Items where contributor is "Maier, Timm"

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Rabbani, Said and Fiege, Brigitte and Eris, Deniz and Silbermann, Marleen and Jakob, Roman Peter and Navarra, Giulio and Maier, Timm and Ernst, Beat. (2018) Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain - Engineering a Minimalistic Allosteric System. Journal of Biological Chemistry, 293 (5). pp. 1835-1849.

Sager, Christoph P. and Fiege, Brigitte and Zihlmann, Pascal and Vannam, Raghu and Rabbani, Said and Jakob, Roman P. and Preston, Roland C. and Zalewski, Adam and Maier, Timm and Peczuh, Mark W. and Ernst, Beat. (2018) The price of flexibility - a case study on septanoses as pyranose mimetics. Chemical Science, 9. pp. 646-654.


Roth, Christian and Weizenmann, Nicole and Bexten, Nicola and Saenger, Wolfram and Zimmermann, Wolfgang and Maier, Timm and Sträter, Norbert. (2017) Amylose recognition and ring-size determination of amylomaltase. Science Advances, 3 (1). e1601386.

Navarra, Giulio and Zihlmann, Pascal and Jakob, Roman P. and Stangier, Katia and Preston, Roland C. and Rabbani, Said and Smiesko, Martin and Wagner, Bea and Maier, Timm and Ernst, Beat. (2017) Carbohydrate-Lectin Interactions - An Unexpected Contribution to Affinity. ChemBioChem, 18 (6). pp. 539-544.

Storm, Philip A. and Herbst, Dominik A. and Maier, Timm and Townsend, Craig A.. (2017) Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chemical Biology, 24 (3). pp. 316-325.

Stuttfeld, Edward and Imseng, Stefan and Maier, Timm. (2017) A central role for a region in the middle. eLife, 6. e25700.

Maier, Timm. (2017) Fatty acid synthases: Re-engineering biofactories. Nature Chemical Biology, 13 (4). pp. 344-345.

Wang, Jing and Brackmann, Maximilian and Castaño-Díez, Daniel and Kudryashev, Mikhail and Goldie, Kenneth N. and Maier, Timm and Stahlberg, Henning and Basler, Marek. (2017) Cryo-EM structure of the extended type VI secretion system sheath-tube complex. Nature Microbiology.

Benning, Friederike M. C. and Sakiyama, Yusuke and Mazur, Adam and Bukhari, Habib S. T. and Lim, Roderick Y. H. and Maier, Timm. (2017) High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase. ACS Nano, 11 (11). pp. 10852-10859.


Silván, Unai and Hyotyla, Janne and Mannherz, Hans-Georg and Ringler, Philippe and Müller, Shirley A. and Aebi, Ueli and Maier, Timm and Schoenenberger, Cora-Ann. (2016) Contributions of the lower dimer to supramolecular actin patterning revealed by TIRF microscopy. Journal of structural biology, 195 (2). pp. 159-166.

Herbst, Dominik A. and Jakob, Roman P. and Zähringer, Franziska and Maier, Timm. (2016) Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. Nature, 531 (7595). pp. 533-537.

Preston, Roland C. and Jakob, Roman P. and Binder, Florian P. C. and Sager, Christoph P. and Ernst, Beat and Maier, Timm. (2016) E-selectin ligand complexes adopt an extended high-affinity conformation. Journal of Molecular Cell Biology, 8 (1). pp. 62-72.

Aylett, Christopher H. S. and Sauer, Evelyn and Imseng, Stefan and Boehringer, Daniel and Hall, Michael N. and Ban, Nenad and Maier, Timm. (2016) Architecture of human mTOR complex 1. Science, 351 (6268). pp. 48-52.

Sauer, Maximilian M. and Jakob, Roman P. and Eras, Jonathan and Baday, Sefer and Eris, Deniz and Navarra, Giulio and Bernèche, Simon and Ernst, Beat and Maier, Timm and Glockshuber, Rudi. (2016) Catch-bond mechanism of the bacterial adhesin FimH. Nature communications, 7. p. 10738.

Hunkeler, Moritz and Stuttfeld, Edward and Hagmann, Anna and Imseng, Stefan and Maier, Timm. (2016) The dynamic organization of fungal acetyl-CoA carboxylase. Nature Communications, 7. p. 11196.

Jakob, Roman P. and Schmidpeter, Philipp A. M. and Koch, Johanna R. and Schmid, Franz X. and Maier, Timm. (2016) Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. PLoS One, 11 (6). e0157070.

Hagmann, Anna and Hunkeler, Moritz and Stuttfeld, Edward and Maier, Timm. (2016) Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans. Structure, 24 (8). pp. 1227-1236.


Blatter, Markus and Dunin-Horkawicz, Stanislaw and Grishina, Inna and Maris, Christophe and Thore, Stephane and Maier, Timm and Bindereif, Albrecht and Bujnicki, Janusz M. and Allain, Frédéric H.-T.. (2015) The signature of the five-stranded vRRM fold defined by functional, structural and computational analysis of the hnRNP L protein. Journal of molecular biology, 427 (19). pp. 3001-3022.

Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239.

Kudryashev, Mikhail and Wang, Ray Yu-Ruei and Brackmann, Maximilian and Scherer, Sebastian and Maier, Timm and Baker, David and DiMaio, Frank and Stahlberg, Henning and Egelman, Edward H. and Basler, Marek. (2015) Structure of the Type VI Secretion System Contractile Sheath. Cell, Vol. 160, H. 5. pp. 952-962.

Jakob, Roman P. and Koch, Johanna R. and Burmann, Björn M. and Schmidpeter, Philipp A. M. and Hunkeler, Moritz and Hiller, Sebastian and Schmid, Franz X. and Maier, Timm. (2015) Dimeric structure of the bacterial extracellular foldase PrsA. Journal of Biological Chemistry, 290 (6). pp. 3278-3292.

Morgado, Leonor and Zeth, Kornelius and Burmann, Björn M. and Maier, Timm and Hiller, Sebastian . (2015) Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. Journal of biomolecular NMR, Vol. 61, H. 3-4. pp. 333-345.

Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246.

Maier, Timm and Clantin, Bernard and Gruss, Fabian and Dewitte, Frédérique and Delattre, Anne-Sophie and Jacob-Dubuisson, Françoise and Hiller, Sebastian and Villeret, Vincent. (2015) Conserved Omp85 lid-lock structure and substrate recognition in FhaC. Nature Communications, 6. p. 7452.

Fujieda, Nobutaka and Schätti, Jonas and Stuttfeld, Edward and Ohkubo, Kei and Maier, Timm and Fukuzumi, Shunichi and Ward, Thomas R.. (2015) Enzyme repurposing of a hydrolase as an emergent peroxidase upon metal binding. Chemical Science, 6 (7). pp. 4060-4065.

Arquint, Christian and Gabryjonczyk, Anna-Maria and Imseng, Stefan and Böhm, Raphael and Sauer, Evelyn and Hiller, Sebastian and Nigg, Erich A. and Maier, Timm. (2015) STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. eLife, 4. e07888.


Bukhari, Habib S. T. and Jakob, Roman P. and Maier, Timm. (2014) Evolutionary origins of the multienzyme architecture of giant fungal Fatty Acid synthase. Structure, Vol. 22, H. 12. pp. 1775-1785.


Gruss, Fabian and Zähringer, Franziska and Jakob, Roman P. and Burmann, Björn M. and Hiller, Sebastian and Maier, Timm. (2013) The structural basis of autotransporter translocation by TamA. Nature structural & molecular biology, Vol. 20, no. 11. pp. 1318-1320.


Mocibob, M. and Ivic, N. and Bilokapic, S. and Maier, T. and Luic, M. and Ban, N. and Weygand-Durasevic, I.. (2010) New links between protein biosynthesis and nonribosomal peptide synthesis. The FEBS journal, Vol. 277. pp. 260-261.

Mocibob, Marko and Ivic, Nives and Bilokapic, Silvija and Maier, Timm and Luic, Marija and Ban, Nenad and Weygand-Durasevic, Ivana. (2010) Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis. Proceedings of the National Academy of Sciences of the United States of America, 107 (33). pp. 14585-14590.

Maier, T. and Leibundgut, M. and Boehringer, D. and Ban, N.. (2010) Structure and function of eukaryotic fatty acid synthases. Quarterly Reviews of Biophysics, 43 (3). pp. 373-422.


Mueller, M. and Grauschopf, U. and Maier, T. and Glockshuber, R. and Ban, N.. (2009) The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature, 459 (7247). pp. 726-730.


Bingel-Erlenmeyer, R. and Kohler, R. and Kramer, G. and Sandikci, A. and Antolic, S. and Maier, T. and Schaffitzel, C. and Wiedmann, B. and Bukau, B. and Ban, N.. (2008) A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature, 452 (7183). 108-U13.

Leibundgut, M. and Maier, T. and Jenni, S. and Ban, N.. (2008) The multienzyme architecture of eukaryotic fatty acid synthases. Current Opinion in Structural Biology, 18 (6). pp. 714-725.

Maier, T. and Leibundgut, M. and Ban, N.. (2008) The crystal structure of a mammalian fatty acid synthase. Science, 321 (5894). pp. 1315-1322.

Merz, F. and Boehringer, D. and Schaffitzel, C. and Preissler, S. and Hoffmann, A. and Maier, T. and Rutkowska, A. and Lozza, J. and Ban, N. and Bukau, B. and Deuerling, E.. (2008) Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. The EMBO Journal, 27 (11). pp. 1622-1632.

Rossmann, M. and Schultz-Heienbrok, R. and Behlke, J. and Remmel, N. and Alings, C. and Sandhoff, K. and Saenger, W. and Maier, T.. (2008) Crystal structures of human saposins C and D: Implications for lipid recognition and membrane interactions. Structure, 16 (5). pp. 809-817.


Schultz-Heienbrok, Robert and Remmel, Natascha and Klingenstein, R. and Rossocha, Maksim and Sandhoff, Konrad and Saenger, Wolfram and Maier, Timm. (2006) Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris. Acta Crystallographica Section F, 62 (2). pp. 117-120.

Bilokapic, S. and Maier, T. and Ahel, D. and Gruic-Sovulj, I. and Soll, D. and Weygand-Durasevic, I. and Ban, N.. (2006) Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition. The EMBO Journal, 25 (11). pp. 2498-2509.

Jenni, S. and Leibundgut, M. and Maier, T. and Ban, N.. (2006) Architecture of a fungal fatty acid synthase at 5 angstrom resolution. Science, 311 (5765). pp. 1263-1267.

Maier, T. and Jenni, S. and Ban, N.. (2006) Architecture of mammalian fatty acid synthase at 4.5 angstrom resolution. Science, 311 (5765). pp. 1258-1262.

Wendeler, M. and Werth, N. and Maier, T. and Schwarzmann, G. and Kolter, T. and Schoeniger, M. and Hoffmann, D. and Lemm, T. and Saenger, W. and Sandhoff, K.. (2006) The enzyme-binding region of human GM2-activator protein. FEBS Journal, 273 (5). pp. 982-991.


Ferbitz, L. and Maier, T. and Patzelt, H. and Bukau, B. and Ban, N. and Deuerling, E.. (2005) Cytosolic proteins at birth: The chaperone trigger factor forms a molecular cradle for newborn proteins. Cell Structure And Function, 30. p. 9.

Maier, T. and Ferbitz, L. and Deuerling, E. and Ban, N.. (2005) A cradle for new proteins: trigger factor at the ribosorne. Current Opinion in Structural Biology, 15 (2). pp. 204-212.

Schultz-Heienbrok, R. and Maier, T. and Strater, N.. (2005) A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5 `-nucleotidase. Biochemistry, 44 (7). pp. 2244-2252.

Maier, T. and Przylas, I. and Strater, N. and Herdewijn, P. and Saenger, W.. (2005) Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. Journal of the American Chemical Society, 127 (9). pp. 2937-2943.


Ferbitz, L. and Maier, Timm and Patzelt, H. and Bukau, B. and Deuerling, E. and Ban, N.. (2004) Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Nature, 431 (7008). pp. 590-596.

Schultz-Heienbrok, R. and Maier, Timm and Strater, N.. (2004) Trapping a 96 degrees domain rotation in two distinct conformations by engineered disulfide bridges. Protein Science, 13 (7). pp. 1811-1822.


Lodge, Jacinta A. and Maier, Timm and Liebl, Wolfgang and Hoffmann, Volker and Sträter, Norbert. (2003) Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases. Journal of Biological Chemistry, 278 (21). pp. 19151-19158.

Maier, T. and Strater, N. and Schuette, C. G. and Klingenstein, R. and Sandhoff, K. and Saenger, W.. (2003) The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease. Journal of Molecular Biology, 328 (3). pp. 669-681.


Niere, M. and Dettloff, M. and Maier, T. and Ziegler, M. and Wiesner, A.. (2001) Insect immune activation by apolipophorin III is correlated with the lipid-binding properties of this protein. Biochemistry, 40 (38). pp. 11502-11508.


Voelter, W. and Wacker, R. and Franz, M. and Maier, T. and Stoeva, S.. (2000) Complete structural characterization of a chitin-binding lectin from mistletoe extracts. Journal für praktische Chemie, 342 (8). pp. 812-818.


Krauspenhaar, R. and Eschenburg, S. and Perbandt, M. and Kornilov, V. and Konareva, N. and Mikailova, I. and Stoeva, S. and Wacker, R. and Maier, T. and Singh, T. and Mikhailov, A. and Voelter, W. and Betzel, C.. (1999) Crystal structure of mistletoe lectin I from Viscum album. Biochemical and Biophysical Research Communications, 257 (2). pp. 418-424.

Stoeva, S. and Maier, T. and Soler, M. and Voelter, W.. (1999) Carbohydrate Chains and Their Binding Sites in Mistletoe Lectin I. Polish Journal of Chemistry, 73 (1). pp. 125-133.