Inhibitors of multidrug efflux transporters : their membrane and protein interactions

Seelig, A. and Gatlik-Landwojtowicz, E.. (2005) Inhibitors of multidrug efflux transporters : their membrane and protein interactions. Mini Reviews in Medicinal Chemistry, 5 (2). pp. 135-151.

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Official URL: http://edoc.unibas.ch/dok/A5258465

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Modulators and inhibitors of multidrug efflux transporters, like P-glycoprotein, are used to reduce or inhibit multidrug resistance, MDR, which leads to a failure of the chemotherapy of e.g. cancers, epilepsy, bacterial, parasitic, and fungal diseases. Binding and transport of first-, second-, and third-generation modulators and inhibitors of P-glycoprotein are discussed, taking into account the properties of the drug (H-bonding potential, dimensions, and pK(a) values) as well as the properties of the membrane.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig A)
UniBasel Contributors:Seelig-Löffler, Anna
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Publ.
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:20 Nov 2017 12:32
Deposited On:22 Mar 2012 13:50

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