Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases

Tsachaki, Maria and Odermatt, Alex. (2019) Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases. Molecular and cellular endocrinology, 489. pp. 98-106.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/71375/

Downloads: Statistics Overview


The 17β-hydroxysteroid dehydrogenases (17β-HSDs) comprise enzymes initially identified by their ability to interconvert active and inactive forms of sex steroids, a vital process for the tissue-specific control of estrogen and androgen balance. However, most 17β-HSDs have now been shown to accept substrates other than sex steroids, including bile acids, retinoids and fatty acids, thereby playing unanticipated roles in cell physiology. This functional divergence is often reflected by their different subcellular localization, with 17β-HSDs found in the cytosol, peroxisome, mitochondria, endoplasmic reticulum and in lipid droplets. Moreover, a subset of 17β-HSDs are integral membrane proteins, with their specific topology dictating the cellular compartment in which they exert their enzymatic activity. Here, we summarize the present knowledge on the subcellular localization and membrane topology of the 17β-HSD enzymes and discuss the correlation with their biological functions.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt)
UniBasel Contributors:Odermatt, Alex and Tsachaki, Maria
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:North Holland Publishing
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 Aug 2020 14:10
Deposited On:17 Aug 2020 14:10

Repository Staff Only: item control page