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Regulation of mTORC2 Signaling

Fu, Wenxiang and Hall, Michael N.. (2020) Regulation of mTORC2 Signaling. Genes, 11 (9). p. 1045.

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Official URL: https://edoc.unibas.ch/78481/

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Abstract

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N. and Fu, Wenxiang
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
e-ISSN:2073-4425
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:15 Sep 2020 10:03
Deposited On:15 Sep 2020 10:03

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