Herbst, Dominik A. and Townsend, Craig A. and Maier, Timm. (2018) The architectures of iterative type I PKS and FAS. Natural Product Reports, 35 (10). pp. 1046-1069.
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Official URL: https://edoc.unibas.ch/65292/
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Abstract
Covering: up to mid of 2018: Type I fatty acid synthases (FASs) are giant multienzymes catalyzing all steps of the biosynthesis of fatty acids from acetyl- and malonyl-CoA by iterative precursor extension. Two strikingly different architectures of FAS evolved in yeast (as well as in other fungi and some bacteria) and metazoans. Yeast-type FAS (yFAS) assembles into a barrel-shaped structure of more than 2 MDa molecular weight. Catalytic domains of yFAS are embedded in an extensive scaffolding matrix and arranged around two enclosed reaction chambers. Metazoan FAS (mFAS) is a 540 kDa X-shaped dimer,
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Maier) |
|---|---|
| UniBasel Contributors: | Maier, Timm |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | The Royal Society of Chemistry |
| ISSN: | 0265-0568 |
| e-ISSN: | 1460-4752 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 11 Sep 2020 10:45 |
| Deposited On: | 11 Sep 2020 10:45 |
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