Items where Author is "Hall, Michael N."

2023

Linder, Markus and Liko, Dritan and Kancherla, Venkatesh and Piscuoglio, Salvatore and Hall, Michael N.. (2023) Colitis Is Associated with Loss of the Histidine Phosphatase LHPP and Upregulation of Histidine Phosphorylation in Intestinal Epithelial Cells. Biomedicine, 11 (2158). pp. 1-8.

Shimobayashi, Mitsugu and Shetty, Sunil and Frei, Irina C. and Wölnerhanssen, Bettina K. and Weissenberger, Diana and Dietz, Nikolaus and Thomas, Amandine and Ritz, Danilo and Meyer-Gerspach, Anne Christin and Maier, Timm and Hay, Nissim and Peterli, Ralph and Rohner, Nicolas and Hall, Michael N.. (2023) Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia. eLife, 12. e85103.

Frei, Irina C. and Weissenberger, Diana and Müller, Christoph and Hall, Michael N. and Shimobayashi, Mitsugu. (2023) Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis. American Journal of Physiology. Endocrinology and Metabolism, 324 (6). E589-E598.

Shetty, Sunil and Hofstetter, Jon and Battaglioni, Stefania and Ritz, Danilo and Hall, Michael N.. (2023) TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes. The EMBO Journal, 42 (5). e112344.

Cortada, Maurizio and Levano, Soledad and Hall, Michael N. and Bodmer, Daniel. (2023) mTORC2 regulates auditory hair cell structure and function. iScience, 26 (9). p. 107687.

8 August 2022

Shetty, Sunil and Hofstetter, Jon and Battaglioni, Stefania and Ritz, Danilo and Hall, Michael N.. (2022) TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.

27 April 2022

Mossmann, Dirk and Park, Sujin and Ryback, Brendan and Weißenberger, Diana and Colombi, Marco and Hindupur, Sravanth K. and Dazert, Eva and Coto-Llerena, Mairene and Caner, Ercan and Cenzano, Veronica J. and Piscuoglio, Salvatore and Bosch, Fatima and Terracciano, Luigi M. and Sauer, Uwe and Hall, Michael N.. (2022) Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth.

22 March 2022

Frei, Irina C. and Weissenberger, Diana and Ritz, Danilo and Heusermann, Wolf and Colombi, Marco and Shimobayashi, Mitsugu and Hall, Michael N.. (2022) Adipose mTORC2 is essential for arborization of sensory neurons in white adipose tissue and whole-body energy homeostasis.

2022

Frei, Irina C. and Weissenberger, Diana and Ritz, Danilo and Heusermann, Wolf and Colombi, Marco and Shimobayashi, Mitsugu and Hall, Michael N.. (2022) Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis. Molecular metabolism, 65. p. 101580.

Benjamin, Don and Hall, Michael N.. (2022) Combining metformin with lactate transport inhibitors as a treatment modality for cancer-recommendation proposal. Frontiers in Oncology, 12. p. 1034397.

Ng, Charlotte K. Y. and Dazert, Eva and Boldanova, Tuyana and Coto-Llerena, Mairene and Nuciforo, Sandro and Ercan, Caner and Suslov, Aleksei and Meier, Marie-Anne and Bock, Thomas and Schmidt, Alexander and Ketterer, Sylvia and Wang, Xueya and Wieland, Stefan and Matter, Matthias S. and Colombi, Marco and Piscuoglio, Salvatore and Terracciano, Luigi M. and Hall, Michael N. and Heim, Markus H.. (2022) Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. Nature Communications, 13. p. 2436.

Suter, Polina and Dazert, Eva and Kuipers, Jack and Ng, Charlotte K. Y. and Boldanova, Tuyana and Hall, Michael N. and Heim, Markus H. and Beerenwinkel, Niko. (2022) Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model. PLoS computational biology, 18 (9). e1009767.

Blandino-Rosano, Manuel and Scheys, Joshua O. and Werneck-de-Castro, Joao Pedro and Louzada, Ruy A. and Almaça, Joana and Leibowitz, Gil and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2022) Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American Journal of Physiology, Endocrinology and Metabolism, 323 (2). E133-E144.

Park, Sujin and Mossmann, Dirk and Chen, Qian and Wang, Xueya and Dazert, Eva and Colombi, Marco and Schmidt, Alexander and Ryback, Brendan and Ng, Charlotte K. Y. and Terracciano, Luigi M. and Heim, Markus H. and Hall, Michael N.. (2022) Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular Cell, 82 (22). pp. 4246-4261.e11.

Battaglioni, Stefania and Benjamin, Don and Wälchli, Matthias and Maier, Timm and Hall, Michael N.. (2022) mTOR substrate phosphorylation in growth control. Cell, 185 (11). pp. 1814-1836.

7 March 2021

Ng, Charlotte K. Y. and Dazert, Eva and Boldanova, Tujana and Coto-Llerena, Mairene and Nuciforo, Sandro and Ercan, Caner and Suslov, Aleksei and Meier, Marie-Anne and Bock, Thomas and Schmidt, Alexander and Ketterer, Sylvia and Wang, Xueya and Wieland , Stefan and Matter, Matthias S. and Colombi, Marco and Piscuoglio, Salvatore and Terracciano, Luigi and Hall, Michael N. and Heim, Markus H.. (2021) Proteogenomic characterization of hepatocellular carcinoma.

2021

Muralidharan, Sneha and Shimobayashi, Mitsugu and Ji, Shanshan and Burla, Bo and Hall, Michael N. and Wenk, Markus R. and Torta, Federico. (2021) A reference map of sphingolipids in murine tissues. Cell Reports, 35 (11). p. 109250.

Shetty, Sunil and Hall, Michael N.. (2021) More writing: mTORC1 promotes m; 6; A mRNA methylation. Molecular Cell, 81 (10). pp. 2057-2058.

Dimitrakopoulos, Christos and Hindupur, Sravanth Kumar and Colombi, Marco and Liko, Dritan and Ng, Charlotte K. Y. and Piscuoglio, Salvatore and Behr, Jonas and Moore, Ariane L. and Singer, Jochen and Ruscheweyh, Hans-Joachim and Matter, Matthias S. and Mossmann, Dirk and Terracciano, Luigi M. and Hall, Michael N. and Beerenwinkel, Niko. (2021) Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma. BMC genomics, 22 (1). p. 592.

Wälchli, Matthias and Berneiser, Karolin and Mangia, Francesca and Imseng, Stefan and Craigie, Louise-Marie and Stuttfeld, Edward and Hall, Michael N. and Maier, Timm. (2021) Regulation of human mTOR complexes by DEPTOR. eLife, 10. p. 70871.

Böhm, Raphael and Imseng, Stefan and Jakob, Roman P. and Hall, Michael N. and Maier, Timm and Hiller, Sebastian. (2021) The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Molecular Cell, 81 (11). pp. 2403-2416.e5.

Gao, Ruize and Buechel, David and Kalathur, Ravi K. R. and Morini, Marco F. and Coto-Llerena, Mairene and Ercan, Caner and Piscuoglio, Salvatore and Chen, Qian and Blumer, Tanja and Wang, Xueya and Dazert, Eva and Heim, Markus H. and Hall, Michael N. and Tang, Fengyuan and Christofori, Gerhard. (2021) USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis. Oncogenesis, 10 (7). p. 52.

Teufel, Claudia and Horvath, Edit and Peter, Annick and Ercan, Caner and Piscuoglio, Salvatore and Hall, Michael N. and Finke, Daniela and Lehmann, Frank M.. (2021) mTOR signaling mediates ILC3-driven immunopathology. Mucosal Immunology, 14 (6). pp. 1323-1334.

11 October 2020

Linder, Markus and Liko, Dritan and Kancherla, Venkatesh and Piscuoglio, Salvatore and Hall, Michael N.. (2020) Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells.

10 April 2020

Scaiola, Alain and Mangia, Francesca and Imseng, Stefan and Boehringer, Daniel and Berneiser, Karolin and Shimobayashi, Mitsugu and Stuttfeld, Edwardt and Hall, Michael N. and Ban, Nenad and Maier, Timm. (2020) The 3.2Å resolution structure of human mTORC2.

19 March 2020

Shimobayashi, Mitsugu and Shetty, Sunil and Frei, Irina C. and Wölnerhanssen, Bettina K. and Weissenberger, Diana and Dietz, Nikolaus and Thomas, Amandine and Ritz, Danilo and Meyer-Gerspach, Anne Christin and Maier, Timm and Hay, Nissim and Peterli, Ralph and Rohner, Nicolas and Hall, Michael N.. (2020) Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia.

3 March 2020

González, Asier and Hall, Michael N. and Lin, Sheng-Cai and Hardie, D. Grahame. (2020) AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control. Cell metabolism, 31 (3). pp. 472-492.

2020

Ding, Xiaolei and Willenborg, Sebastian and Bloch, Wilhelm and Wickström, Sara A. and Wagle, Prerana and Brodesser, Susanne and Roers, Axel and Jais, Alexander and Brüning, Jens C. and Hall, Michael N. and Rüegg, Markus A. and Eming, Sabine A.. (2020) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology, 145 (1). pp. 283-300.E8.

Liko, Dritan and Rzepiela, Andrzej and Vukojevic, Vanja and Zavolan, Mihaela and Hall, Michael N.. (2020) Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs. Proceedings of the National Academy of Sciences, 117 (3). pp. 1524-1532.

Fu, Wenxiang and Hall, Michael N.. (2020) Regulation of mTORC2 Signaling. Genes, 11 (9). p. 1045.

Scaiola, Alain and Mangia, Francesca and Imseng, Stefan and Boehringer, Daniel and Berneiser, Karolin and Shimobayashi, Mitsugu and Stuttfeld, Edward and Hall, Michael N. and Ban, Nenad and Maier, Timm. (2020) The 3.2-Å resolution structure of human mTORC2. Science advances, 6 (45). eabc1251.

2019

Kessi-Pérez, Eduardo I. and Salinas, Francisco and González, Asier and Su, Ying and Guillamón, José M. and Hall, Michael N. and Larrondo, Luis F. and Martínez, Claudio. (2019) KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae. Frontiers in Microbiology, 10. p. 1686.

Tang, Fengyuan and Gao, Ruize and Jeevan-Raj, Beena and Wyss, Christof B. and Kalathur, Ravi K. R. and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Hindupur, Sravanth K. and Nuciforo, Sandro and Dazert, Eva and Bock, Thomas and Song, Shuang and Buechel, David and Morini, Marco F. and Hergovich, Alexander and Matthias, Patrick and Lim, Dae-Sik and Terracciano, Luigi M. and Heim, Markus H. and Hall, Michael N. and Christofori, Gerhard. (2019) LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nature Communications, 10 (1). p. 5755.

Benjamin, Don and Hall, Michael N.. (2019) Lactate jump-starts mTORC1 in cancer cells. EMBO Reports, 20 (6). e48302.

Li, Jing and Vázquez-García, Ignacio and Persson, Karl and González, Asier and Yue, Jia-Xing and Barré, Benjamin and Hall, Michael N. and Long, Anthony and Warringer, Jonas and Mustonen, Ville and Liti, Gianni. (2019) Shared molecular targets confer resistance over short and long evolutionary timescales. Molecular biology and evolution, 36 (4). pp. 691-708.

Suda, Kazuki and Kaneko, Atsuki and Shimobayashi, Mitsugu and Nakashima, Akio and Tatsuya, Maeda and Hall, Michael N. and Ushimaru, Takashi. (2019) TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells. Biochemical and Biophysical Research Communications, 511 (2). pp. 434-439.

Trinh, Beckey and Hepprich, Matthias and Betz, Matthias J. and Burkard, Thilo and Cavelti-Weder, Claudia and Seelig, Eleonora and Meienberg, Fabian and Kratschmar, Denise V. and Beuschlein, Felix and Reincke, Martin and Odermatt, Alex and Hall, Michael N. and Donath, Marc Y. and Swierczynska, Marta M.. (2019) Treatment of Primary Aldosteronism with mTORC1 Inhibitors. The Journal of Clinical Endocrinology and Metabolism, 104 (10). pp. 4703-4714.

Benjamin, Don and Colombi, Marco and Moroni, Christoph and Hall, Michael N.. (2019) mTOR dependent transformed human cells have a distinct set of essential genes from bcr-abl transformed cells. bioRxiv. pp. 1-24.

2018

Stuttfeld, Edward and Aylett, Christopher H. S. and Imseng, Stefan and Boehringer, Daniel and Scaiola, Alain and Sauer, Evelyn and Hall, Michael N. and Maier, Timm and Ban, Nenad. (2018) Architecture of the human mTORC2 core complex. eLife, 7. e33101.

Mostofa, Md Golam and Rahman, Muhammad Arifur and Koike, Naoki and Yeasmin, Akter Mst and Islam, Nafisa and Waliullah, Talukdar Muhammad and Hosoyamada, Shun and Shimobayashi, Mitsugu and Kobayashi, Takehiko and Hall, Michael N. and Ushimaru, Takashi. (2018) CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy. Journal of Cell Biology, 217 (8). p. 2675.

Benjamin, Don and Robay, Dimitri and Hindupur, Sravanth K. and Pohlmann, Jens and Colombi, Marco and El-Shemerly, Mahmoud Y. and Maira, Sauveur-Michel and Moroni, Christoph and Lane, Heidi A. and Hall, Michael N.. (2018) Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Reports, 25 (11). pp. 3047-3058.e4.

Kessi-Pérez, Eduardo I. and Salinas, Francisco and Molinet, Jennifer and González, Asier and Muñiz, Sara and Guillamón, José M. and Hall, Michael N. and Larrondo, Luis F. and Martínez, Claudio. (2018) Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains. Yeast. pp. 1-25.

Shimobayashi, Mitsugu and Albert, Verena and Woelnerhanssen, Bettina and Frei, Irina C. and Weissenberger, Diana and Meyer-Gerspach, Anne Christin and Clement, Nicolas and Moes, Suzette and Colombi, Marco and Meier, Jerome A. and Swierczynska, Marta M. and Jenö, Paul and Beglinger, Christoph and Peterli, Ralph and Hall, Michael N.. (2018) Insulin resistance causes inflammation in adipose tissue. Journal of Clinical Investigation. pp. 1-32.

Bantug, Glenn R. and Fischer, Marco and Grählert, Jasmin and Balmer, Maria L. and Unterstab, Gunhild and Develioglu, Leyla and Steiner, Rebekah and Zhang, Lianjun and Costa, Ana S. H. and Gubser, Patrick M. and Burgener, Anne-Valérie and Sauder, Ursula and Löliger, Jordan and Belle, Réka and Dimeloe, Sarah and Lötscher, Jonas and Jauch, Annaïse and Recher, Mike and Hönger, Gideon and Hall, Michael N. and Romero, Pedro and Frezza, Christian and Hess, Christoph. (2018) Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells. Immunity, 48 (3). pp. 542-555.

Singer, Jochen and Ruscheweyh, Hans-Joachim and Hofmann, Ariane L. and Thurnherr, Thomas and Singer, Franziska and Toussaint, Nora C. and Ng, Charlotte K. Y. and Piscuoglio, Salvatore and Beisel, Christian and Christofori, Gerhard and Dummer, Reinhard and Hall, Michael N. and Krek, Wilhelm and Levesque, Mitchell and Manz, Markus G. and Moch, Holger and Papassotiropoulos, Andreas and Stekhoven, Daniel J. and Wild, Peter and Wüst, Thomas and Rinn, Bernd and Beerenwinkel, Niko. (2018) NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis. Bioinformatics , 34 (1). pp. 107-108.

Dimitrakopoulos, Christos and Kumar Hindupur, Sravanth and Häfliger, Luca and Behr, Jonas and Montazeri, Hesam and Hall, Michael N. and Beerenwinkel, Niko. (2018) Network-based integration of multi-omics data for prioritizing cancer genes. Bioinformatics . pp. 1-7.

Swierczynska, Marta M. and Betz, Matthias J. and Colombi, Marco and Dazert, Eva and Jenö, Paul and Moes, Suzette and Pfaff, Cécile and Glatz, Katharina and Reincke, Martin and Beuschlein, Felix and Donath, Marc Y. and Hall, Michael N.. (2018) Proteomic Landscape of Aldosterone-Producing Adenoma. Hypertension (Dallas, Tex. : 1979), 73 (2). pp. 469-480.

Hindupur, Sravanth K. and Colombi, Marco and Fuhs, Stephen R. and Matter, Matthias S. and Guri, Yakir and Adam, Kevin and Cornu, Marion and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Betz, Charles and Liko, Dritan and Quagliata, Luca and Moes, Suzette and Jenoe, Paul and Terracciano, Luigi M. and Heim, Markus H. and Hunter, Tony and Hall, Michael N.. (2018) The protein histidine phosphatase LHPP is a tumour suppressor. Nature, 555. pp. 678-682.

Mossmann, Dirk and Park, Sujin and Hall, Michael N.. (2018) mTOR signalling and cellular metabolism are mutual determinants in cancer. Nature Reviews. Cancer, 18 (12). pp. 744-757.

Martin, Sally K. and Fitter, Stephen and El Khawanky, Nadia and Grose, Randall H. and Walkley, Carl R. and Purton, Louise E. and Ruegg, Markus A. and Hall, Michael N. and Gronthos, Stan and Zannettino, Andrew C. W.. (2018) mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8 (1). p. 14501.

2017

Tang, Fei and Zhang, Peng and Ye, Peiying and Lazarski, Christopher A. and Wu, Qi and Bergin, Ingrid L. and Bender, Timothy P. and Hall, Michael N. and Cui, Ya and Zhang, Liguo and Jiang, Taijiao and Liu, Yang and Zheng, Pan. (2017) A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. eLife, 6. e32497.

Hall, Michael N.. (2017) An Amazing Turn of Events. Cell, 171 (1). pp. 18-22.

Bozadjieva, Nadejda and Blandino-Rosano, Manuel and Chase, Jennifer and Dai, Xiao-Qing and Cummings, Kelsey and Gimeno, Jennifer and Dean, Danielle and Powers, Alvin C. and Gittes, George K. and Rüegg, Markus A. and Hall, Michael N. and MacDonald, Patrick E. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127 (12). pp. 4379-4393.

Blandino-Rosano, Manuel and Barbaresso, Rebecca and Jimenez-Palomares, Margarita and Bozadjieva, Nadejda and Werneck-de-Castro, Joao Pedro and Hatanaka, Masayuki and Mirmira, Raghavendra G. and Sonenberg, Nahum and Liu, Ming and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature Communications, 8. p. 16014.

González, Asier and Hall, Michael N.. (2017) Nutrient sensing and TOR signaling in yeast and mammals. The EMBO Journal, 36 (4). pp. 397-408.

Benjamin, Don and Hall, Michael N.. (2017) mTORC1 Controls Synthesis of Its Activator GTP. Cell Reports , 19 (13). pp. 2643-2644.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling pre-Osteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Guri, Yakir and Colombi, Marco and Dazert, Eva and Hindupur, Sravanth K. and Roszik, Jason and Moes, Suzette and Jenoe, Paul and Heim, Markus H. and Riezman, Isabelle and Riezman, Howard and Hall, Michael N.. (2017) mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer Cell, 32 (6). pp. 807-832.

17 May 2016

Swierczynska, Marta M. and Hall, Michael N.. (2016) eIF4A moonlights as an off switch for TORC1. The EMBO Journal, 35 (10). pp. 1013-1014.

May 2016

Grahammer, Florian and Nesterov, Viatcheslav and Ahmed, Azaz and Steinhardt, Frederic and Sandner, Lukas and Arnold, Frederic and Cordts, Tomke and Negrea, Silvio and Bertog, Marko and Ruegg, Marcus A. and Hall, Michael N. and Walz, Gerd and Korbmacher, Christoph and Artunc, Ferruh and Huber, Tobias B.. (2016) mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, 126 (5). pp. 1773-1782.

22 April 2016

Drägert, Katja and Bhattacharya, Indranil and Hall, Michael N. and Humar, Rok and Battegay, Edouard and Haas, Elvira. (2016) Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue. Biochemical and Biophysical Research Communications, 473 (1). pp. 317-322.

9 February 2016

Zhang, Lianjun and Tschumi, Benjamin O. and Lopez-Mejia, Isabel C. and Oberle, Susanne G. and Meyer, Marten and Samson, Guerric and Rüegg, Markus A. and Hall, Michael N. and Fajas, Lluis and Zehn, Dietmar and Mach, Jean-Pierre and Donda, Alena and Romero, Pedro. (2016) Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports , 14 (5). pp. 1206-1217.

2 February 2016

Dazert, Eva and Colombi, Marco and Boldanova, Tujana and Moes, Suzette and Adametz, David and Quagliata, Luca and Roth, Volker and Terracciano, Luigi and Heim, Markus H. and Jenoe, Paul and Hall, Michael N.. (2016) Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). pp. 1381-1386.

1 January 2016

Aylett, Christopher H. S. and Sauer, Evelyn and Imseng, Stefan and Boehringer, Daniel and Hall, Michael N. and Ban, Nenad and Maier, Timm. (2016) Architecture of human mTOR complex 1. Science, 351 (6268). pp. 48-52.

January 2016

Shimobayashi, Mitsugu and Hall, Michael N.. (2016) Multiple amino acid sensing inputs to mTORC1. Cell research, 26 (1). pp. 7-20.

2016

Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114.

Fonseca, Bruno D. and Graber, Tyson E. and Hoang, Huy-Dung and González, Asier and Soukas, Alexandre A. and Hernández, Greco and Alain, Tommy and Swift, Stephanie L. and Weisman, Ronit and Meyer, Christian and Robaglia, Christophe and Avruch, Joseph and Hall, Michael N.. (2016) Evolution of TOR and Translation Control. In: Evolution of the Protein Synthesis Machinery and Its Regulation. Cham, pp. 327-412.

Herkert, Barbara and Kauffmann, Audrey and Mollé, Sandra and Schnell, Christian and Ferrat, Thomas and Voshol, Hans and Juengert, Janina and Erasimus, Hélène and Marszalek, Grégory and Kazic-Legueux, Malika and Billy, Eric and Ruddy, David and Stump, Mark and Guthy, Daniel and Ristov, Mitko and Calkins, Keith and Maira, Sauveur-Michel and Sellers, William R. and Hofmann, Francesco and Hall, Michael N. and Brachmann, Saskia M.. (2016) Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition. Cancer Research, 76 (2). pp. 390-402.

Benjamin, Don and Colombi, Marco and Hindupur, Sravanth K. and Betz, Charles and Lane, Heidi A. and El-Shemerly, Mahmoud Y. M. and Lu, Min and Quagliata, Luca and Terracciano, Luigi and Moes, Suzette and Sharpe, Timothy and Wodnar-Filipowicz, Aleksandra and Moroni, Christoph and Hall, Michael N.. (2016) Syrosingopine sensitizes cancer cells to killing by metformin. Science Advances, 2 (12). e1601756.

Hall, Michael N.. (2016) TOR and paradigm change: cell growth is controlled. Molecular Biology of the Cell, 27 (18). pp. 2804-2806.

Guri, Yakir and Hall, Michael N.. (2016) mTOR Signaling Confers Resistance to Targeted Cancer Drugs. Trends in Cancer, 2 (11). pp. 688-697.

Swierczynska, Marta M. and Hall, Michael N.. (2016) mTOR in Metabolic and Endocrine Disorders. In: Molecules to Medicine with mTOR. Translating Critical Pathways into Novel Therapeutic Strategies. London, pp. 347-364.

Ding, Xiaolei and Bloch, Wilhelm and Iden, Sandra and Rüegg, Markus A. and Hall, Michael N. and Leptin, Maria and Partridge, Linda and Eming, Sabine A.. (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7. p. 13226.

Driscoll, David R. and Karim, Saadia A. and Sano, Makoto and Gay, David M. and Jacob, Wright and Yu, Jun and Mizukami, Yusuke and Gopinathan, Aarthi and Jodrell, Duncan I. and Evans, T. R. Jeffry and Bardeesy, Nabeel and Hall, Michael N. and Quattrochi, Brian J. and Klimstra, David S. and Barry, Simon T. and Sansom, Owen J. and Lewis, Brian C. and Morton, Jennifer P.. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76 (23). pp. 6911-6923.

Albert, Verena and Svensson, Kristoffer and Shimobayashi, Mitsugu and Colombi, Marco and Muñoz, Sergio and Jimenez, Veronica and Handschin, Christoph and Bosch, Fatima and Hall, Michael N.. (2016) mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8 (3). pp. 232-246.

4 December 2015

Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705.

October 2015

Liko, Dritan and Hall, Michael N.. (2015) mTOR in health and in sickness. Journal of Molecular Medicine, 93 (10). pp. 1061-1073.

2015

Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem Cells, 33 (4). pp. 1359-1365.

Drägert, Katja and Bhattacharya, Indranil and Pellegrini, Giovanni and Seebeck, Petra and Azzi, Abdelhalim and Brown, Steven A. and Georgiopoulou, Stavroula and Held, Ulrike and Blyszczuk, Przemyslaw and Arras, Margarete and Humar, Rok and Hall, Michael N. and Battegay, Edouard and Haas, Elvira. (2015) Deletion of Rictor in Brain and Fat Alters Peripheral Clock Gene Expression and Increases Blood Pressure. Hypertension, 66 (2). pp. 332-339.

Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135.

Albert, Verena and Hall, Michael N.. (2015) Reduced C/EBPβ-LIP translation improves metabolic health. EMBO reports, Vol. 16, H. 8. pp. 881-882.

Hindupur, Sravanth K. and González, Asier and Hall, Michael N.. (2015) The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control. In: Size Control in Biology: From Organelles to Organisms. New York, pp. 221-240.

Cornu, Marion and de Caudron de Coquereaumont, Grégoire and Hall, Michael N.. (2015) mTOR signaling in liver disease. In: Signaling Pathways in Liver Diseases. West Sussex, pp. 314-325.

Albert, Verena and Cornu, Marion and Hall, Michael N.. (2015) mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior. Biochemical and Biophysical Research Communications, 464 (2). pp. 480-486.

2014

Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765.

Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170.

Stracka, Daniele and Jozefczuk, Szymon and Rudroff, Florian and Sauer, Uwe and Hall, Michael N.. (2014) Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins. Journal of Biological Chemistry, 289 (36). pp. 25010-25020.

2013

Sauer, Evelyn and Imseng, Stefan and Maier, Timm and Hall, Michael N.. (2013) Conserved sequence motifs and the structure of the mTOR kinase domain. Biochemical Society Transactions, 41 (4). pp. 889-895.

Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1). p. 6.

Robitaille, Aaron M. and Christen, Stefan and Shimobayashi, Mitsugu and Cornu, Marion and Fava, Luca and Moes, Suzette and Prescianotto-Baschong, Cristina and Sauer, Uwe and Jenö , Paul and Hall, Michael N.. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science, 339 (6125). pp. 1320-1323.

Shimobayashi, Mitsugu and Oppliger, Wolfgang and Moes, Suzette and Jenö, Paul and Hall, Michael N.. (2013) TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Molecular Biology of the Cell, 24 (6). pp. 870-881.

Cornu, Marion and Albert, Verena and Hall, Michael N.. (2013) mTOR in aging, metabolism, and cancer. Current Opinion in Genetics & Development, 23 (1). pp. 53-62.

2012

Appenzeller-Herzog, Christian and Hall, Michael N.. (2012) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends in Cell Biology, 22 (5). pp. 272-282.

Durán, Raúl V. and Hall, Michael N.. (2012) Glutaminolysis feeds mTORC1. Cell Cycle, 11 (22). pp. 4107-4108.

Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738.

Cybulski, Nadine and Zinzalla, Vittoria and Hall, Michael N.. (2012) Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts. Methods in Molecular Biology, 821. pp. 267-278.

2011

Benjamin, Don and Colombi, Marco and Moroni, Christoph and Hall, Michael N.. (2011) Rapamycin passes the torch: a new generation of mTOR inhibitors. Nature Reviews. Drug Discovery, 10 (11). pp. 868-880.

2010

Blagosklonny, Mikhail V. and Campisi, Judy and Sinclair, David A. and Bartke, Andrzej and Blasco, Maria A. and Bonner, William M. and Bohr, Vilhelm A. and Brosh, Robert M. and Brunet, Anne and Depinho, Ronald A. and Donehower, Lawrence A. and Finch, Caleb E. and Finkel, Toren and Gorospe, Myriam and Gudkov, Andrei V. and Hall, Michael N. and Hekimi, Siegfried and Helfand, Stephen L. and Karlseder, Jan and Kenyon, Cynthia and Kroemer, Guido and Longo, Valter and Nussenzweig, Andre and Osiewacz, Heinz D. and Peeper, Daniel S. and Rando, Thomas A. and Rudolph, K. Lenhard and Sassone-Corsi, Paolo and Serrano, Manuel and Sharpless, Norman E. and Skulachev, Vladimir P. and Tilly, Jonathan L. and Tower, John and Verdin, Eric and Vijg, Jan. (2010) Impact papers on aging in 2009. Aging, 2 (3). pp. 111-121.

2009

Blagosklonny, Mikhail V. and Hall, Michael N.. (2009) Growth and aging : a common molecular mechanism. Aging, Vol. 1, H. 4. pp. 357-362.

2007

Li, Weimin and Petrimpol, Marco and Molle, Klaus D. and Hall, Michael N. and Battegay, Edouard J. and Humar, Rok. (2007) Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circulation Research, 100 (1). pp. 79-87.

2006

Wahl, Patricia R. and Serra, Andreas L. and Le Hir, Michel and Molle, Klaus D. and Hall, Michael N. and Wüthrich, Rudolf P.. (2006) Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrology, Dialysis, Transplantation, 21 (3). pp. 598-604.

Honma, Yoshimi and Kitamura, Aiko and Shioda, Ryo and Maruyama, Hironori and Ozaki, Kanako and Oda, Yoko and Mini, Thierry and Jenö, Paul and Maki, Yasushi and Yonezawa, Kazuyoshi and Hurt, Ed and Ueno, Masaru and Uritani, Masahiro and Hall, Michael N. and Ushimaru, Takashi. (2006) TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. The EMBO Journal, 25 (16). pp. 3832-3842.

2004

Audhya, Anjon and Loewith, Robbie and Parsons, Ainslie B. and Gao, Lu and Tabuchi, Mitsuaki and Zhou, Huilin and Boone, Charles and Hall, Michael N. and Emr, Scott D.. (2004) Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. The EMBO Journal, 23 (19). pp. 3747-3757.