Items where Author is "Meyer, U. A."

Article

Scarsi, M. and Podvinec, M. and Roth, A. and Hug, H. and Kersten, S. and Albrecht, H. and Schwede, T. and Meyer, U. A. and Rucker, C.. (2007) Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity : a combined virtual screening and biological assay approach. Molecular pharmacology, Vol. 71, H. 2. pp. 398-406.

Podvinec, M. and Meyer, U. A.. (2006) Prediction of cis-regulatory elements for drug-activated transcription factors in the regulation of drug-metabolising enzymes and drug transporters. Expert Opinion on Drug Metabolism & Toxicology, Vol. 2, H. 3. pp. 367-379.

Gnerre, C. and Schuster, G. U. and Roth, A. and Handschin, C. and Johansson, L. and Looser, R. and Parini, P. and Podvinec, M. and Robertsson, K. and Gustafsson, J. -A. and Meyer, U. A.. (2005) LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8). pp. 1633-1642.

Handschin, C. and Lin, J. and Rhee, J. and Peyer, A. -K. and Chin, S. and Wu, P. -H. and Meyer, U. A. and Spiegelman, B. M.. (2005) Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, Vol. 122, H. 4. pp. 505-515.

Handschin, C. and Meyer, U. A.. (2005) Regulatory network of lipid-sensing nuclear receptors: : roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433 (2). pp. 387-396.

Handschin, C. and Gnerre, C. and Fraser, D. J. and Martinez-Jimenez, C. and Jover, R. and Meyer, U. A.. (2005) Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434 (1). pp. 75-85.

Podvinec, M. and Handschin, C. and Looser, R. and Meyer, U. A.. (2004) Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24). pp. 9127-9132.

Handschin, C. and Blattler, S. and Roth, A. and Looser, R. and Oscarson, M. and Kaufmann, M. R. and Podvinec, M. and Gnerre, C. and Meyer, U. A.. (2004) The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, Vol. 2, H. 1. p. 7.

Handschin, C. and Meyer, U. A.. (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews, 55 (4). pp. 649-673.

Sanyal, S. and Handschin, C. and Podvinec, M. and Song, K. -H. and Kim, H. -J. and Kim, J. -Y. and Seo, Y. -W. and Kim, S. -A. and Kwon, H. -B. and Lee, K. and Kim, W. -S. and Meyer, U. A. and Choi, H. -S.. (2003) Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3). pp. 474-484.

Ourlin, J. -C. and Handschin, C. and Kaufmann, M. and Meyer, U. A.. (2002) A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291 (2). pp. 378-384.

Handschin, C. and Podvinec, M. and Amherd, R. and Looser, R. and Ourlin, J. -C. and Meyer, U. A.. (2002) Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33). pp. 29561-29567.

Meyer, R. P. and Podvinec, M. and Meyer, U. A.. (2002) Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Molecular pharmacology, Vol. 62, H. 5. pp. 1061-1067.

Fraser, D. J. and Podvinec, M. and Kaufmann, M. R. and Meyer, U. A.. (2002) Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). Journal of biological chemistry, Vol. 277 , no. 38. pp. 34717-34726.

Podvinec, M. and Kaufmann, M. R. and Handschin, C. and Meyer, U. A.. (2002) NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, Vol. 16, H. 6. pp. 1269-1279.

Handschin, C. and Podvinec, M. and Stockli, J. and Hoffmann, K. and Meyer, U. A.. (2001) Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, Vol. 15, H. 9. pp. 1571-1585.

Handschin, C. and Podvinec, M. and Looser, R. and Amherd, R. and Meyer, U. A.. (2001) Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4). pp. 681-689.

Handschin, C. and Meyer, U. A.. (2000) A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Journal of Biological Chemistry, 275 (18). pp. 13362-13369.

Handschin, C. and Podvinec, M. and Meyer, U. A.. (2000) CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 20. pp. 10769-10774.

Amherd, R. and Hintermann, E. and Walz, D. and Affolter, M. and Meyer, U. A.. (2000) Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. DNA and cell biology, Vol. 19, H. 11. pp. 697-705.

Brodbeck, D. and Amherd, R. and Callaerts, P. and Hintermann, E. and Meyer, U. A. and Affolter, M.. (1998) Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster : differential expression of two gene products. DNA and cell biology, Vol. 17, H. 7. pp. 621-633.

Marti, U. and Hauri, H. P. and Meyer, U. A.. (1990) Induction of cytochrome P450 by phenobarbital in rat liver visualized by monoclonal antibody immunoelectron microscopy in situ. European journal of cell biology, Vol. 52, H. 2. pp. 193-200.

Zanger, U. M. and Hauri, H. P. and Loeper, J. and Homberg, J. C. and Meyer, U. A.. (1988) Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, H. 21. pp. 8256-8260.

Bonkovsky, H. L. and Hauri, H. P. and Marti, U. and Gasser, R. and Meyer, U. A.. (1985) Cytochrome P450 of small intestinal epithelial cells : Immunochemical characterization of the increase in cytochrome P450 caused by phenobarbital. Gastroenterology, Vol. 88, H. 2. pp. 458-467.

Meier, P. J. and Gasser, R. and Hauri, H. P. and Stieger, B. and Meyer, U. A.. (1984) Biosynthesis of rat liver cytochrome P-450 in mitochondria-associated rough endoplasmic reticulum and in rough microsomes in vivo. Journal of biological chemistry, Vol. 259 , no. 16. pp. 10194-10200.

Minder, E. I. and Meier, P. J. and Müller, H. K. and Minder, C. and Meyer, U. A.. (1984) Bufuralol metabolism in human liver : a sensitive probe for the debrisoquine-type polymorphism of drug oxidation. European Journal of Clinical Investigation, Vol. 14, H. 3. pp. 184-189.

Meier, P. J. and Mueller, H. K. and Dick, B. and Meyer, U. A.. (1983) Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology, Vol. 85, H. 3. pp. 682-692.

Meyer, U. A. and Meier, P. J.. (1982) Klinisch bedeutsame vererbte Unterschiede in der Arzneimittelwirkung. Schweizerische medizinische Wochenschrift, 112, Nr. 19. pp. 666-669.

Meier, P. J. and Fehr, J. and Meyer, U. A.. (1982) Pyridoxine-responsive primary acquired sideroblastic anaemia : in vitro and in vivo effects of vitamin B6 on decreased 5-aminolaevulinate synthase activity. Scandinavian journal of haematology, Vol. 29, H. 5. pp. 421-424.

Gasser, R. and Hauri, H. P. and Meyer, U. A.. (1982) The turnover of cytochrome P450b. FEBS letters, Vol. 147, H. 2. pp. 239-242.

Meier, P. J. and Spycher, M. A. and Meyer, U. A.. (1981) Isolation and characterization of rough endoplasmic reticulum associated with mitochondria from normal rat liver. Biochimica et biophysica acta, Vol. 646, H. 2. pp. 283-297.

Meyer, U. A. and Meier, P. J. and Hirsiger, H. and Giger, U. and Althaus, F. R.. (1980) Induction of drug-metabolizing enzymes by phenobarbitone : structural and biochemical aspects. Ciba Foundation symposium. New series, 76. pp. 101-118.

Meier, P. J. and Spycher, M. A. and Meyer, U. A.. (1978) Isolation of a subfraction of rough endoplasmic reticulum closely associated with mitochondria : evidence for its role in cytochrome P450 synthesis. Experimental cell research, Vol. 111, H. 2. pp. 479-483.

Book Section

Handschin, C. and Meyer, U. A.. (2005) PXR and CAR: more than meets the eye. In: Proceedings of the 15th Int. symposium on microsomes and drug oxidation. Bologna, pp. 17-21.

Handschin, C. and Meyer, U. A.. (2003) The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics. In: Molecular Investigation of Metabolism and Transport of Drugs - from Animal to Human Tissue, 87. Halle (Saale), pp. 205-211.