shuo and Rüegg, Markus A. and Kopf, Manfred and Toyka, Klaus V. and Suter, Ueli. (2020) Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy. Human Molecular Genetics, 29 (8). pp. 1253-1273. Ham, Daniel J. and Börsch, Anastasiya and Lin, Shuo and Thürkauf, Marco and Weihrauch, Martin and Reinhard, Judith R. and Delezie, Julien and Battilana, Fabienne and Wang, Xueyong and Kaiser, Marco S. and Guridi, Maitea and Sinnreich, Michael and Rich, Mark M. and Mittal, Nitish and Tintignac, Lionel A. and Handschin, Christoph and Zavolan, Mihaela and Rüegg, Markus A.. (2020) The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11 (1). p. 4510. Castets, Perrine and Ham, Daniel J. and Rüegg, Markus A.. (2020) The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? Frontiers in molecular neuroscience, 13. p. 162. Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Eickhorst, Christopher and Rüegg, Markus A.. (2019) mTOR controls embryonic and adult myogenesis via mTORC1. Development, 146 (7). pp. 1-15. Donadon, Irving and Bussani, Erica and Riccardi, Federico and Licastro, Danilo and Romano, Giulia and Pianigiani, Giulia and Pinotti, Mirko and Kostantinova, Pavlina and Evers, Melvin and Lin, Shuo and Rüegg, Markus A. and Pagani, Franco. (2019) Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic acids research, 47 (14). pp. 7618-7632. Delezie, Julien and Weihrauch, Martin and Maier, Geraldine and Tejero, Rocío and Ham, Daniel J. and Gill, Jonathan F. and Karrer-Cardel, Bettina and Rüegg, Markus A. and Tabares, Lucía and Handschin, Christoph. (2019) BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116 (32). pp. 16111-16120. Castets, Perrine and Rion, Nathalie and Théodore, Marine and Falcetta, Denis and Lin, Shuo and Reischl, Markus and Wild, Franziska and Guérard, Laurent and Eickhorst, Christopher and Brockhoff, Marielle and Guridi, Maitea and Ibebunjo, Chikwendu and Cruz, Joseph and Sinnreich, Michael and Rudolf, Rüdiger and Glass, David J. and Rüegg, Markus A.. (2019) mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nature communications, 10 (1). p. 3187. Rion, Nathalie and Castets, Perrine and Lin, Shuo and Enderle, Leonie and Reinhard, Judith R. and Rüegg, Markus A.. (2019) mTORC2 affects the maintenance of the muscle stem cell pool. Skeletal Muscle, 9 (1). p. 30. Boido, Marina and De Amicis, Elena and Valsecchi, Valeria and Trevisan, Marco and Ala, Ugo and Ruegg, Markus A. and Hettwer, Stefan and Vercelli, Alessandro. (2018) Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Frontiers in cellular neuroscience, 12. p. 17. van Putten, Maaike and Aartsma-Rus, Annemieke and Grounds, Miranda D. and Kornegay, Joe N. and Mayhew, Anna and Gillingwater, Thomas H. and Takeda, Shin'ichi and Rüegg, Markus A. and De Luca, Annamaria and Nagaraju, Kanneboyina and Willmann, Raffaella. (2018) Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. Journal of Neuromuscular Diseases, 5 (1). pp. 29-34. Zainul, Zarin and Heikkinen, Anne and Koivisto, Hennariikka and Rautalahti, Iina and Kallio, Mika and Lin, Shuo and Härönen, Heli and Norman, Oula and Rüegg, Markus A. and Tanila, Heikki and Pihlajaniemi, Taina. (2018) Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury. The Journal of neuroscience, 38 (17). pp. 4243-4258. Yurchenco, Peter D. and McKee, Karen K. and Reinhard, Judith R. and Rüegg, Markus A.. (2018) Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix biology : journal of the International Society for Matrix Biology, 71-72. pp. 174-187. Martin, Sally K. and Fitter, Stephen and El Khawanky, Nadia and Grose, Randall H. and Walkley, Carl R. and Purton, Louise E. and Ruegg, Markus A. and Hall, Michael N. and Gronthos, Stan and Zannettino, Andrew C. W.. (2018) mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8 (1). p. 14501. Brockhoff, Marielle and Rion, Nathalie and Chojnowska, Kathrin and Wiktorowicz, Tatiana and Eickhorst, Christopher and Erne, Beat and Frank, Stephan and Angelini, Corrado and Furling, Denis and Rüegg, Markus A. and Sinnreich, Michael and Castets, Perrine. (2017) Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127 (2). pp. 549-563. McKee, Karen K. and Crosson, Stephanie C. and Meinen, Sarina and Reinhard, Judith R. and Rüegg, Markus A. and Yurchenco, Peter D.. (2017) Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127 (3). pp. 1075-1089. Rion, Nathalie and Rüegg, Markus A.. (2017) LncRNA-encoded peptides: More than translational noise? Cell Research, 27 (5). pp. 604-605. Willmann, Raffaella and Gordish-Dressman, Heather and Meinen, Sarina and Rüegg, Markus A. and Yu, Qing and Nagaraju, Kanneboyina and Kumar, Ayar and Girgenrath, Mahasweta and Coffey, Caroline B. M. and Cruz, Vivian and Van Ry, Pam M. and Bogdanik, Laurent and Lutz, Cathleen and Rutkowski, Anne and Burkin, Dean J.. (2017) Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4 (2). pp. 115-126. Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16. Reinhard, Judith R. and Lin, Shuo and McKee, Karen K. and Meinen, Sarina and Crosson, Stephanie C. and Sury, Maurizio and Hobbs, Samantha and Maier, Geraldine and Yurchenco, Peter D. and Rüegg, Markus A.. (2017) Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9 (396). eaal4649. Hoffman, E. P.. (2017) Facilitating orphan drug development: Proceedings of the TREAT-NMD International Conference, December 2015, Washington, DC, USA. Neuromuscular Disorders, 27 (7). pp. 693-701. Kleinert, Maximilian and Parker, Benjamin L. and Fritzen, Andreas M. and Knudsen, Jonas R. and Jensen, Thomas E. and Kjøbsted, Rasmus and Sylow, Lykke and Ruegg, Markus and James, David E. and Richter, Erik A.. (2017) Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595 (14). pp. 4845-4855. Hodson, Nathan and McGlory, Chris and Oikawa, Sara Y. and Jeromson, Stewart and Song, Zhe and Ruegg, Markus A. and Hamilton, D. Lee and Phillips, Stuart M. and Philp, Andrew. (2017) Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. American Journal of Physiology - Cell Physiology, 313 (6). C604-C611. Bozadjieva, Nadejda and Blandino-Rosano, Manuel and Chase, Jennifer and Dai, Xiao-Qing and Cummings, Kelsey and Gimeno, Jennifer and Dean, Danielle and Powers, Alvin C. and Gittes, George K. and Rüegg, Markus A. and Hall, Michael N. and MacDonald, Patrick E. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127 (12). pp. 4379-4393. Karakatsani, Andromachi and Marichal, Nicolás and Urban, Severino and Kalamakis, Georgios and Ghanem, Alexander and Schick, Anna and Zhang, Yina and Conzelmann, Karl-Klaus and Rüegg, Markus A. and Berninger, Benedikt and Ruiz de Almodovar, Carmen and Gascón, Sergio and Kröger, Stephan. (2017) Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144 (24). pp. 4604-4615. Reinhard, Judith R. and Kriz, Alexander and Galic, Milos and Angliker, Nico and Rajalu, Mathieu and Vogt, Kaspar E. and Rüegg, Markus A.. (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7. p. 11613. Guridi, Maitea and Kupr, Barbara and Romanino, Klaas and Lin, Shuo and Falcetta, Denis and Tintignac, Lionel and Rüegg, Markus A.. (2016) Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6 (13). pp. 1-14. Schell, Christoph and Kretz, Oliver and Liang, Wei and Kiefer, Betina and Schneider, Simon and Sellung, Dominik and Bork, Tillmann and Leiber, Christian and Rüegg, Markus A. and Mallidis, Con and Schlatt, Stefan and Mayerhofer, Artur and Huber, Tobias B. and Grahammer, Florian. (2016) The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186 (2). pp. 324-336. Ruegsegger, Céline and Stucki, David M. and Steiner, Silvio and Angliker, Nico and Radecke, Julika and Keller, Eva and Zuber, Benoît and Rüegg, Markus A. and Saxena, Smita. (2016) Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1). pp. 129-146. Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114. Kleinert, Maximilian and Parker, Benjamin L. and Chaudhuri, Rima and Fazakerley, Daniel J. and Serup, Annette and Thomas, Kristen C. and Krycer, James R. and Sylow, Lykke and Fritzen, Andreas M. and Hoffman, Nolan J. and Jeppesen, Jacob and Schjerling, Peter and Rüegg, Markus A. and Kiens, Bente and James, David E. and Richter, Erik A.. (2016) mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5 (8). pp. 646-655. Ding, Xiaolei and Bloch, Wilhelm and Iden, Sandra and Rüegg, Markus A. and Hall, Michael N. and Leptin, Maria and Partridge, Linda and Eming, Sabine A.. (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7. p. 13226. Castets, Perrine and Frank, Stephan and Sinnreich, Michael and Rüegg, Markus A.. (2016) "Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3 (2). pp. 127-155. Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705. Guridi, Maitea and Tintignac, Lionel A. and Lin, Shuo and Kupr, Barbara and Castets, Perrine and Rüegg, Markus A.. (2015) Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8 (402). ra113. Angliker, Nico and Burri, Michael and Zaichuk, Mariana and Fritschy, Jean-Marc and Rüegg, Markus A.. (2015) mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42 (8). pp. 2595-2612. Zhang, Yina and Lin, Shuo and Karakatsani, Andromachi and Rüegg, Markus A. and Kröger, Stephan. (2015) Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41 (1). pp. 69-78. Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135. Venkatesh, A. and Ma, S. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125 (4). pp. 1446-1458. Carr, T. D. and Feehan, R. P. and Hall, M. N. and Rüegg, M. A. and Shantz, L. M.. (2015) Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36 (4). pp. 487-497. Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem Cells, 33 (4). pp. 1359-1365. Ma, S. and Venkatesh, A. and Langellotto, F. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135. pp. 1-13. Tintignac, Lionel A. and Brenner, Hans-Rudolf and Rüegg, Markus A.. (2015) Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95 (3). pp. 809-852. Domi, Teuta and Porrello, Emanuela and Velardo, Daniele and Capotondo, Alessia and Biffi, Alessandra and Tonlorenzi, Rossana and Amadio, Stefano and Ambrosi, Alessandro and Miyagoe-Suzuki, Yuko and Takeda, Shin'ichi and Ruegg, Markus A. and Previtali, Stefano Carlo. (2015) Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5 (30). pp. 1-17. Willmann, Raffaella and De Luca, Annamaria and Nagaraju, Kanneboyina and Rüegg, Markus A.. (2015) Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of Neuromuscular Diseases, 2 (2). pp. 113-117. Chen, J. and Tu, X. and Esen, E. and Joeng, K. S. and Lin, C. and Arbeit, J. M. and Rüegg, M. A. and Hall, M. N. and Ma, L. and Long, F.. (2014) WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10 (1). e1004145. Lebrun-Julien, F. and Bachmann, L. and Norrmén, C. and Trötzmüller, M. and Köfeler, H. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34 (25). pp. 8432-8448. Grahammer, F. and Haenisch, N. and Steinhardt, F. and Sander, L. and Roerden, M. and Arnold, F. and Cordts, T. and Wanner, N. and Reichardt, W. and Kerjaschki, D. and Ruegg, M. A. and Hall, M. N. and Moulin, P. and Busch, H. and Boerries, M. and Walz, G. and Artunc, F. and Huber, T. B.. (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111 (27). E2817-E2826. Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765. Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170. Norrmén, C. and Figlia, G. and Lebrun-Julien, F. and Pereira, J. A. and Trötzmüller, M. and Köfeler, H. C. and Rantanen, V. and Wessig, C. and van Deijk, A. F. and Smit, A. B. and Verheijen, M. G. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports , 9 (2). pp. 646-660. Hettwer, Stefan and Lin, Shuo and Kucsera, Stefan and Haubitz, Monika and Oliveri, Filippo and Fariello, Ruggero G. and Ruegg, Markus A. and Vrijbloed, Jan W.. (2014) Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9 (2). e88739. Miloslavski, Rachel and Cohen, Elad and Avraham, Adam and Iluz, Yifat and Hayouka, Zvi and Kasir, Judith and Mudhasani, Rajini and Jones, Stephen N. and Cybulski, Nadine and Rüegg, Markus A. and Larsson, Ola and Gandin, Valentina and Rajakumar, Arjuna and Topisirovic, Ivan and Meyuhas, Oded. (2014) Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6 (3). pp. 255-266. Kleinert, Maximilian and Sylow, Lykke and Fazakerley, Daniel J. and Krycer, James R. and Thomas, Kristen C. and Oxbøll, Anne-Julie and Jordy, Andreas B. and Jensen, Thomas E. and Yang, Guang and Schjerling, Peter and Kiens, Bente and James, David E. and Ruegg, Markus A. and Richter, Erik A.. (2014) Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3 (6). pp. 630-641. Steiner, Esther and Enzmann, Gaby U. and Lyck, Ruth and Lin, Shuo and Rüegg, Markus A. and Kröger, Stephan and Engelhardt, Britta. (2014) The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358 (2). pp. 465-479. Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1). p. 6. Thomanetz, Venus and Angliker, Nico and Cloëtta, Dimitri and Lustenberger, Regula M. and Schweighauser, Manuel and Oliveri, Filippo and Suzuki, Noboru and Rüegg, Markus A.. (2013) Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, Vol. 201, H. 2. pp. 293-308. Cloëtta, Dimitri and Thomanetz, Venus and Baranek, Constanze and Lustenberger, Regula M. and Lin, Shuo and Oliveri, Filippo and Atanasoski, Suzana and Rüegg, Markus A.. (2013) Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, Vol. 33, H. 18. pp. 7799-7810. Castets, Perrine and Lin, Shuo and Rion, Nathalie and Di Fulvio, Sabrina and Romanino, Klaas and Guridi, Maitea and Frank, Stephan and Tintignac, Lionel A. and Sinnreich, Michael and Ruegg, Markus A.. (2013) Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, 17 (5). pp. 731-744. Song, Jian and Lokmic, Zerina and Lämmermann, Tim and Rolf, Julia and Wu, Chuan and Zhang, Xueli and Hallmann, Rupert and Hannocks, Melanie-Jane and Horn, Nathalie and Ruegg, Markus A. and Sonnenberg, Arnoud and Georges-Labouesse, Elisabeth and Winkler, Thomas H. and Kearney, John F. and Cardell, Susanna and Sorokin, Lydia. (2013) Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31). pp. 2915-E2924. Castets, Perrine and Rüegg, Markus A.. (2013) MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9 (9). pp. 1435-1437. Angliker, Nico and Rüegg, Markus A.. (2013) In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3 (4). pp. 113-118. Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738. Punga, Anna Rostedt and Ruegg, Markus A.. (2012) Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3). pp. 340-346. Blättler, Sharon M. and Cunningham, John T. and Verdeguer, Francisco and Chim, Helen and Haas, Wilhelm and Liu, Huifei and Romanino, Klaas and Rüegg, Markus A. and Gygi, Steven P. and Shi, Yang and Puigserver, Pere. (2012) Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15 (4). pp. 505-517. Meinen, Sarina and Lin, Shuo and Rüegg, Markus A. and Punga, Anna Rostedt. (2012) Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS ONE, Vol. 7, H. 8 , e44148. Blättler, Sharon M. and Verdeguer, Francisco and Liesa, Marc and Cunningham, John T. and Vogel, Rutger O. and Chim, Helen and Liu, Huifei and Romanino, Klaas and Shirihai, Orian S. and Vazquez, Francisca and Rüegg, Markus A. and Shi, Yang and Puigserver, Pere. (2012) Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32 (16). pp. 3333-3346. Meinen, Sarina and Lin, Shuo and Ruegg, Markus A.. (2012) Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal muscle, Vol. 2, H. 1. p. 18. 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Working PaperThürkauf, Marco and Lin, Shuo and Oliveri, Filippo and Grimm, Dirk and Platt, Randall J. and Rüegg, Markus A.. (2023) Fast, multiplexable and highly efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Reinhard, Judith R. and Porrello, Emanuela and Lin, Shuo and Pelczar, Pawel and Previtali, Stefano C. and Rüegg, Markus A.. (2022) Nerve pathology is prevented by linker proteins in mouse models for LAMA2- related muscular dystrophy. Ham, Daniel J. and Börsch, Anastasyia and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2021) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. |