Items where Division is "05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Hiller)"

2023

Brüderlin, Mitchell and Böhm, Raphael and Fadel, Firas and Hiller, Sebastian and Schirmer, Tilman and Dubey, Badri N.. (2023) Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs. Nature communications, 14 (1). p. 1002.

Modaresi, Seyedmajed. Biophysical studies of outer membrane proteins for novel applications in antibiotics and cancer. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

Ude, Johanna Viola. Solution NMR studies of J-domain co-chaperones and bacterial outer membrane permeability. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

2022

Agustoni, Elia and Teixeira, Raphael Dias and Huber, Markus and Flister, Susanne and Hiller, Sebastian and Schirmer, Tilman. (2022) Acquisition of enzymatic progress curves in real time by quenching-free ion exchange chromatography. Analytical biochemistry, 639. p. 114523.

Bärland, Natalie. Structural and functional investigation of the essential secondary active transporter LicB from the human pathogen S. pneumoniae. 2022, Doctoral Thesis, University of Basel, Faculty of Science.

Miller, Ryan D. and Iinishi, Akira and Modaresi, Seyed Majed and Yoo, Byung-Kuk and Curtis, Thomas D. and Lariviere, Patrick J. and Liang, Libang and Son, Sangkeun and Nicolau, Samantha and Bargabos, Rachel and Morrissette, Madeleine and Gates, Michael F. and Pitt, Norman and Jakob, Roman P. and Rath, Parthasarathi and Maier, Timm and Malyutin, Andrey G. and Kaiser, Jens T. and Niles, Samantha and Karavas, Blake and Ghiglieri, Meghan and Bowman, Sarah E. J. and Rees, Douglas C. and Hiller, Sebastian and Lewis, Kim. (2022) Computational identification of a systemic antibiotic for gram-negative bacteria. Nature Microbiology, 7 (10). pp. 1661-1672.

Müntener, Thomas and Joss, Daniel and Häussinger, Daniel and Hiller, Sebastian. (2022) Pseudocontact Shifts in Biomolecular NMR Spectroscopy. Chemical Reviews. in press.

Zhang, Lei and Toplak, Marina and Saleem-Batcha, Raspudin and Höing, Lars Simon and Jakob, Roman and Jehmlich, Nico and von Bergen , Martin and Maier, Timm and Teufel, Robin. (2022) Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol. ChemBioChem, 24 (2). e202200632.

2021

Böhm, Raphael and Imseng, Stefan and Jakob, Roman P. and Hall, Michael N. and Maier, Timm and Hiller, Sebastian. (2021) The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Molecular Cell, 81 (11). pp. 2403-2416.e5.

Böhringer, Nils and Green, Robert and Liu, Yang and Mettal, Ute and Marner, Michael and Modaresi, Seyed Majed and Jakob, Roman P. and Wuisan, Zerlina G. and Maier, Timm and Iinishi, Akira and Hiller, Sebastian and Lewis, Kim and Schäberle, Till F.. (2021) Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs. Microbiology spectrum, 9 (3). e0153521.

Gray, Declan A. and White, Joshua B. R. and Oluwole, Abraham O. and Rath, Parthasarathi and Glenwright, Amy J. and Mazur, Adam and Zahn, Michael and Baslé, Arnaud and Morland, Carl and Evans, Sasha L. and Cartmell, Alan and Robinson, Carol V. and Hiller, Sebastian and Ranson, Neil A. and Bolam, David N. and van den Berg, Bert. (2021) Insights into SusCD-mediated glycan import by a prominent gut symbiont. Nature Communications, 12 (1). p. 44.

He, Wei and Yu, Gangjin and Li, Tianpeng and Bai, Ling and Yang, Yuanyuan and Xue, Zixiao and Pang, Yonghao and Reichmann, Dana and Hiller, Sebastian and He, Lichun and Liu, Maili and Quan, Shu. (2021) Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation. mBio, 12 (5). e0213021.

Hiller, Sebastian. (2021) Molecular chaperones and their denaturing effect on client proteins. Journal of Biomolecular NMR, 75 (1). pp. 1-8.

Hiller, Sebastian and Broz, Petr. (2021) Active membrane rupture spurs a range of cell deaths. Nature, 591 (7848). pp. 36-37.

Kaur, Hundeep and Jakob, Roman P. and Marzinek, Jan K. and Green, Robert and Imai, Yu and Bolla, Jani Reddy and Agustoni, Elia and Robinson, Carol V. and Bond, Peter J. and Lewis, Kim and Maier, Timm and Hiller, Sebastian. (2021) The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase. Nature, 593 (7857). pp. 125-129.

Macošek, Jakub and Mas, Guillaume and Hiller, Sebastian. (2021) Redefining Molecular Chaperones as Chaotropes. Frontiers in molecular biosciences, 8. p. 683132.

Pipercevic, Joka. NMR spectroscopy studies to elucidate the role of SPX domains in phosphate homeostasis. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

Pipercevic, Joka and Jakob, Roman P. and Righetto, Ricardo D. and Goldie, Kenneth N. and Stahlberg, Henning and Maier, Timm and Hiller, Sebastian. (2021) Identification of a Dps contamination in Mitomycin-C-induced expression of Colicin Ia. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863 (7). p. 183607.

Pérez-Schindler, Joaquín and Kohl, Bastian and Schneider-Heieck, Konstantin and Leuchtmann, Aurel B. and Henríquez-Olguín, Carlos and Adak, Volkan and Maier, Geraldine and Delezie, Julien and Sakoparnig, Thomas and Vargas-Fernández, Elyzabeth and Karrer-Cardel, Bettina and Ritz, Danilo and Schmidt, Alexander and Hondele, Maria and Jensen, Thomas E. and Hiller, Sebastian and Handschin, Christoph. (2021) RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates. Proceedings of the National Academy of Sciences of the United States of America, 118 (36). e2105951118.

Ried, Martina K. and Wild, Rebekka and Zhu, Jinsheng and Pipercevic, Joka and Sturm, Kristina and Broger, Larissa and Harmel, Robert K. and Abriata, Luciano A. and Hothorn, Ludwig A. and Fiedler, Dorothea and Hiller, Sebastian and Hothorn, Michael. (2021) Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. Nature communications, 12 (1). p. 384.

Ritzmann, Noah and Manioglu, Selen and Hiller, Sebastian and Müller, Daniel J.. (2021) Monitoring the antibiotic darobactin modulating the β-barrel assembly factor BamA. Structure, 30 (March). pp. 1-10.

Shyp, Viktoriya and Dubey, Badri Nath and Böhm, Raphael and Hartl, Johannes and Nesper, Jutta and Vorholt, Julia A. and Hiller, Sebastian and Schirmer, Tilman and Jenal, Urs. (2021) Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus. Nature Microbiology, 6 (1). pp. 59-72.

Ude, Johanna and Tripathi, Vishwachi and Buyck, Julien M. and Söderholm, Sandra and Cunrath, Olivier and Fanous, Joseph and Claudi, Beatrice and Egli, Adrian and Schleberger, Christian and Hiller, Sebastian and Bumann, Dirk. (2021) Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America, 118 (31). e2107644118.

Vavassori, Stefano and Chou, Janet and Faletti, Laura Eva and Haunerdinger, Veronika and Opitz, Lennart and Joset, Pascal and Fraser, Christopher J. and Prader, Seraina and Gao, Xianfei and Schuch, Luise A. and Wagner, Matias and Hoefele, Julia and Maccari, Maria Elena and Zhu, Ying and Elakis, George and Gabbett, Michael T. and Forstner, Maria and Omran, Heymut and Kaiser, Thomas and Kessler, Christina and Olbrich, Heike and Frosk, Patrick and Almutairi, Abduarahman and Platt, Craig D. and Elkins, Megan and Weeks, Sabrina and Rubin, Tamar and Planas, Raquel and Marchetti, Tommaso and Koovely, Danil and Klämbt, Verena and Soliman, Neveen A. and von Hardenberg, Sandra and Klemann, Christian and Baumann, Ulrich and Lenz, Dominic and Klein-Franke, Andreas and Schwemmle, Martin and Huber, Michael and Sturm, Ekkehard and Hartleif, Steffen and Häffner, Karsten and Gimpel, Charlotte and Brotschi, Barbara and Laube, Guido and Güngör, Tayfun and Buckley, Michael F. and Kottke, Raimund and Staufner, Christian and Hildebrandt, Friedhelm and Reu-Hofer, Simone and Moll, Solange and Weber, Achim and Kaur, Hundeep and Ehl, Stephan and Hiller, Sebastian and Geha, Raif and Roscioli, Tony and Griese, Matthias and Pachlopnik Schmid, Jana. (2021) Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency. The Journal of Allergy & Clinical Immunology, 148 (2). pp. 381-393.

2020

Bibow, Stefan and Böhm, Raphael and Modaresi, Seyed Majed and Hiller, Sebastian. (2020) Detergent Titration as an Efficient Method for NMR Resonance Assignments of Membrane Proteins in Lipid-Bilayer Nanodiscs. Analytical Chemistry, 92 (11). pp. 7786-7793.

Burmann, Björn M. and Gerez, Juan A. and Matečko-Burmann, Irena and Campioni, Silvia and Kumari, Pratibha and Ghosh, Dhiman and Mazur, Adam and Aspholm, Emelie E. and Šulskis, Darius and Wawrzyniuk, Magdalena and Bock, Thomas and Schmidt, Alexander and Rüdiger, Stefan G. D. and Riek, Roland and Hiller, Sebastian. (2020) Regulation of α-synuclein by chaperones in mammalian cells. Nature, 577. pp. 127-132.

Böhm, Raphael and Amodeo, Giuseppe Federico and Murlidaran, Sruthi and Chavali, Shashank and Wagner, Gerhard and Winterhalter, Mathias and Brannigan, Grace and Hiller, Sebastian. (2020) The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating. Structure, 28 (2). pp. 206-214.e4.

Dubey, Badri N. and Agustoni, Elia and Böhm, Raphael and Kaczmarczyk, Andreas and Mangia, Francesca and von Arx, Christoph and Jenal, Urs and Hiller, Sebastian and Plaza-Menacho, Iván and Schirmer, Tilman. (2020) Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation. Proceedings of the National Academy of Sciences of the United States of America, 117 (2). pp. 1000-1008.

Kaczmarczyk, Andreas and Hempel, Antje M. and von Arx, Christoph and Böhm, Raphael and Dubey, Badri N. and Nesper, Jutta and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2020) Precise Timing of Transcription by c-di-GMP Coordinates Cell Cycle and Morphogenesis in Caulobacter. Nature Communications, 11 (1). p. 816.

Kaur, Hundeep and Grahl, Anne and Hartmann, Jean-Baptiste and Hiller, Sebastian. (2020) Sample Preparation and Technical Setup for NMR Spectroscopy with Integral Membrane Proteins. Methods in Molecular Biology, 2127. pp. 373-396.

Kohl, Bastian and Brüderlin, Mitchell and Ritz, Danilo and Schmidt, Alexander and Hiller, Sebastian. (2020) Protocol for High-Yield Production of Photo-Leucine-Labeled Proteins in Escherichia coli. Journal of Proteome Research, 19 (8). pp. 3100-3108.

Mas, Guillaume and Burmann, Björn M. and Sharpe, Timothy and Claudi, Beatrice and Bumann, Dirk and Hiller, Sebastian. (2020) Regulation of chaperone function by coupled folding and oligomerization. Science advances, 6 (43). eabc5822.

Müntener, Thomas and Böhm, Raphael and Atz, Kenneth and Häussinger, Daniel and Hiller, Sebastian. (2020) NMR pseudocontact shifts in a symmetric protein homotrimer. Journal of Biomolecular NMR, 74 (8-9). pp. 413-419.

Orton, Henry W. and Stanek, Jan and Schubeis, Tobias and Foucaudeau, Dylan and Ollier, Claire and Draney, Adrian W. and Le Marchand, Tanguy and Cala-De Paepe, Diane and Felli, Isabella C. and Pierattelli, Roberta and Hiller, Sebastian and Bermel, Wolfgang and Pintacuda, Guido. (2020) Protein NMR resonance assignment without spectral analysis: 5D SOlid-State Automated Projection SpectroscopY (SO-APSY). Angewandte Chemie International Edition, 59 (6). pp. 2380-2384.

Rath, Parthasarathi and Sharpe, Timothy and Hiller, Sebastian. (2020) The electrostatic core of the outer membrane protein X from E. coli. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1862 (1). p. 183031.

Zhang, Bing and Liu, Xue and Lambert, Elisabeth and Mas, Guillaume and Hiller, Sebastian and Veening, Jan-Willem and Perez, Camilo. (2020) Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis. Nature Structural and Molecular Biology, 27. pp. 561-569.

2019

He, Lichun and Hiller, Sebastian. (2019) Frustrated Interfaces Facilitate Dynamic Interactions between Native Client Proteins and Holdase Chaperones. Chembiochem : a European journal of chemical biology, 20 (22). pp. 2803-2806.

Hiller, Sebastian. (2019) Chaperone-Bound Clients: The Importance of Being Dynamic. Trends in Biochemical Sciences, 44 (6). pp. 517-527.

Imai, Yu and Meyer, Kirsten J. and Iinishi, Akira and Favre-Godal, Quentin and Green, Robert and Manuse, Sylvie and Caboni, Mariaelena and Mori, Miho and Niles, Samantha and Ghiglieri, Meghan and Honrao, Chandrashekhar and Ma, Xiaoyu and Guo, Jason J. and Makriyannis, Alexandros and Linares-Otoya, Luis and Böhringer, Nils and Wuisan, Zerlina G. and Kaur, Hundeep and Wu, Runrun and Mateus, André and Typas, Athanasios and Savitski, Mikhail M. and Espinoza, Josh L. and O'Rourke, Aubrie and Nelson, Karen E. and Hiller, Sebastian and Noinaj, Nicholas and Schäberle, Till F. and D'Onofrio, Anthony and Lewis, Kim. (2019) A new antibiotic selectively kills Gram-negative pathogens. Nature, 576 (7787). pp. 459-464.

Kaur, Hundeep and Hartmann, Jean-Baptiste and Jakob, Roman P. and Zahn, Michael and Zimmermann, Iwan and Maier, Timm and Seeger, Markus A. and Hiller, Sebastian. (2019) Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. Journal of Biomolecular NMR, 73. pp. 375-384.

Luther, Anatol and Urfer, Matthias and Zahn, Michael and Müller, Maik and Wang, Shuang-Yan and Mondal, Milon and Vitale, Alessandra and Hartmann, Jean-Baptiste and Sharpe, Timothy and Monte, Fabio Lo and Kocherla, Harsha and Cline, Elizabeth and Pessi, Gabriella and Rath, Parthasarathi and Modaresi, Seyed Majed and Chiquet, Petra and Stiegeler, Sarah and Verbree, Carolin and Remus, Tobias and Schmitt, Michel and Kolopp, Caroline and Westwood, Marie-Anne and Desjonquères, Nicolas and Brabet, Emile and Hell, Sophie and LePoupon, Karen and Vermeulen, Annie and Jaisson, Régis and Rithié, Virginie and Upert, Grégory and Lederer, Alexander and Zbinden, Peter and Wach, Achim and Moehle, Kerstin and Zerbe, Katja and Locher, Hans H. and Bernardini, Francesca and Dale, Glenn E. and Eberl, Leo and Wollscheid, Bernd and Hiller, Sebastian and Robinson, John A. and Obrecht, Daniel. (2019) Chimeric peptidomimetic antibiotics against Gram-negative bacteria. Nature, 576 (7787). pp. 452-458.

Mas, Guillaume and Thoma, Johannes and Hiller, Sebastian. (2019) The Periplasmic Chaperones Skp and SurA. In: Bacterial Cell Walls and Membranes, 92. Cham, pp. 169-186.

Mazur, Adam and Broz, Petr and Hiller, Sebastian. (2019) An integrative protocol for the structure determination of the mouse ASC-PYD filament. In: Methods in Enzymology, 625. New York, pp. 205-222.

Rath, Parthasarathi and Sharpe, Timothy and Kohl, Bastian and Hiller, Sebastian. (2019) Two-state folding of the outer membrane protein X into a lipid bilayer membrane. Angewandte Chemie International Edition, 58 (9). pp. 2665-2669.

January 2018

Melo, Esther and Oertle, Philipp and Trepp, Carolyn and Meistermann, Hélène and Burgoyne, Thomas and Sborgi, Lorenzo and Cabrera, Alvaro Cortes and Chen, Chia-Yi and Hoflack, Jean-Christophe and Kam-Thong, Tony and Schmucki, Roland and Badi, Laura and Flint, Nicholas and Ghiani, Zeynep Eren and Delobel, Fréderic and Stucki, Corinne and Gromo, Giulia and Einhaus, Alfred and Hornsperger, Benoit and Golling, Sabrina and Siebourg-Polster, Juliane and Gerber, Francoise and Bohrmann, Bernd and Futter, Clare and Dunkley, Tom and Hiller, Sebastian and Schilling, Oliver and Enzmann, Volker and Fauser, Sascha and Plodinec, Marija and Iacone, Roberto. (2018) HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine, 27. pp. 258-274.

2018

Bibow, Stefan and Hiller, Sebastian. (2018) A guide to quantifying membrane protein dynamics in lipids and other native-like environments by solution-state NMR spectroscopy. FEBS Journal. pp. 1610-1623.

Frey, Lukas and Hiller, Sebastian and Riek, Roland and Bibow, Stefan. (2018) Lipid- and Cholesterol-Mediated Time-Scale-Specific Modulation of the Outer Membrane Protein X Dynamics in Lipid Bilayers. Journal of the American Chemical Society, 140 (45). pp. 15402-15411.

Hartmann, Jean-Baptiste. NMR studies of the BamA complex proteins at high resolution. 2018, Doctoral Thesis, University of Basel, Faculty of Science.

Hartmann, Jean-Baptiste and Zahn, Michael and Burmann, Irena Matecko and Bibow, Stefan and Hiller, Sebastian. (2018) Sequence-Specific Solution NMR Assignments of the beta-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level. Journal of the American Chemical Society, 140 (36). pp. 11252-11260.

He, Lichun and Hiller, Sebastian. (2018) Common Patterns in Chaperone Interactions with a Native Client Protein. Angewandte Chemie International Edition, 57 (20). pp. 5921-5924.

Heilig, Rosalie and Dick, Mathias S. and Sborgi, Lorenzo and Meunier, Etienne and Hiller, Sebastian and Broz, Petr. (2018) The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice. European journal of immunology, 48 (4). pp. 584-592.

Hiller, Sebastian and Burmann, Björn M.. (2018) Chaperone-client complexes: A dynamic liaison. Journal of Magnetic Resonance, 289. pp. 142-155.

Mas, Guillaume and Hiller, Sebastian. (2018) Conformational plasticity of molecular chaperones involved in periplasmic and outer membrane protein folding. FEMS Microbiology Letters, 365 (13). fny121.

Mulvihill, Estefania and Sborgi, Lorenzo and Mari, Stefania A. and Pfreundschuh, Moritz and Hiller, Sebastian and Müller, Daniel J.. (2018) Mechanism of membrane pore formation by human gasdermin-D. The EMBO journal, 37 (14). e98321.

Rühl, Sebastian. Effector mechanisms of non-canonical inflammasome activation. 2018, Doctoral Thesis, University of Basel, Faculty of Science.

Sborgi, Lorenzo and Ude, Johanna and Dick, Mathias S. and Vesin, Johnathan and Chambon, Marc and Turcatti, Gerardo and Broz, Petr and Hiller, Sebastian. (2018) Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament. Cell Stress, 2 (4). pp. 82-90.

2017

Böhm, Raphael and Wagner, Gerhard and Hiller, Sebastian. (2017) Solution Nuclear Magnetic Resonance Spectroscopy of Integral Membrane Proteins. In: Reference module in Life Sciences. New York, pp. 1-25.

Frey, Lukas and Lakomek, Nils-Alexander and Riek, Roland and Bibow, Stefan. (2017) Micelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics. Angewandte Chemie International Edition, 56 (1). pp. 380-383.

Holdbrook, Daniel A. and Burmann, Björn M. and Huber, Roland G. and Petoukhov, Maxim V. and Svergun, Dmitri I. and Hiller, Sebastian and Bond, Peter J.. (2017) A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone. Structure, 25 (7). pp. 1079-1088.e3.

Lakomek, Nils-Alexander and Frey, Lukas and Bibow, Stefan and Böckmann, Anja and Riek, Roland and Meier, Beat H.. (2017) Proton-Detected NMR Spectroscopy of Nanodisc-Embedded Membrane Proteins: MAS Solid-State vs Solution-State Methods. Journal of Physical Chemistry B, 121 (32). pp. 7671-7680.

Morgado, Leonor and Burmann, Björn M. and Sharpe, Timothy and Mazur, Adam and Hiller, Sebastian. (2017) The dynamic dimer structure of the chaperone Trigger Factor. Nature Communications, 8. p. 1992.

Thoma, Johannes and Ritzmann, Noah and Wolf, Dominik and Mulvihill, Estefania and Hiller, Sebastian and Müller, Daniel J.. (2017) Maltoporin LamB Unfolds β Hairpins along Mechanical Stress-Dependent Unfolding Pathways. Structure, 25 (7). pp. 1139-1144.e2.

15 August 2016

Sborgi, Lorenzo and Rühl, Sebastian and Mulvihill, Estefania and Pipercevic, Joka and Heilig, Rosalie and Stahlberg, Henning and Farady, Christopher J. and Müller, Daniel J. and Broz, Petr and Hiller, Sebastian. (2016) GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. The EMBO Journal, 35 (16). pp. 1766-1778.

10 May 2016

Raschle, Thomas and Rios Flores, Perla and Opitz, Christian and Müller, Daniel J. and Hiller, Sebastian. (2016) Monitoring Backbone Hydrogen-Bond Formation in β-Barrel Membrane Protein Folding. Angewandte Chemie. International edition in English, 55 (20). pp. 5952-5955.

2016

Aragão Correia, Hugo. Structural studies of toxins and toxin-like proteins. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

Dick, Mathias S. and Sborgi, Lorenzo and Rühl, Sebastian and Hiller, Sebastian and Broz, Petr. (2016) ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nature Communications, 7. p. 11929.

He, Lichun and Sharpe, Timothy and Mazur, Adam and Hiller, Sebastian. (2016) A molecular mechanism of chaperone–client recognition. Science Advances, 2 (11). e1601625.

Ravotti, Francesco and Sborgi, Lorenzo and Cadalbert, Riccardo and Huber, Matthias and Mazur, Adam and Broz, Petr and Hiller, Sebastian and Meier, Beat H. and Böckmann, Anja. (2016) Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form. Biomolecular NMR Assignments, 10 (1). pp. 107-115.

Stanger, Frédéric V. and Burmann, Björn M. and Harms, Alexander and Aragão, Hugo and Mazur, Adam and Sharpe, Timothy and Dehio, Christoph and Hiller, Sebastian and Schirmer, Tilman. (2016) Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). E529-E537.

Vögeli, Beat and Bibow, Stefan and Chi, Celestine N.. (2016) Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop. Angewandte Chemie International Edition, 55 (9). pp. 3096-3100.

Zelenay, Viviane and Arzt, Michael E. and Bibow, Stefan and Schwab, Martin E. and Riek, Roland. (2016) The Neurite Outgrowth Inhibitory Nogo-A-Δ20 Region Is an Intrinsically Disordered Segment Harbouring Three Stretches with Helical Propensity. Plos one, 11 (9). e0161813.

Zhong, Franklin L. and Mamaï, Ons and Sborgi, Lorenzo and Boussofara, Lobna and Hopkins, Richard and Robinson, Kim and Szeverényi, Ildikó and Takeichi, Takuya and Balaji, Reshmaa and Lau, Aristotle and Tye, Hazel and Roy, Keya and Bonnard, Carine and Ahl, Patricia J. and Jones, Leigh Ann and Baker, Paul and Lacina, Lukas and Otsuka, Atsushi and Fournie, Pierre R. and Malecaze, François and Lane, E. Birgitte and Akiyama, Masashi and Kabashima, Kenji and Connolly, John E. and Masters, Seth L. and Soler, Vincent J. and Omar, Salma Samir and McGrath, John A. and Nedelcu, Roxana and Gribaa, Moez and Denguezli, Mohamed and Saad, Ali and Hiller, Sebastian and Reversade, Bruno. (2016) Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation. Cell, 167 (1). pp. 187-202.e17.

27 October 2015

Sborgi, Lorenzo and Ravotti, Francesco and Dandey, Venkata Prasad and Dick, Mathias S. and Mazur, Adam and Reckel, Sina and Chami, Mohamed and Scherer, Sebastian and Huber, Matthias and Böckmann, Anja and Egelman, Edward H. and Stahlberg, Henning and Broz, Petr and Meier, Beat H. and Hiller, Sebastian. (2015) Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proceedings of the National Academy of Sciences of the United States of America, 112 (43). pp. 13237-13242.

October 2015

Thoma, Johannes and Burmann, Björn M. and Hiller, Sebastian and Müller, Daniel J.. (2015) Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins. Nature structural & molecular biology, 22 (10). pp. 795-802.

April 2015

Burmann, Björn M. and Hiller, Sebastian. (2015) Chaperones and chaperone-substrate complexes: dynamic playgrounds for NMR spectroscopists. Progress in Nuclear Magnetic Resonance Spectroscopy, 86/87. pp. 41-64.

2015

Arquint, Christian and Gabryjonczyk, Anna-Maria and Imseng, Stefan and Böhm, Raphael and Sauer, Evelyn and Hiller, Sebastian and Nigg, Erich A. and Maier, Timm. (2015) STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. eLife, 4. e07888.

Brahimi-Horn, M. Christiane and Lacas-Gervais, Sandra and Adaixo, Ricardo and Ilc, Karine and Rouleau, Matthieu and Notte, Annick and Dieu, Marc and Michiels, Carine and Voeltzel, Thibault and Maguer-Satta, Véronique and Pelletier, Joffrey and Ilie, Marius and Hofman, Paul and Manoury, Bénédicte and Schmidt, Alexander and Hiller, Sebastian and Pouysségur, Jacques and Mazure, Natalie M.. (2015) Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Molecular and cellular biology, Vol. 35, H. 9. pp. 1491-1505.

Burmann, Björn M. and Holdbrook, Daniel A. and Callon, Morgane and Bond, Peter J. and Hiller, Sebastian . (2015) Revisiting the interaction between the chaperone Skp and lipopolysaccharide. Biophysical journal, 108 (6). pp. 1516-1526.

Callon, Morgane. NMR experiments to characterize cellular and molecular mechanisms : from metabolomics to protein biogenesis. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Chi, Celestine N. and Vögeli, Beat and Bibow, Stefan and Strotz, Dean and Orts, Julien and Güntert, Peter and Riek, Roland. (2015) A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution. Angewandte Chemie International Edition, 54 (40). pp. 11657-11661.

Gruss, Fabian and Hiller, Sebastian and Maier, Timm. (2015) Purification and Bicelle Crystallization for Structure Determination of the E. coli Outer Membrane Protein TamA. Methods in Molecular Biology, 1329. pp. 259-270.

Jakob, Roman P. and Koch, Johanna R. and Burmann, Björn M. and Schmidpeter, Philipp A. M. and Hunkeler, Moritz and Hiller, Sebastian and Schmid, Franz X. and Maier, Timm. (2015) Dimeric structure of the bacterial extracellular foldase PrsA. Journal of Biological Chemistry, 290 (6). pp. 3278-3292.

Lori, Christian and Ozaki, Shogo and Steiner, Samuel and Böhm, Raphael and Abel, Sören and Dubey, Badri N. and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2015) Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, Vol. 523, H. 7559. pp. 236-239.

Maier, Timm and Clantin, Bernard and Gruss, Fabian and Dewitte, Frédérique and Delattre, Anne-Sophie and Jacob-Dubuisson, Françoise and Hiller, Sebastian and Villeret, Vincent. (2015) Conserved Omp85 lid-lock structure and substrate recognition in FhaC. Nature Communications, 6. p. 7452.

Morgado, Leonor and Zeth, Kornelius and Burmann, Björn M. and Maier, Timm and Hiller, Sebastian . (2015) Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. Journal of biomolecular NMR, Vol. 61, H. 3-4. pp. 333-345.

2014

Bibow, Stefan and Carneiro, Marta G. and Sabo, T. Michael and Schwiegk, Claudia and Becker, Stefan and Riek, Roland and Lee, Donghan. (2014) Measuring membrane protein bond orientations in nanodiscs via residual dipolar couplings. Protein Science, 23 (7). pp. 851-856.

Callon, Morgane and Burmann, Björn M. and Hiller, Sebastian . (2014) Structural mapping of a chaperone-substrate interaction surface. Angewandte Chemie. International edition in English, Vol. 53, H. 20. pp. 5069-5072.

Etzkorn, Manuela and Zoonens, Manuel and Catoire, Laurent J. and Popot, Jean-Luc and Hiller, Sebastian . (2014) How amphipols embed membrane proteins : global solvent accessibility and interaction with a flexible protein terminus. The journal of membrane biology, Vol. 247, H. 9-10. pp. 965-970.

Kentner, David and Martano, Giuseppe and Callon, Morgane and Chiquet, Petra and Brodmann, Maj and Burton, Olga and Wahlander, Asa and Nanni, Paolo and Delmotte, Nathanaël and Grossmann, Jonas and Limenitakis, Julien and Schlapbach, Ralph and Kiefer, Patrick and Vorholt, Julia A. and Hiller, Sebastian and Bumann, Dirk. (2014) Shigella reroutes host cell central metabolism to obtain high-flux nutrient supply for vigorous intracellular growth. Proceedings of the National Academy of Sciences of the United States of America, 111 (27). pp. 9929-9934.

Schnarwiler, Felix and Niemann, Moritz and Doiron, Nicholas and Harsman, Anke and Käser, Sandro and Mani, Jan and Chanfon, Astrid and Dewar, Caroline E. and Oeljeklaus, Silke and Jackson, Christopher B. and Pusnik, Mascha and Schmidt, Oliver and Meisinger, Chris and Hiller, Sebastian and Warscheid, Bettina and Schnaufer, Achim C. and Ochsenreiter, Torsten and Schneider, André. (2014) Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance. Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, H. 21. pp. 7624-7629.

Schwalbe, Martin and Ozenne, Valéry and Bibow, Stefan and Jaremko, Mariusz and Jaremko, Lukasz and Gajda, Michal and Jensen, Malene Ringkjøbing and Biernat, Jacek and Becker, Stefan and Mandelkow, Eckhard and Zweckstetter, Markus and Blackledge, Martin. (2014) Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering. Structure, 22 (2). pp. 238-249.

2013

Burmann, Björn M. and Wang, Congwei and Hiller, Sebastian. (2013) Conformation and dynamics of the periplasmic membrane-protein–chaperone complexes OmpX–Skp and tOmpA–Skp. Nature structural & molecular biology, 20 (11). pp. 1265-1272.

Gruss, Fabian and Zähringer, Franziska and Jakob, Roman P. and Burmann, Björn M. and Hiller, Sebastian and Maier, Timm. (2013) The structural basis of autotransporter translocation by TamA. Nature structural & molecular biology, Vol. 20, no. 11. pp. 1318-1320.

Hiller, Sebastian . (2013) The functional heart of the M2 channel. Biophysical journal, Vol. 104, H. 8. pp. 1639-1640.

Reckel, Sina and Hiller, Sebastian. (2013) Perspectives of Solution NMR Spectroscopy for Structural and Functional Studies of Integral Membrane Proteins. Molecular physics, Vol. 111, H. 7. pp. 843-849.

Schwalbe, Martin and Biernat, Jacek and Bibow, Stefan and Ozenne, Valéry and Jensen, Malene R. and Kadavath, Harindranath and Blackledge, Martin and Mandelkow, Eckhard and Zweckstetter, Markus. (2013) Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry, 52 (50). pp. 9068-9079.

2012

Burmann, Björn M. and Hiller, Sebastian. (2012) Solution NMR studies of membrane-protein-chaperone complexes. Chimia, 66 (10). pp. 759-763.

Bühler, Marc and Hiller, Sebastian . (2012) Dynamic nature of heterochromatin highlighted by a HP1(Swi6)-dependent gene silencing mechanism. Cell cycle, Vo. 11, H. 21. pp. 3907-3908.

Harsman, Anke and Niemann, Moritz and Pusnik, Mascha and Schmidt, Oliver and Burmann, Björn M. and Hiller, Sebastian and Meisinger, Chris and Schneider, André and Wagner, Richard. (2012) Bacterial origin of a mitochondrial outer membrane protein translocase : new perspectives from comparative single channel electrophysiology. Journal of biological chemistry, Vol. 287, H. 37. pp. 31437-31445.

Hiller, Sebastian and Wagner, Gerhard. (2012) Solution NMR Spectroscopy of Integral Membrane Proteins. In: Comprehensive Biophysics, 5. Burlington, pp. 120-138.

Hiller, Sebastian and Wider, Gerhard. (2012) Automated projection spectroscopy and its applications. Topics in current chemistry, Vol. 316. pp. 21-47.

Huber, Matthias and Böckmann, Anja and Hiller, Sebastian and Meier, Beat H.. (2012) 4D solid-state NMR for protein structure determination. Physical Chemistry, Chemical Physics, 14 (15). pp. 5239-5246.

Keller, Claudia and Adaixo, Ricardo and Stunnenberg, Rieka and Woolcock, Katrina Jane and Hiller, Sebastian and Bühler, Marc. (2012) HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Molecular cell, 47 (2). pp. 215-227.

Markley, John L. and Akutsu, Hideo and Asakura, Tetsuo and Baldus, Marc and Boelens, Rolf and Bonvin, Alexandre and Kaptein, Robert and Bax, Ad and Bezsonova, Irina and Gryk, Michael R. and Hoch, Jeffrey C. and Korzhnev, Dmitry M. and Maciejewski, Mark W. and Case, Dave and Chazin, Walter J. and Cross, Timothy A. and Dames, Sonja and Kessler, Horst and Lange, Oliver and Madl, Tobias and Reif, Bernd and Sattler, Michael and Eliezer, David and Fersht, Alan and Forman-Kay, Julie and Kay, Lewis E. and Fraser, James and Gross, John and Kortemme, Tanja and Sali, Andrej and Fujiwara, Toshimichi and Gardner, Kevin and Luo, Xuelian and Rizo-Rey, Jose and Rosen, Michael and Gil, Roberto R. and Ho, Chien and Rule, Gordon and Gronenborn, Angela M. and Ishima, Rieko and Klein-Seetharaman, Judith and Tang, Pei and van der Wel, Patrick and Xu, Yan and Grzesiek, Stephan and Hiller, Sebastian and Seelig, Joachim and Laue, Ernest D. and Mott, Helen and Nietlispach, Daniel and Barsukov, Igor and Lian, Lu-Yun and Middleton, David and Blumenschein, Tharin and Moore, Geoffrey and Campbell, Iain and Schnell, Jason and Vakonakis, Ioannis John and Watts, Anthony and Conte, Maria R. and Mason, James and Pfuhl, Mark and Sanderson, Mark R. and Craven, Jeremy and Williamson, Michael and Dominguez, Cyril and Roberts, Gordon and Günther, Ulrich and Overduin, Michael and Werner, Joern and Williamson, Philip and Blindauer, Claudia and Crump, Matthew and Driscoll, Paul and Frenkiel, Tom and Golovanov, Alexander and Matthews, Steve and Parkinson, John and Uhrin, Dusan and Williams, Mark and Neuhaus, David and Oschkinat, Hartmut and Ramos, Andres and Shaw, David E. and Steinbeck, Christoph and Vendruscolo, Michele and Vuister, Geerten W. and Walters, Kylie J. and Weinstein, Harel and Wüthrich, Kurt and Yokoyama, Shigeyuki. (2012) In support of the BMRB. Nature Structural and Molecular Biology, 19 (9). pp. 854-860.

Yu, Tsyr-Yan and Raschle, Thomas and Hiller, Sebastian and Wagner, Gerhard. (2012) Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochimica et biophysica acta. BBA. Biomembranes, Vol. 1818, H. 6. pp. 1562-1569.

4 April 2011

Huber, Matthias and Hiller, Sebastian and Schanda, Paul and Ernst, Matthias and Böckmann, Anja and Verel, René and Meier, Beat H.. (2011) A proton-detected 4D solid-state NMR experiment for protein structure determination. ChemPhysChem, 12 (5). pp. 915-918.

2011

Bibow, Stefan and Mukrasch, Marco D. and Chinnathambi, Subashchandrabose and Biernat, Jacek and Griesinger, Christian and Mandelkow, Eckhard and Zweckstetter, Markus. (2011) The dynamic structure of filamentous tau. Angewandte Chemie International Edition, 50 (48). pp. 11520-11524.

Bibow, Stefan and Ozenne, Valéry and Biernat, Jacek and Blackledge, Martin and Mandelkow, Eckhard and Zweckstetter, Markus. (2011) Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society, 133 (40). pp. 15842-15845.

Gossert, Alvar D. and Hiller, Sebastian and Fernández, César. (2011) Automated NMR resonance assignment of large proteins for protein-ligand interaction studies. Journal of the American Chemical Society, Vol. 133. pp. 210-213.

Krähenbühl, Barbara and Hiller, Sebastian and Wider, Gerhard. (2011) 4D APSY-HBCB(CG)CDHD experiment for automated assignment of aromatic amino acid side chains in proteins. Journal of biomolecular NMR, Vol. 51. pp. 313-318.

September 2010

Kräutler, Vincent and Hiller, Sebastian and Hünenberger, Philippe H.. (2010) Residual structure in a peptide fragment of the outer membrane protein X under denaturing conditions: a molecular dynamics study. European biophysics journal, 39 (10). pp. 1421-1432.

May 2010

Takeuchi, Koh and Frueh, Dominique P. and Sun, Zhen-Yu J. and Hiller, Sebastian and Wagner, Gerhard. (2010) CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification. Journal of biomolecular NMR, 47 (1). pp. 55-63.

April 2010

Hiller, Sebastian and Malia, Thomas J. and Garces, Robert G. and Orekhov, Vladislav Y. and Wagner, Gerhard. (2010) Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1. Biomolecular NMR Assignments, 4 (1). pp. 29-32.

2010

Hiller, Sebastian and Abramson, Jeff and Mannella, Carmen and Wagner, Gerhard and Zeth, Kornelius. (2010) The 3D structures of VDAC represent a native conformation. Trends in biochemical sciences, Vol. 35. pp. 514-521.

Narayanan, Rhagavendran L. and Dürr, Ulrich H. N. and Bibow, Stefan and Biernat, Jacek and Mandelkow, Eckhard and Zweckstetter, Markus. (2010) Automatic assignment of the intrinsically disordered protein Tau with 441-residues. Journal of the American Chemical Society, 132 (34). pp. 11906-11907.

Raschle, Thomas and Hiller, Sebastian and Etzkorn, Manuel and Wagner, Gerhard. (2010) Nonmicellar systems for solution NMR spectroscopy of membrane proteins. Current Opinion in Structural Biology, Vol. 20. pp. 471-479.

16 December 2009

Raschle, Thomas and Hiller, Sebastian and Yu, Tsyr-Yan and Rice, Amanda J. and Walz, Thomas and Wagner, Gerhard. (2009) Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. The journal of the American Chemical Society, 131 (49). pp. 17777-17779.

16 September 2009

Hiller, Sebastian and Ibraghimov, Ilghis and Wagner, Gerhard and Orekhov, Vladislav Y.. (2009) Coupled decomposition of four-dimensional NOESY spectra. The journal of the American Chemical Society, 131 (36). pp. 12970-12978.

August 2009

Hiller, Sebastian and Wagner, Gerhard. (2009) The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins. Current opinion in structural biology, 19 (4). pp. 396-401.

June 2009

Hiller, Sebastian and Arthanari, Haribabu and Wagner, Gerhard. (2009) The T-lock: automated compensation of radio-frequency induced sample heating. Journal of biomolecular NMR, 44 (2). pp. 69-76.

2009

Fischer, Daniela and Mukrasch, Marco D. and Biernat, Jacek and Bibow, Stefan and Blackledge, Martin and Griesinger, Christian and Mandelkow, Eckhard and Zweckstetter, Markus. (2009) Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry, 48 (42). pp. 10047-10055.

Mukrasch, Marco D. and Bibow, Stefan and Korukottu, Jegannath and Jeganathan, Sadasivam and Biernat, Jacek and Griesinger, Christian and Mandelkow, Eckhard and Zweckstetter, Markus. (2009) Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biology, 7 (2). e34.

November 2008

Hiller, Sebastian and Wider, Gerhard and Wüthrich, Kurt. (2008) APSY-NMR with proteins: practical aspects and backbone assignment. Journal of biomolecular NMR, 42 (3). pp. 179-195.

10 September 2008

Hiller, Sebastian and Joss, Rosmarie and Wider, Gerhard. (2008) Automated NMR assignment of protein side chain resonances using automated projection spectroscopy (APSY). The journal of the American Chemical Society, 130 (36). pp. 12073-12079.

29 August 2008

Hiller, Sebastian and Garces, Robert G. and Malia, Thomas J. and Orekhov, Vladislav Y. and Colombini, Marco and Wagner, Gerhard. (2008) Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science, 321 (5893). pp. 1206-1210.

4 March 2008

Suzuki, Chikako and Garces, Robert G. and Edmonds, Katherine A. and Hiller, Sebastian and Hyberts, Sven G. and Marintchev, Assen and Wagner, Gerhard. (2008) PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proceedings of the National Academy of Sciences of the United States of America, 105 (9). pp. 3274-3279.

2008

Hiller, Sebastian and Wider, Gerhard and Imbach, Lukas L. and Wüthrich, Kurt. (2008) Interactions with hydrophobic clusters in the urea-unfolded membrane protein OmpX. Angewandte Chemie. International edition in English, 47 (5). pp. 977-981.

November 2007

Etezady-Esfarjani, Touraj and Hiller, Sebastian and Villalba, Cristina and Wüthrich, Kurt. (2007) Cell-free protein synthesis of perdeuterated proteins for NMR studies. Journal of biomolecular NMR, 39 (3). pp. 229-238.

5 September 2007

Hiller, Sebastian and Wasmer, Christian and Wider, Gerhard and Wüthrich, Kurt. (2007) Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR spectroscopy. The journal of the American Chemical Society, 129 (35). pp. 10823-10828.

June 2007

Gossert, Alvar D. and Hiller, Sebastian and Fiorito, Francesco and Wüthrich, Kurt. (2007) NMR assignment of the E. coli type 1 pilus protein FimF. Journal of biomolecular NMR, 38 (2). p. 195.

May 2006

Fiorito, Francesco and Hiller, Sebastian and Wider, Gerhard and Wüthrich, Kurt. (2006) Automated resonance assignment of proteins: 6D APSY-NMR. Journal of biomolecular NMR, 35 (1). pp. 27-37.

2 August 2005

Hiller, Sebastian and Fiorito, Francesco and Wüthrich, Kurt and Wider, Gerhard. (2005) Automated projection spectroscopy (APSY). Proceedings of the National Academy of Sciences of the United States of America, 102 (31). pp. 10876-10881.

May 2005

Hiller, Sebastian and Wider, Gerhard and Etezady-Esfarjani, Touraj and Horst, Reto and Wüthrich, Kurt. (2005) Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures. Journal of biomolecular NMR, 32 (1). pp. 61-70.

3 February 2004

Tafer, Hakim and Hiller, Sebastian and Hilty, Christian and Fernández, César and Wüthrich, Kurt. (2004) Nonrandom structure in the urea-unfolded Escherichia coli outer membrane protein X (OmpX). Biochemistry, 43 (4). pp. 860-869.

October 2003

Hiller, Sebastian and Kohl, Andreas and Fiorito, Francesco and Herrmann, Thorsten and Wider, Gerhard and Tschopp, Jürg and Grütter, Markus G. and Wüthrich, Kurt. (2003) NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure, 11 (10). pp. 1199-1205.