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Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum

Fiedler, Thomas and Fabrice, Tohnyui Ndinyanka and Studer, Vera and Vinet, Adrien and Faltova, Lenka and Kammerer, Richard A. and Steinmetz, Michel O. and Sharpe, Timothy and Pieters, Jean. (2020) Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum. FEBS Letters, 594 (13). pp. 2116-2127.

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Official URL: https://edoc.unibas.ch/76509/

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Abstract

Coronin proteins are widely expressed among eukaryotic organisms. Most coronins consist of a WD repeat domain followed by a C-terminal coiled coil. Dictyostelium discoideum expresses a single short coronin coronin A, which has been implicated in both actin modulation as well as multicellular differentiation. Whether coronin A's coiled coil is important for functionality, as well as the oligomeric state of coronin A is not known. Here, we show that the coiled-coil domain in Dictyostelium coronin A functions in homodimerization, is dispensable for coronin A stability and localization but essential for multicellular differentiation. These results allow a better understanding of the role for the coiled-coil domain of coronin A in oligomerization and demonstrate that its presence is essential for multicellular differentiation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0014-5793
e-ISSN:1873-3468
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Feb 2021 11:10
Deposited On:01 Feb 2021 11:10

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