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2022

Roos, Noëmi Johanna and Mancuso, Riccardo Vincenzo and Sanvee, Gerda Mawududzi and Bouitbir, Jamal and Krähenbühl, Stephan. (2022) Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food and Chemical Toxicology, 162. p. 112869.

Bouitbir, Jamal and Panajatovic, Miljenko V. and Krähenbühl, Stephan. (2022) Mitochondrial Toxicity Associated with Imatinib and Sorafenib in Isolated Rat Heart Fibers and the Cardiomyoblast H9c2 Cell Line. International journal of molecular sciences, 23 (4). p. 2282.

2021

Duthaler, Urs and Weber, Michael and Hofer, Lorenz and Chaccour, Carlos and Maia, Marta and Müller, Pie and Krähenbühl, Stephan and Hammann, Felix. (2021) The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS Pathogens, 17 (3). e1009382.

Witzigmann, Dominik and Grossen, Philip and Quintavalle, Cristina and Lanzafame, Manuela and Schenk, Susanne H. and Tran, Xue-Ting and Englinger, Bernhard and Hauswirth, Patrick and Grünig, David and van Schoonhoven, Sushilla and Krähenbühl, Stephan and Terracciano, Luigi M. and Berger, Walter and Piscuoglio, Salvatore and Quagliata, Luca and Rommelaere, Jean and Nüesch, Jürg P. F. and Huwyler, Jörg. (2021) Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma. Journal of Controlled Release, 334. pp. 138-152.

Bachmann, Fabio and Duthaler, Urs and Meyer Zu Schwabedissen, Henriette E. and Puchkov, Maxim and Huwyler, Jörg and Haschke, Manuel and Krähenbühl, Stephan. (2021) Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clinical Pharmacology and Therapeutics, 109 (6). pp. 1505-1516.

Panajatovic, Miljenko V. and Singh, Francois and Krähenbühl, Stephan and Bouitbir, Jamal. (2021) Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression. International Journal of Molecular Siences, 22 (9). p. 4950.

Blaser, Lea S. and Duthaler, Urs and Bouitbir, Jamal and Leuppi-Taegtmeyer, Anne B. and Liakoni, Evangelia and Dolf, Reto and Mayr, Michael and Drewe, Jürgen and Krähenbühl, Stephan and Haschke, Manuel. (2021) Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study. Frontiers in Pharmacology, 12. p. 620635.

2020

Roos, Noëmi Johanna and Duthaler, Urs and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells. Free radical biology and medicine, 152. pp. 216-226.

Bouitbir, Jamal and Panajatovic, Miljenko Valentin and Frechard, Theo and Roos, Noëmi Johanna and Krähenbühl, Stephan. (2020) Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells. Frontiers in Pharmacology, 11. p. 1106.

Roos, Noëmi Johanna and Aliu, Diell and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells. Frontiers in pharmacology, 11. p. 944.

Rudin, Deborah and Schmutz, Maurice and Roos, Noëmi Johanna and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis. Biomedicines, 8 (7). p. 212.

Bouitbir, Jamal and Alshaikhali, Abdallah and Panajatovic, Miljenko V. and Abegg, Vanessa F. and Paech, Franziska and Krähenbühl, Stephan. (2020) Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice. European cardiology, 15. e33.

Zhou, Xun and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan and Mancuso, Riccardo V.. (2020) Para; -Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells. International journal of molecular sciences, 21 (8). p. 2841.

Zhou, Xun and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan and Mancuso, Riccardo V.. (2020) Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones. Cells, 9 (4). p. 965.

Panajatovic, Miljenko Valentin and Singh, François and Roos, Noëmi Johanna and Duthaler, Urs and Handschin, Christoph and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 228 (4). e13402.

Sanvee, G. M. and Panajatovic, M. and Bouitbir, D. J. and Krähenbühl, Dmdps. (2020) Statins and Insulin Resistance. European cardiology, 15. e44.

Panajatovic, Miljenko V. and Singh, François and Duthaler, Urs and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity. European cardiology, 15. e35.

Panajatovic, Miljenko Valentin and Singh, François and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression. Biomedicines, 8 (9). p. 351.

2019

Rudin, Deborah and Lanzilotto, Angelo and Bachmann, Fabio and Housecroft, Catherine E. and Constable, Edwin C. and Drewe, Jürgen and Haschke, Manuel and Krähenbühl, Stephan. (2019) Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochemical Pharmacology, 163. pp. 345-356.

Malagnino, Vanessa and Duthaler, Urs and Seibert, Isabell and Krähenbühl, Stephan and Meyer Zu Schwabedissen, Henriette E.. (2019) OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Molecular Pharmacology, 96 (2). pp. 128-137.

Bouitbir, Jamal and Sanvee, Gerda M. and Panajatovic, Miljenko V. and Singh, François and Krähenbühl, Stephan. (2019) Mechanisms of statin-associated skeletal muscle-associated symptoms. Pharmacological research (154). p. 104201.

Sanvee, Gerda M. and Panajatovic, Miljenko V. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle. Biochemical pharmacology, 164. pp. 23-33.

Singh, François and Zoll, Joffrey and Duthaler, Urs and Charles, Anne-Laure and Panajatovic, Miljenko V. and Laverny, Gilles and McWilliams, Thomas G. and Metzger, Daniel and Geny, Bernard and Krähenbühl, Stephan and Bouitbir, Jamal. (2019) PGC-1β modulates statin-associated myotoxicity in mice. Archives of Toxicology, 93 (2). pp. 487-504.

Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports, 9 (1). p. 7409.

Bouitbir, Jamal and Alshaikhali, Abdallah and Panajatovic, Miljenko V. and Abegg, Vanessa F. and Paech, Franziska and Krähenbühl, Stephan. (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts. Toxicology, 426. p. 152281.

Bühler, Tim and Medinger, Michael and Bouitbir, Jamal and Krähenbühl, Stephan and Leuppi-Taegtmeyer, Anne. (2019) Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient. Frontiers in pharmacology, 10. p. 645.

Zhou, Xun and Luethi, Dino and Sanvee, Gerda M. and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan. (2019) Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts. International journal of molecular sciences, 20 (7). p. 1561.

2018

Duthaler, Urs and Berger, Benjamin and Erb, Stefan and Battegay, Manuel and Letang, Emili and Gaugler, Stefan and Natamatungiro, Alex and Mnzava, Dorcas and Donzelli, Massimiliano and Krähenbühl, Stephan and Haschke, Manuel. (2018) Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. Journal of Antimicrobial Chemotherapy, 73 (10). pp. 2729-2737.

Berger, Benjamin and Bachmann, Fabio and Duthaler, Urs and Krähenbühl, Stephan and Haschke, Manuel. (2018) Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. Frontiers in pharmacology, 9. p. 774.

Grünig, David and Duthaler, Urs and Krähenbühl, Stephan. (2018) Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells. Frontiers in pharmacology, 9. p. 257.

Bachmann, Fabio and Duthaler, Urs and Rudin, Deborah and Krähenbühl, Stephan and Haschke, Manuel. (2018) N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120. pp. 172-180.

Grünig, David and Felser, Andrea and Duthaler, Urs and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicological sciences, 164 (2). pp. 477-488.

Duthaler, Urs and Suenderhauf, Claudia and Karlsson, Mats O. and Hussner, Janine and Meyer Zu Schwabedissen, Henriette and Krähenbühl, Stephan and Hammann, Felix. (2018) Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers. British journal of clinical pharmacology, 85 (3). pp. 626-633.

Paech, Franziska and Abegg, Vanessa F. and Duthaler, Urs and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology, 409. pp. 13-23.

Paech, Franziska and Mingard, Cécile and Grünig, David and Abegg, Vanessa F. and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology, 395. pp. 34-44.

Mingard, Cécile and Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines. Journal of applied toxicology : JAT, 38 (3). pp. 418-431.

2017

Bonifacio, Annalisa and Sanvee, Gerda M. and Brecht, Karin and Kratschmar, Denise V. and Odermatt, Alex and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91 (5). pp. 2223-2234.

Duthaler, Urs and Berger, Benjamin and Erb, Stefan and Battegay, Manuel and Letang, Emilio and Gaugler, Stefan and Krähenbühl, Stephan and Haschke, Manuel. (2017) Automated high throughput analysis of antiretroviral drugs in dried blood spots. Journal of Mass Spectrometry, 52 (8). pp. 534-542.

Luethi, Dino and Liechti, Matthias E. and Krähenbühl, Stephan. (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology, 387. pp. 57-66.

Parra-Guillen, Zinnia P. and Berger, Peter B. and Haschke, Manuel and Donzelli, Massimiliano and Winogradova, Daria and Pfister, Bogumila and Früh, Martin and Gillessen, Silke and Krähenbühl, Stephan and Kloft, Charlotte and Joerger, Markus. (2017) Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment. Basic and Clinical Pharmacology and Toxicology, 121 (4). pp. 309-315.

Krähenbühl, Stephan and Pichler, Werner J.. (2017) Medikamentöse Hepatopathien - Drug-induced liver injury. Therapeutische Umschau, 74 (3). pp. 123-130.

Brueckner, David and Krähenbühl, Stephan and Zuber, Ulrich and Bonkat, Gernot and Braissant, Olivier. (2017) An alternative sterility assessment for parenteral drug products using isothermal microcalorimetry. Journal of Applied Microbiology, 123 (3). pp. 773-779.

Krähenbühl, Stephan. (2017) Importance of the skeletal muscle carnitine stores in fuel selection. The Journal of Physiology, 595 (17). pp. 5727-5728.

Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis. Frontiers in Pharmacology, 8. p. 367.

Blaser, Lea and Hassna, Hala and Hofmann, Sarah and Holbro, Andreas and Haschke, Manuel and Rätz Bravo, Alexandra and Zeller, Andreas and Krähenbühl, Stephan and Taegtmeyer, Anne. (2017) Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147. w14438.

Brueckner, David and Solokhina, Anna and Krähenbühl, Stephan and Braissant, Olivier. (2017) A combined application of tunable diode laser absorption spectroscopy and isothermal micro-calorimetry for calorespirometric analysis. Journal of Microbiological Methods, 139. pp. 210-214.

Drago, Sara and Imboden, Roger and Schlatter, Philipp and Buylaert, Mirabel and Krähenbühl, Stephan and Drewe, Juergen. (2017) Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers. Basic and Clinical Pharmacology and Toxicology, 121 (5). pp. 423-429.

Paech, Franziska and Messner, Simon and Spickermann, Jochen and Wind, Mathias and Schmitt-Hoffmann, Anne-Hortense and Witschi, Anne Therese and Howell, Brett A. and Church, Rachel J. and Woodhead, Jeff and Engelhardt, Marc and Krähenbühl, Stephan and Maurer, Martina. (2017) Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072. Archives of Toxicology, 91 (11). pp. 3647-3662.

Grünig, David and Felser, Andrea and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicology in Vitro, 42. pp. 337-347.

Brueckner, David and Roesti, David and Zuber, Ulrich and Sacher, Meik and Duncan, Derek and Krähenbühl, Stephan and Braissant, Olivier. (2017) Tunable diode laser absorption spectroscopy as method of choice for non-invasive and automated detection of microbial growth in media fills. Talanta, 167. pp. 21-29.

Haegler, Patrizia and Joerin, Lorenz and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents. Toxicological sciences, 157 (1). pp. 183-195.

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne. (2017) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicology in Vitro, 40. pp. 55-65.

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Terracciano, Luigi and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice. PLoS One, 12 (1). e0171026.

2016

Bloechliger, Marlene and Ceschi, Alessandro and Rüegg, Stephan and Kupferschmidt, Hugo and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R. and Bodmer, Michael. (2016) Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case-Control Analysis Using the Clinical Practice Research Datalink. Drug Safety , 39 (4). pp. 307-321.

Camblin, Marine and Berger, Benjamin and Haschke, Manuel and Krähenbühl, Stephan and Huwyler, Jörg and Puchkov, Maxim. (2016) CombiCap: A novel drug formulation for the basel phenotyping cocktail. International Journal of Pharmaceutics, 512 (1). pp. 253-261.

Novakova, Katerina and Kummer, Oliver and Bouitbir, Jamal and Stoffel, Sonja D. and Hoerler-Koerner, Ulrike and Bodmer, Michael and Roberts, Paul and Urwyler, Albert and Ehrsam, Rolf and Krähenbühl, Stephan. (2016) Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. European Journal of Nutrition, 55 (1). pp. 207-217.

Bonifacio, Annalisa and Mullen, Peter J. and Mityko, Ileana Scurtu and Navegantes, Luiz C. and Bouitbir, Jamal and Krähenbühl, Stephan. (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Archives of Toxicology, 90 (1). pp. 203-215.

Vogel, Marc and Bucher, Patricia and Strasser, Johannes and Liechti, Matthias E. and Krähenbühl, Stephan and Dürsteler, Kenneth M.. (2016) Similar and Different? Subjective Effects of Methylphenidate and Cocaine in Opioid-Maintained Patients. Journal of Psychoactive Drugs , 48 (2). pp. 93-100.

Neumair, P. and Joos, L. and Warschkow, R. and Ess, S. and Hitz, F. and Frueh, M. and Brutsche, M. H. and Baty, F. and Krahenbuhl, S. and Jorger, M.. (2016) 169P: Chemotherapy is not superior to erlotinib in pretreated patients with advanced non-small cell lung cancer (NSCLC): A retrospective study. Journal of Thoracic Oncology, 11 (4 Suppl). p. 131.

Neumair, P. and Joos, L. and Warschkow, R. and Dutly, A. and Ess, S. and Hitz, F. and Fruh, M. and Brutsche, M. and Baty, F. and Krahenbuhl, S. and Cerny, T. and Joerger, M.. (2016) Erlotinib has comparable clinical efficacy to chemotherapy in pretreated patients with advanced non-small cell lung cancer (NSCLC): A propensity-adjusted, outcomes research-based study. Lung Cancer, 100. pp. 38-44.

Kummer, Oliver and Hammann, Felix and Haschke, Manuel and Krähenbühl, Stephan. (2016) Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II. British Journal of Clinical Pharmacology, 81 (5). pp. 1002-1004.

Krahenbuhl, S. and Pavik-Mezzour, I. and von Eckardstein, A.. (2016) Unmet Needs in LDL-C Lowering: When Statins Won't Do! Drugs, 76 (12). pp. 1175-1190.

Derungs, A. and Donzelli, M. and Berger, B. and Noppen, C. and Krahenbuhl, S. and Haschke, M.. (2016) Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clin Pharmacokinet, 55 (1). pp. 79-91.

Bouitbir, Jamal and Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bonifacio, Annalisa and Echaniz-Laguna, Andoni and Geny, Bernard and Krahenbuhl, Stephan and Zoll, Joffrey. (2016) Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle. Antioxidants and Redox Signaling, 24 (2). pp. 84-98.

Bouitbir, Jamal and Haegler, Patrizia and Singh, François and Joerin, Lorenz and Felser, Andrea and Duthaler, Urs and Krähenbühl, Stephan. (2016) Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency. Frontiers in Physiology, 7. p. 345.

Berger, B. and Donzelli, M. and Maseneni, S. and Boess, F. and Roth, A. and Krahenbuhl, S. and Haschke, M.. (2016) Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail. Front Pharmacol, 7. p. 443.

Mancuso, Riccardo V. and Welzenbach, Karl and Steinberger, Peter and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2016) Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition. Biochemical Pharmacology, 119. pp. 42-55.

2015

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Krähenbühl, Stephan and Bouitbir, Jamal. (2015) Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: a cell model for idiosyncratic toxicity. Toxicology, 336. pp. 48-58.

Roberts, Paul A. and Bouitbir, Jamal and Bonifacio, Annalisa and Singh, François and Kaufmann, Priska and Urwyler, Albert and Krähenbühl, Stephan. (2015) Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency. American Journal of Physiology. Endocrinology and Metabolism, 309 (3). E265-E274.

Liakoni, Evangelia and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2015) Hepatotoxicity of New Oral Anticoagulants (NOACs). Drug safety, 38 (8). pp. 711-720.

Bonifacio, Annalisa and Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2015) The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity. Biochimica et biophysica acta. Molecular cell research, 1853 (8). pp. 1841-1849.

Ceschi, Alessandro and Heistermann, Elja and Gros, Sonja and Reichert, Cornelia and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2015) Acute sirolimus overdose: a multicenter case series. PLoS ONE, 10 (5). e0128033.

Sidharta, Patricia N. and Krähenbühl, Stephan and Dingemanse, Jasper. (2015) Pharmacokinetic and pharmacodynamic evaluation of macitentan , a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension. Expert opinion on drug metabolism & toxicology, 11 (3). pp. 437-449.

Blaser, Lea S. and Tramonti, Alexandra and Egger, Pascal and Haschke, Manuel and Krähenbühl, Stephan and Rätz Bravo, Alexandra E.. (2015) Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports. European journal of clinical pharmacology, 71 (2). pp. 209-217.

Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bouitbir, Jamal and Bonifacio, Annalisa and Piquard, François and Krähenbühl, Stephan and Geny, Bernard and Zoll, Joffrey. (2015) Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. Biochimica et biophysica acta. Molecular cell research, 1853 (7). pp. 1574-1585.

Krahenbuhl, Swenn Maxence and Depairon, Michele and Faure, Marguerite and Vietti Violi, Naik and Applegate, Lee Ann and Raffoul, Wassim. (2015) Sildenafil as a therapeutic option for digital ischemic ulceration: case report. The Journal of Hand Surgery, 40 (5). pp. 890-893.

Welzenbach, Karl and Mancuso, Riccardo V. and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2015) A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood. British Journal of Pharmacology, 172 (20). pp. 4875-4887.

2014

Siller-Matula, J. M. and Trenk, D. and Krähenbühl, S. and Michelson, A. D. and Delle-Karth, G.. (2014) Clinical implications of drug-drug interactions with P2Y12 receptor inhibitors. Journal of thrombosis and haemostasis, Vol. 12, H. 1. pp. 2-13.

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. pp. 232-241.

Morand, Réjane and Bouitbir, Jamal and Felser, Andrea and Hench, Jürgen and Handschin, Christoph and Frank, Stephan and Krähenbühl, Stephan. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6). pp. 1313-1325.

Mengiardi, Seraina and Tsakiris, Dimitrios A. and Molnar, Viviane and Kohlhaas-Styk, Urs and Mittag, Michael and Kraehenbuehl, Stephan and Hersberger, Kurt E.. (2014) Impact of pharmaceutical care on self-administration of outpatient low-molecular-weight heparin therapy. Pharmacology & pharmacy, Vol. 5, H. 4. pp. 372-385.

Donzelli, Massimiliano and Derungs, Adrian and Serratore, Maria-Giovanna and Noppen, Christoph and Nezic, Lana and Krähenbühl, Stephan and Haschke, Manuel. (2014) The Basel Cocktail for Simultaneous Phenotyping of Human Cytochrome P450 Isoforms in Plasma, Saliva and Dried Blood Spots. Clinical pharmacokinetics, Vol. 53, H. 3. pp. 271-282.

Felser, Andrea and Lindinger, Peter W. and Schnell, Dominik and Kratschmar, Denise V. and Odermatt, Alex and Mies, Suzette and Jenö, Paul and Krähenbühl, Stephan. (2014) Hepatocellular toxicity of benzbromarone : Effects on mitochondrial function and structure. Toxicology, Vol. 324. pp. 136-146.

Taegtmeyer, Anne B. and Haschke, Manuel and Tchambaz, Lydia and Buylaert, Mirabel and Tschöpl, Martin and Beuers, Ulrich and Drewe, Jürgen and Krähenbühl, Stephan. (2014) A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls. PLoS ONE, Vol. 9, H. 6 , e97885.

Nezic, Lana and Derungs, Adrian and Bruggisser, Marcel and Tschudin-Sutter, Sarah and Krähenbühl, Stephan and Haschke, Manuel. (2014) Therapeutic drug monitoring of once daily aminoglycoside dosing : comparison of two methods and investigation of the optimal blood sampling strategy. European journal of clinical pharmacology, Vol. 70, H. 7. pp. 829-837.

Wuillemin, Natascha and Terracciano, Luigi and Beltraminelli, Helmut and Schlapbach, Christoph and Fontana, Stefano and Krähenbühl, Stephan and Pichler, Werner J. and Yerly, Daniel. (2014) T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury. American journal of pathology, Vol. 184, no. 6. pp. 1677-1682.

Ceschi, Alessandro and Gregoriano, Claudia and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2014) Acute mycophenolate overdose : case series and systematic literature analysis. Expert opinion on drug safety, Vol. 13, H. 5. pp. 525-534.

Gregoriano, Claudia and Ceschi, Alessandro and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2014) Acute thiopurine overdose : analysis of reports to a National Poison Centre 1995-2013. PLoS ONE, Vol. 9, H. 1 , e86390.

Liakoni, Evangelia and Rätz Bravo, Alexandra E. and Terracciano, Luigi and Heim, Markus and Krähenbühl, Stephan. (2014) Symptomatic hepatocellular liver injury with hyperbilirubinemia in two patients treated with rivaroxaban. JAMA internal medicine, Vol. 174, H. 10. pp. 1683-1686.

Felser, Andrea and Stoller, Andrea and Morand, Réjane and Schnell, Dominik and Donzelli, Massimiliano and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2014) Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. Toxicology, 323. pp. 1-9.

2013

Ceschi, A. and Rauber-Lüthy, C. and Kupferschmidt, H. and Banner, N. R. and Ansari, M. and Krähenbühl, S. and Taegtmeyer, A. B.. (2013) Acute Calcineurin Inhibitor Overdose: Analysis of Cases Reported to a National Poison Center Between 1995 and 2011. American journal of transplantation : official journal of the American Society of Transplant Surgeons (ASTS) and the American Society of Transplantation (AST), Vol. 13 , S. 786–795.

Mueller, F. and Büchel, B. and Köberle, D. and Schürch, S. and Pfister, B. and Krähenbühl, St and Froehlich, T. K. and Largiader, C. R. and Joerger, M.. (2013) Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study. Cancer chemotherapy and pharmacology, Vol. 71, H. 2. pp. 361-370.

Franz, Carmen C. and Hildbrand, Carole and Born, Christa and Egger, Sabin and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2013) Dose adjustment in patients with liver cirrhosis : impact on adverse drug reactions and hospitalizations. European journal of clinical pharmacology, Vol. 69, H. 8. pp. 1565-1573.

Morand, Réjane and Donzelli, Massimiliano and Haschke, Manuel and Krähenbühl, Stephan. (2013) Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. Analytical and bioanalytical chemistry, Vol. 405, H. 27. pp. 8829-8836.

Hirzel, E. and Lindinger, P. W. and Maseneni, S. and Giese, M. and Rhein, V. V. and Eckert, A. and Hoch, M. and Krahenbuhl, S. and Eberle, A. N.. (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. Journal of receptors and signal transduction, Vol. 33, H. 5. pp. 304-312.

Haschke, Manuel and Schuster, Manfred and Poglitsch, Marko and Loibner, Hans and Salzberg, Marc and Bruggisser, Marcel and Penninger, Joseph and Krähenbühl, Stephan. (2013) Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clinical pharmacokinetics, Vol. 52, H. 9. pp. 783-792.

Wuillemin, Natascha and Adam, Jacqueline and Fontana, Stefano and Krähenbühl, Stephan and Pichler, Werner J. and Yerly, Daniel. (2013) HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin. Journal of immunology, Vol. 190, H. 10. pp. 4956-4964.

Maseneni, Swarna and Donzelli, Massimiliano and Brecht, Karin and Krähenbühl, Stephan. (2013) Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes. Toxicology, 308. pp. 11-19.

Giger-Pabst, Urs and Lange, Jochen and Maurer, Christoph and Bucher, Carine and Schreiber, Vital and Schlumpf, Rolf and Kocher, Thomas and Schweizer, Walter and Krähenbühl, Stephan and Krähenbühl, Lukas. (2013) Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition, Vol. 29, H. 5. pp. 724-729.

Caduff Good, Angela and Nobel, Daniel and Krähenbühl, Stephan and Geisen, Christof and Henz, Samuel. (2013) Randomised trial of a clinical dosing algorithm to start anticoagulation with phenprocoumon. Swiss medical weekly, Vol. 143 , w13709.

Krähenbühl, Stephan. (2013) Leicht erhöhte Transaminasen. Therapeutische Umschau, Vol. 70, H. 5. pp. 284-288.

Zahno, Anja and Bouitbir, Jamal and Maseneni, Swarma and Lindinger, Peter W. and Brecht, Karin and Krähenbühl, Stephan. (2013) Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors. Free radical biology and medicine, 65. pp. 208-216.

Felser, Andrea and Blum, Kim and Lindinger, Peter W. and Bouitbir, Jamal and Krähenbühl, Stephan. (2013) Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone. Toxicological sciences, 131 (2). pp. 480-490.

2012

Hysek, C. M. and Simmler, L. D. and Nicola, V. G. and Vischer, N. and Donzelli, M. and Krahenbuhl, S. and Grouzmann, E. and Huwyler, J. and Hoener, M. C. and Liechti, M. E.. (2012) Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS ONE, Vol. 7, H. 5 , e36476.

Pham, T. T. T. and See, H. H. and Morand, R. and Krahenbuhl, S. and Hauser, P. C.. (2012) Determination of free and total valproic acid in human plasma by capillary electrophoresis with contactless conductivity detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Vol. 907. pp. 74-78.

See, Hong Heng and Schmidt-Marzinkowski, Julia and Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2012) Determination of creatine and phosphocreatine in muscle biopsy samples by capillary electrophoresis with contactless conductivity detection. Analytica Chimica Acta, 727. pp. 78-82.

Franz, Carmen C. and Egger, Sabin and Born, Christa and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2012) Potential drug-drug interactions and adverse drug reactions in patients with liver cirrhosis. European journal of clinical pharmacology, Vol. 68, H. 2. pp. 179-188.

Henkel, Verena and Casaulta, Flurina and Seemüller, Florian and Krähenbühl, Stephan and Obermeier, Michael and Hüsler, Jürg and Möller, Hans-Jürgen. (2012) Study design features affecting outcome in antidepressant trials. Journal of affective disorders, Vol. 141, H. 2-3. pp. 160-167.

Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg. (2012) Drug interaction potential of resveratrol. Drug metabolism reviews, Vol. 44, H. 3. pp. 253-265.

Morand, R. and Todesco, L. and Donzelli, M. and Fischer-Barnicol, D. and Mullen, P. J. and Krahenbuhl, S.. (2012) Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. Therapeutic drug monitoring, Vol. 34, H. 4. pp. 406-414.

Hardmeier, M. and Zimmermann, R. and Rüegg, S. and Pflüger, M. and Deuster, S. and Suter, K. and Donzelli, M. and Drewe, J. and Krähenbühl, S. and Fuhr, P. and Haschke, M.. (2012) Intranasal midazolam: pharmacokinetics and pharmacodynamics assessed by quantitative EEG in healthy volunteers. Clinical Pharmacology & Therapeutics, 91 (5). pp. 856-862.

Maseneni, Swarna and Donzelli, Massimiliano and Taegtmeyer, A. B. and Brecht, Karin and Krähenbühl, Stephan. (2012) Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites. Toxicology, 299 (2-3). pp. 139-145.

Joerger, M. and Ferreri, A. J. M. and Krähenbühl, S. and Schellens, J. H. M. and Cerny, Th and Zucca, E. and Huitema, A. D. R.. (2012) Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate. British journal of clinical pharmacology, Vol. 73, H. 2. pp. 240-247.

Nezic, L. and Krähenbühl, S. and Rätz Bravo, A. E.. (2012) Diclofenac-induzierte Leberschäden = Diclofenac induced liver injuries. Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine PRAXIS, Vol. 101, H. 6. pp. 371-379.

Swiss Association for the Study of the Liver, and Moradpour D, Helbling B. and Cerny A, De Gottardi A. and Heim MH, Majno P. and Müllhaupt B, Negro F. and Rubbia-Brandt L, Semela D. and Vilei SB, Bernsmeier C. and Bihl F, Borovicka J. and Dill M, Dufour J. F. and Filipowicz M, Geier A. and Gerlach T, Giostra E. and Gonvers JJ, Goossens N. and Gubler C, Hadengue A. and Heim MH, Helbling B. and Hellstern M, Hirschi C. and Jochum W, Krähenbühl S. and Kullak-Ublick G, Lange C. and Lavanchy D, Majno P. and Malinverni R, McLin V. and Mentha G, Mertens J. C. and Nasser S, Oneta C. and Pache I, Rubbia-Brandt L. and Sauter B, Semela D. and Spahr L, Steuerwald M. and Stickel F, Stieger B. and Wehr K, Zala G.. (2012) Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir. Swiss medical weekly, Vol. 142 , w13516.

2011

Kummer, Oliver and Hammann, Felix and Moser, Claudine and Schaller, Olivier and Drewe, Jürgen and Krähenbühl, Stephan. (2011) Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. European journal of clinical pharmacology, Vol. 67, H. 1. pp. 63-71.

Zahno, Anja and Brecht, Karin and Morand, Réjane and Maseneni, Swarna and Török, Michael and Lindinger, Peter W. and Krähenbühl, Stephan. (2011) The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells. Biochemical pharmacology, Vol. 81, Issue 3. pp. 432-441.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Capillary electrophoresis with contactless conductivity detection for the determination of carnitine and acylcarnitines in clinical samples. Journal of Chromatography B, 879 (13-14). pp. 921-926.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Quantification of plasma lactate concentrations using capillary electrophoresis with contactless conductivity detection. Electrophoresis, 32 (8). pp. 884-889.

Halter, J. and Schüpbach, W. M. M. and Casali, C. and Elhasid, R. and Fay, K. and Hammans, S. and Illa, I. and Kappeler, L. and Krähenbühl, S. and Lehmann, T. and Mandel, H. and Marti, R. and Mattle, H. and Orchard, K. and Savage, D. and Sue, C. M. and Valcarcel, D. and Gratwohl, A. and Hirano, M.. (2011) Allogeneic hematopoietic SCT as treatment option for patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) : a consensus conference proposal for a standardized approach. Bone marrow transplantation, Vol. 46, H. 3. pp. 330-337.

Hoch, Matthias and Hoever, Petra and Haschke, Manuel and Krähenbühl, Stephan and Dingemanse, Jasper. (2011) Food effect and biocomparison of two formulations of the dual orexin receptor antagonist almorexant in healthy male subjects. The journal of clinical pharmacology, Vol. 51, H. 7. pp. 1116-1121.

Bruggisser, M. and Rätz Bravo, A. E. and Krähenbühl, S.. (2011) [Severe pancytopenia and stomatitis in a patient treated with low-dose methostraxate]. Schweizerische Rundschau für Medizin PRAXIS, Vol. 100, H. 13 , S. 765-774; quiz 772.

Franz, C. C. and Bruggisser, M. and Krähenbühl, S. and Rätz Bravo, A. E.. (2011) [Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole]. Schweizerische Rundschau für Medizin PRAXIS, Vol. 100, H. 5. pp. 273-284.

Mullen, Peter J. and Zahno, Anja and Lindinger, Peter and Maseneni, Swarma and Felser, Andrea and Krähenbühl, Stephan and Brecht, Karin. (2011) Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt. Biochimica et biophysica acta, Vol. 1813, H. 12. pp. 2079-2087.

Giger, U. and Ouaissi, M. and Schmitz, S.-F H. and Krähenbühl, S. and Krähenbühl, L.. (2011) Bile duct injury and use of cholangiography during laparoscopic cholecystectomy. British journal of surgery, Vol. 98, H. 3. pp. 391-396.

Halter, Joerg and Schüpbach, W. M. Michael and Casali, Carlo and Elhasid, Ronit and Fay, K. and Hammans, S. and Illa, I. and Kappeler, Liliane and Krähenbühl, Stephan and Lehmann, T. and Mandel, H. and Marti, Ramon and Mattle, Heinrich P. and Orchard, Kim and Savage, David and Sue, Carolyn M. and Valcarcel, David and Gratwohl, Alois and Hirano, M.. (2011) Allogeneic hematopoietic SCT as treatment option for patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a consensus conference proposal for a standardized approach. Bone marrow transplantation, 46 (3). pp. 330-337.

Derungs, Adrian and Schietzel, Simeon and Meyer, Markus R. and Maurer, Hans H. and Krähenbühl, Stephan and Liechti, Matthias E.. (2011) Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone). Clinical toxicology, 49 (7). pp. 691-693.

2010

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. pp. 63-70.

Brauchli, Yolanda B. and Wais, Thomas and Gratwohl, Alois and Heim, Dominik and Schipf, Alexander and Diebold, Joachim and Krähenbühl, Stephan. (2010) Fatal myocardial infarction during nilotinib treatment in a 60-year-old male patient. Acta oncologica, Vol. 49, no. 4. pp. 523-525.

Pormsila, W. and Krähenbühl, S. and Hauser, P. C.. (2010) Determination of carnitine in food and food supplements by capillary electrophoresis with contactless conductivity detection. Electrophoresis, Vol. 31. pp. 2186-2191.

Pormsila, W. and Gong, X. Y. and Hauser, P. C.. (2010) Determination of the enantiomers of alpha-hydroxy- and alpha-amino acids in capillary electrophoresis with contactless conductivity detection. Electrophoresis, Vol. 31. pp. 2044-2048.

Sawatzki, M. and Kummer, O. and Krähenbühl, S. and Siegemund, M.. (2010) 35-jährige Patientin mit generalisiertem Krampfanfall und nicht-kardiogenem Lungenödem nach Intoxikation. Internist, 51 (4). pp. 528-532.

Bodmer, Michael and Meier, Christian and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R.. (2010) Long-term metformin use is associated with decreased risk of breast cancer. Diabetes care, Vol. 33, H. 6. pp. 1304-1308.

Haschke, Manuel and Suter, Katja and Hofmann, Sarah and Witschi, Robert and Fröhlich, Johannes and Imanidis, Georgios and Drewe, Jürgen and Briellmann, Thomas A. and Dussy, Franz E. and Krähenbühl, Stephan and Surber, Christian. (2010) Pharmacokinetics and pharmacodynamics of nasally delivered midazolam. British journal of clinical pharmacology, Vol. 69, H. 6. pp. 607-616.

Egger, S. S. and Meier, S. and Leu, C. and Christen, S. and Gratwohl, A. and Krahenbuhl, S. and Haschke, M.. (2010) Drug interactions and adverse events associated with antimycotic drugs used for invasive aspergillosis in hematopoietic SCT. Bone marrow transplantation, Vol. 45, H. 7. pp. 1197-1203.

Haschke, M. and Vitins, T. and Lude, S. and Todesco, L. and Novakova, K. and Herrmann, R. and Krahenbuhl, S.. (2010) Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs. Nephrology, dialysis, transplantation, Vol. 25, H. 2. pp. 426-433.

Joerger, M. and Huitema, A. D. R. and Krähenbühl, S. and Schellens, J. H. M. and Cerny, T. and Reni, M. and Zucca, E. and Cavalli, F. and Ferreri, A. J. M.. (2010) Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma : a pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial. British journal of cancer, Vol. 102, H. 4. pp. 673-677.

Mullen, Peter James and Lüscher, Barbara and Scharnagl, Hubert and Krähenbühl, Stephan and Brecht, Karin. (2010) Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochemical pharmacology, 79 (8). pp. 1200-1209.

Grisouard, Jean and Timper, Katharina and Radimerski, Tanja M. and Frey, Daniel M. and Peterli, Ralph and Kola, Blerina and Korbonits, Marta and Herrmann, Paul and Krahenbuhl, Stephan and Zulewski, Henryk and Keller, Ulrich and Muller, Beat and Christ-Crain, Mirjam. (2010) Mechanisms of metformin action on glucose transport and metabolism in human adipocytes. Biochemical Pharmacology, 80 (11). pp. 1736-1745.

Zahno, Anja and Brecht, Karin and Bodmer, Michael and Bur, Daniel and Tsakiris, Dimitrios A. and Krähenbühl, Stephan. (2010) Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro. British journal of pharmacology, 161 (2). pp. 393-404.

Schürch, Regula and Todesco, Liliane and Novakova, Katarina and Mevissen, Meike and Stieger, Bruno and Krähenbühl, Stephan. (2010) The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. European journal of pharmacology, Vol. 635, H. 1-3. pp. 171-176.

Krämer, Isabel and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Krähenbühl, Stephan and Ceschi, Alessandro. (2010) Minimal dose for severe poisoning and influencing factors in acute human clozapine intoxication : a 13-year retrospective study. Clinical neuropharmacology, Vol. 33, H. 5. pp. 230-234.

Popov, Yury and Sverdlov, Deanna Y. and Bhaskar, K. Ramakrishnan and Sharma, Anisha K. and Millonig, Gunda and Patsenker, Eleonora and Krahenbuhl, Stephan and Krahenbuhl, Lukas and Schuppan, Detlef. (2010) Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. American journal of physiology. Gastrointestinal and liver physiology, Vol. 298, H. 3 , G323-334.

2009

Bodmer, Michael and Brauchli, Yolanda B. and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R.. (2009) Statin use and risk of gallstone disease followed by cholecystectomy. JAMA : the journal of the American Medical Association, Vol. 302, H. 18. pp. 2001-2007.

Kummer, Oliver and Haschke, Manuel and Hammann, Felix and Bodmer, Michael and Bruderer, Shirin and Regnault, Yann and Dingemanse, Jasper and Krähenbühl, Stephan. (2009) Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan. European journal of pharmaceutical sciences, Vol. 38, H. 4. pp. 384-388.

Sidharta, P. N. and Rave, K. and Heinemann, L. and Chiossi, E. and Krahenbuhl, S. and Dingemanse, J.. (2009) Effect of the urotensin-II receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type 2 diabetes mellitus. British journal of clinical pharmacology, Vol. 68, no. 4. pp. 502-510.

Rätz Bravo, Alexandra E. and Hofer, Silvia and Krähenbühl, Stephan and Ludwig, Christian. (2009) Fatal drug-drug interaction of brivudine and capecitabine. Acta oncologica, Vol. 48, no. 4. pp. 631-633.

Giger, U. and Wente, M. N. and Büchler, M. W. and Krähenbühl, S. and Lerut, J. and Krähenbühl, L.. (2009) Endoscopic retroperitoneal neurectomy for chronic pain after groin surgery. British journal of surgery, Vol. 96, H. 9. pp. 1076-1081.

Schlatter, Chantal and Egger, Sabin S. and Tchambaz, Lydia and Krähenbühl, Stephan. (2009) Pharmacokinetic changes of psychotropic drugs in patients with liver disease : implications for dose adaptation. Drug safety, Vol. 32, no. 7. pp. 561-578.

Todesco, Liliane and Bodmer, Michael and Vonwil, Karin and Häussinger, Daniel and Krähenbühl, Stephan. (2009) Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. Chemico-Biological Interactions , 180 (3). pp. 472-477.

Pormsila, W. and Krahenbuhl, S. and Hauser, P. C.. (2009) Capillary electrophoresis with contactless conductivity detection for uric acid determination in biological fluids. Analytica Chimica Acta, Vol. 636, pp. 224-228.

2008

Knapp, Andrea Caroline and Todesco, Liliane and Beier, Konstantin and Terracciano, Luigi and Saegesser, Hans and Reichen, Juerg and Kraehenbuehl, Stephan. (2008) Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores. The Journal of Pharmacology and Experimental Therapeutics, Vol. 324, H. 2. pp. 568-575.

Knapp, Andrea Caroline and Todesco, Liliane and Torok, Michael and Beier, Konstantin and Krähenbühl, Stephan. (2008) Effect of carnitine deprivation on carnitine homeostasis and energy metabolism in mice with systemic carnitine deficiency. Annals of nutrition and metabolism, Vol. 52, No. 2. pp. 136-144.

Brauchli, Yolanda B. and Gittermann, Matthias and Michot, Marc and Krähenbühl, Stephan and Gnehm, Hanspeter E.. (2008) A fatal tick bite occurring during the course of tick-borne encephalitis vaccination. Pediatric infectious disease journal, Vol. 27. pp. 363-365.

Vonbach, Priska and Dubied, André and Krähenbühl, Stephan and Beer, Jürg H.. (2008) Prevalence of drug-drug interactions at hospital entry and during hospital stay of patients in internal medicine. European journal of internal medicine, Vol. 19, H. 6. pp. 413-420.

Bodmer, M. and Meier, C. and Krähenbühl, S. and Jick, S. S. and Meier, C. R.. (2008) Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia : a nested case-control analysis. Diabetes Care, Vol. 31. pp. 2086-2091.

Brauchli, Yolanda B. and Scholer, André and Schwietert, Martin and Krähenbühl, Stephan. (2008) Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda. Clinica chimica acta, Vol. 389, H. 1-2. pp. 174-176.

Poller, B. and Gutmann, H. and Krähenbühl, S. and Weksler, B. and Romero, I. and Couraud, P. O. and Tuffin, G. and Drewe, J. and Huwyler, J.. (2008) The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies. Journal of Neurochemistry, Vol. 107, H. 5. pp. 1358-1368.

Todesco, L. and Bur, D. and Brooks, H. and Török, M. and Landmann, L. and Stieger, B. and Krähenbühl, S.. (2008) Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2. Cellular and molecular life sciences, Vol. 65, no. 10. pp. 1596-1608.

Bodmer, M. and Burkard, T. and Kummer, O. and Beyrau, R. and Krähenbühl, S. and Haschke, M.. (2008) Pharmacokinetics and pharmacodynamics of quetiapine in a patient with a massive overdose. Therapeutic drug monitoring, Vol. 30, H. 4. pp. 553-556.

Lüde, Saskia and Török, Michael and Dieterle, Sandy and Jäggi, René and Büter, Karin Berger and Krähenbühl, Stephan. (2008) Hepatocellular toxicity of kava leaf and root extracts. Phytomedicine, Vol. 15, H. 1-2. pp. 120-131.

Vonbach, Priska and Dubied, André and Krähenbühl, Stephan and Beer, Jürg H.. (2008) Evaluation of frequently used drug interaction screening programs. Pharmacy world & science, Vol. 30, H. 4. pp. 367-374.

Aschmann, Yvonne Zysset and Kummer, Oliver and Linka, André and Wenk, Markus and Azzola, Andrea and Bodmer, Michael and Krähenbühl, Stephan and Haschke, Manuel. (2008) Pharmacokinetics and pharmacodynamics of sildenafil in a patient treated with human immunodeficiency virus protease inhibitors. Therapeutic drug monitoring, Vol. 30, H. 1. pp. 130-134.

Kummer, O. and Hammann, F. and Bodmer, M. and Novakova, K. and Krähenbühl, S. and Haschke, M.. (2008) [Drug-induced toxic hepatitis]. Schweizerische Rundschau für Medizin PRAXIS, Vol. 97 , S. 235-239 ; quiz 240-241.

Waldhauser, Katri M. and Brecht, Karin and Hebeisen, S. and Ha, H. R. and Konrad, D. and Bur, Daniel and Krähenbühl, Stephan. (2008) Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues. British journal of pharmacology, 155 (4). pp. 585-595.

Bodmer, M. and Link, B. and Grignaschi, N. and Kummer, O. and Ruegg, S. and Haschke, M. and Krähenbühl, S.. (2008) Pharmacokinetics of midazolam and metabolites in a patient with refractory status epilepticus treated with extraordinary doses of midazolam. Therapeutic drug monitoringNew York : Raven Press, Vol. 30, H. 1. pp. 120-124.

Botomino, Andrea and Bruppacher, Rudolf and Krähenbühl, Stephan and Hersberger, Kurt E.. (2008) Change of body weight and lifestyle of persons at risk for diabetes after screening and counselling in pharmacies. Pharmacy world & science, Vol. 30, H. 3. pp. 222-226.

Huwyler, J. and Drewe, J. and Krähenbuhl, S.. (2008) Tumor targeting using liposomal antineoplastic drugs. International Journal of Nanomedicine, 3 (1). pp. 21-29.

Link, Bettina and Haschke, Manuel and Grignaschi, Nathalie and Bodmer, Michael and Aschmann, Yvonne Zysset and Wenk, Markus and Krähenbühl, Stephan. (2008) Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping. British journal of clinical pharmacology, 66 (4). pp. 473-484.

2006

Waldhauser, Katri and Török, Michael and Ha, Huy-Riem and Thomet, Urs and Konrad, Daniel and Brecht, Karin and Follath, Ferenc and Krahenbühl, Stephan. (2006) Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives. Journal of pharmacology and experimental therapeutics, 319 (3). pp. 1413-1423.

Kaufmann, Priska and Török, Michael and Zahno, Anja and Waldhauser, Katri and Brecht, Karin and Krähenbühl, Stephan. (2006) Toxicity of statins on rat skeletal muscle mitochondria. Cellular and Molecular Life Sciences, 63 (19-20). pp. 2415-2425.

2005

Schnyder, Anita and Krähenbühl, Stephan and Drewe, Jürgen and Huwyler, Jörg. (2005) Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects. Journal of Drug Targeting, 13 (5). pp. 325-335.