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Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability

Borsari, Chiara and Keles, Erhan and Treyer, Andrea and De Pascale, Martina and Hebeisen, Paul and Hamburger, Matthias and Wymann, Matthias P.. (2021) Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability. RSC Medicinal Chemistry, 12 (4). pp. 579-583.

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Abstract

Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurological disorders.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Borsari, Chiara and Keles, Erhan and De Pascale, Martina and Hebeisen, Paul and Treyer, Andrea and Hamburger, Matthias and Wymann, Matthias P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
e-ISSN:2632-8682
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:18 Jun 2021 07:52
Deposited On:18 Jun 2021 07:52

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