Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes

Schulze, Friederike and Wehner, Josua and Kratschmar, Denise V. and Makshana, Valmir and Meier, Daniel T. and Häuselmann, Stéphanie P. and Dalmas, Elise and Thienel, Constanze and Dror, Erez and Wiedemann, Sophia J. and Traub, Shuyang and Nordmann, Thierry M. and Rachid, Leila and De Baat, Axel and Rohm, Theresa V. and Zhao, Cheng and Odermatt, Alex and Böni-Schnetzler, Marianne and Donath, Marc Y.. (2020) Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes. Scientific Reports, 10 (1). p. 3035.

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Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1β (IL-1β) expression in the uterus and the placenta along with elevated circulating IL-1β concentrations compared to normoglycemic pregnant mice. Treatment with an anti-IL-1β antibody improved glucose-tolerance of GDM mice without apparent deleterious effects for the fetus. Finally, IL-1β antagonism showed a tendency for reduced plasma corticosterone concentrations, possibly explaining the metabolic improvement. We conclude that IL-1β is a causal driver of impaired glucose tolerance in GDM.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt)
UniBasel Contributors:Odermatt, Alex and Winter, Denise
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Feb 2021 07:52
Deposited On:24 Feb 2021 07:52

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