The architectures of iterative type I PKS and FAS

Herbst, Dominik A. and Townsend, Craig A. and Maier, Timm. (2018) The architectures of iterative type I PKS and FAS. Natural Product Reports, 35 (10). pp. 1046-1069.

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Covering: up to mid of 2018: Type I fatty acid synthases (FASs) are giant multienzymes catalyzing all steps of the biosynthesis of fatty acids from acetyl- and malonyl-CoA by iterative precursor extension. Two strikingly different architectures of FAS evolved in yeast (as well as in other fungi and some bacteria) and metazoans. Yeast-type FAS (yFAS) assembles into a barrel-shaped structure of more than 2 MDa molecular weight. Catalytic domains of yFAS are embedded in an extensive scaffolding matrix and arranged around two enclosed reaction chambers. Metazoan FAS (mFAS) is a 540 kDa X-shaped dimer,
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Maier)
UniBasel Contributors:Maier, Timm
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:The Royal Society of Chemistry
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Sep 2020 10:45
Deposited On:11 Sep 2020 10:45

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