Browse by Basel Contributors ID
NoRizner, Tea Lanisnik and Sasano, Hironobu and Choi, Man Ho and Odermatt, Alex and Adamski, Jerzy. (2016) Recommendations for description and validation for antibodies for research use. The journal of steroid biochemistry and molecular biology, 156. pp. 40-42. YesSchreier, Verena N. and Çörek, Emre and Appenzeller-Herzog, Christian and Brüschweiler, Beat J. and Geueke, Birgit and Wilks, Martin F. and Schilter, Benoit and Muncke, Jane and Simat, Thomas J. and Smie�ko, Martin and Roth, Nicolas and Odermatt, Alex. (2023) Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: A systematic evidence map. Environment international, 176. p. 107978. Schreier, Verena N. and Appenzeller-Herzog, Christian and Brüschweiler, Beat J. and Geueke, Birgit and Wilks, Martin F. and Simat, Thomas J. and Schilter, Benoit and Smiesko, Martin and Muncke, Jane and Odermatt, Alex and Roth, Nicolas. (2022) Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: Protocol for a systematic evidence map. Environment International, 167. p. 107387. Inderbinen, Silvia G. and Zogg, Michael and Kley, Manuel and Smieško, Martin and Odermatt, Alex. (2021) Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole. Toxicology and applied pharmacology, 412. p. 115387. Beck, Katharina R. and Odermatt, Alex. (2021) Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess. Molecular and Cellular Endocrinology, 524. p. 111168. Schnoz, Christina and Moser, Sandra and Kratschmar, Denise V. and Odermatt, Alex and Loffing-Cueni, Dominique and Loffing, Johannes. (2021) Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC. Pflügers Archiv : European journal of physiology, 473 (1). pp. 79-93. Randi, Elisa B. and Vervaet, Benjamin and Tsachaki, Maria and Porto, Elena and Vermeylen, Stijn and Lindenmeyer, Maja T. and Thuy, Le Thi Thanh and Cohen, Clemens D. and Devuyst, Olivier and Kistler, Andreas D. and Szabo, Csaba and Kawada, Norifumi and Hankeln, Thomas and Odermatt, Alex and Dewilde, Sylvia and Wenger, Roland H. and Hoogewijs, David. (2020) The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease. Antioxidants & redox signaling, 32 (16). pp. 1155-1171. Beck, Katharina R. and Telisman, Lucija and van Koppen, Chris J. and Thompson, George R. and Odermatt, Alex. (2020) Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals. The Journal of steroid biochemistry and molecular biology, 199. p. 105605. Inderbinen, Silvia G. and Engeli, Roger T. and Rohrer, Simona R. and Di Renzo, Erminio and Aengenheister, Leonie and Buerki-Thurnherr, Tina and Odermatt, Alex. (2020) Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α. Toxicology letters, 322. pp. 39-49. Patt, Melanie and Beck, Katharina R. and Di Marco, Tobias and Jäger, Marie-Christin and González-Ruiz, Victor and Boccard, Julien and Rudaz, Serge and Hartmann, Rolf W. and Salah, Mohamed and van Koppen, Chris J. and Grill, Matthias and Odermatt, Alex. (2020) Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis. Biochemical pharmacology, 172. p. 113781. Lizák, Beáta and Birk, Julia and Zana, Melinda and Kosztyi, Gergely and Kratschmar, Denise V. and Odermatt, Alex and Zimmermann, Richard and Geiszt, Miklós and Appenzeller-Herzog, Christian and Bánhegyi, Gábor. (2020) Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione. BMC Biology, 18 (1). p. 19. Schulze, Friederike and Wehner, Josua and Kratschmar, Denise V. and Makshana, Valmir and Meier, Daniel T. and Häuselmann, Stéphanie P. and Dalmas, Elise and Thienel, Constanze and Dror, Erez and Wiedemann, Sophia J. and Traub, Shuyang and Nordmann, Thierry M. and Rachid, Leila and De Baat, Axel and Rohm, Theresa V. and Zhao, Cheng and Odermatt, Alex and Böni-Schnetzler, Marianne and Donath, Marc Y.. (2020) Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes. Scientific Reports, 10 (1). p. 3035. Beck, Katharina R. and Thompson, George R. and Odermatt, Alex. (2020) Drug-induced endocrine blood pressure elevation. Pharmacological Research, 154. p. 104311. Nguyen, Minh-Vu H. and Davis, Matthew R. and Wittenberg, Rebecca and McHardy, Ian and Baddley, John W. and Young, Brian Y. and Odermatt, Alex and Thompson, George R.. (2020) Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism. Clinical Infectious Diseases, 70 (12). pp. 2593-2598. Tsachaki, Maria and Strauss, Pirmin and Dunkel, Anja and Navrátilová, Hana and Mladenovic, Natasa and Odermatt, Alex. (2020) Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration. Cellular and Molecular Life Sciences, 77 (6). pp. 1153-1175. Gómez, Cristina and Stücheli, Simon and Kratschmar, Denise V. and Bouitbir, Jamal and Odermatt, Alex. (2020) Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples. Metabolites, 10 (7). p. 282. Mayr, Fabian and Möller, Gabriele and Garscha, Ulrike and Fischer, Jana and Rodríguez Castaño, Patricia and Inderbinen, Silvia G. and Temml, Veronika and Waltenberger, Birgit and Schwaiger, Stefan and Hartmann, Rolf W. and Gege, Christian and Martens, Stefan and Odermatt, Alex and Pandey, Amit V. and Werz, Oliver and Adamski, Jerzy and Stuppner, Hermann and Schuster, Daniela. (2020) Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction. International Journal of Molecular Sciences, 21 (19). p. 7102. Thompson, George R. and Surampudi, Prasanth N. and Odermatt, Alex. (2020) Gynecomastia and hypertension in a patient treated with posaconazole. Clinical case reports, 8 (12). pp. 3157-3160. Davis, Matthew R. and Nguyen, Minh-Vu H. and Gintjee, Thomas J. and Odermatt, Alex and Young, Brian Y. and Thompson, George R.. (2020) Management of posaconazole-induced pseudohyperaldosteronism. Journal of Antimicrobial Chemotherapy, 75 (12). pp. 3688-3693. Patt, Melanie and Gysi, Joël and Faresse, Nourdine and Cidlowski, John A. and Odermatt, Alex. (2020) Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211. Molecular and cellular endocrinology, 518. p. 110873. Strajhar, Petra and Vizeli, Patrick and Patt, Melanie and Dolder, Patrick C. and Kratschmar, Denise V. and Liechti, Matthias E. and Odermatt, Alex. (2019) Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study. Journal of Steroid Biochemistry and Molecular Biology, 186. pp. 212-225. Trinh, Beckey and Hepprich, Matthias and Betz, Matthias J. and Burkard, Thilo and Cavelti-Weder, Claudia and Seelig, Eleonora and Meienberg, Fabian and Kratschmar, Denise V. and Beuschlein, Felix and Reincke, Martin and Odermatt, Alex and Hall, Michael N. and Donath, Marc Y. and Swierczynska, Marta M.. (2019) Treatment of Primary Aldosteronism with mTORC1 Inhibitors. The Journal of Clinical Endocrinology and Metabolism, 104 (10). pp. 4703-4714. Akram, Muhammad and Patt, Melanie and Kaserer, Teresa and Temml, Veronika and Waratchareeyakul, Watcharee and Kratschmar, Denise V. and Haupenthal, Joerg and Hartmann, Rolf W. and Odermatt, Alex and Schuster, Daniela. (2019) Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase. Journal of Steroid Biochemistry and Molecular Biology, 192. p. 105358. Crane, Erika A. and Heydenreuter, Wolfgang and Beck, Katharina R. and Strajhar, Petra and Vomacka, Jan and Smiesko, Martin and Mons, Elma and Barth, Lydia and Neuburger, Markus and Vedani, Angelo and Odermatt, Alex and Sieber, Stephan A. and Gademann, Karl. (2019) Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorganic & medicinal chemistry, 27 (12). pp. 2508-2520. Beck, Katharina R. and Kanagaratnam, Sharavan and Kratschmar, Denise V. and Birk, Julia and Yamaguchi, Hideaki and Sailer, Andreas W. and Seuwen, Klaus and Odermatt, Alex. (2019) Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2. The Journal of steroid biochemistry and molecular biology, 190. pp. 19-28. Tsachaki, Maria and Odermatt, Alex. (2019) Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases. Molecular and cellular endocrinology, 489. pp. 98-106. Boccard, Julien and Tonoli, David and Strajhar, Petra and Jeanneret, Fabienne and Odermatt, Alex and Rudaz, Serge. (2019) Removal of batch effects using stratified subsampling of metabolomic data for in vitro endocrine disruptors screening. Talanta, 195. pp. 77-86. Sandström, Jenny and Kratschmar, Denise V. and Broyer, Alexandra and Poirot, Olivier and Marbet, Philippe and Chantong, Boonrat and Zufferey, Fanny and Dos Santos, Tania and Boccard, Julien and Chrast, Roman and Odermatt, Alex and Monnet-Tschudi, Florianne. (2019) In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice. Archives of toxicology, 93. pp. 1649-1664. Egli, Jerome and Schlothauer, Tilman and Spick, Christian and Seeber, Stefan and Singer, Thomas and Odermatt, Alex and Iglesias, Antonio. (2019) The Binding of Human IgG to Minipig FcγRs - Implications for Preclinical Assessment of Therapeutic Antibodies. Pharmaceutical research, 36 (3). p. 47. Beck, Katharina R. and Inderbinen, Silvia G. and Kanagaratnam, Sharavan and Kratschmar, Denise V. and Jetten, Anton M. and Yamaguchi, Hideaki and Odermatt, Alex. (2019) 11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ. Journal of Lipid Research, 60. pp. 1535-1546. Egli, Jerome and Schmucki, Roland and Loos, Benjamin and Reichl, Stephan and Grabole, Nils and Roller, Andreas and Ebeling, Martin and Odermatt, Alex and Iglesias, Antonio. (2019) The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig. Immunogenetics, 71 (2). pp. 123-136. Keppner, Anna and Maric, Darko and Sergi, Chloé and Ansermet, Camille and De Bellis, Damien and Kratschmar, Denise V. and Canonica, Jérémie and Klusonova, Petra and Fenton, Robert A. and Odermatt, Alex and Crambert, Gilles and Hoogewijs, David and Hummler, Edith. (2019) Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion. Scientific Reports, 9 (1). p. 19540. Canonica, Jérémie and Frateschi, Simona and Boscardin, Emilie and Ebering, Anna and Sergi, Chloé and Jäger, Yannick and Peyrollaz, Thibaud and Mérillat, Anne-Marie and Maillard, Marc and Klusonova, Petra and Odermatt, Alex and Koesters, Robert and Debonneville, Anne and Staub, Olivier and Verouti, Sophia N. and Hummler, Edith. (2019) Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling. Frontiers in physiology, 10. p. 989. Thompson, George R. and Beck, Katharina R. and Patt, Melanie and Kratschmar, Denise V. and Odermatt, Alex. (2019) Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2. Journal of the Endocrine Society, 3 (7). pp. 1361-1366. Boudon, Stephanie and Heidl, Marc and Vuorinen, Anna and Wandeler, Eliane and Campiche, Remo and Odermatt, Alex and Jackson, Eileen. (2018) Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1. Bioorganic & medicinal chemistry, 26 (18). pp. 5128-5139. Engeli, Roger T. and Fürstenberger, Cornelia and Kratschmar, Denise V. and Odermatt, Alex. (2018) Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis. Heliyon, 4 (2). e00527. Emmerich, Juliette and van Koppen, Chris J. and Burkhart, Jens L. and Engeli, Roger T. and Hu, Qingzhong and Odermatt, Alex and Hartmann, Rolf W.. (2018) Accelerated skin wound healing by selective 11β²-Hydroxylase (CYP11B1) inhibitors. European journal of medicinal chemistry, 143. pp. 591-597. Marbet, Philippe and Klusonova, Petra and Birk, Julia and Kratschmar, Denise V. and Odermatt, Alex. (2018) Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11β-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation. The FEBS journal, 285 (21). pp. 3993-4004. Liao, Wan-Hui and Suendermann, Claudia and Steuer, Andrea Eva and Pacheco Lopez, Gustavo and Odermatt, Alex and Faresse, Nourdine and Henneberg, Maciej and Langhans, Wolfgang. (2018) Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity. JCI insight, 3 (14). e99015. Lister, Adam and Bourgeois, Soline and Imenez Silva, Pedro H. and Rubio-Aliaga, Isabel and Marbet, Philippe and Walsh, Joanne and Shelton, Luke M. and Keller, Bettina and Verrey, Francois and Devuyst, Olivier and Giesbertz, Pieter and Daniel, Hannelore and Goldring, Christopher E. and Copple, Ian M. and Wagner, Carsten A. and Odermatt, Alex. (2018) NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. Scientific reports, 8 (1). p. 5629. Tsachaki, Maria and Mladenovic, Natasa and Štambergová, Hana and Birk, Julia and Odermatt, Alex. (2018) Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance. FASEB journal, 32 (5). pp. 2690-2705. Dolder, Patrick C. and Strajhar, Petra and Vizeli, Patrick and Odermatt, Alex and Liechti, Matthias E.. (2018) Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects. Psychopharmacology, 235 (5). pp. 1389-1402. Tsachaki, Maria and Meyer, Arne and Weger, Benjamin and Kratschmar, Denise V. and Tokarz, Janina and Adamski, Jerzy and Belting, Heinz-Georg and Affolter, Markus and Dickmeis, Thomas and Odermatt, Alex. (2017) Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. Journal of Endocrinology, 232 (2). pp. 323-335. Araya, Selene and Kratschmar, Denise V. and Tsachaki, Maria and Stücheli, Simon and Beck, Katharina R. and Odermatt, Alex. (2017) DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone? Journal of Steroid Biochemistry and Molecular Biology, 27. pp. 288-295. Beck, Katharina R. and Kaserer, Teresa and Schuster, Daniela and Odermatt, Alex. (2017) Virtual screening applications in short-chain dehydrogenase/reductase research. Journal of Steroid Biochemistry and Molecular Biology, 171. pp. 157-177. Strajhar, Petra and Tonoli, David and Jeanneret, Fabienne and Imhof, Raphaella M. and Malagnino, Vanessa and Patt, Melanie and Kratschmar, Denise V. and Boccard, Julien and Rudaz, Serge and Odermatt, Alex. (2017) Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology, 381. pp. 51-63. Boudon, Stéphanie M. and Vuorinen, Anna and Geotti-Bianchini, Piero and Wandeler, Eliane and Kratschmar, Denise V. and Heidl, Marc and Campiche, Remo and Jackson, Eileen and Odermatt, Alex. (2017) Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV. PLoS ONE, 12 (2). e0171079. Beck, Katharina R. and Bächler, Murielle and Vuorinen, Anna and Wagner, Sandra and Akram, Muhammad and Griesser, Ulrich and Temml, Veronika and Klusonova, Petra and Yamaguchi, Hideaki and Schuster, Daniela and Odermatt, Alex. (2017) Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochemical pharmacology, 130. pp. 93-103. Bonifacio, Annalisa and Sanvee, Gerda M. and Brecht, Karin and Kratschmar, Denise V. and Odermatt, Alex and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91 (5). pp. 2223-2234. Ben Rhouma, Bochra and Kallabi, Fakhri and Mahfoudh, Nadia and Ben Mahmoud, Afif and Engeli, Roger T. and Kamoun, Hassen and Keskes, Leila and Odermatt, Alex and Belguith, Neila. (2017) Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect. Journal of Steroid Biochemistry and Molecular Biology, 165 (A). pp. 86-94. Randazzo, Giuseppe Marco and Tonoli, David and Strajhar, Petra and Xenarios, Ioannis and Odermatt, Alex and Boccard, Julien and Rudaz, Serge. (2017) Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study. Journal of Chromatography B, 1071. pp. 11-18. Jiménez-Canino, Rubén and Lorenzo-Díaz, Fabián and Odermatt, Alex and Bailey, Matthew A. and Livingstone, Dawn E. W. and Jaisser, Frederic and Farman, Nicolette and Alvarez de la Rosa, Diego. (2017) 11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation. Endocrinology, 158 (11). pp. 4047-4063. Dolder, Patrick C. and Strajhar, Petra and Vizeli, Patrick and Hammann, Felix and Odermatt, Alex and Liechti, Matthias E.. (2017) Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects. Frontiers in pharmacology, 8. p. 617. Knöpfel, Thomas and Pastor-Arroyo, Eva M. and Schnitzbauer, Udo and Kratschmar, Denise V. and Odermatt, Alex and Pellegrini, Giovanni and Hernando, Nati and Wagner, Carsten A.. (2017) The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction. Scientific reports, 7 (1). p. 11018. Engeli, Roger T. and Tsachaki, Maria and Hassan, Heba A. and Sager, Christoph P. and Essawi, Mona L. and Gad, Yehia Z. and Kamel, Alaa K. and Mazen, Inas and Odermatt, Alex. (2017) Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients. The journal of sexual medicine, 14 (9). pp. 1165-1174. Alesutan, Ioana and Voelkl, Jakob and Feger, Martina and Kratschmar, Denise V. and Castor, Tatsiana and Mia, Sobuj and Sacherer, Michael and Viereck, Robert and Borst, Oliver and Leibrock, Christina and Gawaz, Meinrad and Kuro-O, Makoto and Pilz, Stefan and Tomaschitz, Andreas and Odermatt, Alex and Pieske, Burkert and Wagner, Carsten A. and Lang, Florian. (2017) Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells. Scientific Reports, 7 (1). p. 2059. Morgan, Ruth A. and Beck, Katharina R. and Nixon, Mark and Homer, Natalie Z. M. and Crawford, Andrew A. and Melchers, Diana and Houtman, René and Meijer, Onno C. and Stomby, Andreas and Anderson, Anna J. and Upreti, Rita and Stimson, Roland H. and Olsson, Tommy and Michoel, Tom and Cohain, Ariella and Ruusalepp, Arno and Schadt, Eric E. and Björkegren, Johan L. M. and Andrew, Ruth and Kenyon, Christopher J. and Hadoke, Patrick W. F. and Odermatt, Alex and Keen, John A. and Walker, Brian R.. (2017) Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Scientific Reports, 7 (1). p. 10633. Aghagolzadeh, Parisa and Radpour, Ramin and Bachtler, Matthias and van Goor, Harry and Smith, Edward R. and Lister, Adam and Odermatt, Alex and Feelisch, Martin and Pasch, Andreas. (2017) Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation. Atherosclerosis, 265. pp. 78-86. Engeli, Roger T. and Rohrer, Simona R. and Vuorinen, Anna and Herdlinger, Sonja and Kaserer, Teresa and Leugger, Susanne and Schuster, Daniela and Odermatt, Alex. (2017) Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases. International Journal of Molecular Sciences, 18 (9). pp. 1-13. Vuorinen, Anna and Engeli, Roger T. and Leugger, Susanne and Kreutz, Christoph R. and Schuster, Daniela and Odermatt, Alex and Matuszczak, Barbara. (2017) Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis. Bioorganic & Medicinal Chemistry Letters, 27 (13). pp. 2982-2985. Vuorinen, Anna and Engeli, Roger T. and Leugger, Susanne and Bachmann, Fabio and Akram, Muhammad and Atanasov, Atanas G. and Waltenberger, Birgit and Temml, Veronika and Stuppner, Hermann and Krenn, Liselotte and Ateba, Sylvin B. and Njamen, Dieudonné and Davis, Rohan A. and Odermatt, Alex and Schuster, Daniela. (2017) Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2. Journal of Natural Products, 80 (4). pp. 965-974. Legeza, Balázs and Marcolongo, Paola and Gamberucci, Alessandra and Varga, Viola and Bánhegyi, Gábor and Benedetti, Angiolo and Odermatt, Alex. (2017) Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome. Nutrients, 9 (5). E426. Mani, Orlando and Nashev, Lyubomir G. and Livelo, Christopher and Baker, Michael E. and Odermatt, Alex. (2016) Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone. The Journal of steroid biochemistry and molecular biology, 159. pp. 31-40. Canonica, Jérémie and Sergi, Chloé and Maillard, Marc and Klusonova, Petra and Odermatt, Alex and Koesters, Robert and Loffing-Cueni, Dominique and Loffing, Johannes and Rossier, Bernard and Frateschi, Simona and Hummler, Edith. (2016) Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype. Pflügers Archiv : European journal of physiology, 468 (5). pp. 895-908. Odermatt, Alex and Strajhar, Petra and Engeli, Roger T.. (2016) Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools. The Journal of steroid biochemistry and molecular biology, 158. pp. 9-21. Strajhar, Petra and Schmid, Y. and Liakoni, E. and Dolder, P. C. and Rentsch, K. M. and Kratschmar, Denise V. and Odermatt, Alex and Liechti, Matthias E.. (2016) Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects. Journal of Neuroendocrinology, 28 (3). p. 12374. Engeli, Roger T. and Rhouma, Bochra Ben and Sager, Christoph P. and Tsachaki, Maria and Birk, Julia and Fakhfakh, Faiza and Keskes, Leila and Belguith, Neila and Odermatt, Alex. (2016) Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development. The Journal of steroid biochemistry and molecular biology, 155. pp. 147-154. Hammond, Thomas G. and Moes, Suzette and Youhanna, Sonia and Jennings, Paul and Devuyst, Olivier and Odermatt, Alex and Jenö, Paul. (2016) Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine. Bioanalysis, 8 (12). pp. 1279-1296. Beck, Katharina R. and Sommer, Tanja J. and Schuster, Daniela and Odermatt, Alex. (2016) Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays. Toxicology, 370. pp. 70-77. Shelton, Luke M. and Lister, Adam and Walsh, Joanne and Jenkins, Rosalind E. and Wong, Michael H. L. and Rowe, Cliff and Ricci, Emanuele and Ressel, Lorenzo and Fang, Yongxiang and Demougin, Philippe and Vukojevic, Vanja and O'Neill, Paul M. and Goldring, Christopher E. and Kitteringham, Neil R. and Park, B. Kevin and Odermatt, Alex and Copple, Ian M.. (2015) Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. Kidney international, 88 (6). pp. 1261-1273. Kaserer, Teresa and Beck, Katharina and Akram, Muhamad and Odermatt, Alex and Schuster, Daniela. (2015) Pharmacophore models and pharmacophore-based virtual screening: concepts and applications exemplified on hydroxysteroid dehydrogenases. Molecules, 20 (12). pp. 22799-22832. Di Chiara, Marianna and Glaudemans, Bob and Loffing-Cueni, Dominique and Odermatt, Alex and Al-Hasani, Hadi and Devuyst, Olivier and Faresse, Nourdine and Loffing, Johannes. (2015) Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney. American journal of physiology. Gastrointestinal and liver physiology, 309 (9). F779-F790. Seibert, Julia K. and Quagliata, Luca and Quintavalle, Cristina and Hammond, Thomas G. and Terracciano, Luigi and Odermatt, Alex. (2015) A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer. Cancer medicine, 4 (11). pp. 1717-1729. Tsachaki, Maria and Birk, Julia and Egert, Aurélie and Odermatt, Alex. (2015) Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions. Biochimica et biophysica acta. Molecular cell research, 1853 (7). pp. 1672-1682. Odermatt, Alex and Klusonova, Petra. (2015) 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. The journal of steroid biochemistry and molecular biology, 151. pp. 85-92. Tonoli, David and Fürstenberger, Cornelia and Boccard, Julien and Hochstrasser, Denis and Jeanneret, Fabienne and Odermatt, Alex and Rudaz, Serge. (2015) Steroidomic Footprinting Based on Ultra-High Performance Liquid Chromatography Coupled with Qualitative and Quantitative High-Resolution Mass Spectrometry for the Evaluation of Endocrine Disrupting Chemicals in H295R Cells. Chemical research in toxicology, 28 (5). pp. 955-966. Vuorinen, Anna and Seibert, Julia and Papageorgiou, Vassilios P. and Rollinger, Judith M. and Odermatt, Alex and Schuster, Daniela and Assimopoulou, Andreana N.. (2015) Pistacia lentiscus Oleoresin: Virtual Screening and Identification of Masticadienonic and Isomasticadienonic Acids as Inhibitors of 11β-Hydroxysteroid Dehydrogenase 1. Planta medica, 81 (6). pp. 525-532. Vuorinen, Anna and Odermatt, Alex and Schuster, Daniela. (2015) Reprint of "In silico methods in the discovery of endocrine disrupting chemicals". The Journal of steroid biochemistry and molecular biology, 153 (September 2015). pp. 93-101. Penno, Carlos A. and Morgan, Stuart A. and Rose, Adam J. and Herzig, Stephan and Lavery, Gareth G. and Odermatt, Alex. (2014) 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Molecular metabolism, Vol. 3, H. 5. pp. 554-564. Legeza, Balázs and Balázs, Zoltán and Odermatt, Alex. (2014) Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism. FEBS letters, Vol. 588, H. 3. pp. 490-496. Vuorinen, Anna and Engeli, Roger and Meyer, Arne and Bachmann, Fabio and Griesser, Ulrich J. and Schuster, Daniela and Odermatt, Alex. (2014) Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17β-hydroxysteroid dehydrogenase 2 inhibitors. Journal of medicinal chemistry, Vol. 57, H. 14. pp. 5995-6007. Seibert, Julia and Hysek, Cédric M. and Penno, Carlos A. and Schmid, Yasmin and Kratschmar, Denise V. and Liechti, Matthias E. and Odermatt, Alex. (2014) Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects. Neuroendocrinology, 100 (1). pp. 17-25. Chantong, Boonrat and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex. (2014) Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G i -proteins in murine BV-2 microglia cells. Journal of neuroinflammation, Vol. 11, H. 1. p. 190. Chantong, Boonrat and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex. (2014) Dibutyltin promotes oxidative stress and increases inflammatory mediators in BV-2 microglia cells. Toxicology letters, Vol. 230, H. 2. pp. 177-187. Felser, Andrea and Lindinger, Peter W. and Schnell, Dominik and Kratschmar, Denise V. and Odermatt, Alex and Mies, Suzette and Jenö, Paul and Krähenbühl, Stephan. (2014) Hepatocellular toxicity of benzbromarone : Effects on mitochondrial function and structure. Toxicology, Vol. 324. pp. 136-146. Copple, Ian M. and Shelton, Luke M. and Walsh, Joanne and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex and Goldring, Christopher E. and Dinkova-Kostova, Albena T. and Honda, Tadashi and Park, B. Kevin. (2014) Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids. Review of Economic Dynamics, 140 (2). pp. 462-469. Blüthgen, Nancy and Meili, Nicole and Chew, Geraldine and Odermatt, Alex and Fent, Karl. (2014) Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). Science of the Total Environment, 476-477. pp. 207-217. Gai, Zhibo and Chu, Lei and Hiller, Christian and Arsenijevic, Denis and Penno, Carlos A. and Montani, Jean-Pierre and Odermatt, Alex and Kullak-Ublick, Gerd A.. (2014) Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters. American Journal of Physiology - Renal Physiology, 306 (1). F130-137. Boudon, Stéphanie Marie and Plappert-Helbig, Ulla and Odermatt, Alex and Bauer, Daniel. (2014) Characterization of vemurafenib phototoxicity in a mouse model. Review of Economic Dynamics, 137 (1). pp. 259-267. Boudon, Stéphanie Marie and Morandi, Grégory and Prideaux, Brendan and Staab, Dieter and Junker, Ursula and Odermatt, Alex and Stoeckli, Markus and Bauer, Daniel. (2014) Evaluation of sparfloxacin distribution by mass spectrometry imaging in a phototoxicity model. Journal of the American Society for Mass Spectrometry, 25 (10). pp. 1803-1809. Vuorinen, Anna and Nashev, Lyubomir G. and Odermatt, Alex and Rollinger, Judith M. and Schuster, Daniela. (2014) Pharmacophore model refinement for 11β-hydroxysteroid dehydrogenase inhibitors: Search for modulators of intracellular glucocorticoid concentrations. Molecular Informatics, 33. pp. 15-25. Legeza, Balázs and Balázs, Zoltán and Nashev, Lyubomir G. and Odermatt, Alex. (2013) The microsomal enzyme 17β-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase. Endocrinology, Vol. 154, H. 1. pp. 205-213. Marchais-Oberwinkler, Sandrine and Xu, Kuiying and Wetzel, Marie and Perspicace, Enrico and Negri, Matthias and Meyer, Arne and Odermatt, Alex and Möller, Gabriele and Adamski, Jerzy and Hartmann, Rolf W.. (2013) Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis. Journal of Medicinal Chemistry, Vol. 56, H. 1. pp. 167-181. Penno, Carlos A. and Morgan, Stuart A. and Vuorinen, Anna and Schuster, Daniela and Lavery, Gareth G. and Odermatt, Alex. (2013) Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid. Journal of Lipid Research, 54 (10). pp. 2874-2883. Pandya, Keyur and Dietrich, David and Seibert, Julia and Vederas, John C. and Odermatt, Alex. (2013) Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists. Bioorganic & medicinal chemistry letters, Vol. 21, H. 21. pp. 6274-6281. Meyer, Arne and Vuorinen, Anna and Zielinska, Agnieszka E. and Da Cunha, Thierry and Strajhar, Petra and Lavery, Gareth G. and Schuster, Daniela and Odermatt, Alex. (2013) Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1. Biochemical pharmacology, Vol. 85, H. 9. pp. 1370-1378. Meyer, Arne and Vuorinen, Anna and Zielinska, Agnieszka E. and Strajhar, Petra and Lavery, Gareth G. and Schuster, Daniela and Odermatt, Alex. (2013) Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1. Drug metabolism and disposition, Vol. 41, H. 9. pp. 1671-1678. Birk, Julia and Ramming, Thomas and Odermatt, Alex and Appenzeller-Herzog, Christian. (2013) Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise. Frontiers in genetics, Vol. 4, art. 108 , 10 S.. p. 108. Nashev, Lyubomir G. and Atanasov, Atanas G. and Baker, Michael E. and Odermatt, Alex. (2013) Cysteine-10 on 17 β-Hydroxysteroid dehydrogenase 1 has stabilizing interactions in the cofactor binding region and renders sensitivity to sulfhydryl modifying chemicals. International journal of cell biology, Vol. 2013 , art. 769536. Penno, C. A. and Arsenijevic, D: Da Cunha and Kullak-Ublick, G. A. and Montani, J.-P. and Odermatt, A.. (2013) Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry. Analytical Methods, 5. pp. 1155-1164. Blüthgen, Nancy and Sumpter, John P. and Odermatt, Alex and Fent, Karl. (2013) Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquatic Toxicology, 144-145. pp. 96-104. Hofer, Sandra and Kratschmar, Denise V. and Schernthanner, Brigitte and Vuorinen, Anna and Schuster, Daniela and Odermatt, Alex and Easmon, Johnny. (2013) Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors. Bioorganic and Medicinal Chemistry Letters, 23 (19). pp. 5397-5400. Vuorinen, Anna and Odermatt, Alex and Schuster, Daniela. (2013) In silico methods in the discovery of endocrine disrupting chemicals. Journal of Steroid Biochemistry and Molecular Biology, 137. pp. 18-26. Sorensen, Mads V. and Grossmann, Solveig and Roesinger, Marian and Gresko, Nikolay and Todkar, Abhijeet P. and Barmettler, Gery and Ziegler, Urs and Odermatt, Alex and Loffing-Cueni, Dominique and Loffing, Johannes. (2013) Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney International, 83 (5). pp. 811-824. Leunig, M. and Jüni, P. and Werlen, S. and Limacher, A. and Nüesch, E. and Pfirrmann, C. W. and Trelle, S. and Odermatt, A. and Hofstetter, W. and Ganz, R. and Reichenbach, S.. (2013) Prevalence of cam and pincer-type deformities on hip MRI in an asymptomatic young Swiss female population: a cross-sectional study. Osteoarthritis and Cartilage , 21 (4). pp. 544-550. Birk, Julia and Meyer, Mariangela and Aller, Isabel and Hansen, Henning G. and Odermatt, Alex and Dick, Tobias P. and Meyer, Andreas J. and Appenzeller-Herzog, Christian. (2013) Endoplasmic reticulum: reduced and oxidized glutathione revisited. Journal of Cell Science, 126. pp. 1604-1617. Kratschmar, Denise V. and Calabrese, Diego and Walsh, Jo and Lister, Adam and Birk, Julia and Appenzeller-Herzog, Christian and Moulin, Pierre and Goldring, Chris E. and Odermatt, Alex. (2012) Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells. PLoS ONE, 7 (5). e36774. Veyrat-Durebex, Christelle and Deblon, Nicolas and Caillon, Aurélie and Andrew, Ruth and Altirriba, Jordi and Odermatt, Alex and Rohner-Jeanrenaud, Françoise. (2012) Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue. PLoS ONE, Vol. 7, H. 3 , e34002. Meyer, Arne and Strajhar, Petra and Murer, Céline and Da Cunha, Thierry and Odermatt, Alex. (2012) Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology, Vol. 301, H. 1-3. pp. 72-78. Nashev, Lyubomir G. and Vuorinen, Anna and Praxmarer, Lukas and Chantong, Boonrat and Cereghetti, Diego and Winiger, Rahel and Schuster, Daniela and Odermatt, Alex. (2012) Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action. PLoS ONE, Vol. 7, H. 10 , e46958. Chantong, Boonrat and Kratschmar, Denise V. and Nashev, Lyubomir G. and Balazs, Zoltan and Odermatt, Alex. (2012) Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. Journal of neuroinflammation, Vol. 9. p. 260. Fürstenberger, Cornelia and Vuorinen, Anna and Da Cunha, Thierry and Kratschmar, Denise V. and Saugy, Martial and Schuster, Daniela and Odermatt, Alex. (2012) The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicological sciences, Vol. 126, H. 2. pp. 353-361. Odermatt, Alex and Kratschmar, Denise V.. (2012) Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases : an overview. Molecular and cellular endocrinology, Vol. 350, H. 2. pp. 168-186. Kratschmar, Denise V. and Vuorinen, Anna and Da Cunha, Thierry and Wolber, Gerhard and Classen-Houben, Dirk and Doblhoff, Otto and Schuster, Daniela and Odermatt, Alex. (2011) Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11?-hydroxysteroid dehydrogenase type 2. The journal of steroid biochemistry and molecular biology, Vol. 125, H. 1-2. pp. 129-142. Reichenbach, Stephan and Leunig, Michael and Werlen, Stefan and Nüesch, Eveline and Pfirrmann, Christian W. and Bonel, Harald and Odermatt, Alex and Hofstetter, Willy and Ganz, Reinhold and Jüni, Peter. (2011) Association between cam-type deformities and magnetic resonance imaging-detected structural hip damage : a cross-sectional study in young men. Arthritis and rheumatism, Vol. 63, H. 12. pp. 4023-4030. Gaware, Rawindra and Khunt, Rupesh and Czollner, Laszlo and Stanetty, Christian and Da Cunha, Thierry and Kratschmar, Denise V. and Odermatt, Alex and Kosma, Paul and Jordis, Ulrich and Classen-Houben, Dirk. (2011) Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11?-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & medicinal chemistry, Vol. 19, H. 6. pp. 1866-1880. Odermatt, Alex. (2011) The Western-style diet : a major risk factor for impaired kidney function and chronic kidney disease. American journal of physiology. Renal Physiology, Vol. 301, H. 5 , F919-931. Odermatt, Alex and Da Cunha, Thierry and Penno, Carlos A. and Chandsawangbhuwana, Charlie and Reichert, Christian and Wolf, Armin and Dong, Min and Baker, Michael E.. (2011) Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11?-hydroxysteroid dehydrogenase 1. The Biochemical Journal, Vol. 436, H. 3. pp. 621-629. Schuster, Daniela and Kowalik, Dorota and Kirchmair, Johannes and Laggner, Christian and Markt, Patrick and Aebischer-Gumy, Christel and Ströhle, Fabian and Möller, Gabriele and Wolber, Gerhard and Wilckens, Thomas and Langer, Thierry and Odermatt, Alex and Adamski, Jerzy. (2011) Identification of chemically diverse, novel inhibitors of 17?-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. The journal of steroid biochemistry and molecular biology, Vol. 125, H. 1-2. pp. 148-161. Blumberg, Bruce and Iguchi, Taisen and Odermatt, Alex. (2011) Endocrine disrupting chemicals. The journal of steroid biochemistry and molecular biology, Vol. 127, H. 1/2. pp. 1-3. Nashev, Lyubomir G. and Schuster, Daniela and Laggner, Christian and Sodha, Seloni and Langer, Thierry and Wolber, Gerhard and Odermatt, Alex. (2010) The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3 : virtual screening as a strategy to identify potential endocrine disrupting chemicals. Biochemical Pharmacology, Vol. 79, Issue 8. pp. 1189-1199. Reichenbach, Stephan and Jüni, Peter and Werlen, Stefan and Nüesch, Eveline and Pfirrmann, Christian W. and Trelle, Sven and Odermatt, Alex and Hofstetter, Willy and Ganz, Reinhold and Leunig, Michael. (2010) Prevalence of cam-type deformity on hip magnetic resonance imaging in young males : a cross-sectional study. Arthritis care & research, Vol. 62, H. 9. pp. 1319-1327. Stanetty, Christian and Czollner, Laszlo and Koller, Iris and Shah, Priti and Gaware, Rawindra and Cunha, Thierry Da and Odermatt, Alex and Jordis, Ulrich and Kosma, Paul and Classen-Houben, Dirk. (2010) Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11?-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & medicinal chemistry, Vol. 18, H. 21. pp. 7522-7541. Senesi, Silvia and Legeza, Balázs and Balázs, Zoltán and Csala, Miklós and Marcolongo, Paola and Kereszturi, Eva and Szelényi, Péter and Egger, Christine and Fulceri, Rosella and Mandl, József and Giunti, Roberta and Odermatt, Alex and Bánhegyi, Gábor and Benedetti, Angelo. (2010) Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum : possible implication in the metabolic syndrome. Endocrinology, Vol. 151, H. 10. pp. 4830-4839. Rollinger, Judith M. and Kratschmar, Denise V. and Schuster, Daniela and Pfisterer, Petra H. and Gumy, Christel and Aubry, Evelyne M. and Brandstötter, Sarah and Stuppner, Hermann and Wolber, Gerhard and Odermatt, Alex. (2010) 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorganic & medicinal chemistry, Vol. 18, H. 4. pp. 1507-1515. Odermatt, Alex and Nashev, Lyubomir G.. (2010) The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations. The journal of steroid biochemistry and molecular biology, Vol. 119, H. 1-2. pp. 1-13. Beseda, Igor and Czollner, Laszlo and Shah, Priti S. and Khunt, Rupesh and Gaware, Rawindra and Kosma, Paul and Stanetty, Christian and Del Ruiz-Ruiz, Maria Carmen and Amer, Hassan and Mereiter, Kurt and Da Cunha, Thierry and Odermatt, Alex and Classen-Houben, Dirk and Jordis, Ulrich. (2010) Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorganic & medicinal chemistry, Vol. 18, H. 1. pp. 433-454. Classen-Houben, D. and Schuster, D. and Da Cunha, T. and Odermatt, A. and Wolber, G. and Jordis, U. and Kueenburg, B.. (2009) Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. The journal of steroid biochemistry and molecular biology, Vol. 113, H. 3-5. pp. 248-252. Gumy, C. and Thurnbichler, C. and Aubry, E. M. and Balazs, Z. and Pfisterer, P. and Baumgartner, L. and Stuppner, H. and Odermatt, A. and Rollinger, J. M.. (2009) Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, Vol. 80, no.3. pp. 200-205. Balazs, Z. and Nashev, L. G. and Chandsawangbhuwana, C. and Baker, M. E. and Odermatt, A.. (2009) Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. Molecular and cellular endocrinology, Vol. 301, H. 1-2. pp. 117-122. Dzyakanchuk, A. A. and Balazs, Z. and Nashev, L. G. and Amrein, K. E. and Odermatt, A.. (2009) 11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose. Molecular and cellular endocrinology, Vol. 301, H. 1-2. pp. 137-141. Odermatt, A.. (2009) Diazepane-acetamide derivatives as selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors. Expert opinion on therapeutic patents, Vol. 19, H. 10. pp. 1477-1483. Odermatt, A. and Atanasov, A. G.. (2009) Mineralocorticoid receptors : Emerging complexity and functional diversity. Steroids, Vol. 74, H. 2. pp. 163-171. Gumy, C. and Chandsawangbhuwana, C. and Dzyakanchuk, A. A. and Kratschmar, D. V. and Baker, M. E. and Odermatt, A.. (2008) Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production. PLoS ONE, Vol. 3, H. 10 , e3545. Odermatt, Alex and Gumy, Christel. (2008) Disruption of glucocorticoid and mineralocorticoid receptor-mediated responses by environmental chemicals. Chimia, 62 (5). pp. 335-339. Balazs, Z. and Schweizer, R. A. and Frey, F. J. and Rohner-Jeanrenaud, F. and Odermatt, A.. (2008) DHEA induces 11beta-HSD2 by acting on CCAAT/enhancer-binding proteins. Journal of the American Society of Nephrology, Vol. 19, H. 1. pp. 92-101. Odermatt, Alex and Gumy, Christel. (2008) Glucocorticoid and mineralocorticoid action : Why should we consider influences by environmental chemicals? Biochemical Pharmacology, Volume 76, Issue 10. pp. 1184-1193. Schuster, Daniela and Nashev, Lyubomir G. and Kirchmair, Johannes and Laggner, Christian and Wolber, Gerhard and Langer, Thierry and Odermatt, Alex. (2008) Discovery of nonsteroidal 17 beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. Journal of medicinal chemistry, Vol. 51, no. 14. pp. 4188-4199. Atanasov, Atanas G. and Nashev, Lyubomir G. and Gelman, Laurent and Legeza, Balazs and Sack, Ragna and Portmann, Reto and Odermatt, Alex. (2008) Direct protein-protein interaction of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochimica et biophysica acta. Molecular cell research, Vol. 1783, Issue 8. pp. 1536-1543. Nashev, L. G. and Chandsawangbhuwana, C. and Balazs, Z. and Atanasov, A. G. and Dick, B. and Frey, F. J. and Baker, M. E. and Odermatt, A.. (2007) Hexose-6-phosphate Dehydrogenase Modulates 11beta-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PLoS ONE, Vol. 2, H. 6 , e561. Atanasov, A. G. and Ignatova, I. D. and Nashev, L. G. and Dick, B. and Ferrari, P. and Frey, F. J. and Odermatt, A.. (2007) Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type : a novel mechanism of apparent mineralocorticoid excess. Journal of the American Society of Nephrology, Vol. 18, H. 4. pp. 1262-1270. |
