Hinnu, Mariliis and Putrinš, Marta and Kogermann, Karin and Bumann, Dirk and Tenson, Tanel. (2022) Making Antimicrobial Susceptibility Testing More Physiologically Relevant with Bicarbonate? Antimicrobial Agents and Chemotherapy, 66 (5). e0241221.
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Abstract
Azithromycin is a clinically important drug for treating invasive salmonellosis despite poor activity in laboratory assays for MIC. Addition of the main buffer in blood, bicarbonate, has been proposed for more physiologically relevant and more predictive testing conditions. However, we show here that bicarbonate-triggered lowering of azithromycin MIC is entirely due to alkalization of insufficiently buffered media. In addition, bicarbonate is unlikely to be altering efflux pump activity.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann) |
|---|---|
| UniBasel Contributors: | Bumann, Dirk |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| e-ISSN: | 1098-6596 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 21 Feb 2023 14:22 |
| Deposited On: | 21 Feb 2023 14:22 |
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