edoc

Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses

Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Sharpe, Timothy and Pang, Lijuan and Hadorn, Adrian and Rabbani, Said and Ernst, Beat. (2021) Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem, 16 (15). pp. 2345-2353.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/84296/

Downloads: Statistics Overview

Abstract

The C-type lectin receptor DC-SIGN mediates interactions with envelope glycoproteins of many viruses such as SARS-CoV-2, ebola, and HIV and contributes to virus internalization and dissemination. In the context of the recent SARS-CoV-2 pandemic, involvement of DC-SIGN has been linked to severe cases of COVID-19. Inhibition of the interaction between DC-SIGN and viral glycoproteins has the potential to generate broad spectrum antiviral agents. Here, we demonstrate that mannose-functionalized poly-l-lysine glycoconjugates efficiently inhibit the attachment of viral glycoproteins to DC-SIGN-presenting cells with picomolar affinity. Treatment of these cells leads to prolonged receptor internalization and inhibition of virus binding for up to 6 h. Furthermore, the polymers are fully bio-compatible and readily cleared by target cells. The thermodynamic analysis of the multivalent interactions reveals enhanced enthalpy-driven affinities and promising perspectives for the future development of multivalent therapeutics.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Biophysics Facility (Sharpe)
UniBasel Contributors:Sharpe, Timothy and Ernst, Beat and Rabbani, Said and Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Pang, Lijuan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1860-7179
e-ISSN:1860-7187
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2021 13:45
Deposited On:31 Aug 2021 13:45

Repository Staff Only: item control page