Lactate jump-starts mTORC1 in cancer cells

Benjamin, Don and Hall, Michael N.. (2019) Lactate jump-starts mTORC1 in cancer cells. EMBO Reports, 20 (6). e48302.

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Official URL: https://edoc.unibas.ch/70776/

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The kinase mammalian target of rapamycin ( mTOR ) is a major regulatory hub that senses and integrates nutrient, energy, and growth factor inputs to promote cell growth. In this issue of EMBO Reports , Byun et al [1] report that high intracellular levels of lactate activate mTORC 1 in KRAS transformed cells independently of a growth factor input. This suggests a mechanism for how mTORC 1 can be co‐opted to support oncogenic growth and proliferation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article
Article Subtype:Research Article
Publisher:Embo Press
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:07 Jan 2020 07:35
Deposited On:03 Jan 2020 10:57

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