Items where Division is "03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Molecular Genetics (Schär)"

2024

Baumann, Zora. Immuno-metabolic effects of a ketogenic diet on mammary cancer metastases. 2024, Doctoral Thesis, University of Basel, Faculty of Science.

Keller, Lena. Inflammatory dynamics in the gut: exploring diet-immune interplay in obesity. 2024, Doctoral Thesis, University of Basel, Faculty of Science.

2023

Gjeta, Bruno. Unveiling cellular dynamics: exploring human disease progression and therapeutic potential through organoid models and single-cell technologies. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

Kusch, Anja. The role of H3K27me3 dosage for thymus development and function. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

Richina, Federica. Connecting TDG and active DNA demethylation with chromatin dynamics in mouse embryonic stem cells. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

2022

Auf der Maur, Priska. Identification of resistance mechanisms to PI3K alpha inhibition in breast cancer. 2022, Doctoral Thesis, University of Basel, Faculty of Science.

Richina, Veronica. The effects of tobacco smoke on breast cancer lung metastasis. 2022, Doctoral Thesis, University of Basel, Faculty of Science.

2021

Schwarz, Simon D. TDG-mediated Active DNA Demethylation in the Genome-wide Control of Transcriptional Initiation and Elongation. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

2020

Monogiou Belik, Daria. The role of the cancer kinome in the healthy and injured heart: focus on Flt3 and Plk2. 2020, Doctoral Thesis, University of Basel, Faculty of Science.

2017

Manser, Melissa and Sater, Mohamad R. Abdul and Schmid, Christoph D. and Noreen, Faiza and Murbach, Manuel and Kuster, Niels and Schuermann, David and Schär, Primo. (2017) ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis. Scientific Reports, 7. p. 43345.

2016

Liu, Y. and Duong, W. and Krawczyk, C. and Bretschneider, N. and Borbely, G. and Varshney, M. and Zinser, C. and Schar, P. and Ruegg, J.. (2016) Oestrogen receptor beta regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics Chromatin, 9. p. 7.

Manser, Melissa. Influence of extremely-low-frequency magnetic fields on epigenetic programming and cellular differentiation. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

Schuermann, D. and Scheidegger, S. P. and Weber, A. R. and Bjoras, M. and Leumann, C. J. and Schar, P.. (2016) 3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic Acids Res, 44 (5). pp. 2187-2198.

Schuermann, D. and Weber, A. R. and Schar, P.. (2016) Active DNA demethylation by DNA repair: Facts and uncertainties. DNA Repair (Amst), 44. pp. 92-102.

Weber, A. R. and Krawczyk, C. and Robertson, A. B. and Kusnierczyk, A. and Vagbo, C. B. and Schuermann, D. and Klungland, A. and Schar, P.. (2016) Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun, 7. p. 10806.

2015

Li, Zheng and Gu, Tian-Peng and Weber, Alain R. and Shen, Jia-Zhen and Li, Bin-Zhong and Xie, Zhi-Guo and Yin, Ruichuan and Guo, Fan and Liu, Xiaomeng and Tang, Fuchou and Wang, Hailin and Schär, Primo and Xu, Guo-Liang. (2015) Gadd45a promotes DNA demethylation through TDG. Nucleic Acids Research, 43 (8). pp. 3986-3997.

Weber, Alain. The biochemistry of DNA Oxidation- and repair-mediated active DNA demethylation. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Weis, Stefan. Unravelling molecular mechanisms underlying genetic and epigenetic instabilities in colorectal cancer. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

2014

Krawczyk, C. and Dion, V. and Schär, P. and Fritsch, O.. (2014) Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability. Nucleic Acids Research, 42 (8). pp. 4985-4995.

Krawczyk, Claudia. Novel functional aspects of topoisomerase Top1 and DNA Glycosylase Thp1 in the maintenance of genetic and epigenetic stability in Yeast. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Noreen, Faiza and Röösli, Martin and Gaj, Pawel and Pietrzak, Jakub and Weis, Stefan and Urfer, Patric and Regula, Jaroslaw and Schär, Primo and Truninger, Kaspar. (2014) Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. Journal of the National Cancer Institute, Vol. 106, Iss. 7 , dju161.

Pfaffeneder, T. and Spada, F. and Wagner, M. and Brandmayr, C. and Laube, S. K. and Eisen, D. and Truss, M. and Steinbacher, J. and Hackner, B. and Kotljarova, O. and Schuermann, D. and Michalakis, S. and Kosmatchev, O. and Schiesser, S. and Steigenberger, B. and Raddaoui, N. and Kashiwazaki, G. and Muller, U. and Spruijt, C. G. and Vermeulen, M. and Leonhardt, H. and Schar, P. and Muller, M. and Carell, T.. (2014) Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nature chemical biology, Vol. 10, H. 7. pp. 574-581.

Weber, A. R. and Schuermann, D. and Schär, P.. (2014) Versatile recombinant SUMOylation system for the production of SUMO-modified protein. PLoS ONE, 9 (7). e102157.

Wirz, Annika. Linking active DNA demethylation by Thymine DNA Glycosylase with epigenetic regulation of gene expression. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

2013

Capstick, M. and Schar, P. and Schuermann, D. and Romann, A. and Kuster, N.. (2013) ELF exposure system for live cell imaging. Bioelectromagnetics, Vol. 34, H. 3. pp. 231-239.

Jacobs, Angelika L.. A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Siegrist, Fredy. Transcriptional responses of tumor cell lines to interferon-alpha. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Talhaoui, Ibtissam and Couve, Sophie and Ishchenko, Alexander A. and Kunz, Christophe and Schär, Primo and Saparbaev, Murat. (2013) 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic Acids Research, 41 (2). pp. 912-923.

2012

Jacobs, A. L. and Schar, P.. (2012) DNA glycosylases: in DNA repair and beyond. Chromosoma, Vol. 121, H. 1. pp. 1-20.

Piscuoglio, Salvatore. Identification of novel genetic and prognostic markers in hereditary and sporadic cancer: "two sides of the same coin". 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Wilson, Gareth A. and Dhami, Pawandeep and Feber, Andrew and Cortázar, Daniel and Suzuki, Yuka and Schulz, Reiner and Schär, Primo and Beck, Stephan. (2012) Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. GigaScience, Vol. 1, H. 1 , 3.

2011

Cortázar, Daniel. Identification of a possible role of thymine DNA glycosylase (TDG) in epigenome maintenance. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Cortázar, Daniel and Kunz, Christophe and Selfridge, Jim and Lettieri, Teresa and Saito, Yusuke and MacDougall, Eilidh and Wirz, Annika and Schuermann, David and Jacobs, Angelika L. and Siegrist, Fredy and Steinacher, Roland and Jiricny, Josef and Bird, Adrian and Schär, Primo. (2011) Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, Vol. 470, H. 7334. pp. 419-423.

Filges, Isabel and Kunz, Christophe and Miny, Peter and Boesch, Nemya and Szinnai, Gabor and Wenzel, Friedel and Tschudin, Sibil and Zumsteg, Urs and Heinimann, Karl. (2011) A novel missense mutation in the high mobility group domain of SRY drastically reduces its DNA-binding capacity and causes paternally transmitted 46,XY complete gonadal dysgenesis. Fertility and sterility, 96 (4). pp. 851-855.

Schär, Primo and Fritsch, Olivier. (2011) DNA repair and the control of DNA methylation. Progress in drug research, Vol. 67. pp. 51-68.

2010

Focke, F. and Schuermann, D. and Kuster, N. and Schär, P.. (2010) DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure. Mutation research, Vol. 683, no. 1-2. pp. 74-83.

2009

Kunz, C. and Saito, Y. and Schär, P.. (2009) DNA Repair in mammalian cells: mismatched repair : variations on a theme. Cellular and molecular life sciences, Vol. 66, no. 6. pp. 1021-1038.

Kunz, Christophe and Focke, Frauke and Saito, Yusuke and Schuermann, David and Lettieri, Teresa and Selfridge, Jim and Schär, Primo. (2009) Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biology, Vol. 7, H. 4 , e91.

Menigatti, Mirco and Truninger, Kaspar and Gebbers, J.-O. and Marbet, Urs and Marra, Giancarlo and Schär, Primo. (2009) Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene, Vol. 28, H. 6. pp. 899-909.

Messner, Simon and Schuermann, David and Altmeyer, Matthias and Kassner, Ingrid and Schmidt, Darja and Schär, Primo and Müller, Stefan and Hottiger, Michael O.. (2009) Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. The FASEB Journal, Vol. 23, H. 11. pp. 3978-3989.

2008

Focke, Frauke. Insights into genotoxic effects of electromagnetic fields. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

2007

Cortázar, Daniel and Kunz, Christophe and Saito, Yusuke and Steinacher, Roland and Schär, Primo. (2007) The enigmatic thymine DNA glycosylase. DNA repair, 6 (4). pp. 489-504.

Hardeland, Ulrike and Kunz, Christophe and Focke, Frauke and Szadkowski, Marta and Schär, Primo. (2007) Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2. Nucleic Acids Research, 35 (11). pp. 3859-3867.

Herrmann, Gernot and Kais, Sanja and Hoffbauer, Jan and Shah-Hosseini, Kijwasch and Brüggenolte, Nicole and Schober, Heiko and Fäsi, Margaret and Schär, Primo. (2007) Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism. Nucleic Acids Research, 35 (7). pp. 2321-2332.

Menigatti, Mirco and Pedroni, Monica and Verrone, Anna Maria and Borghi, Francesca and Scarselli, Alessandra and Benatti, Piero and Losi, Lorena and Di Gregorio, Carmela and Schär, Primo and Marra, Giancarlo and Ponz de Leon, Maurizio and Roncucci, Luca. (2007) O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology reports, Vol. 17, no. 6. pp. 1421-1427.

2006

El-Andaloussi, Nazim and Valovka, Taras and Toueille, Magali and Steinacher, Roland and Focke, Frauke and Gehrig, Peter and Covic, Marcela and Hassa, Paul O. and Schär, Primo and Hübscher, Ulrich and Hottiger, Michael O.. (2006) Arginine methylation regulates DNA polymerase beta. Molecular cell, Vol. 22, H. 1. pp. 51-62.

2005

Borys-Brzywczy, Ewa and Arczewska, Katarzyna D. and Saparbaev, Murat and Hardeland, Ulrike and Schär, Primo and Kuzmierek, Jaroszaw T.. (2005) Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. Acta biochimica Polonica, Vol. 52, Nr. 1. pp. 149-165.

Cejka, Petr and Mojas, Nina and Gillet, Ludovic and Schär, Primo and Jiricny, Josef. (2005) Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current biology, Vol. 15, H. 15. pp. 1395-1400.

Lucey, Marie J. and Chen, Dongsheng and Lopez-Garcia, Jorge and Hart, Stephen M. and Phoenix, Fladia and Al-Jehani, Rajai and Alao, John P. and White, Roger and Kindle, Karin B. and Losson, Régine and Chambon, Pierre and Parker, Malcolm G. and Schär, Primo and Heery, David M. and Buluwela, Lakjaya and Ali, Simak. (2005) T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif. Nucleic Acids Research, 33 (19). pp. 6393-6404.

Steinacher, Roland and Schär, Primo. (2005) Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Current biology, Vol. 15, H. 7. pp. 616-623.

Truninger, Kaspar and Menigatti, Mirco and Luz, Judith and Russell, Anna and Haider, Ritva and Gebbers, Jan-Olaf and Bannwart, Fridolin and Yurtsever, Hueseyin and Neuweiler, Joerg and Riehle, Hans-Martin and Cattaruzza, Maria Sofia and Heinimann, Karl and Schär, Primo and Jiricny, Josef and Marra, Giancarlo. (2005) Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology, Vol. 128, H. 5. pp. 1160-1171.

2004

Fleck, Oliver and Schär, Primo. (2004) Translesion DNA synthesis : little fingers teach tolerance. Current biology, Vol. 14, H. 10 , R389-391.

Kunz, Christophe and Schär, Primo. (2004) Meiotic recombination: sealing the partnership at the junction. Current Biology, 14 (22). R962-R964.

Schär, Primo and Fäsi, Margaret and Jessberger, Rolf. (2004) SMC1 coordinates DNA double-strand break repair pathways. Nucleic Acids Research, 32 (13). pp. 3921-3929.

Springer, Burkhard and Sander, Peter and Sedlacek, Ludwig and Hardt, Wolf-Dietrich and Mizrahi, Valerie and Schär, Primo and Böttger, Erik C.. (2004) Lack of mismatch correction facilitates genome evolution in mycobacteria. Molecular Microbiology, Vol. 53, H. 6. pp. 1601-1609.

2003

Chen, Dongsheng and Lucey, Marie J. and Phoenix, Fladia and Lopez-Garcia, Jorge and Hart, Stephen M. and Losson, Régine and Buluwela, Lakjaya and Coombes, R. Charles and Chambon, Pierre and Schär, Primo and Ali, Simak. (2003) T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. Journal of biological chemistry, Vol. 278, H. 40. pp. 38586-38592.

Hardeland, Ulrike and Bentele, Marc and Jiricny, Josef and Schär, Primo. (2003) The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Nucleic Acids Research, 31 (9). pp. 2261-2271.

Kunz, Christophe and Zurbriggen, Karin and Fleck, Oliver. (2003) Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage. Biochemical Journal, 372 (2). pp. 651-660.

Marti, Thomas M. and Kunz, Christophe and Fleck, Oliver. (2003) Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast. Genetics, 164 (2). pp. 457-467.

Wellinger, Ralf Erik and Schär, Primo and Sogo, Jose M.. (2003) Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae. Molecular and cellular biology, Vol. 23, H. 18. pp. 6363-6372.

2002

Hardeland, Ulrike and Steinacher, Roland and Jiricny, Josef and Schär, Primo. (2002) Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. The EMBO Journal, Vol. 21, H. 6. pp. 1456-1464.

Hasan, Sameez and El-Andaloussi, Nazim and Hardeland, Ulrike and Hassa, Paul O. and Bürki, Christine and Imhof, Ralph and Schär, Primo and Hottiger, Michael O.. (2002) Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Molecular cell, Vol. 10, H. 5. pp. 1213-1222.

Marti, Thomas M. and Kunz, Christophe and Fleck, Oliver. (2002) DNA mismatch repair and mutation avoidance pathways. Journal of Cellular Physiology, 191 (1). pp. 28-41.

2001

Hardeland, U. and Bentele, M. and Lettieri, T. and Steinacher, R. and Jiricny, J. and Schär, P.. (2001) Thymine DNA glycosylase. Progress in nucleic acid research and molecular biology, Vol. 68. pp. 235-253.

Hohl, Marcel and Christensen, Olaf and Kunz, Christophe and Naegeli, Hanspeter and Fleck, Oliver. (2001) Binding and repair of mismatched DNA mediated by Rhp14, the fission yeast homologue of human XPA. Journal of Biological Chemistry, 276 (33). pp. 30766-30772.

Kunz, Christophe and Fleck, Oliver. (2001) Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction. Journal of Molecular Biology, 313 (2). pp. 241-253.

Sartori, A. A. and Schär, P. and Fitz-Gibbon, S. and Miller, J. H. and Jiricny, J.. (2001) Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of biological chemistry, Vol. 276, H. 32. pp. 29979-29986.

Schär, Primo. (2001) Spontaneous DNA damage, genome instability, and cancer - when DNA replication escapes control. Cell, Vol. 104, H. 3. pp. 329-332.

Valencia, Maia and Bentele, Marc and Vaze, M. B. and Herrmann, Gernot and Lee, S. E. and Schär, Primo* and Haber, James E*. (2001) NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature, Vol. 414, H. 6864. pp. 666-699.

2000

Hardeland, Ulrike and Bentele, Marc and Jiricny, Josef and Schär, Primo. (2000) Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of biological chemistry, Vol. 275, H. 43. pp. 33449-33456.

1999

Fleck, Oliver and Lehmann, Elisabeth and Schär, Primo and Kohli, Jürg. (1999) Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair. Nature genetics, Vol. 21, H. 3. pp. 314-317.

Marra, Giancaro and Schär, Primo. (1999) Recognition of DNA alterations by the mismatch repair system. The biochemical journal, Vol. 338, Pt. 1. pp. 1-13.

Rudolph, Claudia and Kunz, Christophe and Parisi, Sandro and Lehmann, Elisabeth and Hartsuiker, Edgar and Fartmann, Berthold and Kramer, Wilfried and Kohli, Jürg and Fleck, Oliver. (1999) The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization. Molecular and Cellular Biology, 19 (1). pp. 241-250.

Räschle, M. and Marra, G. and Nyström-Lahti, M. and Schär, P. and Jiricny, J.. (1999) Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of biological chemistry, Vol. 274, H. 45. pp. 32368-32375.

1998

Fleck, Oliver and Kunz, Christophe and Rudolph, Claudia and Kohli, Jürg. (1998) The high mobility group domain protein Cmb1 of Schizosaccharomyces pombe binds to cytosines in base mismatches and opposite chemically altered guanines. Journal of Biological Chemistry, 273 (46). pp. 30398-30405.