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TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells

Suda, Kazuki and Kaneko, Atsuki and Shimobayashi, Mitsugu and Nakashima, Akio and Tatsuya, Maeda and Hall, Michael N. and Ushimaru, Takashi. (2019) TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells. Biochemical and biophysical research communications, 511 (2). pp. 434-439.

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Official URL: https://edoc.unibas.ch/69854/

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Abstract

Misfolded and aggregated proteins are eliminated to maintain protein homeostasis. Autophagy contributes to the removal of protein aggregates. However, if and how proteotoxic stress induces autophagy is poorly understood. Here we show that proteotoxic stress after treatment with azetidine-2-carboxylic acid (AZC), a toxic proline analog, induces autophagy in budding yeast. AZC treatment attenuated target of rapamycin complex 1 (TORC1) activity, resulting in the dephosphorylation of Atg13, a key factor of autophagy. By contrast, AZC treatment did not affect target of rapamycin complex 2 (TORC2). Proteotoxic stress also induced TORC1 inactivation and autophagy in fission yeast and human cells. This study suggested that TORC1 is a conserved key factor to cope with proteotoxic stress in eukaryotic cells.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0006-291X
e-ISSN:1090-2104
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Language:English
Language:English
Identification Number:
Last Modified:09 Sep 2019 15:39
Deposited On:28 Mar 2019 15:26

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