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TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients

Honma, Yoshimi and Kitamura, Aiko and Shioda, Ryo and Maruyama, Hironori and Ozaki, Kanako and Oda, Yoko and Mini, Thierry and Jenö, Paul and Maki, Yasushi and Yonezawa, Kazuyoshi and Hurt, Ed and Ueno, Masaru and Uritani, Masahiro and Hall, Michael N. and Ushimaru, Takashi. (2006) TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. The EMBO Journal, 25 (16). pp. 3832-3842.

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Official URL: http://edoc.unibas.ch/dok/A5262069

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Abstract

The protein kinase TOR (target of rapamycin) controls several steps of ribosome biogenesis, including gene expression of rRNA and ribosomal proteins, and processing of the 35S rRNA precursor, in the budding yeast Saccharomyces cerevisiae. Here we show that TOR also regulates late stages of ribosome maturation in the nucleoplasm via the nuclear GTP-binding protein Nog1. Nog1 formed a complex that included 60S ribosomal proteins and pre-ribosomal proteins Nop7 and Rlp24. The Nog1 complex shuttled between the nucleolus and the nucleoplasm for ribosome biogenesis, but it was tethered to the nucleolus by both nutrient depletion and TOR inactivation, causing cessation of the late stages of ribosome biogenesis. Furthermore, after this, Nog1 and Nop7 proteins were lost, leading to complete cessation of ribosome maturation. Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0261-4189
e-ISSN:1460-2075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Nov 2017 08:32
Deposited On:22 Mar 2012 13:23

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