Items where Division is "05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig A)"

2023

Seelig, Anna and Li-Blatter, Xiaochun. (2023) P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport. Cancer Drug Resistance, 6. pp. 1-29.

2020

Seelig, Anna. (2020) P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers. Frontiers in Oncology, 10. p. 576559.

2017

Assmus, Frauke and Ross, Alfred and Fischer, Holger and Seelig, Joachim and Seelig, Anna. (2017) (31)P and (1)H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay. Molecular Pharmaceutics, 14 (1). pp. 284-295.

Xu, Yanyan and Seelig, Anna and Bernèche, Simon. (2017) Unidirectional Transport Mechanism in an ATP Dependent Exporter. ACS Central Science, 3 (3). pp. 250-258.

8 July 2016

Zwick, Matthias and Esposito, Cinzia and Hellstern, Manuel and Seelig, Anna. (2016) Interplay between CFTR Phosphorylation, CFTR-ATPase Activity, and Anion Flux. Journal of Biological Chemistry, 291 (28). pp. 14483-14498.

15 November 2015

Assmus, Frauke and Seelig, Anna and Gobbi, Luca and Borroni, Edilio and Glaentzlin, Patricia and Fischer, Holger. (2015) Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates. European journal of pharmaceutical sciences, 79. pp. 27-35.

November 2015

Egido, Estefanía and Müller, Rita and Li-Blatter, Xiaochun and Merino, Gracia and Seelig, Anna. (2015) Predicting Activators and Inhibitors of the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1) Based on Mechanistic Considerations. Molecular pharmaceutics, 12 (11). pp. 4026-4037.

20 February 2015

Wagner, Bjoern and Fischer, Holger and Kansy, Manfred and Seelig, Anna and Assmus, Frauke. (2015) Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients. European journal of pharmaceutical sciences, 68. pp. 68-77.

2015

Assmus, Frauke. Artificial tissue binding models : development and comparative evaluation of high - throughput lipophilicity assays and their use for PET tracer optimization. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

2014

Zolnerciks, Joseph K. and Akkaya, Begum G. and Snippe, Marjolein and Chiba, Peter and Seelig, Anna and Linton, Kenneth J.. (2014) The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle. FASEB Journal, 28 (10). pp. 4335-4346.

2013

Beck, Andreas and Aanismaa, Paivi and Li-Blatter, Xiaochun and Dawson, Roger and Locher, Kaspar P. and Seelig, Anna. (2013) SAV1866 from Staphylococcus aureus and P-Glycoprotein – Similarities and Differences in ATPase Activity Assessed with Detergents as Allocrites. Biochemistry, Vol. 52, H. 19 , S. 3297–3309.

Marzolini, Catia and Mueller, Rita and Li-Blatter, Xiaochun and Battegay, Manuel and Seelig, Anna. (2013) The Brain Entry of HIV-1 Protease Inhibitors Is Facilitated When Used in Combination. Molecular Pharmaceutics, 10 (6). pp. 2340-2349.

2012

Barrera, Borja and Otero, Jon A. and Egido, Estefanía and Prieto, Julio G. and Seelig, Anna and Alvarez, Ana I. and Merino, Gracia. (2012) The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP. Antimicrobial Agents and Chemotherapy, 56 (7). pp. 3535-3543.

Beck, Andreas. On the interaction of cationic compounds with ABC-transporters and lipid membranes. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Li-Blatter, Xiaochun and Beck, Andreas and Seelig, Anna. (2012) P-glycoprotein-ATPase modulation: the molecular mechanisms. Biophysical journal, Vol. 102, H. 6. pp. 1383-1393.

Zwick, Matthias. Towards an understanding of CFTR regulation by ATP hydrolysis. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

2010

Beck, A. and Li-Blatter, X. and Seelig, A. and Seelig, J.. (2010) On the Interaction of Ionic Detergents with Lipid Membranes : Thermodynamic Comparison of n-Alkyl-+N(CH3)3 and n-Alkyl-SO4-. Journal of Physical Chemistry B, 114 (48). pp. 15862-15871.

Li-Blatter, Xiaochun and Seelig, Anna. (2010) Exploring the p-glycoprotein binding cavity with polyoxyethylene alkyl ethers. Biophysical Journal, 99 (11). pp. 3589-3598.

Nervi, P. and Li-Blatter, X. and Aanismaa, P. and Seelig, A.. (2010) P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity. Biochimica et biophysica acta, Vol. 1798. pp. 515-525.

2009

Li-Blatter, X. and Nervi, P. and Seelig, A.. (2009) Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochimica et biophysica acta, 1788 (10). pp. 2335-2344.

Seelig, A.. (2009) Toward understanding P-glycoprotein structure-activity relationships. In: Drug bioavailability. Weinheim, pp. 497-519.

2008

Aanismaa, P. and Gatlik-Landwojtowicz, E. and Seelig, A.. (2008) P-glycoprotein senses its substrates and the lateral membrane packing density : consequences for the catalytic cycle. Biochemistry, Vol. 47, H. 38. pp. 10197-10207.

Turunen, B. J. and Ge, H. and Oyetunji, J. and Desino, K. E. and Vasandani, V. and Guthe, S. and Himes, R. H. and Audus, K. L. and Seelig, A. and Georg, G. I.. (2008) Paclitaxel succinate analogs : anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & medicinal chemistry letters, Vol. 18. pp. 5971-5974.

2007

Aanismaa, P. and Seelig, A.. (2007) P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells. Biochemistry, Vol. 46, H. 11. pp. 3394-3404.

Seelig, A.. (2007) The role of size and charge for blood-brain barrier permeation of drugs and fatty acids. Journal of Molecular Neuroscience, 33 (1). pp. 32-41.

Äänismaa, Päivi. Thermodynamics and kinetics of P-glycoprotein-substrate interactions. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

2006

Gatlik-Landwojtowicz, E. and Aanismaa, P. and Seelig, A.. (2006) Quantification and characterization of P-glycoprotein-substrate interactions. Biochemistry, Vol. 45, H. 9. pp. 3020-3032.

Ge, H. and Vasandani, V. and Huff, J. K. and Audus, K. L. and Himes, R. H. and Seelig, A. and Georg, G. I.. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. Bioorganic & medicinal chemistry letters, Vol. 16, H. 2. pp. 433-436.

Gerebtzoff, G. and Seelig, A.. (2006) In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter. Journal of Chemical Information and Modeling, Vol. 46, H. 6. pp. 2638-2650.

Meier, M. and Blatter, X. L. and Seelig, A. and Seelig, J.. (2006) Interaction of verapamil with lipid membranes and P-glycoprotein : connecting thermodynamics and membrane structure with functional activity. Biophysical journal, Vol. 91, H. 8. pp. 2943-2955.

Seelig, A.. (2006) Unraveling membrane-mediated substrate-transporter interactions. Biophysical journal, Vol. 90, H. 11. pp. 3825-3826.

Seelig, A. and Gerebtzoff, G.. (2006) Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding. Expert Opinion on Drug Metabolism & Toxicology, Vol. 2, H. 5. pp. 733-752.

Spletstoser, J. T. and Turunen, B. J. and Desino, K. and Rice, A. and Datta, A. and Dutta, D. and Huff, J. K. and Himes, R. H. and Audus, K. L. and Seelig, A. and Georg, G. I.. (2006) Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & medicinal chemistry letters, Vol. 16, H. 3. pp. 495-498.

2005

Seelig, A. and Gatlik-Landwojtowicz, E.. (2005) Inhibitors of multidrug efflux transporters : their membrane and protein interactions. Mini Reviews in Medicinal Chemistry, 5 (2). pp. 135-151.

2004

Gatlik-Landwojtowicz, E. and Aanismaa, P. and Seelig, A.. (2004) The rate of P-glycoprotein activation depends on the metabolic state of the cell. Biochemistry, Vol. 43, H. 46. pp. 14840-14851.

Gerebtzoff, G. and Li-Blatter, X. and Fischer, H. and Frentzel, A. and Seelig, A.. (2004) Halogenation of drugs enhances membrane binding and permeation. ChemBioChem, Vol. 5, H. 5. pp. 676-684.

Green, J. D. and Kreplak, L. and Goldsbury, C. and Li Blatter, X. and Stolz, M. and Cooper, G. S. and Seelig, A. and Kistler, J. and Aebi, U.. (2004) Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. Journal of molecular biology, Vol. 342, H. 3. pp. 877-887.

Seelig, A.. (2004) Screening for multidrug resistance. Screening, Vol. 4. pp. 20-21.

2003

Seelig, A. and Gatlik, E. and Fischer, H. and Li-Blatter, X.. (2003) Towards P-glycoprotein structure-activity relationships. In: Drug bioavailability. Weinheim, pp. 461-492.

Ziegler, A. and Blatter, X. L. and Seelig, A. and Seelig, J.. (2003) Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles : binding mechanism and thermodynamic analysis. Biochemistry, Vol. 42, H. 30. pp. 9185-9194.

2002

Landwojtowicz, E. and Nervi, P. and Seelig, A.. (2002) Real-time monitoring of P-glycoprotein activation in living cells. Biochemistry, Vol. 41, H. 25. pp. 8050-8057.

Seelig, A. and Seelig, J.. (2002) Membrane structure. In: Encyclopedia of physical science and technology, Vol. 9. San Diego, pp. 355-367.

2000

Seelig, A. and Blatter, X. L. and Frentzel, A. and Isenberg, G.. (2000) Phospholipid binding of synthetic talin peptides provides evidence for an intrinsic membrane anchor of talin. Journal of Biological Chemistry, 275 (24). pp. 17954-17961.

Seelig, A. and Blatter, X. L. and Wohnsland, F.. (2000) Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1 : a comparison. International Journal of Clinical Pharmacology and Therapeutics, 38 (3). pp. 111-121.

Seelig, A. and Landwojtowicz, E.. (2000) Structure-activity relationship of P-glycoprotein substrates and modifiers. European journal of pharmaceutical sciences, Vol. 12, H. 1. pp. 31-40.

Zurbriggen, R. and Novak-Hofer, I. and Seelig, A. and Gluck, R.. (2000) IRIV-adjuvanted hepatitis A vaccine : in vivo absorption and biophysical characterization. Progress in Lipid Research, 39 (1). pp. 3-18.

1999

Andre, J. P. and Toth, E. and Fischer, H. and Seelig, A. and Macke, H. R. and Merbach, A. E.. (1999) High relaxivity for monomeric Gd(DOTA)-based MRI contrast agents, thanks to micellar self-organization. Chemistry, Vol. 5, no. 10. pp. 2977-2983.

Fischer, H. and Seelig, A. and Beier, N. and Raddatz, P. and Seelig, J.. (1999) New drugs for the Na+/H+ exchanger : Influence of Na+ concentration and determination of inhibition constants with a microphysiometer. The Journal of Membrane Biology, 168 (1). pp. 39-45.

Seitz, H. R. and Heck, M. and Hofmann, K. P. and Alt, T. and Pellaud, J. and Seelig, A.. (1999) Molecular determinants of the reversible membrane anchorage of the G-protein transducin. Biochemistry, Vol. 38, H. 25. pp. 7950-7960.

1998

Fischer, H. and Gottschlich, R. and Seelig, A.. (1998) Blood-brain barrier permeation : molecular parameters governing passive diffusion. The Journal of Membrane Biology, 165 (3). pp. 201-211.

Seelig, A.. (1998) A general pattern for substrate recognition by P-glycoprotein. European journal of biochemistry, Vol. 251, H. 1/2. pp. 252-261.

Seelig, A.. (1998) How does P-glycoprotein recognize its substrates? International Journal of Clinical Pharmacology and Therapeutics, 36 (1). pp. 50-54.

1997

Wenk, M. R. and Alt, T. and Seelig, A. and Seelig, J.. (1997) Octyl-beta-D-glucopyranoside partitioning into lipid bilayers: thermodynamics of binding and structural changes of the bilayer. Biophysical Journal, 72 (4). pp. 1719-1731.

1996

Dathe, M. and Wieprecht, T. and Seelig, A. and Matsuzaki, K. and Bienert, M.. (1996) Antimikrobiell wirksame Peptide : zur Rolle der Primär- und Sekundärstruktur für die Peptid-Membran-Interaktion. Nova acta Leopoldina. [Neue Folge]. Supplementum, Nr. 14. pp. 33-45.

Hanakam, F. and Gerisch, G. and Lotz, S. and Alt, T. and Seelig, A.. (1996) Binding of hisactophilin I and II to lipid membranes is controlled by a pH-dependent myristoyl-histidine switch. Biochemistry, Vol. 35, H. 34. pp. 11036-11044.

Seelig, A. and Alt, T. and Lotz, S. and Holzemann, G.. (1996) Binding of substance P agonists to lipid membranes and to the neurokinin-1 receptor. Biochemistry, Vol. 35, H. 14. pp. 4365-4374.

Seelig, A. and Seelig, J.. (1996) Interaction of drugs and peptides with the lipid membrane. In: Structure and Function of 7TM Receptors. Copenhagen, pp. 184-191.

1994

Holzemann, G. and Gotsmann, W. and Greiner, H. and Seelig, A.. (1994) Surface activity measurements of NK-2 antagonists. In: Proceedings of the 5th Akabori Conference. München, pp. 116-119.

Seelig, A. and Gottschlich, R. and Devant, R. M.. (1994) A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, H. 1. pp. 68-72.

1993

Holzemann, G. and Greiner, H. E. and Harting, J. and Barnickel, G. and Seelig, A.. (1993) Do substance P agonists insert into the lipid membrane? Regulatory Peptides, Vol. 46, H. 1-2. pp. 453-454.

Seelig, A. and Alt, T. and Kuerz, L. and Mutter, M.. (1993) The Gibbs Adsorption isotherm provides information on the secondary structure formation of amphiphilic peptides. In: Peptides 1992. Leiden, pp. 113-114.

1992

Seelig, A.. (1992) Interaction of a substance P agonist and of substance P antagonists with lipid membranes : a thermodynamic analysis. Biochemistry, Vol. 31, H. 11. pp. 2897-2904.

1991

Mutter, M. and Altmann, K. -H. and Buttkus, U. and Gassmann, R. and Kuerz, L. and Seelig, A.. (1991) Switch peptides : medium induced alpha-helix to beta-sheet transitions of bis-amphiphilic secondary structures and their membrane activity. In: Peptides, 1991. Leiden, pp. 344-345.

Seelig, A. and Doelz, R.. (1991) Substance P and antagonists : Surface activity, conformations, and lipid binding. Annals of the New York Academy of Sciences, Vol. 632. pp. 468-470.

1990

Seelig, A.. (1990) Substance P and antagonists : surface activity and molecular shapes. Biochimica et biophysica acta, Vol. 1030, H. 1. pp. 111-118.

Seelig, A.. (1990) The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance P. Cell Biology International Reports, Vol. 14, H. 4. pp. 369-380.

1989

Seelig, A. and Macdonald, P. M.. (1989) Binding of a neuropeptide, substance P, to neutral and negatively charged lipids. Biochemistry, Vol. 28, H. 6. pp. 2490-2496.

1988

Seelig, A. and Allegrini, P. R. and Seelig, J.. (1988) Partitioning of local anesthetics into membranes : surface charge effects monitored by the phospholipid head-group. Biochimica et biophysica acta, Vol. 939, H. 2. pp. 267-276.

1987

Seelig, A.. (1987) Local anesthetics and pressure : a comparison of dibucaine binding to lipid monolayers and bilayers. Biochimica et biophysica acta, Vol. 899, H. 2. pp. 196-204.

1985

Seelig, A. and Seelig, J.. (1985) Phospholipid composition and organization of cytochrome c oxidase preparations as determined by 31P-nuclear magnetic resonance. Biochimica et biophysica acta, Vol. 815, H. 2. pp. 153-158.

1982

Seelig, J. and Seelig, A. and Tamm, L.. (1982) Nuclear magnetic resonance and lipid-protein interactions : a review. In: Lipid-Protein Interactions, Vol. 2. New York, pp. 127-148.

1981

Seelig, A. and Ludwig, B. and Seelig, J. and Schatz, G.. (1981) Copper and manganese electron spin resonance studies of cytochrome c oxidase from Paracoccus denitrificans. Biochimica et biophysica acta, Vol. 636, H. 2. pp. 162-167.

1980

Seelig, J. and Seelig, A.. (1980) Lipid conformation in model membranes and biological membranes. Quarterly Reviews of Biophysics, 13 (1). pp. 19-61.

1979

Zaccai, G. and Buldt, G. and Seelig, A. and Seelig, J.. (1979) Neutron diffraction studies on phosphatidylcholine model membranes : II. Chain conformation and segmental disorder. Journal of molecular biology, Vol. 134, H. 4. pp. 693-706.

1978

Buldt, G. and Gally, H. U. and Seelig, A. and Seelig, J. and Zaccai, G.. (1978) Neutron diffraction studies on selectively deuterated phospholipid bilayers. Nature, Vol. 271. pp. 182-184.

Seelig, A. and Seelig, J.. (1978) Lipid-protein interaction in reconstituted cytochrome c oxidase/phospholipid membranes. Hoppe-Seyler's Zeitschrift für physiologische Chemie, Vol. 359, H. 12. pp. 1747-1756.

1977

Seelig, A. and Seelig, J.. (1977) Effect of a single cis double bond on the structures of a phospholipid bilayer. Biochemistry, Vol. 16, H. 1. pp. 45-50.

1976

Gally, H. U. and Seelig, A. and Seelig, J.. (1976) Cholesterol-induced rod-like motion of fatty acyl chains in lipid bilayers a deuterium magnetic resonance study. Hoppe-Seyler's Zeitschrift für physiologische Chemie, Vol. 357, H. 10. pp. 1447-1450.

1975

Robinson, B. H. and Seelig-Loffler, A. and Schwarz, G.. (1975) Kinetic and amplitude measurements for process of association of acridine-orange studied by temperature-jump relaxation spectroscopy. Journal of the Chemical Society, Vol. 71, H. 4. pp. 815-830.

Robinson, B. H. and Seelig-Loffler, A. and Schwarz, G.. (1975) The thermodynamics and kinetics of association of acridine dyes in aqueous media : a model system for the study of stacking and charge effects on self-aggregation. In: Chemical and biological applications of relaxation spectrometry. Dordrecht, pp. 481-485.

Schwarz, G. and Seelig-Loffler, A.. (1975) Aggregation of linear biopolymers induced by cooperative binding of ligands. Biochimica et biophysica acta, Vol. 379, H. 1. pp. 125-138.

Seelig, A. and Seelig, J.. (1975) Bilayers of dipalmitoyl-3-sn-phosphatidylcholine : conformational differences between the fatty acyl chains. Biochimica et biophysica acta, Vol. 406, H. 1. pp. 1-5.

1974

Seelig, A. and Seelig, J.. (1974) The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance. Biochemistry, Vol. 13, H. 23. pp. 4839-4845.

Seelig, J. and Seelig, A.. (1974) Deuterium magnetic resonance studies of phospholipid bilayers. Biochemical and biophysical research communications, Vol. 57, H. 2. pp. 406-411.

1973

Robinson, B. H. and Loffler, A. and Schwarz, G.. (1973) Thermodynamic behavior of acridine-orange in solution : Model system for studying stacking and charge-effects on self-aggregation. Journal of the Chemical Society, Vol. 69, H. 1. pp. 56-69.