Multiple amino acid sensing inputs to mTORC1

Shimobayashi, Mitsugu and Hall, Michael N.. (2016) Multiple amino acid sensing inputs to mTORC1. Cell research, 26 (1). pp. 7-20.

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Official URL: http://edoc.unibas.ch/40861/

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The evolutionarily conserved target of rapamycin complex 1 (TORC1) is a master regulator of cell growth and metabolism. In mammals, growth factors and cellular energy stimulate mTORC1 activity through inhibition of the TSC complex (TSC1-TSC2-TBC1D7), a negative regulator of mTORC1. Amino acids signal to mTORC1 independently of the TSC complex. Here, we review recently identified regulators that link amino acid sufficiency to mTORC1 activity and how mutations affecting these regulators cause human disease.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Institute of Biochemistry and Cell Biology
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Aug 2016 07:08
Deposited On:11 Aug 2016 07:08

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