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Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

Zhang, Bing and Liu, Xue and Lambert, Elisabeth and Mas, Guillaume and Hiller, Sebastian and Veening, Jan-Willem and Perez, Camilo. (2020) Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis. Nature Structural and Molecular Biology, 27. pp. 561-569.

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Official URL: https://edoc.unibas.ch/76568/

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Abstract

Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections.
Faculties and Departments:05 Faculty of Science
05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Hiller)
05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Perez)
UniBasel Contributors:Zhang, Bing and Lambert, Elisabeth and Hiller, Sebastian and Mas, Guillaume and Perez, Camilo
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1545-9993
e-ISSN:1545-9985
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Nov 2021 16:13
Deposited On:24 Nov 2021 16:13

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