edoc

Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome

Legeza, Balázs and Marcolongo, Paola and Gamberucci, Alessandra and Varga, Viola and Bánhegyi, Gábor and Benedetti, Angiolo and Odermatt, Alex. (2017) Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome. Nutrients, 9 (5). E426.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/63052/

Downloads: Statistics Overview

Abstract

The modern Western society lifestyle is characterized by a hyperenergetic, high sugar containing food intake. Sugar intake increased dramatically during the last few decades, due to the excessive consumption of high-sugar drinks and high-fructose corn syrup. Current evidence suggests that high fructose intake when combined with overeating and adiposity promotes adverse metabolic health effects including dyslipidemia, insulin resistance, type II diabetes, and inflammation. Similarly, elevated glucocorticoid levels, especially the enhanced generation of active glucocorticoids in the adipose tissue due to increased 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity, have been associated with metabolic diseases. Moreover, recent evidence suggests that fructose stimulates the 11β-HSD1-mediated glucocorticoid activation by enhancing the availability of its cofactor NADPH. In adipocytes, fructose was found to stimulate 11β-HSD1 expression and activity, thereby promoting the adipogenic effects of glucocorticoids. This article aims to highlight the interconnections between overwhelmed fructose metabolism, intracellular glucocorticoid activation in adipose tissue, and their metabolic effects on the progression of the metabolic syndrome.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt)
UniBasel Contributors:Odermatt, Alex
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2072-6643
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:09 Apr 2019 15:45
Deposited On:09 Apr 2019 15:45

Repository Staff Only: item control page