Items where Division is "03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Pharmacology (Krähenbühl)"

2021

Roos, Noëmi Johanna. Role of the NRF2-mediated oxidative stress response and lysosomal dysfunction in drug-induced liver injury associated with mitochondrial damage. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

2017

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne. (2017) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicology in Vitro, 40. pp. 55-65.

2016

Berger, B. and Donzelli, M. and Maseneni, S. and Boess, F. and Roth, A. and Krahenbuhl, S. and Haschke, M.. (2016) Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail. Front Pharmacol, 7. p. 443.

Bonifacio, Annalisa and Mullen, Peter J. and Mityko, Ileana Scurtu and Navegantes, Luiz C. and Bouitbir, Jamal and Krähenbühl, Stephan. (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Archives of Toxicology, 90 (1). pp. 203-215.

Bouitbir, Jamal and Haegler, Patrizia and Singh, François and Joerin, Lorenz and Felser, Andrea and Duthaler, Urs and Krähenbühl, Stephan. (2016) Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency. Frontiers in Physiology, 7. p. 345.

Bouitbir, Jamal and Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bonifacio, Annalisa and Echaniz-Laguna, Andoni and Geny, Bernard and Krahenbuhl, Stephan and Zoll, Joffrey. (2016) Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle. Antioxidants and Redox Signaling, 24 (2). pp. 84-98.

Derungs, A. and Donzelli, M. and Berger, B. and Noppen, C. and Krahenbuhl, S. and Haschke, M.. (2016) Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clin Pharmacokinet, 55 (1). pp. 79-91.

Krahenbuhl, S. and Pavik-Mezzour, I. and von Eckardstein, A.. (2016) Unmet Needs in LDL-C Lowering: When Statins Won't Do! Drugs, 76 (12). pp. 1175-1190.

Kummer, Oliver and Hammann, Felix and Haschke, Manuel and Krähenbühl, Stephan. (2016) Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II. British Journal of Clinical Pharmacology, 81 (5). pp. 1002-1004.

Mancuso, Riccardo V. and Welzenbach, Karl and Steinberger, Peter and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2016) Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition. Biochemical Pharmacology, 119. pp. 42-55.

Neumair, P. and Joos, L. and Warschkow, R. and Dutly, A. and Ess, S. and Hitz, F. and Fruh, M. and Brutsche, M. and Baty, F. and Krahenbuhl, S. and Cerny, T. and Joerger, M.. (2016) Erlotinib has comparable clinical efficacy to chemotherapy in pretreated patients with advanced non-small cell lung cancer (NSCLC): A propensity-adjusted, outcomes research-based study. Lung Cancer, 100. pp. 38-44.

Neumair, P. and Joos, L. and Warschkow, R. and Ess, S. and Hitz, F. and Frueh, M. and Brutsche, M. H. and Baty, F. and Krahenbuhl, S. and Jorger, M.. (2016) 169P: Chemotherapy is not superior to erlotinib in pretreated patients with advanced non-small cell lung cancer (NSCLC): A retrospective study. Journal of Thoracic Oncology, 11 (4 Suppl). p. 131.

Novakova, Katerina and Kummer, Oliver and Bouitbir, Jamal and Stoffel, Sonja D. and Hoerler-Koerner, Ulrike and Bodmer, Michael and Roberts, Paul and Urwyler, Albert and Ehrsam, Rolf and Krähenbühl, Stephan. (2016) Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. European Journal of Nutrition, 55 (1). pp. 207-217.

Stoikou, Maria. Identification of the factors that modulate neutrophil response towards NET formation during normal pregnancy and in gestational diabetes mellitus. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

Vogel, Marc and Bucher, Patricia and Strasser, Johannes and Liechti, Matthias E. and Krähenbühl, Stephan and Dürsteler, Kenneth M.. (2016) Similar and Different? Subjective Effects of Methylphenidate and Cocaine in Opioid-Maintained Patients. Journal of Psychoactive Drugs , 48 (2). pp. 93-100.

2015

Krahenbuhl, Swenn Maxence and Depairon, Michele and Faure, Marguerite and Vietti Violi, Naik and Applegate, Lee Ann and Raffoul, Wassim. (2015) Sildenafil as a therapeutic option for digital ischemic ulceration: case report. The Journal of Hand Surgery, 40 (5). pp. 890-893.

2014

Donzelli, Massimiliano and Derungs, Adrian and Serratore, Maria-Giovanna and Noppen, Christoph and Nezic, Lana and Krähenbühl, Stephan and Haschke, Manuel. (2014) The Basel Cocktail for Simultaneous Phenotyping of Human Cytochrome P450 Isoforms in Plasma, Saliva and Dried Blood Spots. Clinical pharmacokinetics, Vol. 53, H. 3. pp. 271-282.

Felser, Andrea Debora. Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

2013

Haschke, Manuel and Schuster, Manfred and Poglitsch, Marko and Loibner, Hans and Salzberg, Marc and Bruggisser, Marcel and Penninger, Joseph and Krähenbühl, Stephan. (2013) Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clinical pharmacokinetics, Vol. 52, H. 9. pp. 783-792.

Hirzel, E. and Lindinger, P. W. and Maseneni, S. and Giese, M. and Rhein, V. V. and Eckert, A. and Hoch, M. and Krahenbuhl, S. and Eberle, A. N.. (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. Journal of receptors and signal transduction, Vol. 33, H. 5. pp. 304-312.

Maseneni, Swarna and Donzelli, Massimiliano and Brecht, Karin and Krähenbühl, Stephan. (2013) Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes. Toxicology, 308. pp. 11-19.

Morand, Réjane and Donzelli, Massimiliano and Haschke, Manuel and Krähenbühl, Stephan. (2013) Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. Analytical and bioanalytical chemistry, Vol. 405, H. 27. pp. 8829-8836.

Zahno, Anja and Bouitbir, Jamal and Maseneni, Swarma and Lindinger, Peter W. and Brecht, Karin and Krähenbühl, Stephan. (2013) Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors. Free radical biology and medicine, 65. pp. 208-216.

2012

Hardmeier, M. and Zimmermann, R. and Rüegg, S. and Pflüger, M. and Deuster, S. and Suter, K. and Donzelli, M. and Drewe, J. and Krähenbühl, S. and Fuhr, P. and Haschke, M.. (2012) Intranasal midazolam: pharmacokinetics and pharmacodynamics assessed by quantitative EEG in healthy volunteers. Clinical Pharmacology & Therapeutics, 91 (5). pp. 856-862.

Hysek, C. M. and Simmler, L. D. and Nicola, V. G. and Vischer, N. and Donzelli, M. and Krahenbuhl, S. and Grouzmann, E. and Huwyler, J. and Hoener, M. C. and Liechti, M. E.. (2012) Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS ONE, Vol. 7, H. 5 , e36476.

Maseneni, Swarna and Donzelli, Massimiliano and Taegtmeyer, A. B. and Brecht, Karin and Krähenbühl, Stephan. (2012) Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites. Toxicology, 299 (2-3). pp. 139-145.

Morand, R. and Todesco, L. and Donzelli, M. and Fischer-Barnicol, D. and Mullen, P. J. and Krahenbuhl, S.. (2012) Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. Therapeutic drug monitoring, Vol. 34, H. 4. pp. 406-414.

See, Hong Heng and Schmidt-Marzinkowski, Julia and Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2012) Determination of creatine and phosphocreatine in muscle biopsy samples by capillary electrophoresis with contactless conductivity detection. Analytica Chimica Acta, 727. pp. 78-82.

Swiss Association for the Study of the Liver, and Moradpour D, Helbling B. and Cerny A, De Gottardi A. and Heim MH, Majno P. and Müllhaupt B, Negro F. and Rubbia-Brandt L, Semela D. and Vilei SB, Bernsmeier C. and Bihl F, Borovicka J. and Dill M, Dufour J. F. and Filipowicz M, Geier A. and Gerlach T, Giostra E. and Gonvers JJ, Goossens N. and Gubler C, Hadengue A. and Heim MH, Helbling B. and Hellstern M, Hirschi C. and Jochum W, Krähenbühl S. and Kullak-Ublick G, Lange C. and Lavanchy D, Majno P. and Malinverni R, McLin V. and Mentha G, Mertens J. C. and Nasser S, Oneta C. and Pache I, Rubbia-Brandt L. and Sauter B, Semela D. and Spahr L, Steuerwald M. and Stickel F, Stieger B. and Wehr K, Zala G.. (2012) Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir. Swiss medical weekly, Vol. 142 , w13516.

2011

Derungs, Adrian and Schietzel, Simeon and Meyer, Markus R. and Maurer, Hans H. and Krähenbühl, Stephan and Liechti, Matthias E.. (2011) Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone). Clinical toxicology, 49 (7). pp. 691-693.

Kummer, Oliver and Hammann, Felix and Moser, Claudine and Schaller, Olivier and Drewe, Jürgen and Krähenbühl, Stephan. (2011) Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. European journal of clinical pharmacology, Vol. 67, H. 1. pp. 63-71.

Mullen, Peter J. and Zahno, Anja and Lindinger, Peter and Maseneni, Swarma and Felser, Andrea and Krähenbühl, Stephan and Brecht, Karin. (2011) Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt. Biochimica et biophysica acta, Vol. 1813, H. 12. pp. 2079-2087.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Capillary electrophoresis with contactless conductivity detection for the determination of carnitine and acylcarnitines in clinical samples. Journal of Chromatography B, 879 (13-14). pp. 921-926.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Quantification of plasma lactate concentrations using capillary electrophoresis with contactless conductivity detection. Electrophoresis, 32 (8). pp. 884-889.

Zahno, Anja and Brecht, Karin and Morand, Réjane and Maseneni, Swarna and Török, Michael and Lindinger, Peter W. and Krähenbühl, Stephan. (2011) The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells. Biochemical pharmacology, Vol. 81, Issue 3. pp. 432-441.

2009

Todesco, Liliane and Bodmer, Michael and Vonwil, Karin and Häussinger, Daniel and Krähenbühl, Stephan. (2009) Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. Chemico-Biological Interactions , 180 (3). pp. 472-477.