Items where Division is "05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Biophysics Facility (Sharpe)"

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Abiko, Layara Akemi and Dias Teixeira, Raphael and Engilberge, Sylvain and Grahl, Anne and Mühlethaler, Tobias and Sharpe, Timothy and Grzesiek, Stephan. (2022) Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol. Nature Chemistry, 14 (10). pp. 1133-1141.

Adams, Cassandra J. and Pike, Ashley C. W. and Maniam, Sandra and Sharpe, Timothy D. and Coutts, Amanda S. and Knapp, Stefan and La Thangue, Nicholas B. and Bullock, Alex N.. (2012) The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proceedings of the National Academy of Sciences, 109 (10). pp. 3778-3783.

Arbely, Eyal and Neuweiler, Hannes and Sharpe, Timothy D. and Johnson, Christopher M. and Fersht, Alan R.. (2010) The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces. Protein Science, 19 (9). pp. 1704-1713.

Arbely, Eyal and Rutherford, Trevor J. and Neuweiler, Hannes and Sharpe, Timothy D. and Ferguson, Neil and Fersht, Alan R.. (2010) Carboxyl pK(a) values and acid denaturation of BBL. Journal of Molecular Biology, 403 (2). pp. 313-327.

Arbely, Eyal and Rutherford, Trevor J. and Sharpe, Timothy D. and Ferguson, Neil and Fersht, Alan R.. (2009) Downhill versus barrier-limited folding of BBL 1: energetic and structural perturbation effects upon protonation of a histidine of unusually low pKa. Journal of Molecular Biology, 387 (4). pp. 986-992.

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Collu, Gabriella and Bierig, Tobias and Krebs, Anna-Sophia and Engilberge, Sylvain and Varma, Niveditha and Guixà-González, Ramon and Sharpe, Timothy and Deupi, Xavier and Olieric, Vincent and Poghosyan, Emiliya and Benoit, Roger M.. (2022) Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology. Structure, 30 (1). pp. 95-106.e7.

Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Sharpe, Timothy and Pang, Lijuan and Hadorn, Adrian and Rabbani, Said and Ernst, Beat. (2021) Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem, 16 (15). pp. 2345-2353.

Canning, Peter and Park, Kwangjin and Gonçalves, João and Li, Chunmei and Howard, Conor J. and Sharpe, Timothy D. and Holt, Liam J. and Pelletier, Laurence and Bullock, Alex N. and Leroux, Michel R.. (2018) CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Reports, 22 (4). pp. 885-894.

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Dixon-Clarke, Sarah E. and Shehata, Saifeldin N. and Krojer, Tobias and Sharpe, Timothy D. and von Delft, Frank and Sakamoto, Kei and Bullock, Alex N.. (2017) Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochemical Journal, 474 (5). pp. 699-713.

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Fiedler, Thomas and Fabrice, Tohnyui Ndinyanka and Studer, Vera and Vinet, Adrien and Faltova, Lenka and Kammerer, Richard A. and Steinmetz, Michel O. and Sharpe, Timothy and Pieters, Jean. (2020) Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum. FEBS Letters, 594 (13). pp. 2116-2127.

Filippakopoulos, Panagis and Low, Andrew and Sharpe, Timothy D. and Uppenberg, Jonas and Yao, Shenggen and Kuang, Zhihe and Savitsky, Pavel and Lewis, Rowena S. and Nicholson, Sandra E. and Norton, Raymond S. and Bullock, Alex N.. (2010) Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. Journal of Molecular Biology, 401 (3). pp. 389-402.

Ferguson, Neil and Sharpe, Timothy D. and Johnson, Christopher M. and Schartau, Pamela J. and Fersht, Alan R.. (2007) Structural biology: analysis of `downhill` protein folding. Nature, 445 (7129). E14-E15.

Ferguson, Neil and Becker, Johanna and Tidow, Henning and Tremmel, Sandra and Sharpe, Timothy D. and Krause, Gerd and Flinders, Jeremy and Petrovich, Miriana and Berriman, John and Oschkinat, Hartmut and Fersht, Alan R.. (2006) General structural motifs of amyloid protofilaments. Proceedings of the National Academy of Sciences of the United States of America, 103 (44). pp. 16248-16253.

Ferguson, Neil and Sharpe, Timothy D. and Johnson, Christopher M. and Fersht, Alan R.. (2006) The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics. Journal of Molecular Biology, 356 (5). pp. 1237-1247.

Ferguson, Neil and Sharpe, Timothy D. and Schartau, Pamela J. and Sato, Satoshi and Allen, Mark D. and Johnson, Christopher M. and Rutherford, Trevor J. and Fersht, Alan R.. (2005) Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. Journal of Molecular Biology, 353 (2). pp. 427-446.

Ferguson, Neil and Schartau, Pamela J. and Sharpe, Timothy D. and Sato, Satoshi and Fersht, Alan R.. (2004) One-state downhill versus conventional protein folding. Journal of Molecular Biology, 344 (2). pp. 295-301.

Ferguson, Neil and Berriman, John and Petrovich, Miriana and Sharpe, Timothy D. and Finch, John T. and Fersht, Alan R.. (2003) Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proceedings of the National Academy of Sciences of the United States of America, 100 (17). pp. 9814-9819.

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Huang, Fang and Sato, Satoshi and Sharpe, Timothy D. and Ying, Liming and Fersht, Alan R.. (2007) Distinguishing between cooperative and unimodal downhill protein folding. Proceedings of the National Academy of Sciences of the United States of America, 104 (1). pp. 123-127.

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Julou, Thomas and Zweifel, Ludovit and Blank, Diana and Fiori, Athos and van Nimwegen, Erik. (2020) Subpopulations of sensorless bacteria drive fitness in fluctuating environments. PLoS biology, 18 (12). e3000952.

Johnson, Christopher and Sharpe, Timothy. (2018) Protein Folding, Energy Landscapes and Downhill Protein Folding Scenarios. In: Encyclopedia of Biophysics. Berlin, pp. 1-19.

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Kuenzl, Tilmann and Li-Blatter, Xiaochun and Srivastava, Puneet and Herdewijn, Piet and Sharpe, Timothy and Panke, Sven. (2018) Mutant Variants of the Substrate-Binding Protein DppA from Escherichia coli Enhance Growth on Nonstandard γ-Glutamyl Amide-Containing Peptides. Applied and Environmental Microbiology, 84 (13). e00340-18.

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Li-Blatter, Xiaochun and Zweifel, Ludovit and Sharpe, Timothy. (2021) A Familiar Protein-Ligand Interaction Revisited with Multiple Methods. Methods in Molecular Biology, 2263. pp. 47-79.

López-Méndez, Blanca and Baron, Bruno and Brautigam, Chad A. and Jowitt, Thomas A. and Knauer, Stefan H. and Uebel, Stephan and Williams, Mark A. and Sedivy, Arthur and Abian, Olga and Abreu, Celeste and Adamczyk, Malgorzata and Bal, Wojciech and Berger, Sylvie and Buell, Alexander K. and Carolis, Carlo and Daviter, Tina and Fish, Alexander and Garcia-Alai, Maria and Guenther, Christian and Hamacek, Josef and Holková, Jitka and Houser, Josef and Johnson, Chris and Kelly, Sharon and Leech, Andrew and Mas, Caroline and Matulis, Daumantas and McLaughlin, Stephen H. and Montserret, Roland and Nasreddine, Rouba and Nehmé, Reine and Nguyen, Quyen and Ortega-Alarcón, David and Perez, Kathryn and Pirc, Katja and Piszczek, Grzegorz and Podobnik, Marjetka and Rodrigo, Natalia and Rokov-Plavec, Jasmina and Schaefer, Susanne and Sharpe, Tim and Southall, June and Staunton, David and Tavares, Pedro and Vanek, Ondrej and Weyand, Michael and Wu, Di. (2021) Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study. European Biophysics Journal, 50 (3-4). pp. 411-427.

Luther, Anatol and Urfer, Matthias and Zahn, Michael and Müller, Maik and Wang, Shuang-Yan and Mondal, Milon and Vitale, Alessandra and Hartmann, Jean-Baptiste and Sharpe, Timothy and Monte, Fabio Lo and Kocherla, Harsha and Cline, Elizabeth and Pessi, Gabriella and Rath, Parthasarathi and Modaresi, Seyed Majed and Chiquet, Petra and Stiegeler, Sarah and Verbree, Carolin and Remus, Tobias and Schmitt, Michel and Kolopp, Caroline and Westwood, Marie-Anne and Desjonquères, Nicolas and Brabet, Emile and Hell, Sophie and LePoupon, Karen and Vermeulen, Annie and Jaisson, Régis and Rithié, Virginie and Upert, Grégory and Lederer, Alexander and Zbinden, Peter and Wach, Achim and Moehle, Kerstin and Zerbe, Katja and Locher, Hans H. and Bernardini, Francesca and Dale, Glenn E. and Eberl, Leo and Wollscheid, Bernd and Hiller, Sebastian and Robinson, John A. and Obrecht, Daniel. (2019) Chimeric peptidomimetic antibiotics against Gram-negative bacteria. Nature, 576 (7787). pp. 452-458.

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Mas, Guillaume and Burmann, Björn M. and Sharpe, Timothy and Claudi, Beatrice and Bumann, Dirk and Hiller, Sebastian. (2020) Regulation of chaperone function by coupled folding and oligomerization. Science advances, 6 (43). eabc5822.

Morgado, Leonor and Burmann, Björn M. and Sharpe, Timothy and Mazur, Adam and Hiller, Sebastian. (2017) The dynamic dimer structure of the chaperone Trigger Factor. Nature Communications, 8. p. 1992.

Moschetti, Tommaso and Sharpe, Timothy and Fischer, Gerhard and Marsh, May E. and Ng, Hong Kin and Morgan, Matthew and Scott, Duncan E. and Blundell, Tom L. and R. Venkitaraman, Ashok and Skidmore, John and Abell, Chris and Hyvönen, Marko. (2016) Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. Journal of Molecular Biology, 428 (23). pp. 4589-4607.

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Neuweiler, Hannes and Sharpe, Timothy D. and Johnson, Christopher M. and Teufel, Daniel P. and Ferguson, Neil and Fersht, Alan R.. (2009) Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes. Journal of Molecular Biology, 387 (4). pp. 975-985.

Neuweiler, Hannes and Sharpe, Timothy D. and Rutherford, Trevor J. and Johnson, Christopher M. and Allen, Mark D. and Ferguson, Neil and Fersht, Alan R.. (2009) The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. Journal of Molecular Biology, 390 (5). pp. 1060-1073.

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Scott, Duncan E. and Francis-Newton, Nicola J. and Marsh, May E. and Coyne, Anthony G. and Fischer, Gerhard and Moschetti, Tommaso and Bayly, Andrew R. and Sharpe, Timothy D. and Haas, Kalina T. and Barber, Lorraine and Valenzano, Chiara R. and Srinivasan, Rajavel and Huggins, David J. and Lee, Miyoung and Emery, Amy and Hardwick, Bryn and Ehebauer, Matthias and Dagostin, Claudio and Esposito, Alessandro and Pellegrini, Luca and Perrior, Trevor and McKenzie, Grahame and Blundell, Tom L. and Hyvönen, Marko and Skidmore, John and Venkitaraman, Ashok R. and Abell, Chris. (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell chemical biology, 28 (6). pp. 835-847.e5.

Sundriyal, Amit and Massa, Claudia and Samoray, Dietrich and Zehender, Fabian and Sharpe, Timothy and Jenal, Urs and Schirmer, Tilman. (2014) Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10). pp. 6978-6990.

Smith, Clive A. and Li, Xin and Mize, Todd H. and Sharpe, Timothy D. and Graziani, Edmund I. and Abell, Chris and Huck, Wilhelm T. S.. (2013) Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. Analytical Chemistry, 85 (8). pp. 3812-3816.

Sharpe, Timothy D. and Ferguson, Neil and Johnson, Christopher M. and Fersht, Alan R.. (2008) Conservation of transition state structure in fast folding peripheral subunit-binding domains. Journal of Molecular Biology, 383 (1). pp. 224-237.

Sharpe, Tim and Jonsson, Amanda L. and Rutherford, Trevor J. and Daggett, Valerie and Fersht, Alan R.. (2007) The role of the turn in b-hairpin formation during WW domain folding. Protein Science, 1. pp. 2233-2239.

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Valkov, Eugene and Sharpe, Tim and Marsh, May and Greive, Sandra and Hyvönen, Marko. (2012) Targeting protein-protein interactions and fragment-based drug discovery. Topics in Current Chemistry, 317. pp. 145-179.