Items where Author is "Wymann, Matthias P."

2021

Borsari, Chiara and Keles, Erhan and Treyer, Andrea and De Pascale, Martina and Hebeisen, Paul and Hamburger, Matthias and Wymann, Matthias P.. (2021) Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability. RSC Medicinal Chemistry, 12 (4). pp. 579-583.

Mori, Mayumi and Ruer-Laventie, Julie and Duchemin, Wandrille and Demougin, Philippe and Ndinyanka Fabrice, Tohnyui and Wymann, Matthias P. and Pieters, Jean. (2021) Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling. Science Signaling, 14 (714). eabj0057.

2020

Borsari, Chiara and Keles, Erhan and Rageot, Denise and Treyer, Andrea and Bohnacker, Thomas and Bissegger, Lukas and De Pascale, Martina and Melone, Anna and Sriramaratnam, Rohitha and Beaufils, Florent and Hamburger, Matthias and Hebeisen, Paul and Löscher, Wolfgang and Fabbro, Doriano and Hillmann, Petra and Wymann, Matthias P.. (2020) 4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a potent, orally available, and brain-penetrant mTOR inhibitor for the treatment of neurological disorders. Journal of Medicinal Chemistry, 63 (22). pp. 13595-13617.

2017

Beaufils, Florent and Cmiljanovic, Natasa and Cmiljanovic, Vladimir and Bohnacker, Thomas and Melone, Anna and Marone, Romina and Jackson, Eileen and Zhang, Xuxiao and Sele, Alexander and Borsari, Chiara and Mestan, Jurgen and Hebeisen, Paul and Hillmann, Petra and Giese, Bernd and Zvelebil, Marketa and Fabbro, Doriano and Williams, Roger L. and Rageot, Denise and Wymann, Matthias P.. (2017) 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. Journal of Medicinal Chemistry, 60 (17). pp. 7524-7538.

Bohnacker, Thomas and Prota, Andrea E. and Beaufils, Florent and Burke, John E. and Melone, Anna and Inglis, Alison J. and Rageot, Denise and Sele, Alexander M. and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Bargsten, Katja and Aher, Amol and Akhmanova, Anna and Fernando Diaz, J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2017) Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nature communications, 8. p. 14683.

Breasson, Ludovic and Becattini, Barbara and Sardi, Claudia and Molinaro, Angela and Zani, Fabio and Marone, Romina and Botindari, Fabrizio and Bousquenaud, Melanie and Ruegg, Curzio and Wymann, Matthias P. and Solinas, Giovanni. (2017) PI3K gamma activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Science signaling, 10 (488). eaaf2969.

2016

Sele, Alexander M. and Rageot, Denise and Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Steinmetz, Michel O. and Wymann, Matthias P.. (2016) Novel 4-(pyrimidin-2-yl)morpholines targeting the colchicine-binding site of tubulin. Cancer Research, 76 (14). p. 1364.

Beaufils, Florent and Rageot, Denise and Melone, Anna and Sele, Alexander and Lang, Marc and Mestan, Juergen and Ettlin, Robert A. and Hillmann, Petra and Cmiljanovic, Vladimir and Walter, Carolin and Singer, Elisabeth and Nguyen, Hoa H. P. and Hebeisen, Paul and Fabbro, Dorian and Wymann, Matthias P.. (2016) Pharmacological characterization of the selective, orally bioavailable, potent mTORC1/2 inhibitor PQR620. Cancer Research, 76 (14). 393A.

Beaufils, Florent and Rageot, Denise and Melone, Anna and Lang, Marc and Mestan, Jürgen and Cmiljanovic, Vladimir and Hillmann, Petra and Hebeisen, Paul and Fabbro, Doriano and Wymann, Matthias P.. (2016) Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research, 76 (14). p. 1336.

2015

Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Burke, John E. and Melone, Anna and Inglis, Alison J. and Fusco, Ludovico and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Rageot, Denise and Bargsten, Katja and Saez-Calvo, Gonzalo and Pertz, Olivier and Aher, Amol B. and Akhmanova, Anna and Diaz, Fernando J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2015) BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition. Cancer Research, 75 (15). p. 671.

Cmiljanovic, Vladimir and Ettlin, Robert A. and Beautils, Florent and Dieterle, Walter and Hillmann, Petra and Mestan, Juergen and Melone, Anna and Bohnacker, Thomas and Lang, Marc and Cmiljanovic, Natasa and Giese, Bernd and Hebeisen, Paul and Wymann, Matthias P. and Fabbro, Doriano. (2015) PQR309: A potent, brain-penetrant, dual pan-PI3K/mTOR inhibitor with excellent oral bioavailability and tolerability. Cancer Research, 75 (15). p. 4514.

Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Marone, Romina and Beaufils, Florent and Zhang, Xuxiao and Zvelebil, Marketa and Hebeisen, Paul and Lang, Marc and Mestan, Juergen and Melone, Anna and Bohnacker, Thomas and Gaudio, Eugenio and Tarantelli, Chiara and Bertoni, Francesco and Ritschard, Reto and Pretre, Vincent and Wicki, Andreas and Fabbro, Doriano and Hillmann, Petra and Williams, Roger and Giese, Bernd and Wymann, Matthias P.. (2015) PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor. Cancer Research, 75 (15). p. 2664.

Tarantelli, Chiara and Gaudio, Eugenio and Kwee, Ivo and Rinaldi, Andrea and Bernasconi, Elena and Cascione, Luciano and Hillmann, Petra and Stathis, Anastasios and Carrassa, Laura and Broggini, Massimo and Stussi, Georg and Fabbro, Doriano and Beaufils, Florent and Melone, Anna and Bohnacker, Thomas and Wymann, Matthias P. and Wicki, Andreas and Zucca, Emanuele and Cmiljanovic, Vladimir and Bertoni, Francesco. (2015) Pre-clinical activity and mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas. Cancer Research, 75 (15). p. 2652.

2014

Zimmermann, Mirjam and Cal, Ruben and Janett, Elia and Hoffmann, Viktor and Bochet, Christian G. and Constable, Edwin and Beaufils, Florent and Wymann, Matthias P.. (2014) Cell-Permeant and Photocleavable Chemical Inducer of Dimerization. Angewandte Chemie International Edition, 53 (18). pp. 4717-4720.

Gayral, Stephanie and Garnotel, Roselyne and Castaing-Berthou, Audrey and Blaise, Sebastien and Fougerat, Anne and Berge, Elodie and Montheil, Aurelie and Malet, Nicole and Wymann, Matthias P. and Maurice, Pascal and Debelle, Laurent and Martiny, Laurent and Martinez, Laurent O. and Pshezhetsky, Alexey V. and Duca, Laurent and Laffargue, Muriel. (2014) Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway. Cardiovascular Research, 102 (1). pp. 118-127.

Smirnova, Natalia F. and Gayral, Stephanie and Pedros, Christophe and Loirand, Gervaise and Vaillant, Nathalie and Malet, Nicole and Kassem, Sahar and Calise, Denis and Goudouneche, Dominique and Wymann, Matthias P. and Hirsch, Emilio and Gadeau, Alain-Pierre and Martinez, Laurent O. and Saoudi, Abdelhadi and Laffargue, Muriel. (2014) Targeting PI3Kgamma activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response. Journal of experimental medicine, 211 (9). pp. 1779-1792.

2012

Anzinger, Joshua J. and Chang, Janet and Xu, Qing and Barthwal, Manoj K. and Bohnacker, Thomas and Wymann, Matthias P. and Kruth, Howard S.. (2012) Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL. Journal of Lipid Research, 53 (1). pp. 34-42.

2011

Wymann, Matthias P. and Wenk, Markus R.. (2011) Neutral not a loss : phosphoinositides beyond the head group. Nature methods, Vol. 8, H. 3. pp. 219-220.

Becattini, Barbara and Marone, Romina and Zani, Fabio and Arsenijevic, Denis and Seydoux, Josiane and Montani, Jean-Pierre and Dulloo, Abdul G. and Thorens, Bernard and Preitner, Frédéric and Wymann, Matthias P. and Solinas, Giovanni. (2011) PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 42 , E854-E863.

2010

Ciraolo, Elisa and Morello, Fulvio and Hobbs, Robin M. and Wolf, Frieder and Marone, Romina and Iezzi, Manuela and Lu, Xiaoyun and Mengozzi, Giulio and Altruda, Fiorella and Sorba, Giovanni and Guan, Kaomei and Pandolfi, Pier Paolo and Wymann, Matthias P. and Hirsch, Emilio. (2010) Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Molecular Biology of the Cell, 21 (5). pp. 704-711.

2009

Thomas, Matthew and Edwards, Matthew J. and Sawicka, Elzbieta and Duggan, Nicholas and Hirsch, Emilio and Wymann, Matthias P. and Owen, Charles and Trifilieff, Alexandre and Walker, Christoph and Westwick, John and Finan, Peter. (2009) Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. Immunology : an official journal of the British Society for Immunology, Vol. 126. pp. 413-422.

Santos-Sierra, Sandra and Deshmukh, Sachin D. and Kalnitski, Julia and Küenzi, Peter and Wymann, Matthias P. and Golenbock, Douglas T. and Henneke, Philipp. (2009) Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. The EMBO journal, Vol. 28. pp. 2018-2027.

Bohnacker, Thomas and Marone, Romina and Collmann, Emilie and Calvez, Ronan and Hirsch, Emilio and Wymann, Matthias P.. (2009) PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells. Science signaling : the signal transduction knowledge environment, Vol. 2 , ra27.

Kurig, Barbara and Shymanets, Aliaksei and Bohnacker, Thomas and Prajwal, and Brock, Carsten and Ahmadian, Mohammad Reza and Schaefer, Michael and Gohla, Antje and Harteneck, Christian and Wymann, Matthias P. and Jeanclos, Elisabeth and Nürnberg, Bernd. (2009) Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proceedings of the National Academy of Sciences of the United States of America, Vol. 106. pp. 20312-20317.

Marone, Romina and Erhart, Dominik and Mertz, Ann C. and Bohnacker, Thomas and Schnell, Christian and Cmiljanovic, Vladimir and Stauffer, Frédéric and Garcia-Echeverria, Carlos and Giese, Bernd and Maira, Sauveur-Michel and Wymann, Matthias P.. (2009) Targeting melanoma with dual phosphoinosite 3-kinase/mammalian target of rapamycin inhibitors. Molecular Cancer Research, Vol. 7. pp. 601-613.

2008

Hui, Rosaline C.-Y. and Gomes, Ana R. and Constantinidou, Demetra and Costa, Joana R. and Karadedou, Christina T. and Fernandez de Mattos, Silvia and Wymann, Matthias P. and Brosens, Jan J. and Schulze, Almut and Lam, Eric W.-F.. (2008) The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Molecular and Cellular Biology, 28 (19). pp. 5886-5898.