# Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid

Maier, T. and Przylas, I. and Strater, N. and Herdewijn, P. and Saenger, W.. (2005) Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. Journal of the American Chemical Society, 127 (9). pp. 2937-2943.

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Official URL: http://edoc.unibas.ch/51407/

The crystal structure of a decameric HNA/RNA (HNA = 2,3-dideoxy-l,5-anhydro-D-arabinohexitol nucleic acid) hybrid with the RNA sequence 5-GGCAUUACGG-3 is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.