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Architecture of the human mTORC2 core complex

Stuttfeld, Edward and Aylett, Christopher H. S. and Imseng, Stefan and Boehringer, Daniel and Scaiola, Alain and Sauer, Evelyn and Hall, Michael N. and Maier, Timm and Ban, Nenad. (2018) Architecture of the human mTORC2 core complex. eLife, 7. e33101.

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Abstract

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Maier)
UniBasel Contributors:Maier, Timm and Stuttfeld, Edward and Imseng, Stefan and Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:eLife Sciences Publications
e-ISSN:2050-084X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:12 Sep 2018 10:09
Deposited On:12 Sep 2018 10:09

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