Leibundgut, M. and Maier, T. and Jenni, S. and Ban, N.. (2008) The multienzyme architecture of eukaryotic fatty acid synthases. Current Opinion in Structural Biology, 18 (6). pp. 714-725.
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Official URL: http://edoc.unibas.ch/45837/
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Abstract
Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic steps essential for fatty acid biosynthesis. Recent crystallographic studies provide new insights into the architecture of the two distinct eukaryotic FAS systems, the 2.6 MDa heterododecameric fungal and the 540 kDa dimeric animal FAS. In this review, we compare the fundamentally different organization of these two megasynthases and discuss the structural principles of enzyme integration and substrate shuttling in FAS multienzymes.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Maier) |
|---|---|
| UniBasel Contributors: | Maier, Timm |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0959-440X |
| e-ISSN: | 1879-033X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 29 Nov 2017 07:22 |
| Deposited On: | 29 Nov 2017 07:22 |
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