mTOR signaling in liver disease

Cornu, Marion and de Caudron de Coquereaumont, Grégoire and Hall, Michael N.. (2015) mTOR signaling in liver disease. In: Signaling Pathways in Liver Diseases. West Sussex, pp. 314-325.

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Official URL: http://edoc.unibas.ch/40032/

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The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that forms two structurally and functionally distinct complexes, TORC1 and TORC2. In response to nutrients, growth factors and cellular energy, mammalian TOR (mTOR) controls cell growth and metabolism. mTOR plays an important role in metabolic organs, particularly in the liver, to mediate whole-body energy homeostasis. Dysregulation of mTOR signaling is associated with the development of several metabolic diseases such as diabetes, obesity, and cancer. Here, we review the role of hepatic mTORC1 and mTORC2 in linking metabolism, cancer development, and circadian rhythm-related processes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:John Wiley
Note:Publication type according to Uni Basel Research Database: Book item -- Edition: 3rd
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Last Modified:04 Dec 2017 13:21
Deposited On:04 Dec 2017 13:21

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