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Items where Author is "Brun, Reto"

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Number of items: 113.

2019

Fayez, Shaimaa and Li, Jun and Feineis, Doris and Aké Assi, Laurent and Kaiser, Marcel and Brun, Reto and Anany, Mohamed A. and Wajant, Harald and Bringmann, Gerhard. (2019) A Near-Complete Series of Four Atropisomeric Jozimine A; 2; -Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from; Ancistrocladus abbreviatus;. Journal of natural products, 82 (11). pp. 3033-3046.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2019) An unusually broad series of seven cyclombandakamines, bridged dimeric naphthylisoquinoline alkaloids from the congolese liana ancistrocladus ealaensis. Scientific reports, 9. p. 9812.

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet Alvarez, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Pepe, Giacomo and Cirilli, Roberto and Faggi, Cristina and Di Marco, Annalise and Battista, Maria Rosaria and Summa, Vincenzo and Costi, Roberta and Di Santo, Roberto. (2019) Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. Journal of Medicinal Chemistry, 62 (3). pp. 1330-1347.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Schmidt, David and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Würthner, Frank and Awale, Suresh and Bringmann, Gerhard. (2019) Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana; Ancistrocladus ealaensis; , Targeting Pancreatic Cancer Cells. Journal of natural products, 82 (11). pp. 3150-3164.

2018

Giroud, Maude and Kuhn, Bernd and Saint-Auret, Sarah and Kuratli, Christoph and Martin, Rainer E. and Schuler, Franz and Diederich, François and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Haap, Wolfgang. (2018) 2 H-1,2,3-Triazole-based dipeptidyl nitriles : potent, selective, and Trypanocidal rhodesain inhibitors by structure-based design. Journal of medicinal chemistry, 61 (8). pp. 3370-3388.

Fayez, Shaimaa and Feineis, Doris and Aké Assi, Laurent and Kaiser, Marcel and Brun, Reto and Awale, Suresh and Bringmann, Gerhard. (2018) Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells. Fitoterapia, 131. pp. 245-259.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Antiprotozoal sesquiterpene lactones and other constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products, 81 (1). pp. 124-130.

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Costi, Roberta and Di Santo, Roberto. (2018) Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. European journal of medicinal chemistry, 156. pp. 53-60.

Uliassi, Elisa and Piazzi, Lorna and Belluti, Federica and Mazzanti, Andrea and Kaiser, Marcel and Brun, Reto and Moraes, Carolina B. and Freitas-Junior, Lucio H. and Gul, Sheraz and Kuzikov, Maria and Ellinger, Bernhard and Borsari, Chiara and Costi, Maria Paola and Bolognesi, Maria Laura. (2018) Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against protozoan parasitic infections. ChemMedChem, 13 (7). pp. 678-683.

Farahat, Abdelbasset A. and Ismail, Mohamed A. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Paul, Ananya and Wilson, W. David and Boykin, David W.. (2018) Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity. European Journal of Medicinal Chemistry, 143. pp. 1590-1596.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2018) Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana ancistrocladus ealaensis with antiparasitic and antileukemic activities. Journal of natural products, 81 (4). pp. 918-933.

Giroud, Maude and Dietzel, Uwe and Anselm, Lilli and Banner, David and Kuglstatter, Andreas and Benz, Jörg and Blanc, Jean-Baptiste and Gaufreteau, Delphine and Liu, Haixia and Lin, Xianfeng and Stich, August and Kuhn, Bernd and Schuler, Franz and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Kisker, Caroline and Diederich, François and Haap, Wolfgang. (2018) Repurposing a library of human cathepsin L ligands : identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 61 (8). pp. 3350-3369.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Sesquiterpene lactones from Vernonia cinerascens sch. bip. and their in vitro antitrypanosomal activity. Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry , 23 (2). E248.

2017

Althaus, Julia B. and Malyszek, Claudine and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Alkamides from Anacyclus pyrethrum L. and their in vitro antiprotozoal activity. Molecules, 22 (5). p. 796.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Anti-trypanosomatid elemanolide sesquiterpene lactones from Vernonia lasiopus O. Hoffm. Molecules, 22 (4). E597.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Xu, Minjuan and Zhang, Guoliang and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2017) Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 121. pp. 76-85.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2017) Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis. Scientific Reports, 7. p. 5767.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant. Organic Letters, 19 (24). pp. 6740-6743.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Cyclombandakamines A1 and A2, oxygen-bridged naphthylisoquinoline dimers from a congolese Ancistrocladus liana. Organic letters, 19 (6). pp. 1342-1345.

Li, Jun and Seupel, Raina and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Brünnert, Daniela and Chatterjee, Manik and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2017) Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the congolese liana Ancistrocladus ileboensis with potent activities against Plasmodium falciparum and against multiple myeloma and leukemia cell lines. Journal of natural products, 80 (2). pp. 443-458.

Gillingwater, Kirsten and Kunz, Christina and Braghiroli, Christiane and Boykin, David W. and Tidwell, Richard R. and Brun, Reto. (2017) In vitro, ex vivo and in vivo activity of diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial agents and chemotherapy, 61 (5). e02356-16.

Li, Jun and Seupel, Raina and Bruhn, Torsten and Feineis, Doris and Kaiser, Marcel and Brun, Reto and Mudogo, Virima and Awale, Suresh and Bringmann, Gerhard. (2017) Jozilebomines A and B, naphthylisoquinoline dimers from the congolese liana ancistrocladus ileboensis, with antiausterity activities against the PANC-1 human pancreatic cancer cell line. Journal of natural products, 80 (10). pp. 2807-2817.

Pagliero, Romina J. and Kaiser, Marcel and Brun, Reto and Nieto, Marcelo J. and Mazzieri, María R.. (2017) Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles. Bioorganic & medicinal chemistry, 27 (17). pp. 3945-3949.

Nnadi, Charles Okeke and Nwodo, Ngozi Justina and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. Molecules, 22 (7). E1129.

Tran, Huu-Anh and Zheng, Zhaoyan and Wen, Xianghui and Manivannan, Srinivasan and Pastor, Arnaud and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2017) Synthesis and activity of nucleoside-based antiprotozoan compounds. Bioorganic & medicinal chemistry, 25 (7). pp. 2091-2104.

Greve, Hippolyt L. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Terpenoids from the oleo-gum-resin of Boswellia serrata and their antiplasmodial effects In Vitro. Planta medica, 83 (14-15). pp. 1214-1226.

2016

Wenzler, Tanja and Schumann Burkard, Gabriela and S. Schmidt, Remo and Mäser, Pascal and Bergner, Andreas and Roditi, Isabel and Brun, Reto. (2016) A new approach to chemotherapy : drug-induced differentiation kills African trypanosomes. Scientific Reports, 6. p. 22451.

Pirttimaa, Minni and Nasereddin, Abedelmajeed and Kopelyanskiy, Dmitry and Kaiser, Marcel and Yli-Kauhaluoma, Jari and Oksman-Caldentey, Kirsi-Marja and Brun, Reto and Jaffe, Charles L. and Moreira, Vânia M. and Alakurtti, Sami. (2016) Abietane-type diterpenoid amides with highly potent and selective activity against Leishmania donovani and Trypanosoma cruzi. Journal of natural products, 79 (2). pp. 362-368.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Zhang, Guoliang and Xu, Minjuan and Wu, Jun and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2016) Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 115. pp. 1-8.

Faist, Johanna and Seebacher, Werner and Saf, Robert and Brun, Reto and Kaiser, Marcel and Weis, Robert. (2016) Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead. Bioorganic & medicinal chemistry, 24 (16). pp. 3781-3789.

Le Bihan, Amélie and de Kanter, Ruben and Angulo-Barturen, Iñigo and Binkert, Christoph and Boss, Christoph and Brun, Reto and Brunner, Ralf and Buchmann, Stephan and Burrows, Jeremy and Dechering, Koen J. and Delves, Michael and Ewerling, Sonja and Ferrer, Santiago and Fischli, Christoph and Gamo-Benito, Francisco Javier and Gnädig, Nina F. and Heidmann, Bibia and Jiménez-Díaz, María Belén and Leroy, Didier and Martínez, Maria Santos and Meyer, Solange and Moehrle, Joerg J. and Ng, Caroline L. and Noviyanti, Rintis and Ruecker, Andrea and Sanz, Laura María and Sauerwein, Robert W. and Scheurer, Christian and Schleiferboeck, Sarah and Sinden, Robert and Snyder, Christopher and Straimer, Judith and Wirjanata, Grennady and Marfurt, Jutta and Price, Ric N. and Weller, Thomas and Fischli, Walter and Fidock, David A. and Clozel, Martine and Wittlin, Sergio. (2016) Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling. PLoS medicine, 13 (10). e1002138.

Seupel, Raina and Hertlein-Amslinger, Barbara and Gulder, Tanja and Stawski, Philipp and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2016) Directed synthesis of all four pure stereoisomers of the N,C-Coupled naphthylisoquinoline alkaloid ancistrocladinium A. Organic letters, 18 (24). pp. 6508-6511.

Boss, Christoph and Aissaoui, Hamed and Amaral, Nathalie and Bauer, Aude and Bazire, Stephanie and Binkert, Christoph and Brun, Reto and Bürki, Cédric and Ciana, Claire-Lise and Corminboeuf, Olivier and Delahaye, Stephane and Dollinger, Claire and Fischli, Christoph and Fischli, Walter and Flock, Alexandre and Frantz, Marie-Céline and Girault, Malory and Grisostomi, Corinna and Friedli, Astrid and Heidmann, Bibia and Hinder, Claire and Jacob, Gael and Le Bihan, Amelie and Malrieu, Sophie and Mamzed, Saskia and Merot, Aurelien and Meyer, Solange and Peixoto, Sabrina and Petit, Nolwenn and Siegrist, Romain and Trollux, Julien and Weller, Thomas and Wittlin, Sergio. (2016) Discovery and characterization of ACT-451840 : an antimalarial drug with a novel mechanism of action. ChemMedChem, 11 (18). pp. 1995-2014.

Nogueira, Mauro S. and Da Costa, Fernando B. and Brun, Reto and Kaiser, Marcel and Schmidt, Thomas J.. (2016) Ent-pimarane and ent-kaurane diterpenes from Aldama discolor (asteraceae) and their antiprotozoal activity. Molecules, 21 (9). p. 1237.

Zheng, Zhaoyan and Tran, Huu-Anh and Manivannan, Srinivasan and Wen, Xianghui and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2016) Novel nucleoside-based antimalarial compounds. Bioorganic & medicinal chemistry letters, 26 (12). pp. 2861-2865.

Karaaslan, Cigdem and Kaiser, Marcel and Brun, Reto and Göker, Hakan. (2016) Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenz-imidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense. Bioorganic and Medicinal Chemistry, 24 (18). pp. 4038-4044.

Patrick, Donald A. and Wenzler, Tanja and Yang, Sihyung and Weiser, Patrick T. and Wang, Michael Zhuo and Brun, Reto and Tidwell, Richard R.. (2016) Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 24 (11). pp. 2451-2465.

Farahat, Abdelbasset A. and Bennett-Vaughn, Cheree and Mineva, Ekaterina M. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Liu, Yang and Wilson, W. David and Boykin, David W.. (2016) Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI. Bioorganic & medicinal chemistry letters, 26 (24). pp. 5907-5910.

Ahmad, Sarfraz and Seebacher, Werner and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2016) The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, 39 (10). pp. 1391-1403.

2015

Prati, Federica and Bergamini, Christian and Molina, Maria Teresa and Falchi, Federico and Cavalli, Andrea and Kaiser, Marcel and Brun, Reto and Fato, Romana and Bolognesi, Maria Laura. (2015) 2-Phenoxy-1,4-naphthoquinones : from a multitarget antitrypanosomal to a potential antitumor profile. Journal of medicinal chemistry, 58 (16). pp. 6422-6434.

Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Brun, Reto and Kaiser, Marcel and Van Kiem, Phan and Van Minh, Chau and Schmidt, Thomas J. and Kang, Jong Seong and Kim, Young Ho. (2015) Anti-protozoal activities of cembrane-type diterpenes from Vietnamese soft corals. Molecules, Vol. 20, H. 7. pp. 12459-12468.

Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS ONE, Vol. 10, H. 8 , e0135556.

Tasdemir, Deniz and Tierney, Michelle and Sen, Rupashree and Bergonzi, Maria Camilla and Demirci, Betül and Bilia, Anna Rita and Baser, Kemal Hüsnü Can and Brun, Reto and Chatterjee, Mitali. (2015) Antiprotozoal effect of Artemisia indica extracts and essential oil. Planta medica, 81 (12-13). pp. 1029-1037.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Bridges, Arlene S. and Boykin, David W. and Mutuku, James N. and Liu, Qiang and Jones, Susan K. and Gem, Charles O. and Ching, Shelley and Tidwell, Richard R. and Wang, Michael Z. and Paine, Mary F. and Brun, Reto. (2015) Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. PLoS neglected tropical diseases, Vol. 9, H. 2 , e3409.

Woodland, Andrew and Thompson, Stephen and Cleghorn, Laura A. T. and Norcross, Neil and De Rycker, Manu and Grimaldi, Raffaella and Hallyburton, Irene and Rao, Bhavya and Norval, Suzanne and Stojanovski, Laste and Brun, Reto and Kaiser, Marcel and Frearson, Julie A. and Gray, David W. and Wyatt, Paul G. and Read, Kevin D. and Gilbert, Ian H.. (2015) Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library. ChemMedChem, 10 (11). pp. 1809-1820.

Nwodo, Ngozi and Okoye, Festus and Lai, Daowan and Debbab, Abdesammed and Kaiser, Marcel and Brun, Reto and Proksch, Peter. (2015) Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC complementary and alternative medicine, Vol. 15 , 82.

Hemberger, Yasmin and Zhang, Guoliang and Brun, Reto and Kaiser, Marcel and Bringmann, Gerhard. (2015) Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability. Chemistry, a European journal, 21 (41). pp. 14507-14518.

Herrmann, Fabian C. and Lenz, Mairin and Jose, Joachim and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) In silico identification and in vitro activity of novel natural inhibitors of Trypanosoma brucei glyceraldehyde-3-phosphate-dehydrogenase. Molecules, Vol. 20, H. 9. pp. 16154-16169.

Ellendorff, Therese and Brun, Reto and Kaiser, Marcel and Sendker, Jandirk and Schmidt, Thomas J.. (2015) PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of "Juglans spp.". Molecules, Vol. 20, H. 6. pp. 10082-10094.

Montesino, Núria Llurba and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) Search for antiprotozoal activity in herbal medicinal preparations : new natural leads against neglected tropical diseases. Molecules, Vol. 20, H. 8. pp. 14118-14138.

Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467.

Seebacher, Werner and Wolkinger, Volker and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Bucar, Franz and Gröblacher, Barbara and Brantner, Adelheid and Merino, Virginia and Kalia, Yogeshvar and Scapozza, Leonardo and Perozzo, Remo and Weis, Robert. (2015) Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Bioorganic & medicinal chemistry letters, Vol. 25, H. 7. pp. 1390-1393.

Rodenko, Boris and Wanner, Martin J. and Alkhaldi, Abdulsalam A. M. and Ebiloma, Godwin U. and Barnes, Rebecca L. and Kaiser, Marcel and Brun, Reto and McCulloch, Richard and Koomen, Gerrit-Jan and de Koning, Harry P.. (2015) Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. Antimicrobial agents and chemotherapy, 59 (11). pp. 6708-6716.

2014

Wube, Abraham and Hüfner, Antje and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Bauer, Rudolf and Bucar, Franz. (2014) 1,2-substituted 4-(1H)-quinolones : synthesis, antimalarial and antitrypanosomal activities in vitro. Molecules, Vol. 19, H. 9. pp. 14204-14220.

Mokoka, Tsholofelo A. and Peter, Xolani K. and Fouche, Gerda and Moodley, Nivan and Adams, Michael and Hamburger, Matthias and Kaiser, Marcel and Brun, Reto and Maharaj, Vinesh and Koorbanally, Neil. (2014) Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae). South African journal of botany, Vol. 90. pp. 93-95.

Orhan, Ilkay Erdogan and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2014) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Turkish journal of biochemistry, Vol. 38, H. 4. pp. 403-408.

Carvalho, Samir Aquino and Kaiser, Marcel and Brun, Reto and Silva, Edson Ferreira da and Fraga, Carlos Alberto Manssour. (2014) Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives. Molecules, Vol. 19, H. 12. pp. 20374-20381.

Althaus, Julia B. and Jerz, Gerold and Winterhalter, Peter and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6184-6201.

Althaus, Julia B. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6428-6438.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Wenzler, Tanja and Brun, Reto and Tidwell, Richard R.. (2014) Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 22 (1). pp. 559-576.

Hata, Yoshie and Ebrahimi, Samad Nejad and De Mieri, Maria and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Potterat, Olivier and Hamburger, Matthias. (2014) Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, Vol. 93. pp. 81-87.

Ayyari, Mahdi and Salehi, Peyman and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Portmann, Lena and Krauth-Siegel, R. Luise and Kaiser, Marcel and Brun, Reto and Rezadoost, Hassan and Rezazadeh, Shamsali and Hamburger, Matthias. (2014) Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina. Planta Medica, 80 (1). pp. 86-89.

Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798.

Portmann, Cyril and Sieber, Simon and Wirthensohn, Silvan and Blom, Judith F. and Da Silva, Laeticia and Baudat, Emilie and Kaiser, Marcel and Brun, Reto and Gademann, Karl. (2014) Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. Journal of natural products, Vol. 77, H. 3. pp. 557-562.

Persch, Elke and Bryson, Steve and Todoroff, Nickolay K. and Eberle, Christian and Thelemann, Jonas and Dirdjaja, Natalie and Kaiser, Marcel and Weber, Maria and Derbani, Hassan and Brun, Reto and Schneider, Gisbert and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2014) Binding to large enzyme pockets : small-molecule inhibitors of trypanothione reductase. ChemMedChem, Vol. 9, H. 8. pp. 1880-1891.

Giordani, Federica and Buschini, Annamaria and Baliani, Alessandro and Kaiser, Marcel and Brun, Reto and Barrett, Michael P. and Pellacani, Claudia and Poli, Paola and Gilbert, Ian H.. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 10. pp. 5747-5757.

Reker, Daniel and Seet, Michael and Pillong, Max and Koch, Christian P. and Schneider, Petra and Witschel, Matthias C. and Rottmann, Matthias and Freymond, Céline and Brun, Reto and Schweizer, Bernd and Illarionov, Boris and Bacher, Adelbert and Fischer, Markus and Diederich, François and Schneider, Gisbert. (2014) Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. Angewandte Chemie, Jg. 53, Nr. 27. pp. 7079-7084.

Julianti, Tasqiah and De Mieri, Maria and Zimmermann, Stefanie and Ebrahimi, Samad N. and Kaiser, Marcel and Neuburger, Markus and Raith, Melanie and Brun, Reto and Hamburger, Matthias. (2014) HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of ethnopharmacology, Vol. 155, H. 1. pp. 426-434.

Schmidt, Thomas J. and Da Costa, Fernando B. and Lopes, Norberto P. and Kaiser, Marcel and Brun, Reto. (2014) In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial agents and chemotherapy, Vol. 58, H. 1. pp. 325-332.

Wenzler, Tanja and Yang, Sihyung and Patrick, Donald A. and Braissant, Olivier and Ismail, Mohamed A. and Tidwell, Richard R. and Boykin, David W. and Wang, Michael Zhuo and Brun, Reto. (2014) In vitro and In vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial agents and chemotherapy, Vol. 58, H. 8. pp. 4452-4463.

D. A. Silva, Cristiane França and Batista, Denise DA Gama Jaen and Batista, Marcos Meuser and Lionel, Jessica and Hammer, Erica Ripoll and Brun, Reto and Soeiro, Maria DE Nazaré Correia. (2014) In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, Vol. 141, H. 3. pp. 367-373.

Mizukawa, Yuki and Ge, Jian-Feng and Bakar Md, Abu and Itoh, Isamu and Scheurer, Christian and Wittlin, Sergio and Brun, Reto and Matsuoka, Hiroyuki and Ihara, Masataka. (2014) Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorganic & medicinal chemistry, 22 (14). pp. 3749-3752.

Yang, Sihyung and Wenzler, Tanja and Miller, Patrik N. and Wu, Huali and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2014) Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 7. pp. 4064-4074.

Tatipaka, Hari Babu and Gillespie, J. Robert and Chatterjee, Arnab K. and Norcross, Neil R. and Hulverson, Matthew A. and Ranade, Ranae M. and Nagendar, Pendem and Creason, Sharon A. and McQueen, Joshua and Duster, Nicole A. and Nagle, Advait and Supek, Frantisek and Molteni, Valentina and Wenzler, Tanja and Brun, Reto and Glynne, Richard and Buckner, Frederick S. and Gelb, Michael H.. (2014) Substituted 2-phenylimidazopyridines : a new class of drug leads for human African trypanosomiasis. Journal of medicinal chemistry, 57 (3). pp. 828-835.

Liu, Zong-Ying and Wenzler, Tanja and Brun, Reto and Zhu, Xiaohua and Boykin, David W.. (2014) Synthesis and antiparasitic activity of new bis-arylimidamides : DB766 analogs modified in the terminal groups. European journal of medicinal chemistry, 83. pp. 167-173.

Belluti, Federica and Uliassi, Elisa and Veronesi, Giacomo and Bergamini, Christian and Kaiser, Marcel and Brun, Reto and Viola, Angelo and Fato, Romana and Michels, Paul A. M. and Krauth-Siegel, R. Luise and Cavalli, Andrea and Bolognesi, Maria Laura. (2014) Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem : chemistry enabling drug discovery, Vol. 9, H. 2. pp. 371-382.

Nwodo, Ngozi Justina and Okoye, Festus Basden C. and Lai, Daowan and Debbab, Abdessamad and Brun, Reto and Proksch, Peter. (2014) Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae). Molecules, Vol. 19, H. 5. pp. 5470-5477.

2013

Endeshaw, Molla and Zhu, Xiaohua and He, Shanshan and Pandharkar, Trupti and Cason, Emily and Mahasenan, Kiran V. and Agarwal, Hitesh and Li, Chenglong and Munde, Manoj and Wilson, W. David and Bahar, Mark and Doskotch, Raymond W. and Kinghorn, A. Douglas and Kaiser, Marcel and Brun, Reto and Drew, Mark E. and Werbovetz, Karl A.. (2013) 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of natural products, Vol. 76, H. 3. pp. 311-315.

Lödige, Melanie and Lewis, Matthew D. and Paulsen, Eleonora S. and Esch, Harald L. and Pradel, Gabriele and Lehmann, Leane and Brun, Reto and Bringmann, Gerhard and Mueller, Ann-Kristin. (2013) A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. International journal of medical microbiology, Vol. 303, H. 8. pp. 539-547.

Ebrahimi, Samad N. and Zimmermann, Stefanie and Zaugg, Janine and Smiesko, Martin and Brun, Reto and Hamburger, Matthias. (2013) Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations. Planta medica, Vol. 79, H. 2. pp. 150-156.

da Silva, Cristiane Franca and Batista, Denise da Gama Jaen and Siciliano, Julianna Araujo and Batista, Marcos Meuser and Lionel, Jessica and de Souza, Elen Mello and Hammer, Erica Ripoll and da Silva, Patricia Bernardino and De Mieri, Maria and Adams, Michael and Zimmermann, Stefanie and Hamburger, Matthias and Brun, Reto and Schühly, Wolfgang and de Nazare, Maria Correia Soeiro. (2013) Activities of psilostachyin A and cynaropicrin against trypanosoma cruzi in vitro and in vivo. Antimicrobial Agents and Chemotherapy, 57 (11). pp. 5307-5314.

Malebo, Hamisi M. and Wenzler, Tanja and Cal, Monical and Swaleh, Sauda M. and Hassanali, Ahmed and Sequin, Urs and Machocho, Alex K and Haeussinger, Daniel and Dalsgaard, Petur and Omolo, Maurice O. and Hamburger, Matthias and Brun, Reto and Ndiege, Isaiah O.. (2013) Anti-protozoal and structure-activity relationships of chemical constituents of Acridocarpus chloropterus Oliver (Malpighiaceae) from Tanzania. International Journal of Natural Products Research, 3 (4). pp. 74-81.

Hata, Yoshie and Raith, Melanie and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2013) Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, 79 (6). pp. 492-498.

Faist, Johanna and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2013) Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 21 (17). pp. 4988-4996.

Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475.

Moradi-Afrapoli, Fahimeh and Ebrahimi, Samad Nejad and Smiesko, Martin and Raith, Melanie and Zimmermann, Stefanie and Nadjafi, Farsad and Brun, Reto and Hamburger, Matthias. (2013) Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD. Phytochemistry, Vol. 85. pp. 143-152.

Zimmermann, Stefanie and Oufir, Mouhssin and Leroux, Alejandro and Krauth-Siegel, R. Luise and Becker, Katja and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2013) Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei. Bioorganic & Medicinal Chemistry, 21 (22). pp. 7202-7209.

Belluti, Federica and Perozzo, Remo and Lauciello, Leonardo and Colizzi, Francesco and Kostrewa, Dirk and Bisi, Alessandra and Gobbi, Silvia and Rampa, Angela and Bolognesi, Maria Laura and Recanatini, Maurizio and Brun, Reto and Scapozza, Leonardo and Cavalli, Andrea. (2013) Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). Journal of medicinal chemistry, 56 (19). pp. 7516-7526.

Munigunti, Ranjith and Becker, Katja and Brun, Reto and Calderón, Angela I.. (2013) Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, Vol. 8, H. 8. pp. 1135-1136.

Harel, Dipak and Schepmann, Dirk and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Enantioselective synthesis of encecaline-derived potent antimalarial agents. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 11, H. 42. pp. 7342-7349.

Bringmann, Gerhard and Zhang, Guoliang and Olschläger, Tobias and Stich, August and Wu, Jun and Chatterjee, Manik and Brun, Reto. (2013) Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry : an international journal of plant biochemistry, Vol. 91. pp. 220-228.

Schleiferböck, Sarah and Scheurer, Christian and Ihara, Masataka and Itoh, Isamu and Bathurst, Ian and Burrows, Jeremy N. and Fantauzzi, Pascal and Lotharius, Julie and Charman, Susan A. and Morizzi, Julia and Shackleford, David M. and White, Karen L. and Brun, Reto and Wittlin, Sergio. (2013) In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug design, development and therapy, Vol. 7. pp. 1377-1384.

Abiodun, Oyindamola O. and Brun, Reto and Wittlin, Sergio. (2013) In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Malaria journal, Vol. 12 , 43.

Bringmann, Gerhard and Lombe, Blaise Kimbadi and Steinert, Claudia and Ioset, Karine Ndjoko and Brun, Reto and Turini, Florian and Heubl, Günther and Mudogo, Virima. (2013) Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese ancistrocladus species. Organic letters, Vol. 15, H. 11. pp. 2590-2593.

Pieretti, Simone and Haanstra, Jurgen R. and Mazet, Muriel and Perozzo, Remo and Bergamini, Christian and Prati, Federica and Fato, Romana and Lenaz, Giorgio and Capranico, Giovanni and Brun, Reto and Bakker, Barbara M. and Michels, Paul A. M. and Scapozza, Leonardo and Bolognesi, Maria Laura and Cavalli, Andrea. (2013) Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS neglected tropical diseases, Vol. 7 , e2012.

Harel, Dipak and Schepmann, Dirk and Prinz, Helge and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Natural product derived antiprotozoal agents : synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. Journal of medicinal chemistry, 56 (18). pp. 7442-7448.

Hwang, Jong Yeon and Smithson, David C. and Holbrook, Gloria and Zhu, Fangyi and Connelly, Michele C. and Kaiser, Marcel and Brun, Reto and Kiplin Guy, R.. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 14. pp. 4127-4131.

Wenzler, Tanja and Yang, Sihyung and Braissant, Olivier and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2013) Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 57, H. 11. pp. 5330-5343.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Liu, Qiang and Mutuku, James N. and Chen, Yao and Bridges, Arlene S. and Mdachi, Raymond E. and Ismail, Mohamed A. and Ching, Shelley and Boykin, David W. and Hall, James Edwin and Tidwell, Richard R. and Paine, Mary F. and Brun, Reto and Wang, Michael Zhuo. (2013) Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 7, H. 6 , e2230.

von Bargen, Katharina Walburga and Niehaus, Eva-Maria and Bergander, Klaus and Brun, Reto and Tudzynski, Bettina and Humpf, Hans-Ulrich. (2013) Structure elucidation and antimalarial activity of apicidin F : an apicidin-like compound produced by Fusarium fujikuroi. Journal of natural products, Vol. 76, H. 11. pp. 2136-2140.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Jones, Susan Kilgore and Wenzler, Tanja and Barszcz, Todd and Kumar, Arvind and Boykin, David W. and Werbovetz, Karl A. and Brun, Reto and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 67. pp. 310-324.

Hu, Laixing and Patel, Alpa and Bondada, Lavanya and Yang, Sihyung and Wang, Michael Zhuo and Munde, Manoj and Wilson, W. David and Wenzler, Tanja and Brun, Reto and Boykin, David W.. (2013) Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 21 (21). pp. 6732-6741.

Patrick, Donald A. and Ismail, Mohamed A. and Arafa, Reem K. and Wenzler, Tanja and Zhu, Xiaohua and Pandharkar, Trupti and Jones, Susan Kilgore and Werbovetz, Karl A. and Brun, Reto and Boykin, David W. and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 56 (13). pp. 5473-5494.

2011

Mokoka, Tsholofelo A. and Zimmermann, Stefanie and Julianti, Tasqiah and Hata, Yoshie and Moodley, Nivan and Cal, Monica and Adams, Michael and Kaiser, Marcel and Brun, Reto and Koorbanally, Neil and Hamburger, Matthias. (2011) In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta medica, Vol. 77, H. 14. pp. 1663-1667.

Baschong, Werner and Wittlin, Sergio and Inglis, Kirstine A. and Fairlamb, Alan H. and Croft, Simon L. and Kumar, T. R. Santha and Fidock, David A. and Brun, Reto. (2011) Triclosan is minimally effective in rodent malaria models. Nature medicine, Vol. 17. pp. 33-34.

2010

Orhan, Ilkay and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2010) Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Marine drugs, Vol. 8, H. 1. pp. 47-58.

Link, Andreas and Heidler, Philipp and Kaiser, Marcel and Brun, Reto. (2010) Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites. Molecular Diversity, 14 (2). pp. 215-224.

2009

Adams, Michael and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2009) A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites. Natural Product Communications, 4 (10). pp. 1377-1381.

Nyongbela, Kennedy and Ndjoko, Karine Ioset and Brun, Reto and Wittlin, Sergio and Mbah, James and Makolo, Felix and Akam, Marc and Wirmum, Claire and Efange, Simon and Hostettmann, Kurt. (2009) Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae). Natural product communications : NPC, Vol. 4, H. 1. pp. 5-8.

2007

Maina, Naomi and Maina, Kagira Joseph and Mäser, Pascal and Brun, Reto. (2007) Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine, 104 (2-3). pp. 84-90.

Bernhard, Sonja C. and Nerima, Barbara and Mäser, Pascal and Brun, Reto. (2007) Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, Vol. 37, H. 13. pp. 1443-1448.

2006

Brun, Reto and Balmer, Oliver. (2006) New developments in human African trypanosomiasis. Current opinion in infectious diseases, Vol. 19, H. 5. pp. 415-420.

2002

Mäser, Pascal and Grether-Bühler, Yvonne and Kaminsky, Ronald and Brun, Reto. (2002) An anti-contamination cocktail for the in vitro isolation and cultivation of parasitic protozoa. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 88, H. 2. pp. 172-174.

This list was generated on Sat Sep 19 12:24:02 2020 CEST.